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1. Full Text Airway reflux
by Johnston, Nikki and Ondrey, Frank and Rosen, Rachel and Hurley, Bryan P and Gould, Jon and Allen, Jacquie and DelGaudio, John and Altman, Kenneth W
Annals of the New York Academy of Sciences, ISSN 0077-8923, 10/2016, Volume 1381, Issue 1, pp. 5 - 13
An ever‐increasing number of adult and pediatric disorders have been shown to be influenced or caused by airway reflux. This has become a controversial and... 
surgical approaches | airway | reflux | therapeutic approaches | laryngopharyngeal reflux (LPR) | extraesophageal reflux (EER) | pepsin | POSTNASAL DRIP | EXTRAESOPHAGEAL REFLUX | COUGH HYPERSENSITIVITY SYNDROME | LARYNGEAL | ATPASE PROTON PUMP | IMPEDANCE | FUNDOPLICATION | GASTROENTEROLOGY & HEPATOLOGY | LARYNGOPHARYNGEAL REFLUX | BILE-ACIDS | Biomarkers - metabolism | Gastroesophageal Reflux - metabolism | Sinusitis - metabolism | Laryngoscopy - methods | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring - methods | Sinusitis - diagnosis | Humans | Pepsin A - metabolism | Proton Pump Inhibitors - therapeutic use | Laryngopharyngeal Reflux - drug therapy | Animals | Gastroesophageal Reflux - drug therapy | Sinusitis - drug therapy | Laryngopharyngeal Reflux - diagnosis | Laryngopharyngeal Reflux - metabolism | Respiratory tract | Surgery | Disorders | Pepsin | In vitro testing | In vivo methods and tests | Tissues | Bile
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2. Full Text The acid pocket: A target for treatment in reflux disease
by Kahrilas, Peter J and McColl, Kenneth and Fox, Mark and O'Rourke, Lisa and Sifrim, Daniel and Smout, Andre J.P.M and Boeckxstaens, Guy
American Journal of Gastroenterology, ISSN 0002-9270, 07/2013, Volume 108, Issue 7, pp. 1058 - 1064
The nadir esophageal pH of reflux observed during pH monitoring in the postprandial period is often more acidic than the concomitant intragastric pH. This... 
PRESSURE | GASTROESOPHAGEAL-REFLUX | SQUAMOCOLUMNAR JUNCTION | HIATUS-HERNIA | ESOPHAGEAL SPHINCTER RELAXATIONS | GASTRIC-SECRETION | GASTROENTEROLOGY & HEPATOLOGY | SODIUM ALGINATE | STOMACH | EXPOSURE | Gastroesophageal Reflux - metabolism | Alginates - therapeutic use | Humans | Gastroesophageal Reflux - etiology | Hernia, Hiatal - complications | Proton Pump Inhibitors - therapeutic use | Antacids - therapeutic use | Esophagogastric Junction | Gastric Acid - secretion | Magnetic Resonance Imaging | Gastric Acidity Determination | Postprandial Period | Gastroesophageal Reflux - drug therapy
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3. Full Text Gastroesophageal Reflux Might Cause Esophagitis Through a Cytokine-Mediated Mechanism Rather Than Caustic Acid Injury
by Souza, Rhonda F and Huo, Xiaofang and Mittal, Vivek and Schuler, Christopher M and Carmack, Susanne W and Zhang, Hui Ying and Zhang, Xi and Yu, Chunhua and Hormi–Carver, Kathy and Genta, Robert M and Spechler, Stuart J
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 5, pp. 1776 - 1784
Background & Aims Reflux esophagitis is believed to be caused by the caustic effects of refluxed gastric acid on esophageal epithelial cells. However, caustic... 
Gastroenterology and Hepatology | MUCOSA | PATHOGENESIS | GERD | EPITHELIAL-CELLS | DISEASE | GENE-EXPRESSION | BARRETTS-ESOPHAGUS | MODEL | GASTROENTEROLOGY & HEPATOLOGY | INTERLEUKIN-8 | PATHOPHYSIOLOGY | Cell Line | Gastroesophageal Reflux - metabolism | Bile Acids and Salts - pharmacology | Epithelial Cells - metabolism | Cytokines - metabolism | Esophagitis, Peptic - etiology | Epithelial Cells - drug effects | Gastroesophageal Reflux - pathology | Humans | Rats | Male | Esophagitis, Peptic - metabolism | Rats, Sprague-Dawley | Gastrointestinal Agents - pharmacology | Animals | Esophagitis, Peptic - pathology | Gastroesophageal Reflux - complications | Chemotaxis, Leukocyte - drug effects | Esophagostomy | Duodenostomy | Cell Culture Techniques | Disease Models, Animal | Animal experimentation | Gastroesophageal reflux | Esophagitis | Analysis
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4. Full Text The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD
by Beaumont, Hanneke and Bennink, Roelof J and de Jong, Jan and Boeckxstaens, Guy E
Gut, ISSN 0017-5749, 04/2010, Volume 59, Issue 4, pp. 441 - 451
IntroductionGastro-oesophageal reflux occurs twice as much during transient lower oesophageal sphincter relaxations (TLOSRs) in patients with... 
HIATAL-HERNIA SIZE | GASTROESOPHAGEAL-REFLUX | SQUAMOCOLUMNAR JUNCTION | GASTRIC DISTENSION | HIGH-RESOLUTION MANOMETRY | HIGH-PRESSURE ZONE | DISEASE | LOWER ESOPHAGEAL SPHINCTER | RELAXATION | ESOPHAGOGASTRIC JUNCTION | GASTROENTEROLOGY & HEPATOLOGY | Gastroesophageal Reflux - metabolism | Humans | Middle Aged | Risk Factors | Esophagogastric Junction - metabolism | Gastroesophageal Reflux - etiology | Hernia, Hiatal - metabolism | Hernia, Hiatal - complications | Male | Postprandial Period - physiology | Esophagogastric Junction - diagnostic imaging | Gastroesophageal Reflux - diagnostic imaging | Young Adult | Gastric Acidity Determination | Radionuclide Imaging | Sodium Pertechnetate Tc 99m | Adult | Female | Aged | Gastric Acid - metabolism | Radiopharmaceuticals | Manometry - methods | Gastroesophageal reflux | Complications and side effects | Hiatal hernia | Esophagogastric junction | Physiological aspects | Research | Gastric acid | Risk factors | Studies | Stomach | Acids | Pathogenesis | Hernias
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5. Full Text Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro‐oesophageal reflux disease
by Zerbib, F and Bruley des Varannes, S and Roman, S and Tutuian, R and Galmiche, J.‐P and Mion, F and Tack, J and Malfertheiner, P and Keywood, C
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 04/2011, Volume 33, Issue 8, pp. 911 - 921
Aliment Pharmacol Ther 2011; 33: 911–921 Summary Background  ADX10059, a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator, has been... 
ACID | EFFICACY | GABA(B) AGONIST BACLOFEN | TOLERABILITY | CONSENSUS | PROTON PUMP INHIBITORS | PHARMACOLOGY & PHARMACY | ESOPHAGEAL SPHINCTER RELAXATIONS | NEGATIVE ALLOSTERIC MODULATOR | RECEPTORS | GASTROENTEROLOGY & HEPATOLOGY | PH-IMPEDANCE | Allosteric Regulation - drug effects | Gastroesophageal Reflux - metabolism | Double-Blind Method | Proton Pump Inhibitors | Receptors, Metabotropic Glutamate - administration & dosage | Esophageal pH Monitoring | Humans | Middle Aged | Male | Treatment Outcome | Heartburn - drug therapy | Randomized Controlled Trials as Topic | Postprandial Period | Receptor, Metabotropic Glutamate 5 | Adult | Female | Aged | Gastroesophageal Reflux - drug therapy | Heartburn - metabolism | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Hydrogen-Ion Concentration | Gastroesophageal reflux | Complications and side effects | Sleep disorders | Gastrointestinal diseases | Clinical trials | Proton pump inhibitors | Amino acids | Glutamate | Antacids
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6. Full Text Control of Gastric Acid Secretion in Health and Disease
by Schubert, Mitchell L and Peura, David A
Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 7, pp. 1842 - 1860
Recent milestones in the understanding of gastric acid secretion and treatment of acid-peptic disorders include the (1) discovery of histamine H2 -receptors... 
Gastroenterology and Hepatology | RABBIT PARIETAL-CELLS | PERFUSED RAT STOMACH | COMMUNITY-ACQUIRED PNEUMONIA | ATRIAL-NATRIURETIC-PEPTIDE | HELICOBACTER-PYLORI INFECTION | GASTROESOPHAGEAL-REFLUX DISEASE | PROTON PUMP INHIBITORS | ENTEROCHROMAFFIN-LIKE CELLS | SOMATOSTATIN RECEPTOR SCINTIGRAPHY | GASTROENTEROLOGY & HEPATOLOGY | GLYCINE-EXTENDED GASTRINS | Gastrointestinal Diseases - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Acetylcholine - metabolism | Stomach - metabolism | Gastric Mucosa - metabolism | Gastrointestinal Diseases - microbiology | Gastric Acid - secretion | Histamine - metabolism | Helicobacter pylori | Gastrointestinal Diseases - drug therapy | Helicobacter Infections - metabolism | Duodenal Ulcer - metabolism | Stomach - innervation | Stomach - drug effects | Somatostatin - metabolism | Helicobacter Infections - physiopathology | Anti-Ulcer Agents - therapeutic use | Eating | Proton Pump Inhibitors - adverse effects | Gastroesophageal Reflux - metabolism | Stomach Ulcer - metabolism | H(+)-K(+)-Exchanging ATPase - metabolism | Paracrine Communication | Anti-Ulcer Agents - adverse effects | Histamine H2 Antagonists - adverse effects | Digestion | Duodenal Ulcer - physiopathology | Gastrins - metabolism | Proton Pump Inhibitors - therapeutic use | Histamine H2 Antagonists - therapeutic use | Stomach Ulcer - physiopathology | Animals | Gastrointestinal Diseases - metabolism | Ion Channels - metabolism | Gastric Mucosa - secretion | Stomach - enzymology | Stomach - microbiology | Gastroesophageal reflux | Polypeptides | Gastrin
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7. Full Text Nonerosive reflux disease: clinical concepts
by Gyawali, C. Prakash and Azagury, Dan E and Chan, Walter W and Chandramohan, Servarayan M and Clarke, John O and Bortoli, Nicola and Figueredo, Edgar and Fox, Mark and Jodorkovsky, Daniela and Lazarescu, Adriana and Malfertheiner, Peter and Martinek, Jan and Murayama, Kenric M and Penagini, Roberto and Savarino, Edoardo and Shetler, Katerina P and Stein, Ellen and Tatum, Roger P and Wu, Justin
Annals of the New York Academy of Sciences, ISSN 0077-8923, 12/2018, Volume 1434, Issue 1, pp. 290 - 303
Esophageal symptoms can arise from gastroesophageal reflux disease (GERD) as well as other mucosal and motor processes, structural disease, and functional... 
ambulatory reflux monitoring | esophageal manometry | proton pump inhibitors | antireflux surgery | nonerosive reflux disease | Proton pump inhibitors | Ambulatory reflux monitoring | Esophageal manometry | Nonerosive reflux disease | Antireflux surgery | MULTIDISCIPLINARY SCIENCES | ESOPHAGEAL PH-IMPEDANCE | BASE-LINE IMPEDANCE | PROTON-PUMP INHIBITORS | GASTROESOPHAGEAL-REFLUX | HIGH-RESOLUTION MANOMETRY | ESOPHAGOGASTRIC JUNCTION | IDIOPATHIC PULMONARY-FIBROSIS | EARLY ALLOGRAFT INJURY | FUNCTIONAL HEARTBURN | Gastroesophageal Reflux - metabolism | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring - methods | Esophagogastric Junction - physiopathology | Gastroesophageal Reflux - physiopathology | Humans | Esophagogastric Junction - metabolism | Esophagoscopy - methods | Manometry - methods | Gastroesophageal reflux | Therapy | Mucosa | Esophagitis | Management | pH effects | Esophagus | Endoscopes | Acids | Hernias | Surgery | Physiological tests | pH | Differential diagnosis | Endoscopy | Diagnosis | Monitoring | Structure-function relationships
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8. Full Text Pepsin: biomarker, mediator, and therapeutic target for reflux and aspiration
by Johnston, Nikki and Dettmar, Peter W and Ondrey, Frank G and Nanchal, Rahul and Lee, Sang‐Hyuk and Bock, Jonathan M
Annals of the New York Academy of Sciences, ISSN 0077-8923, 12/2018, Volume 1434, Issue 1, pp. 282 - 289
Extra‐esophageal reflux is suspected to cause a wide range of clinical symptoms in the upper airways. Diagnosis and treatment has focused on acid, but... 
therapeutics | reflux | carcinogenesis | inflammation | airway | pepsin | Reflux | Inflammation | Pepsin | Airway | Carcinogenesis | Therapeutics | DIAGNOSIS | MULTIDISCIPLINARY SCIENCES | MECHANICAL VENTILATION | SYMPTOMS | PANTOPRAZOLE | LARYNGEAL | LARYNGITIS | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | LARYNGOPHARYNGEAL REFLUX | BILE-ACIDS | Biomarkers - metabolism | Gastroesophageal Reflux - therapy | Pneumonia, Aspiration - diagnosis | Gastroesophageal Reflux - metabolism | Gastroesophageal Reflux - complications | Gastroesophageal Reflux - diagnosis | Humans | Pneumonia, Aspiration - metabolism | Pepsin A - metabolism | Pneumonia, Aspiration - etiology | Pneumonia, Aspiration - therapy | Respiratory tract | Acids | Therapeutic applications | Dependence | pH | Biomarkers | Diagnostic systems | Diagnosis | Esophagus
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9. Full Text Esophageal remodeling in pediatric eosinophilic esophagitis
by Aceves, Seema S., MD, PhD and Newbury, Robert O., MD and Dohil, Ranjan, MD and Bastian, John F., MD and Broide, David H., MBChB
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2007, Volume 119, Issue 1, pp. 206 - 212
Background Eosinophils are associated with airway remodeling in asthma, but studies have not yet determined whether eosinophilic esophagitis (EE) is associated... 
Allergy and Immunology | strictures | vascularity | fibrosis | children | Eosinophilic esophagitis | REFLUX | ANTIBODY | IMMUNOLOGY | FEATURES | vascularily | INHIBITION | THERAPY | ALLERGY | INFLAMMATION | eosinophilic esophagitis | GASTROINTESTINAL DISORDERS | EXPRESSION | SEVERITY | Eosinophilia - metabolism | Gastroesophageal Reflux - metabolism | Esophagus - blood supply | Gastroesophageal Reflux - pathology | Humans | Transforming Growth Factor beta1 - metabolism | Child, Preschool | Esophagus - metabolism | Smad Proteins, Receptor-Regulated - metabolism | Male | Esophagitis - metabolism | Esophagitis - pathology | Eosinophilia - pathology | Esophagitis - complications | Esophagus - pathology | Gastroesophageal Reflux - complications | Fibrosis - etiology | Adolescent | Female | Eosinophilia - complications | Fibrosis - pathology | Child | Pediatrics | Gastroesophageal reflux | Cytokines | Medical records | Smooth muscle | Patients | Data bases | Children & youth | Studies | Pain | Microscopy | Dysphagia | Constipation
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10. Full Text Esophageal pH-Impedance Monitoring and Symptom Analysis in GERD: A Study in Patients off and on Therapy
by Zerbib, Frank and Roman, Sabine and Ropert, Alain and des Varannes, Stanislas Bruley and Pouderoux, Philippe and Chaput, Ulriikka and Mion, Francois and Verin, Eric and Galmiche, Jean-Paul and Sifrim, Daniel
The American Journal of Gastroenterology, ISSN 0002-9270, 09/2006, Volume 101, Issue 9, pp. 1956 - 1963
INTRODUCTION: Combined esophageal pH-impedance monitoring allows detection of nearly all gastroesophageal reflux episodes, acid as well as nonacid. However,... 
WEAKLY ACIDIC REFLUX | ASSOCIATION ANALYSIS | NORMAL VALUES | GASTROENTEROLOGY & HEPATOLOGY | GASTROESOPHAGEAL-REFLUX DISEASE | PPI THERAPY | Severity of Illness Index | Gastroesophageal Reflux - metabolism | Omeprazole - therapeutic use | Reproducibility of Results | Follow-Up Studies | Gastroesophageal Reflux - diagnosis | Proton Pump Inhibitors | Esophageal pH Monitoring | Humans | Middle Aged | Male | Enzyme Inhibitors - therapeutic use | Adolescent | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies | Gastric Acid - metabolism | Gastroesophageal Reflux - drug therapy | Gastroesophageal reflux | Physiological aspects | Medicine, Experimental | Medical research | Care and treatment
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