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1. Full Text Hepatic function imaging using dynamic Gd‐EOB‐DTPA enhanced MRI and pharmacokinetic modeling
by Ning, Jia and Yang, Zhiying and Xie, Sheng and Sun, Yongliang and Yuan, Chun and Chen, Huijun
Magnetic Resonance in Medicine, ISSN 0740-3194, 10/2017, Volume 78, Issue 4, pp. 1488 - 1495
PurposeTo determine whether pharmacokinetic modeling parameters with different output assumptions of dynamic contrast-enhanced MRI (DCE-MRI) using Gd-EOB-DTPA... 
function evaluation | different output assumptions | pharmacokinetic modeling | Gd‐EOB‐DTPA | Gd-EOB-DTPA | FIBROSIS | DIAGNOSIS | INITIAL-EXPERIENCE | TRANSPORTERS | STELLATE CELLS | CONTRAST AGENT | LIVER-FUNCTION TESTS | PERFUSION | SELECTION | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Gadolinium DTPA - therapeutic use | Models, Biological | Humans | Middle Aged | Liver - physiology | Magnetic Resonance Imaging - methods | Adult | Female | Gadolinium DTPA - pharmacokinetics | Male | Aged | Medical examination | Magnetic resonance imaging | Liver | Thrombin | Models | Bilirubin | Blood | Correlation | Feasibility studies | Pharmacology | Bile duct | Goodness of fit | Prothrombin | Biomarkers | Bioindicators | Modelling | Mathematical models | Index Medicus
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2. Full Text Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent
by Radbruch, Alexander and Weberling, Lukas D and Kieslich, Pascal J and Eidel, Oliver and Burth, Sina and Kickingereder, Philipp and Heiland, Sabine and Wick, Wolfgang and Schlemmer, Heinz-Peter and Bendszus, Martin
Radiology, ISSN 0033-8419, 06/2015, Volume 275, Issue 3, pp. 783 - 791
Purpose: To compare changes in signal intensity (SI) ratios of the dentate nucleus (DN) and the globus pallidus (GP) to those of other structures on unenhanced... 
T1-WEIGHTED MR-IMAGES | SPECTROSCOPY | OMNISCAN | STABILITY | HUMAN BONE TISSUE | HYPOTHESIS | CONSEQUENCES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | SIGNAL INTENSITY | Magnetic Resonance Imaging | Globus Pallidus - metabolism | Humans | Middle Aged | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Female | Gadolinium DTPA - pharmacokinetics | Male | Retrospective Studies | Cerebellar Nuclei - metabolism | Meglumine - pharmacokinetics
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3. Full Text Residual or retained gadolinium: Practical implications for radiologists and our patients
by Kanal, Emanuel and Tweedle, Michael F
Radiology, ISSN 0033-8419, 06/2015, Volume 275, Issue 3, pp. 630 - 634
DENTATE NUCLEUS | GD(HP-DO3A) | OMNISCAN | IMAGES | RETENTION | HUMAN BONE TISSUE | CONTRAST | GADODIAMIDE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NEPHROGENIC SYSTEMIC FIBROSIS | SIGNAL INTENSITY | Brain - metabolism | Magnetic Resonance Imaging | Globus Pallidus - metabolism | Gadolinium - pharmacokinetics | Humans | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Female | Gadolinium DTPA - pharmacokinetics | Male | Cerebellar Nuclei - metabolism | Meglumine - pharmacokinetics
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4. Full Text Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA: a pilot study
by Dahlqvist Leinhard, O and Dahlström, N and Kihlberg, J and Sandström, P and Brismar, T B and Smedby, Ö and Lundberg, P and Diagnostikcentrum and Centrum för kirurgi, ortopedi och cancervård and Kirurgi and Röntgenkliniken i Linköping and Radiofysikavdelningen US and Linköpings universitet and Medicinsk radiofysik and Institutionen för klinisk och experimentell medicin and Institutionen för medicin och hälsa and Östergötlands Läns Landsting and Centrum för medicinsk bildvetenskap och visualisering, CMIV and Hälsouniversitetet and Medicinsk radiologi
European Radiology, ISSN 0938-7994, 3/2012, Volume 22, Issue 3, pp. 642 - 653
To develop and evaluate a procedure for quantifying the hepatocyte-specific uptake of Gd-BOPTA and Gd-EOB-DTPA using dynamic contrast-enhanced (DCE) MRI.Ten... 
Dynamic contrast-enhanced MRI | Gadobenate Dimeglumine | Medicine & Public Health | Diagnostic Radiology | Liver | Internal Medicine | Interventional Radiology | Imaging / Radiology | Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid | Pharmacokinetics | Ultrasound | Neuroradiology | RAT LIVERS | QUANTIFICATION | NONALCOHOLIC STEATOHEPATITIS | MODEL | SIGNAL INTENSITY | PHASE | MAGNETIC-RESONANCE | RELAXATION-TIMES | ENHANCED MRI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Prospective Studies | Humans | Liver - metabolism | Middle Aged | Contrast Media - pharmacokinetics | Image Interpretation, Computer-Assisted | Magnetic Resonance Imaging - methods | Organometallic Compounds - pharmacokinetics | Male | Treatment Outcome | Meglumine - analogs & derivatives | Pilot Projects | Analysis of Variance | Spleen - metabolism | Aged, 80 and over | Adult | Female | Gadolinium DTPA - pharmacokinetics | Liver Diseases - diagnosis | Aged | Retrospective Studies | Liver Diseases - metabolism | Meglumine - pharmacokinetics | Rare earth metals | Analysis | Medical and Health Sciences | Gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid – Gadobenate Dimeglumine – Dynamic contrast-enhanced MRI – Pharmacokinetics – Liver | Medicin och hälsovetenskap
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5. Full Text Progressive Increase of T1 Signal Intensity of the Dentate Nucleus on Unenhanced Magnetic Resonance Images Is Associated With Cumulative Doses of Intravenously Administered Gadodiamide in Patients With Normal Renal Function, Suggesting Dechelation
by Errante, Yuri and Cirimele, Vincenzo and Mallio, Carlo Augusto and Di Lazzaro, Vincenzo and Zobel, Bruno Beomonte and Quattrocchi, Carlo Cosimo
Investigative Radiology, ISSN 0020-9996, 10/2014, Volume 49, Issue 10, pp. 685 - 690
OBJECTIVESThe purpose of this study was to assess the association between the serial number of gadolinium-enhanced magnetic resonance imaging (MRI)... 
Cumulative doses | Gadolinium | Signal intensity | Dentate nucleus | Magnetic resonance | Contrast agent | magnetic resonance | CONTRAST AGENTS | cumulative doses | BIODISTRIBUTION | dentate nucleus | contrast agent | signal intensity | T1-WEIGHTED MR-IMAGES | MULTIPLE-SCLEROSIS | OMNISCAN | INJECTION | TRANSMETALATION | HUMAN BONE TISSUE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | GADOLINIUM RETENTION | gadolinium | NEPHROGENIC SYSTEMIC FIBROSIS | Humans | Middle Aged | Brain Neoplasms - pathology | Chelating Agents - chemistry | Contrast Media - pharmacokinetics | Magnetic Resonance Imaging - methods | Male | Cerebellar Nuclei - pathology | Brain Neoplasms - secondary | Chelating Agents - pharmacokinetics | Multiple Sclerosis - pathology | Contrast Media - chemistry | Female | Gadolinium DTPA - pharmacokinetics | Retrospective Studies | Gadolinium DTPA - chemistry
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6. Full Text Quantification and assessment of the chemical form of residual gadolinium in the brain after repeated administration of gadolinium-based contrast agents comparative study in rats
by Frenzel, Thomas and Apte, Chirag and Jost, Gregor and Schöckel, Laura and Lohrke, Jessica and Pietsch, Hubertus
Investigative Radiology, ISSN 0020-9996, 2017, Volume 52, Issue 7, pp. 396 - 404
Objective: Multiple clinical and preclinical studies have reported a signal intensity increase and the presence of gadolinium (Gd) in the brain after repeated... 
Brain tissue extraction | Gadodiamide | Gadolinium brain retention | Gadopentetate | Gadobutrol | Globus pallidus | Gadoterate | Gadolinium-based contrast agents | Dentate nucleus | Chromatography | Gadobenate | gadopentetate | gadolinium-based contrast agents | GADODIAMIDE INJECTION | SAFETY | gadolinium brain retention | MACROCYCLIC-AGENTS | gadoterate | gadobenate | dentate nucleus | gadodiamide | INTRAVENOUS-INJECTION | brain tissue extraction | PHARMACOKINETICS | gadobutrol | chromatography | PLASMA-MASS SPECTROSCOPY | GADOBENATE DIMEGLUMINE | HEALTHY-VOLUNTEERS | globus pallidus | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NEPHROGENIC SYSTEMIC FIBROSIS | Chromatography, Gel - methods | Rats, Wistar | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Rats | Sodium Chloride - administration & dosage | Meglumine - analogs & derivatives | Brain - metabolism | Animals | Contrast Media - administration & dosage | Meglumine - administration & dosage | Gadolinium DTPA - pharmacokinetics | Models, Animal | Gadolinium DTPA - administration & dosage | Chemical Fractionation - methods | Meglumine - pharmacokinetics | Organometallic Compounds - administration & dosage | Original
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7. Full Text Revisiting the Pharmacokinetic Profiles of Gadolinium-Based Contrast Agents: Differences in Long-Term Biodistribution and Excretion
by Lancelot, Eric
Investigative Radiology, ISSN 0020-9996, 11/2016, Volume 51, Issue 11, pp. 691 - 700
OBJECTIVESGadolinium-based contrast agents (GBCAs) have been used for years for magnetic resonance imaging examinations. Because of their rapid blood... 
HIGH-SIGNAL INTENSITY | urine | GD-EOB-DTPA | bone | blood | contrast agent | IMAGING ENHANCEMENT AGENT | T1-WEIGHTED MR-IMAGES | INTRAVENOUS-INJECTION | DENTATE NUCLEUS | GBCA | pharmacokinetics | PLASMA-MASS SPECTROSCOPY | GADOBENATE DIMEGLUMINE | HEALTHY-VOLUNTEERS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | stability | gadolinium | NEPHROGENIC SYSTEMIC FIBROSIS | Gadolinium DTPA - blood | Gadolinium - pharmacokinetics | Humans | Contrast Media - pharmacokinetics | Metabolic Clearance Rate | Reference Values | Tissue Distribution | Gadolinium - urine | Gadolinium DTPA - pharmacokinetics | Models, Animal | Gadolinium - blood | Gadolinium DTPA - urine | Meglumine - blood | Meglumine - urine | Organometallic Compounds - pharmacokinetics | Rats | Heterocyclic Compounds - blood | Animals | Organometallic Compounds - blood | Contrast Media - metabolism | Heterocyclic Compounds - pharmacokinetics | Mice | Heterocyclic Compounds - urine | Organometallic Compounds - urine | Meglumine - pharmacokinetics
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8. Full Text Gd-DTPA-loaded polymer–metal complex micelles with high relaxivity for MR cancer imaging
by Mi, Peng and Cabral, Horacio and Kokuryo, Daisuke and Rafi, Mohammad and Terada, Yasuko and Aoki, Ichio and Saga, Tsuneo and Takehiko, Ishii and Nishiyama, Nobuhiro and Kataoka, Kazunori
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 2, pp. 492 - 500
Abstract Nanodevices for magnetic resonance imaging of cancer were self-assembled to core–shell micellar structures by metal complex formation of K2 PtCl6 with... 
Advanced Basic Science | Dentistry | Magnetic resonance imaging (MRI) | Polymer-metal complex | Drug delivery | Cancer diagnosis | Micelles | SYSTEM | GADOLINIUM | DESIGN | MATERIALS SCIENCE, BIOMATERIALS | CONTRAST AGENTS | ENGINEERING, BIOMEDICAL | VISIBLE DRUG-DELIVERY | MAGNETIC-RESONANCE PROBES | TUMORS | T-1 CONTRAST | Human Umbilical Vein Endothelial Cells | Humans | Contrast Media - pharmacokinetics | Polyethylene Glycols - chemistry | Neoplasms - diagnosis | Coordination Complexes - chemistry | Drug Carriers - chemistry | Tissue Distribution | Magnetic Resonance Imaging | Animals | Contrast Media - administration & dosage | Cell Line, Tumor | Female | Gadolinium DTPA - pharmacokinetics | Gadolinium DTPA - administration & dosage | Mice | Proteins - chemistry | Drugs | Medical colleges | Ethylene glycol | Drug delivery systems | Polyethylene | Biological products | Magnetic resonance imaging | Fluorescence | Chromophores | Vehicles | Cancer
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9. Full Text Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors
by Mi, Peng and Kokuryo, Daisuke and Cabral, Horacio and Kumagai, Michiaki and Nomoto, Takahiro and Aoki, Ichio and Terada, Yasuko and Kishimura, Akihiro and Nishiyama, Nobuhiro and Kataoka, Kazunori
Journal of Controlled Release, ISSN 0168-3659, 01/2014, Volume 174, Issue 1, pp. 63 - 71
Organic–inorganic hybrid nanoparticles with calcium phosphate (CaP) core and PEGylated shell were developed to incorporate magnetic resonance imaging (MRI)... 
Gd-DTPA | Hydrothermal synthesis | Cancer diagnosis | MRI | Calcium phosphate nanoparticles | Block copolymer | GADOLINIUM | COMPLEX | VESICLES | VISIBLE DRUG-DELIVERY | POLYMERIC MICELLES | HYDROXYAPATITE | RELAXIVITY | CHEMISTRY, MULTIDISCIPLINARY | AGENT | SURFACTANT | T-1 | PHARMACOLOGY & PHARMACY | Human Umbilical Vein Endothelial Cells | Neoplasms - metabolism | Nanoparticles - chemistry | Humans | Contrast Media - pharmacokinetics | Biological Availability | Polyethylene Glycols - chemistry | Neoplasms - diagnosis | Drug Carriers - chemistry | Contrast Media - pharmacology | Female | Gadolinium DTPA - pharmacokinetics | Gadolinium DTPA - chemistry | Cell Survival - drug effects | Gadolinium DTPA - pharmacology | Calcium Phosphates - chemistry | Hot Temperature | Drug Carriers - pharmacology | Magnetic Resonance Imaging | Animals | Mice, Nude | Cell Line, Tumor | Contrast Media - chemistry | Drug Carriers - pharmacokinetics | Mice | Nanoparticles | Ethylene glycol | Magnetic resonance imaging | Aspartate | Calcium phosphate | Diagnosis | Permeability | Contrast media | Tumors
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10. Full Text Comparison of Gd(DTPA-BMA) (Omniscan) Versus Gd(HP-DO3A) (ProHance) Relative to Gadolinium Retention in Human Bone Tissue by Inductively Coupled Plasma Mass Spectroscopy
by White, Gregory W and Gibby, Wendell A and Tweedle, Michael F
Investigative Radiology, ISSN 0020-9996, 03/2006, Volume 41, Issue 3, pp. 272 - 278
OBJECTIVE:The objective of this study was to determine the gadolinium (Gd) concentration remaining in human bone tissue after administration of standard... 
GD(HP-DO3A) | ICP-MS | Gadolinium retention | Human bone | Gd(DTPA-BMA) | gadolinium retention | IMAGING CONTRAST AGENTS | TRANSMETALATION | human bone | BIODISTRIBUTION | MICE | RELEASE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Femur Head - metabolism | Humans | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Arthroplasty, Replacement, Hip | Gadolinium | Heterocyclic Compounds - metabolism | Gadolinium DTPA - metabolism | Regression Analysis | Organometallic Compounds - metabolism | Mass Spectrometry | Contrast Media - metabolism | Gadolinium DTPA - pharmacokinetics | Heterocyclic Compounds - pharmacokinetics | Connective Tissue
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11. Full Text T1-Weighted Hypersignal in the Deep Cerebellar Nuclei After Repeated Administrations of Gadolinium-Based Contrast Agents in Healthy Rats: Difference Between Linear and Macrocyclic Agents
by Robert, Philippe and Lehericy, Stéphane and Grand, Sylvie and Violas, Xavier and Fretellier, Nathalie and Idée, Jean-Marc and Ballet, Sébastien and Corot, Claire
Investigative Radiology, ISSN 0020-9996, 08/2015, Volume 50, Issue 8, pp. 473 - 480
OBJECTIVESTo prospectively compare in healthy rats the effect of multiple injections of macrocyclic (gadoterate meglumine) and linear (gadodiamide)... 
signal intensity | magnetic resonance | gadoterate meglumine | deep cerebellar nuclei | cumulative doses | contrast agent | dentate nucleus | gadodiamide | gadolinium | DENTATE NUCLEUS | TRANSMETALATION | DEPOSITION | GLOBUS-PALLIDUS | CONSEQUENCES | BIODISTRIBUTION | MR-IMAGES | GADODIAMIDE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NEPHROGENIC SYSTEMIC FIBROSIS | SIGNAL INTENSITY | Injections, Intravenous | Follow-Up Studies | Contrast Media - pharmacokinetics | Organometallic Compounds - pharmacokinetics | Rats | Cerebellar Nuclei - metabolism | Rats, Sprague-Dawley | Cerebellar Nuclei - drug effects | Magnetic Resonance Imaging | Animals | Contrast Media - administration & dosage | Meglumine - administration & dosage | Female | Gadolinium DTPA - pharmacokinetics | Gadolinium DTPA - administration & dosage | Meglumine - pharmacokinetics | Organometallic Compounds - administration & dosage | Original
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12. Full Text Pharmacokinetics and Imaging Properties of Gd-EOB-DTPA in Patients With Hepatic and Renal Impairment
by Gschwend, Simone and Ebert, Wolfgang and Schultze-Mosgau, Marcus and Breuer, Josy
Investigative Radiology, ISSN 0020-9996, 09/2011, Volume 46, Issue 9, pp. 556 - 566
OBJECTIVES:The purpose of this study was to determine the pharmacokinetics (PKs), imaging properties, and safety of the liver-specific magnetic resonance (MR)... 
hepatic impairment | end-stage renal failure | magnetic resonance imaging | Gd-EOB-DTPA | liver | SAFETY | CONTRAST AGENT | INTRAVENOUS-INJECTION | FOCAL LIVER-LESIONS | GADOBENATE DIMEGLUMINE | HISTOPATHOLOGIC FINDINGS | GADOLINIUM CHELATE | SPIRAL CT | HEALTHY-VOLUNTEERS | GADOXETIC-ACID | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Gadolinium DTPA - adverse effects | Prospective Studies | Risk Assessment | Area Under Curve | Health Status Indicators | Kidney Diseases - pathology | Humans | Middle Aged | Liver Diseases - pathology | Contrast Media - pharmacokinetics | Male | Metabolic Clearance Rate | Young Adult | Regression Analysis | Contrast Media - adverse effects | Magnetic Resonance Imaging - instrumentation | Adolescent | Statistics, Nonparametric | Adult | Female | Gadolinium DTPA - pharmacokinetics | Liver Diseases - metabolism | Kidney Diseases - metabolism
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13. Full Text High signal intensity in globus pallidus and dentate nucleus on unenhanced T1-weighted MR images: Evaluation of two linear gadolinium-based contrast agents
by Ramalho, Joana and Castillo, Mauricio and AlObaidy, Mamdoh and Nunes, Renato H and Ramalho, Miguel and Dale, Brian M and Semelka, Richard C
Radiology, ISSN 0033-8419, 09/2015, Volume 276, Issue 3, pp. 836 - 844
Purpose: To determine if a correlation exists between the number of previous enhanced magnetic resonance (MR) imaging examinations and high signal intensity in... 
GADOTERIDOL | BIODISTRIBUTION | GADODIAMIDE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NEPHROGENIC SYSTEMIC FIBROSIS | Thalamus - metabolism | Humans | Middle Aged | Contrast Media - pharmacokinetics | Magnetic Resonance Imaging - methods | Organometallic Compounds - pharmacokinetics | Male | Thalamus - pathology | Cerebellar Nuclei - pathology | Cerebellar Nuclei - metabolism | Meglumine - analogs & derivatives | Tissue Distribution | Young Adult | Globus Pallidus - metabolism | Adolescent | Aged, 80 and over | Adult | Female | Gadolinium DTPA - pharmacokinetics | Aged | Retrospective Studies | Globus Pallidus - pathology | Longitudinal Studies | Meglumine - pharmacokinetics
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14. Full Text Conversion of arterial input functions for dual pharmacokinetic modeling using Gd‐DTPA/MRI and 18F‐FDG/PET
by Poulin, Eric and Lebel, Réjean and Croteau, Etienne and Blanchette, Marie and Tremblay, Luc and Lecomte, Roger and Bentourkia, M'hamed and Lepage, Martin
Magnetic Resonance in Medicine, ISSN 0740-3194, 03/2013, Volume 69, Issue 3, pp. 781 - 792
Reaching the full potential of magnetic resonance imaging (MRI)‐positron emission tomography (PET) dual modality systems requires new methodologies in... 
arterial input function | rats | MRI | combined MRI‐PET | PET | pharmacokinetic modeling | combined MRI-PET | REFERENCE REGION MODEL | CONTRAST-ENHANCED MRI | DCE-MRI | LUMPED CONSTANT | BREAST-CANCER | BRAIN-TUMOR | POSITRON-EMISSION-TOMOGRAPHY | RAT-BRAIN | SIMULTANEOUS PET/MRI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | FDG PET | Fluorodeoxyglucose F18 - pharmacokinetics | Reproducibility of Results | Radiopharmaceuticals - pharmacokinetics | Glioblastoma - diagnosis | Brain Neoplasms - diagnosis | Image Interpretation, Computer-Assisted - methods | Rats, Inbred F344 | Contrast Media - pharmacokinetics | Magnetic Resonance Imaging - methods | Rats | Brain Neoplasms - blood supply | Positron-Emission Tomography - methods | Brain Neoplasms - metabolism | Animals | Models, Biological | Computer Simulation | Sensitivity and Specificity | Cell Line, Tumor | Gadolinium DTPA - pharmacokinetics | Glioblastoma - metabolism | Models | Medical examination | Glucose | Dextrose | Blood | Rodents
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