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1. Full Text Association of Acute Gastroesophageal Reflux Disease With Esophageal Histologic Changes
by Dunbar, Kerry B and Agoston, Agoston T and Odze, Robert D and Huo, Xiaofang and Pham, Thai H and Cipher, Daisha J and Castell, Donald O and Genta, Robert M and Souza, Rhonda F and Spechler, Stuart J
JAMA, ISSN 0098-7484, 05/2016, Volume 315, Issue 19, pp. 2104 - 2112
IMPORTANCE: The histologic changes associated with acute gastroesophageal reflux disease (GERD) have not been studied prospectively in humans. Recent studies... 
Omeprazole - therapeutic use | Esophagitis, Peptic - etiology | Gastroesophageal Reflux - pathology | Humans | Middle Aged | Male | Proton Pump Inhibitors - therapeutic use | Withholding Treatment | Esophagitis, Peptic - drug therapy | Esophagus - pathology | Lymphocytes - pathology | Esophagitis, Peptic - pathology | Gastroesophageal Reflux - complications | Biopsy | 2-Pyridinylmethylsulfinylbenzimidazoles - therapeutic use | Female | Eosinophils - pathology | Neutrophils - pathology | Esophagitis | Proton pump inhibitors | Care and treatment | Dosage and administration | Hyperplasia | Risk factors | Gastroesophageal reflux | Inhibitor drugs | Clinical outcomes | Gastroenterology
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2. Full Text Gastroesophageal Reflux and Pulmonary Fibrosis in Scleroderma: A Study Using pH-Impedance Monitoring
by Savarino, Edoardo and Bazzica, Marco and Zentilin, Patrizia and Pohl, Daniel and Parodi, Andrea and Cittadini, Giuseppe and Negrini, Simone and Indiveri, Francesco and Tutuian, Radu and Savarino, Vincenzo and Ghio, Massimo
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 03/2009, Volume 179, Issue 5, pp. 408 - 413
Interstitial lung disease (ILD) in patients with systemic sclerosis (SSc) is associated with increased morbidity and mortality. Gastroesophageal reflux (GER)... 
Pulmonary fibrosis | Impedance pH-metry | Systemic sclerosis | Acid and nonacid reflux | Prospective Studies | Esophageal pH Monitoring | Pulmonary Fibrosis - complications | Gastroesophageal Reflux - pathology | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Scleroderma, Systemic - pathology | Male | Tomography, X-Ray Computed | Pulmonary Fibrosis - pathology | Electric Impedance | Case-Control Studies | Young Adult | Esophagus - physiopathology | Esophagus - pathology | Gastroesophageal Reflux - complications | Scleroderma, Systemic - complications | Scleroderma, Systemic - physiopathology | Pulmonary Fibrosis - physiopathology | Adult | Female | Aged | Respiratory Function Tests
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3. Full Text Analyses of the Post-reflux Swallow-induced Peristaltic Wave Index and Nocturnal Baseline Impedance Parameters Increase the Diagnostic Yield of Impedance-pH Monitoring of Patients With Reflux Disease
by Frazzoni, Marzio and Savarino, Edoardo and de Bortoli, Nicola and Martinucci, Irene and Furnari, Manuele and Frazzoni, Leonardo and Mirante, Vincenzo Giorgio and Bertani, Helga and Marchi, Santino and Conigliaro, Rita and Savarino, Vincenzo
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2016, Volume 14, Issue 1, pp. 40 - 46
Background & Aims Analyses of impedance parameters such as the post-reflux swallow-induced peristaltic wave (PSPW) index and the mean nocturnal baseline... 
Gastroenterology and Hepatology | ROC AUC | Esophageal Chemical Clearance | GERD | Esophageal Baseline Impedance | Heartburn | Impedance pH Monitoring | ESOPHAGEAL | GASTROENTEROLOGY & HEPATOLOGY | NERD | FUNCTIONAL HEARTBURN | Prospective Studies | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring - methods | Gastroesophageal Reflux - pathology | Humans | Middle Aged | Male | Electric Impedance | Peristalsis | Animals | Adult | Female | Italy | Hydrogen-Ion Concentration | Swallows | Hydrogen-ion concentration | Statistics | Analysis
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4. Full Text Eosinophilic esophagitis in adults: Distinguishing features from gastroesophageal reflux disease: A study of 41 patients
by Parfitt, Jeremy R and Gregor, James C and Suskin, Neville G and Jawa, Hani A and Driman, David K
Modern Pathology, ISSN 0893-3952, 01/2006, Volume 19, Issue 1, pp. 90 - 96
Eosinophilic esophagitis in adults is a recently described entity occurring in young males with dysphagia, in whom esophageal biopsies show eosinophilic... 
Esophagitis | Eosinophil | Eosinophilic | eosinophilic | PATHOLOGY | eosinophil | esophagitis | CHILDREN | Diagnosis, Differential | Gastroesophageal Reflux - pathology | Humans | Middle Aged | Male | Esophagitis - pathology | Eosinophilia - pathology | Deglutition Disorders - complications | Esophagitis - complications | Esophagus - pathology | Biopsy | Adult | Aged
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5. Full Text Inflammation and Intestinal Metaplasia of the Distal Esophagus Are Associated With Alterations in the Microbiome
by Yang, Liying and Lu, Xiaohua and Nossa, Carlos W and Francois, Fritz and Peek, Richard M and Pei, Zhiheng
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 2, pp. 588 - 597
Background & Aims Gastroesophageal reflux causes inflammation and intestinal metaplasia and its downstream sequelum adenocarcinoma in the distal esophagus. The... 
Gastroenterology and Hepatology | GASTROESOPHAGEAL-REFLUX DISEASE | RIBOSOMAL-RNA SEQUENCES | BACTERIAL BIOTA | ADENOCARCINOMA | GUT | DIVERSITY | BARRETTS-ESOPHAGUS | COMMUNITIES | PREVALENCE | KNOCKOUT MICE | GASTROENTEROLOGY & HEPATOLOGY | Immunohistochemistry | Confidence Intervals | Gastroesophageal Reflux - microbiology | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Streptococcus - pathogenicity | Case-Control Studies | Esophagitis - pathology | Metagenome - physiology | Esophagitis - microbiology | Esophagitis - genetics | Metagenome - genetics | Barrett Esophagus - pathology | Adult | Female | Precancerous Conditions - pathology | Barrett Esophagus - microbiology | Odds Ratio | Barrett Esophagus - genetics | Intestinal Neoplasms - microbiology | Tissue Culture Techniques | Gastroesophageal Reflux - pathology | Intestinal Mucosa - microbiology | Intestinal Neoplasms - pathology | Metaplasia - pathology | Analysis of Variance | Streptococcus - genetics | Biopsy, Needle | Intestinal Mucosa - pathology | Gastroesophageal reflux | Inflammation | Barrett's esophagus | Prevalence studies (Epidemiology)
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6. Full Text Microscopic esophagitis distinguishes patients with non-erosive reflux disease from those with functional heartburn
by Savarino, Edoardo and Zentilin, Patrizia and Mastracci, Luca and Dulbecco, Pietro and Marabotto, Elisa and Gemignani, Lorenzo and Bruzzone, Luca and de Bortoli, Nicola and Frigo, Anna Chiara and Fiocca, Roberto and Savarino, Vincenzo
Journal of Gastroenterology, ISSN 0944-1174, 4/2013, Volume 48, Issue 4, pp. 473 - 482
Microscopic esophagitis (ME) is common in patients with non-erosive reflux disease (NERD), and dilation of intercellular spaces (DIS) has been regarded as the... 
Gastroesophageal reflux | Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Functional heartburn | Surgical Oncology | Dilated intercellular spaces | NERD | NONACID GASTROESOPHAGEAL-REFLUX | ACID | OMEPRAZOLE | CLASSIFICATION | HISTOLOGY | GERD | EPITHELIUM | IMPEDANCE | GASTROENTEROLOGY & HEPATOLOGY | Prospective Studies | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring | Esophagitis, Peptic - etiology | Humans | Middle Aged | Esophagitis, Peptic - diagnosis | Male | Case-Control Studies | Esophagitis - pathology | Young Adult | Esophagus - physiopathology | Esophagitis, Peptic - pathology | Adult | Female | Endoscopy, Gastrointestinal - methods | Diagnosis, Differential | Gastroesophageal Reflux - pathology | Heartburn - diagnosis | Electric Impedance | Esophagitis - etiology | Esophagus - pathology | Gastroesophageal Reflux - complications | Biopsy | Aged | Heartburn - pathology | Esophagitis | Endoscopic surgery | Endoscopy | Heartburn
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7. Full Text Clinical, Endoscopic, and Histologic Findings Distinguish Eosinophilic Esophagitis From Gastroesophageal Reflux Disease
by Dellon, Evan S and Gibbs, Wood B and Fritchie, Karen J and Rubinas, Tara C and Wilson, Lindsay A and Woosley, John T and Shaheen, Nicholas J
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2009, Volume 7, Issue 12, pp. 1305 - 1313
Background & Aims Features of eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) overlap; because they cannot be differentiated on the... 
Gastroenterology and Hepatology | VARIABILITY | DYSPHAGIA | DIAGNOSIS | PEDIATRIC-PATIENTS | ADULTS | CASE SERIES | GASTROENTEROLOGY & HEPATOLOGY | SEVERITY | FEATURES | CHILDREN | Diagnosis, Differential | Gastroesophageal Reflux - diagnosis | Gastroesophageal Reflux - pathology | Gastroesophageal Reflux - physiopathology | Histocytochemistry - methods | Humans | Middle Aged | Child, Preschool | Infant | Male | Case-Control Studies | Esophagitis - pathology | Young Adult | Biopsy | Adolescent | Aged, 80 and over | Esophagitis - diagnosis | Adult | Esophagitis - physiopathology | Female | Aged | Endoscopy, Gastrointestinal - methods | Retrospective Studies | Child | Gastroesophageal reflux | Medical research | Medical colleges | Medical examination | C-reactive protein | Esophagitis | Cytogenetics | Medicine, Experimental | Blood
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8. Full Text Gastroesophageal Reflux Might Cause Esophagitis Through a Cytokine-Mediated Mechanism Rather Than Caustic Acid Injury
by Souza, Rhonda F and Huo, Xiaofang and Mittal, Vivek and Schuler, Christopher M and Carmack, Susanne W and Zhang, Hui Ying and Zhang, Xi and Yu, Chunhua and Hormi–Carver, Kathy and Genta, Robert M and Spechler, Stuart J
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 5, pp. 1776 - 1784
Background & Aims Reflux esophagitis is believed to be caused by the caustic effects of refluxed gastric acid on esophageal epithelial cells. However, caustic... 
Gastroenterology and Hepatology | MUCOSA | PATHOGENESIS | GERD | EPITHELIAL-CELLS | DISEASE | GENE-EXPRESSION | BARRETTS-ESOPHAGUS | MODEL | GASTROENTEROLOGY & HEPATOLOGY | INTERLEUKIN-8 | PATHOPHYSIOLOGY | Cell Line | Gastroesophageal Reflux - metabolism | Bile Acids and Salts - pharmacology | Epithelial Cells - metabolism | Cytokines - metabolism | Esophagitis, Peptic - etiology | Epithelial Cells - drug effects | Gastroesophageal Reflux - pathology | Humans | Rats | Male | Esophagitis, Peptic - metabolism | Rats, Sprague-Dawley | Gastrointestinal Agents - pharmacology | Animals | Esophagitis, Peptic - pathology | Gastroesophageal Reflux - complications | Chemotaxis, Leukocyte - drug effects | Esophagostomy | Duodenostomy | Cell Culture Techniques | Disease Models, Animal | Animal experimentation | Gastroesophageal reflux | Esophagitis | Analysis
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9. Full Text Erosive Esophagitis and Nonerosive Reflux Disease (NERD): Comparison of Epidemiologic, Physiologic, and Therapeutic Characteristics
by Fass, Ronnie
Journal of Clinical Gastroenterology, ISSN 0192-0790, 02/2007, Volume 41, Issue 2, pp. 131 - 137
Nonerosive reflux disease (NERD) and erosive esophagitis are the main presentations of gastroesophageal reflux disease. However, NERD is the most common... 
Heartburh | GERD | Esophagus | ACID REFLUX | LANSOPRAZOLE | CONTROLLED TRIAL | OMEPRAZOLE | FOLLOW-UP | BARRETTS-ESOPHAGUS | PREVALENCE | heartburn | NATURAL-HISTORY | MINIMAL CHANGE ESOPHAGITIS | GASTROENTEROLOGY & HEPATOLOGY | esophagus | SYMPTOMATIC GASTROESOPHAGEAL-REFLUX | Gastroesophageal Reflux - therapy | Esophagitis, Peptic - pathology | Gastroesophageal Reflux - pathology | Gastroesophageal Reflux - physiopathology | Humans | Esophagitis, Peptic - physiopathology | Gastroesophageal Reflux - epidemiology | Esophagitis, Peptic - therapy | Esophagitis, Peptic - epidemiology
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10. Full Text Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification
by Lundell, L. R and Dent, J and Bennett, J. R and Blum, A. L and Armstrong, D and Galmiche, J. P and Johnson, F and Hongo, M and Richter, J. E and Spechler, S. J and Tytgat, G. N and Wallin, L
Gut, ISSN 0017-5749, 1999, Volume 45, Issue 2, pp. 172 - 180
Endoscopic oesophageal changes are diagnostically helpful and identify patients exposed to the risk of disease chronicity. However, there is a serious lack of... 
Oesophagitis | Omeprazole | Acid reflux | Stricture | Endoscopy | Heartburn | Columnar lined mucosa | DIAGNOSIS | omeprazole | CISAPRIDE | endoscopy | GASTROESOPHAGEAL REFLUX DISEASE | heartburn | ANTISECRETORY DRUG | TRIAL | RELAPSE | ESOPHAGITIS | columnar lined mucosa | DOUBLE-BLIND | acid reflux | oesophagitis | stricture | GASTROENTEROLOGY & HEPATOLOGY | RANITIDINE | Gastroesophageal reflux | Studies | Video recorders | Disease | Working groups | Gastroenterology | Classification | Clinical trials | Agreements
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11. Full Text Epithelial Thickness is a Marker of Gastroesophageal Reflux Disease
by Vieth, Michael and Mastracci, Luca and Vakil, Nimish and Dent, John and Wernersson, Börje and Baldycheva, Irina and Wissmar, Jenny and Ruth, Magnus and Fiocca, Roberto
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 2016, Volume 14, Issue 11, pp. 1544 - 1551.e1
Background & Aims Histologic criteria have been refined for the diagnosis of gastroesophageal reflux disease (GERD). We aimed to evaluate these criteria for... 
Gastroenterology and Hepatology | Diagnostic | Esophageal Mucosa | Histology | Esophagus | DIAGNOSTIC-VALUE | ESOPHAGEAL EPITHELIUM | HEARTBURN | CLASSIFICATION | SYMPTOMS | DILATED INTERCELLULAR SPACES | GASTROENTEROLOGY & HEPATOLOGY | DAMAGE | Epithelium - pathology | Gastroesophageal Reflux - diagnosis | Europe | Gastroesophageal Reflux - pathology | Humans | Middle Aged | Male | Young Adult | Canada | Esophagus - pathology | Biopsy | Adolescent | Histocytochemistry | Biomarkers | Adult | Female | Aged | Gastroesophageal reflux | Medical colleges | Analysis
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12. Full Text Esophageal Dilated Intercellular Spaces (DIS) and Nonerosive Reflux Disease
by van Malenstein, Hannah and Farre, Ricard and Sifrim, Daniel
The American Journal of Gastroenterology, ISSN 0002-9270, 04/2008, Volume 103, Issue 4, pp. 1021 - 1028
Esophageal mucosal dilated intercellular spaces (DIS) are frequently observed in patients with nonerosive reflux disease (NERD) and patients with esophagitis.... 
ACID REFLUX | GASTROESOPHAGEAL-REFLUX | EPITHELIUM | PERMEABILITY | MUCOSAL BARRIER DISRUPTION | MORPHOLOGICAL FEATURE | BILE REFLUX | INJURY | RABBIT ESOPHAGUS | NATURAL-HISTORY | GASTROENTEROLOGY & HEPATOLOGY | Esophagus - physiopathology | Esophagus - pathology | Mucous Membrane - pathology | Mucous Membrane - physiopathology | Esophageal Diseases - physiopathology | Esophagus - ultrastructure | Gastroesophageal Reflux - pathology | Gastroesophageal Reflux - physiopathology | Humans | Mucous Membrane - ultrastructure | Extracellular Space | Esophageal Diseases - pathology | Gastroesophageal reflux | Bile acids
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13. Full Text Superficial Esophageal Mucosal Afferent Nerves May Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease
by Woodland, Philip and Shen Ooi, Joanne Li and Grassi, Federica and Nikaki, Kornilia and Lee, Chung and Evans, James A and Koukias, Nikolaos and Triantos, Christos and McDonald, Stuart A and Peiris, Madusha and Aktar, Rubina and Blackshaw, L. Ashley and Sifrim, Daniel
Gastroenterology, ISSN 0016-5085, 11/2017, Volume 153, Issue 5, pp. 1230 - 1239
Little is known about the causes of heartburn in patients with gastro-esophageal reflux disease. Visible epithelial damage is seldom associated with symptom... 
Esophagitis | GERD | NERD | Barrett’s | DEFINITION | CRITERIA | ACID | RAT ESOPHAGUS | MORPHOLOGICAL FEATURE | INNERVATION | SENSITIVITY | DILATED INTERCELLULAR SPACES | Barrett's | GASTROENTEROLOGY & HEPATOLOGY | SEGMENT BARRETTS-ESOPHAGUS | VAGAL | Immunohistochemistry | Prospective Studies | Calcitonin Gene-Related Peptide - analysis | Heartburn - physiopathology | Esophageal Mucosa - innervation | Gastroesophageal Reflux - physiopathology | Humans | Middle Aged | Male | Case-Control Studies | Hyperalgesia - pathology | Greece | Young Adult | Barrett Esophagus - pathology | Adult | Female | Sensory Receptor Cells - pathology | Gastroesophageal Reflux - pathology | Biomarkers - analysis | United Kingdom | Hyperalgesia - physiopathology | Barrett Esophagus - physiopathology | Biopsy | Aged | Sensory Receptor Cells - chemistry | Heartburn - pathology | Medicine, Experimental | Allergy | Medical research | Allergic reaction
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