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EUROPEAN JOURNAL OF IMMUNOLOGY, ISSN 0014-2980, 04/2018, Volume 48, Issue 4, pp. 584 - 592
The pro-inflammatory cytokine IL-1 is well known for its role in host defense and the initiation of potent inflammatory responses. It is processed from its... 
RAT-LIVER | Interleukin-1 | Pyroptosis | IL-1-BETA SECRETION | INFLAMMATORY DISEASES | Gasdermin-D pore | MACROPHAGES | INTERLEUKIN-1-BETA SECRETION | Inflammasome | IMMUNOLOGY | CELL-DEATH | FAMILY | PATHOGENESIS | Unconventional protein secretion | CASPASE-11 | Proteins | Permeability | Interleukins | Dendritic cells | Cell death
Journal Article
Cell Reports, ISSN 2211-1247, 08/2018, Volume 24, Issue 6, pp. 1425 - 1433
IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages... 
pyroptosis | unconventional protein secretion | interleukin-1 | inflammasome | macrophage | gasdermin | caspase-1 | neutrophil | trafficking | phosphoinositides | ACTIVATION | MACROPHAGES | MONOCYTES | RECEPTOR | PORE FORMATION | IL-1-BETA | NLRP3 INFLAMMASOME | RELEASE | CASPASE-11 | PYROPTOTIC CELL-DEATH | CELL BIOLOGY
Journal Article
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 9, pp. 2671 - 2693
Journal Article
The EMBO journal, 07/2018, Volume 37, Issue 14
Gasdermin-D (GSDMD), a member of the gasdermin protein family, mediates pyroptosis in human and murine cells. Cleaved by inflammatory caspases, GSDMD inserts... 
Recombinant Proteins - metabolism | Caspases - metabolism | Humans | Protein Multimerization | Microscopy, Atomic Force | Liposomes - metabolism | Cell Membrane - metabolism | Recombinant Proteins - genetics | Neoplasm Proteins - genetics | Neoplasm Proteins - metabolism | Time-Lapse Imaging | Protein Transport
Journal Article
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 12/2018, Volume 14, Issue 12, pp. 690 - 692
Journal Article
Journal Article
Structure, ISSN 0969-2126, 05/2018, Volume 26, Issue 5, pp. 778 - 784.e3
Pyroptosis is an inflammatory form of programmed cell death that plays important roles in immune protection against infections and in inflammatory disorders.... 
Salmonella infection | crystal structure | pyroptosis | gasdermin D | autoinhibition | inflammasome | GSDMD | CASPASE-1 | INFLAMMASOME ACTIVATION | CRYSTAL-STRUCTURE | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PORE FORMATION | PYROPTOSIS | MODEL | DRIVEN | CLEAVAGE | CELL BIOLOGY | BIOPHYSICS | Physiological aspects | Structure | Cell death | Crystals
Journal Article
Kidney International, ISSN 0085-2538, 11/2019, Volume 96, Issue 5, pp. 1105 - 1120
Inflammation and tubular cell death are the hallmarks of acute kidney injury. However, the precise mechanism underlying these effects has not been fully... 
caspase-11 | acute kidney injury | gasdermin D | interleukin-18 | GSDMD | APOPTOSIS | ACTIVATION | MINCLE | RECEPTOR | INHIBITION | UROLOGY & NEPHROLOGY | INFLAMMATORY CASPASES | MICE | STEATOHEPATITIS
Journal Article