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Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 514 - 527
Interleukin-21 (IL-21) has broad actions on T and B cells, but its actions in innate immunity are poorly understood. Here we show that IL-21 induced apoptosis... 
NKT CELLS | HOMEOSTASIS | FOLLICULAR-HELPER-CELLS | HUMAN B-CELLS | STEADY-STATE | INTERLEUKIN-21 | DIFFERENTIATION | IMMUNOLOGY | IMMUNE TOLERANCE | T-CELLS | NEGATIVE REGULATOR | Natural Killer T-Cells - drug effects | Oligonucleotide Array Sequence Analysis | Apoptosis - drug effects | Dendritic Cells - immunology | STAT5 Transcription Factor - immunology | Receptors, Interleukin-21 - genetics | Interferon-gamma - metabolism | CD4-Positive T-Lymphocytes - immunology | Interleukins - genetics | Gene Expression - immunology | STAT3 Transcription Factor - genetics | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Mice, Transgenic | DNA, Intergenic - genetics | Protein Binding - immunology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - genetics | Mice, Knockout | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Galactosylceramides - immunology | Mice | STAT3 Transcription Factor - immunology | Gene Expression - drug effects | Galactosylceramides - pharmacology | DNA-Binding Proteins - deficiency | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Receptors, Interleukin-21 - deficiency | Flow Cytometry | Bcl-2-Like Protein 11 | Natural Killer T-Cells - metabolism | DNA, Intergenic - metabolism | Interleukins - immunology | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Interleukins - pharmacology | Dendritic Cells - metabolism | STAT3 Transcription Factor - metabolism | Proto-Oncogene Proteins - metabolism | Receptors, Interleukin-21 - immunology | Mice, Inbred C57BL | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Membrane Proteins - immunology | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | Animals | Apoptosis - immunology | Interferon-gamma - immunology | CD4-Positive T-Lymphocytes - drug effects | DNA, Intergenic - immunology | Natural Killer T-Cells - immunology | Interleukins | Dendritic cells | Analysis | Genomics | Macrophage colony stimulating factor | Biological response modifiers | T cells | Apoptosis | Cytokines | Genes | Genomes | Kinases | Binding sites | Deoxyribonucleic acid--DNA | apoptosis | dendritic cells | GM-CSF | IL-21
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 566 - 578
Three subsets of invariant natural killer T (iNKT) cells have been identified, NKT1, NKT2, and NKT17, which produce distinct cytokines when stimulated, but... 
ACTIVATION | HOMEOSTASIS | ALPHA-GALACTOSYLCERAMIDE | INVARIANT NKT CELLS | KILLER T-CELLS | ORPHAN RECEPTOR | IMMUNOLOGY | IDENTIFICATION | EXPRESSION | PROGRAM | CUTTING EDGE | Organ Specificity - drug effects | T-Lymphocyte Subsets - immunology | Spleen - immunology | T-Lymphocyte Subsets - cytology | Thymocytes - metabolism | Interferon-gamma - metabolism | Galactosylceramides - pharmacology | Lung - cytology | Organ Specificity - immunology | Liver - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Natural Killer T-Cells - metabolism | Lung - metabolism | Thymus Gland - metabolism | Cytokines - immunology | Cytokines - metabolism | Interleukin-4 - metabolism | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Thymus Gland - cytology | Lymph Nodes - metabolism | Mice, Transgenic | Spleen - cytology | Lymph Nodes - immunology | Lymph Nodes - cytology | Natural Killer T-Cells - classification | Mice, Knockout | Thymocytes - immunology | Interleukin-4 - immunology | Animals | Galactosylceramides - immunology | Spleen - metabolism | Lymphocyte Activation - drug effects | T-Lymphocyte Subsets - metabolism | Interferon-gamma - immunology | Fluorescent Antibody Technique | Mice, Inbred NOD | Thymus Gland - immunology | Liver - cytology | Mice, Inbred BALB C | Lung - immunology | Natural Killer T-Cells - immunology | Cytokines | Biological response modifiers | T cells | Studies | Flow cytometry | Transcription factors | Statistical analysis | Lymphocytes | Rodents | Lipids | T cell receptors | Software | Experiments
Journal Article
Infection and Immunity, ISSN 0019-9567, 03/2014, Volume 82, Issue 3, pp. 937 - 948
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
FUNGAL-INFECTION | INFECTIOUS DISEASES | REPEATED EXPOSURE | DENDRITIC CELLS | ALPHA-GALACTOSYLCERAMIDE | KILLER T-CELLS | ALLERGIC BRONCHOPULMONARY-MYCOSIS | NEOFORMANS INFECTION | IMMUNOLOGY | PROTECTIVE TH1 RESPONSE | PULMONARY CRYPTOCOCCOSIS | ASPERGILLUS-FUMIGATUS CONIDIA | Antigens, CD - immunology | Lung - microbiology | Cryptococcosis - microbiology | Dendritic Cells - immunology | Interleukin-17 - immunology | Cryptococcus neoformans - immunology | Th2 Cells - immunology | Th1 Cells - immunology | Lung Diseases, Fungal - microbiology | Th2 Cells - microbiology | CD4-Positive T-Lymphocytes - immunology | Leukocytes - immunology | Myeloid Cells - immunology | Leukocytes - microbiology | Neutrophils - microbiology | Macrophages - immunology | Macrophages - microbiology | B-Lymphocytes - microbiology | Inflammation - microbiology | CD4-Positive T-Lymphocytes - microbiology | CD8-Positive T-Lymphocytes - microbiology | Lung Diseases, Fungal - immunology | Mice, Inbred C57BL | Neutrophils - immunology | Inflammation - immunology | Cryptococcosis - immunology | Th1 Cells - microbiology | Animals | B-Lymphocytes - immunology | Interferon-gamma - immunology | Dendritic Cells - microbiology | Mice | CD8-Positive T-Lymphocytes - immunology | Lung - immunology | Myeloid Cells - microbiology | Fungal and Parasitic Infections
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2014, Volume 193, Issue 2, pp. 961 - 969
Immunotherapy aiming at enhancing innate and acquired host immunity is a promising approach for cancer treatment. The invariant NKT (iNKT) cell ligand... 
IMMUNITY | ACTIVATION | CANCER-PATIENTS | VIVO | KRN7000 | KILLER T-CELLS | CYTOKINE BIAS | ANTIGEN PRESENTATION | ANERGY | IMMUNOLOGY | TLR LIGANDS | Antigens, CD - immunology | Nanoparticles - chemistry | Minor Histocompatibility Antigens | Antibodies - chemistry | Dendritic Cells - immunology | Lectins, C-Type - immunology | Male | Galactosylceramides - administration & dosage | Neoplasms, Experimental - pathology | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Natural Killer T-Cells - metabolism | Neoplasms, Experimental - immunology | Antibodies - immunology | CD8-Positive T-Lymphocytes - metabolism | Dendritic Cells - metabolism | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell, gamma-delta - metabolism | Mice, Inbred C57BL | Neoplasms, Experimental - therapy | Mice, Transgenic | Receptors, Antigen, T-Cell, gamma-delta - immunology | Antigen Presentation - immunology | Galactosylceramides - chemistry | Receptors, Cell Surface - immunology | CD8 Antigens - immunology | Mice, Knockout | CD8 Antigens - metabolism | Animals | Galactosylceramides - immunology | T-Lymphocytes, Cytotoxic - metabolism | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Nanoparticles - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Drug Delivery Systems - methods | Natural Killer T-Cells - immunology | Tumor Burden - immunology
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 05/2012, Volume 109, Issue 19, pp. E1143 - E1152
Obesity triggers a low-grade systemic inflammation, which plays an important role in the development of obesity-associated metabolic diseases. In searching for... 
Cluster of differentiation 1d | Alpha-galactosylceramide | Glycolipid-reactive T cells | Obesity-induced inflammation | glycolipid-reactive T cells | NKT CELLS | INKT CELLS | GLUCOSE-INTOLERANCE | MULTIDISCIPLINARY SCIENCES | GLYCOLIPID ANTIGENS | INNATE IMMUNE-SYSTEM | FATTY-ACIDS | NONALCOHOLIC STEATOHEPATITIS | DEFICIENT MICE | DANGER SIGNALS | alpha-galactosylceramide | cluster of differentiation 1d | obesity-induced inflammation | ADIPOSE-TISSUE | Adipose Tissue, White - immunology | Antigens, CD1d - immunology | Obesity - immunology | Adipose Tissue, White - metabolism | Lipids - immunology | Male | Dietary Fats - immunology | Galactosylceramides - administration & dosage | Obesity - genetics | Lymphocyte Activation - immunology | Flow Cytometry | Natural Killer T-Cells - metabolism | Dietary Fats - administration & dosage | Inflammation Mediators - metabolism | Antigens, CD1d - genetics | CD8-Positive T-Lymphocytes - metabolism | Female | Macrophages - immunology | Cytokines - immunology | Fatty Liver - genetics | Inflammation Mediators - immunology | Adipose Tissue, White - pathology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Lipids - administration & dosage | Galactosylceramides - physiology | Antigens, CD1d - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Galactosylceramides - immunology | Fatty Liver - immunology | Insulin Resistance - genetics | Inflammation - genetics | Insulin Resistance - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Natural Killer T-Cells - immunology | Biological Sciences | PNAS Plus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1827 - 1832
CD1d-restricted natural killer T (NKT) cells include two major subgroups. The most widely studied are Vα14Jα18⁺ invariant NKT (iNKT) cells that recognize the... 
T lymphocytes | Antigens | Reactivity | Natural killer T cells | Hybridomas | Antigen presenting cells | Lipids | Infections | Phospholipids | T cell antigen receptors | CD1 antigen presentation | Innate immunity | Adaptive immunity | Type II natural killer T cell | SULFATIDE | REPERTOIRE | POPULATION | ACTIVATION | MULTIDISCIPLINARY SCIENCES | DISTINCT | type II natural killer T cell | RECEPTOR | adaptive immunity | CD1 | innate immunity | KILLER T-CELLS | INNATE-LIKE | GLYCOLIPIDS | Hybridomas - metabolism | Corynebacterium glutamicum - genetics | Antigens, CD1d - immunology | Transferases (Other Substituted Phosphate Groups) - genetics | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Transferases (Other Substituted Phosphate Groups) - immunology | Cardiolipins - immunology | Galactosylceramides - metabolism | Receptors, Antigen, T-Cell, alpha-beta - immunology | Corynebacterium glutamicum - metabolism | Transferases (Other Substituted Phosphate Groups) - metabolism | Natural Killer T-Cells - metabolism | Myeloid Differentiation Factor 88 - immunology | Antigens, CD1d - genetics | Bacterial Proteins - immunology | Phospholipids - metabolism | Toll-Like Receptors - metabolism | Mycobacterium tuberculosis - metabolism | Phosphatidylglycerols - metabolism | Macrophages - immunology | Macrophages - microbiology | Cell Line | Antigen-Presenting Cells - metabolism | Mice, Inbred C57BL | Phosphatidylglycerols - immunology | Phospholipids - immunology | Toll-Like Receptors - immunology | Bacterial Proteins - genetics | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Cardiolipins - metabolism | Antigen-Presenting Cells - immunology | Antigens, CD1d - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Galactosylceramides - immunology | Hybridomas - immunology | Bacterial Proteins - metabolism | Mice | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Corynebacterium glutamicum - immunology | Antigens, Bacterial - metabolism | Myeloid Differentiation Factor 88 - metabolism | Natural Killer T-Cells - immunology | Autoimmunity | Killer cells | Antigen receptors, T cell | Receptors | Research | Properties | T cells | Biological Sciences | glycolipids | KazuyoshiKawakami | distinct | Mikrobiologi inom det medicinska området | VictorNizet | population | MoriyaTsuji | cd1 | receptor | Gurdyal S.Besra | Microbiology in the medical area | killer t-cells | innate-like | sulfatide | repertoire | KNizet | VBesra | GSTsuji | activation | Kawakami
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2003, Volume 171, Issue 10, pp. 5140 - 5147
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 05/2008, Volume 3, Issue 5, pp. 304 - 315
Journal Article
Immunity, ISSN 1074-7613, 2007, Volume 27, Issue 4, pp. 597 - 609
Invariant natural killer T (iNKT) cells are a subset of innate lymphocytes that recognize lipid antigens in the context of CD1d and mediate potent immune... 
CELLIMMUNO | DEFENSE | INFECTIONS | RECOGNITION | BIOSYNTHESIS | GLYCOLIPID ANTIGENS | KILLER T-CELLS | MICE | ISOGLOBOTRIHEXOSYLCERAMIDE | IMMUNOLOGY | GALACTOSYLCERAMIDE | INNATE IMMUNITY | Membrane Glycoproteins - metabolism | Coculture Techniques | Dendritic Cells - immunology | RNA, Messenger - analysis | Interferon-gamma - metabolism | Interferon Type I - immunology | Toll-Like Receptor 9 - immunology | Lymphocyte Activation - immunology | T-Lymphocytes - metabolism | Antigens, CD1d | Neoplasms, Experimental - immunology | Toll-Like Receptor 7 - immunology | Interferon Type I - metabolism | Killer Cells, Natural - immunology | Female | Membrane Glycoproteins - immunology | Dendritic Cells - metabolism | Antigens, CD1 - immunology | Toll-Like Receptor 7 - metabolism | Immunotherapy, Adoptive | Acidic Glycosphingolipids - immunology | Mice, Inbred C57BL | Cells, Cultured | Acidic Glycosphingolipids - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Animals | Antigens, CD1 - metabolism | Interferon-gamma - immunology | T-Lymphocytes - immunology | Mice | Killer Cells, Natural - metabolism | Neoplasms, Experimental - metabolism | Toll-Like Receptor 9 - metabolism | Studies | Liver | Melanoma | Lipids | T cell receptors | Software | Autoimmune diseases | Immune system | Killer Cells, Natural | Dendritic Cells | T-Lymphocytes | Lymphocyte Activation | Antigens, CD1 | Toll-Like Receptor 9 | Toll-Like Receptor 7 | Interferon Type I | Life Sciences | Immunology | Interferon Type II | Neoplasms, Experimental | Acidic Glycosphingolipids | Membrane Glycoproteins | RNA, Messenger
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 129, Issue 1, pp. 216 - 227.e6
Journal Article