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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2018, Volume 28, Issue 23-24, pp. 3658 - 3664
Heat-shock protein 90 (HSP90) is a molecular chaperone that activates oncogenic transformation in several solid tumors, including lung and breast cancers.... 
HSP 90 | Tumor hypoxia | Ganetespib | PET imaging | TNBC breast cancer
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2018, Volume 13, Issue 4, pp. 473 - 474
Journal Article
by Kang, J and Lee, JY and Tas, I and More, KN and Kim, H and Park, JH and Chang, DJ
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 12/2018, Volume 28, Issue 23-24, pp. 3658 - 3664
Heat-shock protein 90 (HSP90) is a molecular chaperone that activates oncogenic transformation in several solid tumors, including lung and breast cancers.... 
HSP 90 | BROAD-SPECTRUM | Ganetespib | CHEMISTRY, MEDICINAL | HEAT-SHOCK-PROTEIN-90 | PET imaging | CHEMISTRY, ORGANIC | Tumor hypoxia | IDENTIFICATION | CANCER | POTENT ANTITUMOR-ACTIVITY | IN-VITRO | TNBC breast cancer | INHIBITOR GANETESPIB | EXHIBITS POTENT | STA-9090 | PROTEINS
Journal Article
Current Oncology, ISSN 1198-0052, 2014, Volume 21, Issue 5, pp. 663 - 667
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2018, Volume 24, Issue 24, pp. 6396 - 6407
Purpose: STA-1474, prodrug of the heat shock protein 90 inhibitor (HSP90i) ganetespib, previously demonstrated activity in canine preclinical models of cancer;... 
PHASE-II TRIAL | 17-ALLYLAMINO | ONCOLOGY | EGF | SHOCK-PROTEIN 90 | KINASE | GROWTH | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | 17-DEMETHOXYGELDANAMYCIN | GANETESPIB | CHAPERONE
Journal Article
Annals of Oncology, ISSN 0923-7534, 05/2018, Volume 29, Issue 5, pp. 1325 - 1328
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2015, Volume 54, Issue 10, pp. 1147 - 1158
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 07/2019, Volume 20, Issue 7, pp. 1035 - 1045
Pharmacological inhibition of PARP is a promising approach in treating high grade serous ovarian carcinoma (HGSOC). PARP inhibitors (PARPi) are most active in... 
targeted therapy | HSP90 inhibitor | PARP inhibitor | Ovarian cancer | GANETESPIB | AUTOPHAGY | TUMORS | BREAST-CANCER | OLAPARIB | REPAIR | ONCOLOGY | RESISTANCE | ATM
Journal Article
American journal of clinical oncology, ISSN 0277-3732, 8/2018, Volume 41, Issue 8, pp. 772 - 776
Journal Article
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7560, pp. 352 - 356
Journal Article
CANCER, ISSN 0008-543X, 12/2017, Volume 123, Issue 24, pp. 4924 - 4933
BACKGROUNDHeat shock protein 90 (HSP90) and the ubiquitin-proteasome pathway play crucial roles in the homeostasis of pancreatic cancer cells. This study... 
SYSTEM | proteasome | HSP90 INHIBITOR | ER STRESS | carfilzomib | MECHANISMS | ENDOPLASMIC-RETICULUM STRESS | AUTOPHAGY | INDUCTION | ganetespib | pancreatic cancer | ONCOLOGY | heat shock protein 90 (HSP90) | GROWTH | RESISTANCE
Journal Article
Endocrine-related cancer, ISSN 1351-0088, 02/2019, Volume 26, Issue 4, pp. 437 - 449
177Lu-octreotate is an FDA-approved radionuclide therapy for patients with gastroenteropancreatic neuroendocrine tumours (NETs) expressing somatostatin... 
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 08/2017, Volume 16, Issue 8, pp. 1658 - 1668
a A subset of non-small cell lung cancers (NSCLC) are dependent upon oncogenic driver mutations, including the most frequently observed driver mutant KRAS,... 
CELL LUNG-CANCER | BRAF-MUTATED MELANOMA | IN-VITRO | ONCOLOGY | EGG EXTRACTS | HSP90 INHIBITOR GANETESPIB | PHASE-II | CDC25 PHOSPHATASES | ACUTE MYELOID-LEUKEMIA | RSK FAMILY | KINASES
Journal Article
Cancer Discovery, ISSN 2159-8274, 04/2013, Volume 3, Issue 4, pp. 430 - 443
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 01/2019, Volume 106, pp. 35 - 45
Although microglial reaction to heat shock is considered to be protective, heat shock is still a potential hazard caused by high temperatures. Recent studies... 
HSP90 | Ganetespib | N9 microglia | Pro-inflammatory response | Heat shock | CELLS | TRANSCRIPTIONAL ACTIVATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | STAT3 | INVOLVEMENT | INDUCTION | CELL BIOLOGY | GELDANAMYCIN | PROTEIN 90 | STRESS | EXPRESSION | Index Medicus
Journal Article
American Journal of Clinical Oncology: Cancer Clinical Trials, ISSN 0277-3732, 08/2018, Volume 41, Issue 8, pp. 772 - 776
Objectives: Heat shock protein 90 regulates multiple signaling proteins involved in key pathways of pancreatic cancer pathogenesis. Ganetespib binds to heat... 
ganetespib | pancreatic cancer | phase II clinical trial | Heat shock protein 90 | HSP90 INHIBITOR | STATISTICS | PROTEIN 90 INHIBITOR | COMBINATION | GEMCITABINE | POTENT ANTITUMOR-ACTIVITY | ONCOLOGY | PATHWAY | STA-9090 | heat shock protein 90 | Index Medicus
Journal Article
ENDOCRINE-RELATED CANCER, ISSN 1351-0088, 04/2019, Volume 26, Issue 4, pp. 437 - 449
Journal Article
Journal Article
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