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Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 209, pp. 209ra151 - 209ra151
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones... 
MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | GLYCEMIC CONTROL | HIGH-FAT DIET | GLUCOSE-INTOLERANCE | ENTEROINSULAR AXIS | PANCREATIC BETA-CELLS | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | LIPOPROTEIN-LIPASE | PEPTIDE YY3-36 | CELL BIOLOGY | Acylation - drug effects | Glucagon-Like Peptide 1 - administration & dosage | Humans | Middle Aged | Male | Rodentia - metabolism | Weight Loss - drug effects | Hyperglycemia - drug therapy | Young Adult | Incretins - pharmacology | Adult | Female | Gastric Inhibitory Polypeptide - pharmacology | Receptors, Glucagon - agonists | Glucose Tolerance Test | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Rats | Receptors, Glucagon - metabolism | Treatment Outcome | Haplorhini - metabolism | Gastric Inhibitory Polypeptide - administration & dosage | Peptides - pharmacology | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Adolescent | Aged | Mice | Venoms - pharmacology | Incretins - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Gastrointestinal Hormone | Incretins - administration & dosage | Liraglutide | Index Medicus | Medicin och hälsovetenskap | Medicinsk bioteknologi (inriktn. mot cellbiologi (inkl. stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 11/2014, Volume 99, Issue 11, pp. E2325 - E2329
Journal Article
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2013, Volume 369, Issue 22, pp. 2115 - 2125
Journal Article
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 12/2007, Volume 293, Issue 6, pp. 1746 - 1755
The gut hormone gastric inhibitory polypeptide (GIP) plays a key role in glucose homeostasis and lipid metabolism. This study investigated the effects of... 
Gastric inhibitory polypeptide | High-fat feeding | Antagonist | CAFETERIA DIETS | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | gastric inhibitory polypeptide | LIPOPROTEIN-LIPASE ACTIVITY | GLUCOSE-INTOLERANCE | HYPERGLYCEMIC OB/OB MICE | antagonist | high-fat feeding | DIABETES-MELLITUS | BODY-WEIGHT | ENDOCRINOLOGY & METABOLISM | PLASMA-GLUCOSE | GASTRIC-INHIBITORY POLYPEPTIDE | RAT ADIPOSE-TISSUE | Glucose Intolerance - metabolism | Incretins - blood | Obesity - drug therapy | Gastric Inhibitory Polypeptide - therapeutic use | Body Weight - drug effects | Motor Activity - drug effects | Glucagon-Like Peptide 1 - blood | Male | Muscle, Skeletal - metabolism | Insulin - blood | Glucagon - blood | Anti-Obesity Agents - therapeutic use | Glucose Intolerance - blood | Adipokines - blood | Adipose Tissue - metabolism | Liver - drug effects | Dietary Fats - pharmacology | Insulin Resistance - physiology | Lipids - blood | Muscle, Skeletal - drug effects | Dietary Fats - administration & dosage | Corticosterone - blood | Gastric Inhibitory Polypeptide - pharmacology | Insulin - pharmacology | Liver - metabolism | Pancreas - drug effects | Pancreas - metabolism | Obesity - metabolism | Obesity - pathology | Receptors, Gastrointestinal Hormone - antagonists & inhibitors | Eating - drug effects | Insulin - metabolism | Animals | Mice | Lipids - analysis | Blood Glucose - metabolism | Adipose Tissue - drug effects | Anti-Obesity Agents - pharmacology | Obesity | Peptides | Diet | Rodents | Oils & fats | Hormones | Diabetes | Insulin | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 09/2011, Volume 60, Issue 9, pp. 2424 - 2433
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 01/2018, Volume 20, Issue 1, pp. 60 - 68
AimTo investigate the effects of the novel glucose-dependent insulinotropic polypeptide (GIP) analogue, ZP4165, on body weight and glycaemic control in... 
GLP | glycaemic control | diabetes | HbA | obesity | GIP | GLP-1 | HbA1c | RAT | AMIDE | PEPTIDE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | DEPENDENT INSULINOTROPIC POLYPEPTIDE | FAT-FED MICE | GASTRIC-INHIBITORY POLYPEPTIDE | RECEPTORS | AGONIST | Anti-Obesity Agents - blood | Gastric Inhibitory Polypeptide - pharmacokinetics | Obesity - drug therapy | Gastric Inhibitory Polypeptide - therapeutic use | Humans | Half-Life | Male | Diabetes Mellitus, Type 2 - metabolism | Weight Loss - drug effects | Receptors, Gastrointestinal Hormone - metabolism | Obesity - blood | Receptors, Gastrointestinal Hormone - agonists | Anti-Obesity Agents - therapeutic use | Glucagon-Like Peptide-1 Receptor - genetics | Hypoglycemic Agents - blood | Glucagon-Like Peptide-1 Receptor - metabolism | Anti-Obesity Agents - pharmacokinetics | Liraglutide - pharmacology | Mice, Mutant Strains | Drug Design | HEK293 Cells | Incretins - pharmacology | Drug Therapy, Combination | Gastric Inhibitory Polypeptide - pharmacology | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - genetics | Recombinant Proteins - metabolism | Hyperglycemia - prevention & control | Hypoglycemic Agents - pharmacokinetics | Mice, Inbred C57BL | Receptors, Glucagon - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Rats, Sprague-Dawley | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Diabetes Mellitus, Type 2 - blood | Animals | Liraglutide - therapeutic use | Receptors, Gastrointestinal Hormone - genetics | Incretins - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Anti-Obesity Agents - pharmacology | Gastric Inhibitory Polypeptide - analogs & derivatives | Glucagon-Like Peptide-1 Receptor - agonists | Type 2 diabetes | Obesity | Control | Glucagon | Rodents | Body weight | Weight loss | Glycosylated hemoglobin | Glucose | Glucose tolerance tests | Dextrose | Diabetes mellitus | Body weight loss | GIP protein | Studies | Glucose tolerance | Weight control | Hemoglobin | Diabetes | Glucagon-like peptide 1 | Long-term effects | Index Medicus
Journal Article
Journal Article