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1. Full Text Somatostatin receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors
by Kwekkeboom, Dik J and Kam, Boen L and van Essen, Martijn and Teunissen, Jaap J M and van Eijck, Casper H J and Valkema, Roelf and de Jong, Marion and de Herder, Wouter W and Krenning, Eric P
Endocrine-related cancer, ISSN 1351-0088, 3/2010, Volume 17, Issue 1, pp. R53 - R73
Review | Oncology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Humans | Digestive System Neoplasms - radiotherapy | Antineoplastic Agents - therapeutic use | Yttrium Radioisotopes - pharmacokinetics | Octreotide - pharmacokinetics | Digestive System Neoplasms - drug therapy | Gallium Radioisotopes - therapeutic use | Digestive System Neoplasms - diagnostic imaging | Neuroendocrine Tumors - diagnostic imaging | Receptors, Somatostatin - analysis | Organometallic Compounds - therapeutic use | Yttrium Radioisotopes - therapeutic use | Somatostatin - analogs & derivatives | Radiopharmaceuticals - pharmacokinetics | Octreotide - analogs & derivatives | Organometallic Compounds - pharmacokinetics | Treatment Outcome | Clinical Trials as Topic | Combined Modality Therapy | Indium Radioisotopes - pharmacokinetics | Positron-Emission Tomography - methods | Octreotide - therapeutic use | Somatostatin - pharmacokinetics | Peptides, Cyclic - pharmacokinetics | Neuroendocrine Tumors - radiotherapy | Animals | Organotechnetium Compounds - pharmacokinetics | Positron-Emission Tomography - standards | Receptors, Somatostatin - drug effects | Gallium Radioisotopes - pharmacokinetics | Neuroendocrine Tumors - drug therapy | Peptides, Cyclic - therapeutic use | Quality of Life | Indium Radioisotopes - therapeutic use | Somatostatin - therapeutic use | Radiopharmaceuticals - therapeutic use | Index Medicus
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2. Full Text Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides
by Mansi, Rosalba and Wang, Xuejuan and Forrer, Flavio and Kneifel, Stefan and Tamma, Maria-Luisa and Waser, Beatrice and Cescato, Renzo and Reubi, Jean Claude and Maecke, Helmut R
Clinical cancer research, ISSN 1078-0432, 08/2009, Volume 15, Issue 16, pp. 5240 - 5249
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Neoplasms - metabolism | Receptors, Bombesin - agonists | Radioisotopes - pharmacokinetics | Tomography, Emission-Computed, Single-Photon - methods | Receptors, G-Protein-Coupled - metabolism | Humans | Transplantation, Heterologous | Receptors, G-Protein-Coupled - agonists | Gallium Radioisotopes - therapeutic use | Heterocyclic Compounds, 1-Ring - chemistry | Female | Bombesin - chemistry | Oligopeptides - chemistry | Radioisotopes - therapeutic use | Oligopeptides - pharmacokinetics | Cells, Cultured | Indium Radioisotopes - chemistry | Gallium Radioisotopes - chemistry | Indium Radioisotopes - pharmacokinetics | Positron-Emission Tomography - methods | Neoplasms - diagnostic imaging | Receptors, Bombesin - antagonists & inhibitors | Receptors, Bombesin - metabolism | Animals | Mice, Nude | Models, Biological | Receptors, G-Protein-Coupled - antagonists & inhibitors | Gallium Radioisotopes - pharmacokinetics | Indium Radioisotopes - therapeutic use | Mice | Drug Delivery Systems - methods | Radioisotopes - chemistry | Index Medicus
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3. Full Text Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals
by Evans, Brendan J and King, Andrew T and Katsifis, Andrew and Matesic, Lidia and Jamie, Joanne F
Molecules (Basel, Switzerland), ISSN 1420-3049, 05/2020, Volume 25, Issue 10, p. 2314
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Radiopharmaceuticals - pharmacokinetics | Peptidomimetics - chemical synthesis | Carbon Radioisotopes - pharmacokinetics | Humans | Peptides - pharmacokinetics | Rodentia | Half-Life | Gallium Radioisotopes - chemistry | Positron-Emission Tomography - methods | Radiopharmaceuticals - chemical synthesis | Carbon Radioisotopes - chemistry | Animals | Fluorine Radioisotopes - pharmacokinetics | Peptides - chemical synthesis | Cyclization | Peptidomimetics - pharmacokinetics | Gallium Radioisotopes - pharmacokinetics | Protein Processing, Post-Translational | Protein Stability | Fluorine Radioisotopes - chemistry | Methylation | Acylation | Drugs | Nuclear medicine | Biological products | Stability | Peptides | Therapeutic applications | Positron emission | Antibodies | Amino acids | Pharmacology | Fluorides | Bioavailability | Metabolism | Regulatory approval | Proteins | Metabolites | Proteolysis | Tomography | Physiology | Positron emission tomography | Pharmaceuticals | Tumors | Index Medicus | radiopharmaceuticals | peptides | positron emission tomography | metabolic stability | proteolysis
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4. Full Text Comparison Study of [18F]FAl-NOTA-PRGD2, [18F]FPPRGD2, and [68Ga]Ga-NOTA-PRGD2 for PET Imaging of U87MG Tumors in Mice
by Lang, Lixin and Li, Weihua and Guo, Ning and Ma, Ying and Zhu, Lei and Kiesewetter, Dale O and Shen, Baozhong and Niu, Gang and Chen, Xiaoyuan
Bioconjugate chemistry, ISSN 1043-1802, 12/2011, Volume 22, Issue 12, pp. 2415 - 2422
Humans | Oligopeptides - pharmacokinetics | Neoplasms - diagnosis | Gallium Radioisotopes - chemistry | Positron-Emission Tomography - methods | Animals | Fluorine Radioisotopes - pharmacokinetics | Heterocyclic Compounds - chemistry | Cell Line, Tumor | Gallium Radioisotopes - pharmacokinetics | Heterocyclic Compounds - pharmacokinetics | Mice | Fluorine Radioisotopes - chemistry | Oligopeptides - chemistry | Comparative studies | Tomography | Angiogenesis | Peptides | Rodents | Tumors | Index Medicus | Ga-68 | Arg-Gly-Asp (RGD) peptide | integrin αvβ3 | fluorine-aluminum complex | positron emission tomography (PET) | F-18
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5. Full Text Radiometal-labeled anti-VCAM-1 nanobodies as molecular tracers for atherosclerosis – impact of radiochemistry on pharmacokinetics
by Bala, Gezim and Crauwels, Maxine and Blykers, Anneleen and Remory, Isabel and Marschall, Andrea L.J and Dübel, Stefan and Dumas, Laurent and Broisat, Alexis and Martin, Charlotte and Ballet, Steven and Cosyns, Bernard and Caveliers, Vicky and Devoogdt, Nick and Xavier, Catarina and Hernot, Sophie
Biological chemistry, ISSN 1431-6730, 02/2019, Volume 400, Issue 3, pp. 323 - 332
VCAM-1 knock-down mice | mass effect | single-domain antibody fragment | specific activity | molecular imaging | vulnerable plaque | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Vascular Cell Adhesion Molecule-1 - immunology | Single-Domain Antibodies - metabolism | Mice, Inbred C57BL | Molecular Imaging | Mice, Knockout | Single-Domain Antibodies - immunology | Animals | Atherosclerosis - diagnostic imaging | Single-Domain Antibodies - chemistry | Gallium Radioisotopes | Isotope Labeling | Mice | Indium Radioisotopes | Phenotypes | Vascular cell adhesion molecule 1 | Radiolabelling | Organs | Radioisotopes | Pharmacology | Intrabodies | Mimicry | Proteins | Apolipoprotein E | Arteriosclerosis | Atherosclerosis | Radiochemistry | Chelation | In vivo methods and tests | Lesions | Pharmacokinetics | Tracers | Index Medicus
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6. Full Text N-terminal modifications improve the receptor affinity and pharmacokinetics of radiolabeled peptidic gastrin-releasing peptide receptor antagonists: Examples of 68Ga-and 64Cu-labeled peptides for PET imaging
by Gourni, Eleni and Mansi, Rosalba and Jamous, Mazen and Waser, Beatrice and Smerling, Christiane and Burian, Antje and Buchegger, Franz and Reubi, Jean Claude and Maecke, Helmut R
The Journal of nuclear medicine (1978), ISSN 0161-5505, 10/2014, Volume 55, Issue 10, pp. 1719 - 1725
PET imaging | Gastrin-releasing peptide receptor antagonists | Neoplasm Transplantation | Radiopharmaceuticals - pharmacokinetics | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Humans | Peptides - pharmacokinetics | Pancreas - pathology | Positron-Emission Tomography - methods | Copper Radioisotopes - pharmacokinetics | Receptors, Bombesin - antagonists & inhibitors | Calcium - chemistry | Animals | Gallium Radioisotopes - pharmacokinetics | Inhibitory Concentration 50 | Heterocyclic Compounds - pharmacokinetics | Mice | Bombesin - pharmacokinetics | Acetates - pharmacokinetics | Pancreas - diagnostic imaging | Index Medicus
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7. Full Text Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols
by Saatchi, Katayoun and Gelder, Nikolaus and Gershkovich, Pavel and Sivak, Olena and Wasan, Kishor M and Kainthan, Rajesh K and Brooks, Donald E and Häfeli, Urs O
International journal of pharmaceutics, ISSN 0378-5173, 2012, Volume 422, Issue 1, pp. 418 - 427
Stability | Radiolabelling | Gallium-68 | PET imaging | Cardiac imaging | Blood pool imaging | Polymer | Biocompatibility | Gallium-67 | Blood pharmacokinetics and biodistribution | Plasma lipoprotein distribution | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Polymers - administration & dosage | Injections, Intravenous | Molecular Weight | Complement Activation | Gallium Radioisotopes - blood | Humans | Prothrombin Time | Half-Life | Glycerol - administration & dosage | Positron-Emission Tomography | Gallium Radioisotopes - toxicity | Tissue Distribution | Gated Blood-Pool Imaging - methods | Erythrocyte Aggregation - drug effects | Molecular Structure | Glycerol - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Thrombelastography | Cell Survival | Gallium Radioisotopes - administration & dosage | Glycerol - pharmacokinetics | Cells, Cultured | Rats | Radiopharmaceuticals - toxicity | Gallium Radioisotopes - chemistry | Glycerol - toxicity | Rats, Sprague-Dawley | Radiopharmaceuticals - blood | Radiopharmaceuticals - administration & dosage | Animals | Blood Coagulation - drug effects | Partial Thromboplastin Time | Polymers - pharmacokinetics | Polymers - toxicity | Gallium Radioisotopes - pharmacokinetics | Human Umbilical Vein Endothelial Cells - pathology | Polymers - chemistry | Glycerol - blood | Platelet Activation - drug effects | Index Medicus
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8. Full Text Dual SPECT imaging of 111 In and 67 Ga to simultaneously determine in vivo the pharmacokinetics of different radiopharmaceuticals: A quantitative tool in pre-clinical research
by Esquinas, Pedro L and Rodríguez-Rodríguez, Cristina and Esposito, Tullio V. F and Harboe, Jeppe and Bergamo, Marta and Celler, Anna and Saatchi, Katayoun and Sossi, Vesna and Häfeli, Urs O
Physics in medicine & biology, ISSN 0031-9155, 12/2018, Volume 63, Issue 23, p. 235029
Ga-67 | dual-isotope imaging | In-111 | In vivo preclinical studies | Multi-pinhole SPECT | Tomography, Emission-Computed, Single-Photon - methods | Animals | Radiopharmaceuticals - pharmacokinetics | Humans | Gallium Radioisotopes - pharmacokinetics | Image Processing, Computer-Assisted - methods | Indium Radioisotopes - pharmacokinetics | Phantoms, Imaging
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9. Full Text Preclinical Evaluation of NHS-Activated Gold Nanoparticles Functionalized with Bombesin or Neurotensin-Like Peptides for Targeting Colon and Prostate Tumours
by Chilug, Livia Elena and Niculae, Dana and Leonte, Radu Anton and Nan, Alexandrina and Turcu, Rodica and Mustaciosu, Cosmin and Serban, Radu Marian and Lavric, Vasile and Manda, Gina
Molecules (Basel, Switzerland), ISSN 1420-3049, 07/2020, Volume 25, Issue 15, p. 3363
Neoplasm Transplantation | Prostatic Neoplasms - metabolism | Gold - administration & dosage | Receptors, Neurotensin - metabolism | Humans | Peptides - pharmacokinetics | Biological Availability | Male | Positron-Emission Tomography | Colonic Neoplasms - metabolism | Peptides - administration & dosage | Neurokinin B - analogs & derivatives | Neurotensin - chemistry | Prostatic Neoplasms - diagnostic imaging | Bombesin - chemistry | Gold - chemistry | Cell Survival - drug effects | Peptides - chemistry | Gallium Radioisotopes - administration & dosage | Metal Nanoparticles - chemistry | Gallium Radioisotopes - chemistry | HT29 Cells | Gold - pharmacokinetics | Peptide Fragments - chemistry | Receptors, Bombesin - metabolism | Animals | Colonic Neoplasms - diagnostic imaging | Cell Line, Tumor | Gallium Radioisotopes - pharmacokinetics | Cell Proliferation - drug effects | Mice | Neurokinin B - chemistry | Drug carriers | Nuclear medicine | Prostate carcinoma | Peptides | Lung cancer | Radioisotopes | Drug delivery | Nanoparticles | Computed tomography | Bioaccumulation | Polyethylene glycol | Tomography | Colon | Emitters | Labeling | Binding | Gold | Evaluation | Medical imaging | Bombesin | Positron emission | Neurotensin | Pharmacokinetics | Prostate | Positron emission tomography | Tumors | Neuromedin | Index Medicus | neurotensin | drug delivery | PET imaging | gold nanoparticles | 68Ga | bombesin
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10. Full Text Preparation, Characterization, and Radiolabeling of [ 68 Ga]Ga-NODAGA-Pamidronic Acid: A Potential PET Bone Imaging Agent
by Ashhar, Zarif and Yusof, Nor Azah and Ahmad Saad, Fathinul Fikri and Mohd Nor, Siti Mariam and Mohammad, Faruq and Bahrin Wan Kamal, Wan Hamirul and Hassan, Muhammad Hishar and Ahmad Hassali, Hazlina and Al-Lohedan, Hamad A
Molecules (Basel, Switzerland), ISSN 1420-3049, 06/2020, Volume 25, Issue 11, p. 2668
Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Pamidronate - pharmacokinetics | Rats | Acetates - chemistry | Male | Chromatography, High Pressure Liquid | Gallium Radioisotopes - chemistry | Positron-Emission Tomography - methods | Rats, Sprague-Dawley | Tissue Distribution | Animals | Heterocyclic Compounds, 1-Ring - chemistry | Bone and Bones - diagnostic imaging | Bone and Bones - metabolism | Mass Spectrometry | Gallium Radioisotopes - pharmacokinetics | Pamidronate - chemistry | Acetates - pharmacokinetics | Gallium | Renal function | Radiochemical analysis | Radioisotopes | Hydroxyapatite | Bisphosphonates | Metastases | Hydrochloric acid | Tomography | Binding | Spectroscopy | Medical imaging | Radiolabelling | Invasiveness | Positron emission | Mass spectroscopy | Liquid chromatography | High-performance liquid chromatography | Chromatography | Pamidronic acid | Image quality | Bone cancer | Scientific imaging | Bone imaging | Mass spectrometry | Image enhancement | High performance liquid chromatography | Pharmaceuticals | Index Medicus | bone metastases | bisphosphonate | radiopharmaceuticals | positron emitting tomography (PET), contrasting agents | [68Ga]Ga-NODAGA-pamidronic acid | ion suppression
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11. Full Text PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions
by Afshar-Oromieh, A and Afshar-Oromieh, A and Malcher, A and Malcher, A and Eder, M and Eder, M and Eisenhut, M and Eisenhut, M and Linhart, H G and Linhart, H G and Hadaschik, B A and Hadaschik, B A and Holland-Letz, T and Holland-Letz, T and Giesel, F L and Giesel, F L and Kratochwil, C and Kratochwil, C and Haufe, S and Haufe, S and Haberkorn, U and Haberkorn, U and Zechmann, C M and Zechmann, C M
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 4/2013, Volume 40, Issue 4, pp. 486 - 495
PSMA | Medicine & Public Health | Orthopedics | PET/CT | Prostate-specific membrane antigen | Oncology | Nuclear Medicine | Imaging / Radiology | Cardiology | Prostate cancer | Positron emission tomography | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Science & Technology | Edetic Acid - pharmacokinetics | Radiopharmaceuticals - pharmacokinetics | Humans | Middle Aged | Oligopeptides - pharmacokinetics | Glutamate Carboxypeptidase II - analysis | Male | Tomography, X-Ray Computed | Positron-Emission Tomography | Carcinoma - diagnostic imaging | Edetic Acid - analogs & derivatives | Tissue Distribution | Multimodal Imaging | Aged, 80 and over | Gallium Radioisotopes - pharmacokinetics | Prostatic Neoplasms - diagnostic imaging | Ligands | Aged | Antigens, Surface - analysis | Index Medicus | Spleen | Nuclear medicine | Liver | Salivary gland | Cell surface | Kidney | Metastases | Lacrimal gland | Computed tomography | Intestine | Pheochromocytoma cells | prostate carcinoma | Tracers | prostate-specific antigen
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12. Full Text Evaluation of Bifunctional Chelates for the Development of Gallium-Based Radiopharmaceuticals
by Ferreira, Cara L and Lamsa, Eric and Woods, Michael and Duan, Yin and Fernando, Pasan and Bensimon, Corinne and Kordos, Myra and Guenther, Katharina and Jurek, Paul and Kiefer, Garry E
Bioconjugate chemistry, ISSN 1043-1802, 03/2010, Volume 21, Issue 3, pp. 531 - 536
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Multidisciplinary | Science & Technology | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Chelating Agents - chemistry | Organometallic Compounds - pharmacokinetics | Male | Positron-Emission Tomography | Gallium Radioisotopes - chemistry | Mice, Inbred Strains | Radiopharmaceuticals - chemical synthesis | Tissue Distribution | Animals | Chelating Agents - pharmacokinetics | Organometallic Compounds - chemical synthesis | Gallium Radioisotopes - pharmacokinetics | Organometallic Compounds - chemistry | Mice | Molecular Structure | Kinetics | Radioisotopes | Kidneys | Comparative analysis | Tissues | Rodents | Index Medicus
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