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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15140 - 15144
Between the genetic extremes of rare monogenic and common polygenic diseases lie diverse oligogenic disorders involving mutations in more than one locus in... 
Deficiency diseases | Sex hormones | Nervous system diseases | Disease models | Medical genetics | Genetic diseases | Genetic mutation | Kallmann syndrome | Human genetics | Hypogonadism | Rare variant | Digenic | Idiopathic hypogonadotropic hypogonadism | FGFR1 | idiopathic hypogonadotropic hypogonadism | GPR54 | MULTIDISCIPLINARY SCIENCES | CLINICAL HETEROGENEITY | MISSENSE MUTATIONS | PUBERTY | digenic | GENE | BARDET-BIEDL-SYNDROME | LINKED KALLMANN-SYNDROME | FIBROBLAST-GROWTH-FACTOR-RECEPTOR-1 | GNRH RECEPTOR | rare variant | Receptors, LHRH - genetics | Humans | Male | Gene Regulatory Networks | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Case-Control Studies | Receptors, Peptide - genetics | Genetic Variation | DNA Mutational Analysis | Female | Neuropeptides - genetics | Fibroblast Growth Factor 8 - genetics | Kallmann Syndrome - genetics | Extracellular Matrix Proteins - genetics | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Hypogonadism - genetics | Homozygote | Phenotype | Pedigree | Gastrointestinal Hormones - genetics | Heterozygote | Models, Genetic | Receptors, G-Protein-Coupled - genetics | Mutation | Receptors, Kisspeptin-1 | Gonadotropin-Releasing Hormone - deficiency | Cohort Studies | Multifactorial diseases | Genetic aspects | Hormones | Gonadotropin | Health aspects | Pathogens | Genetics | Genetic disorders | Pathogenesis | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2007, Volume 104, Issue 44, pp. 17447 - 17452
Journal Article
Journal Article
by Saxena, Richa and Hivert, Marie-France and Langenberg, Claudia and Tanaka, Toshiko and Pankow, James and Vollenweider, Peter and Lyssenko, Valeriya and Bouatia-Naji, Nabila and Dupuis, Josée and Jackson, Anne and Kao, Wen and Li, Man and Glazer, Nicole and Manning, Alisa and Anluan, Jian and Stringham, Heather and Prokopenko, Inga and Johnson, Toby and Grarup, Niels and Boesgaard, Trine and Lecoeur, Cécile and Shrader, Peter and O´Connell, J.R and Ingelsson, Erik and Couper, David and Rice, Kenneth and Song, Kijoung and Aneasen, Camilla and Dina, Christian and Köttgen, Anna and Bacquer, Olivier and Pattou, François and Taneera, Jalal and Steinthorsdottir, Valgerdur and Rybin, Denis and Ardlie, Kristin and Sampson, Michael and Qi, Lu and Hoek, M.V and Weedon, Michael and Aulchenko, Yurii and Voight, Benjamin and Grallert, Harald and Balkau, Beverley and Bergman, Richard and Bielinski, Suzette and Bonnefond, Amélie and Bonnycastle, Lori and Borch-Johnsen, K and Böttcher, Yvonne and Brunner, Eric and Buchanan, Thomas and Bumpstead, Suzannah and Cavalcanti-Proença, Christine and Charpentier, Guillaume and Chen, Chao and Chines, Peter and Collins, Francis and Cornelis, Marilyn and Crawford, Gabe and Delplanque, Jerome and Doney, Alex and Egan, Josephine and Erdos, Michael and Firmann, Mathieu and Forouhi, Nita and Fox, Caroline and Goodarzi, Mark and Graessler, Jürgen and Hingorani, Aroon and Isomaa, Bo and Jørgensen, Torben and Kivimaki, Mika and Kovacs, Peter and Krohn, Knut and Kumari, Meena and Lauritzen, Torsten and Lévy-Marchal, Claire and Mayor, Vladimir and McAteer, Jarred and Meyre, David and Mitchell, Braxton and Mohlke, Karen and Morken, Mario and Narisu, Narisu and Palmer, Colin and Pakyz, Ruth and Pascoe, Laura and Payne, Felicity and Pearson, Daniel and Rathmann, Wolfgang and Sandbaek, Annelli and Sayer, A.A and Scott, Laura and Sharp, Stephen and Sijbrands, Eric and Singleton, Anew and Siscovick, David and Smith, Nicholas and Sparsø, Thomas and ... and GIANT Consortium and MAGIC Investigators and GIANT consortium and MAGIC investigators and the MAGIC investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 02/2010, Volume 42, Issue 2, pp. 142 - 148
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, pp. e86872 - e86872
In contrast to normal differentiated cells that depend on mitochondrial oxidative phosphorylation for energy production, cancer cells have evolved to utilize... 
LIVER-CANCER | REGULATOR | NETWORK | PKM2 | MULTIDISCIPLINARY SCIENCES | ISOFORM | TUMOR-GROWTH | MICRORNA-122 | RNA, Small Interfering - genetics | Carcinoma, Hepatocellular - mortality | Cell Proliferation | Prognosis | Oligonucleotide Array Sequence Analysis | Humans | Middle Aged | Male | Gene Expression Profiling | Liver Neoplasms - mortality | Neoplasm Recurrence, Local - mortality | Immunoenzyme Techniques | Neoplasm Recurrence, Local - pathology | Carcinoma, Hepatocellular - genetics | Biomarkers, Tumor - metabolism | Female | Liver Neoplasms - pathology | Membrane Proteins - metabolism | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Liver Neoplasms - genetics | Neoplasm Recurrence, Local - metabolism | Membrane Proteins - genetics | Lactic Acid - metabolism | RNA, Messenger - genetics | Carrier Proteins - antagonists & inhibitors | Oxygen Consumption | Survival Rate | Thyroid Hormones - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Carrier Proteins - genetics | Carrier Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Thyroid Hormones - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Glycolysis | Neoplasm Recurrence, Local - genetics | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Neoplasm Staging | Apoptosis | Carcinoma, Hepatocellular - metabolism | Lactates | Glucose metabolism | RNA | Analysis | Genes | Physiological aspects | Hepatoma | Gene expression | Health aspects | Cell proliferation | Phosphorylation | Liver | Correlation coefficients | Science | Pyruvic acid | Oncology | Hepatocellular carcinoma | Kinases | Tissues | Metastases | Liver cancer | Angiogenesis | Mitochondria | Rodents | Surgery | Correlation coefficient | Pyruvate kinase | MiRNA | Oxygen consumption | Pharmacology | Metabolism | Biological activity | Intermediates | Hospitals | Oxidative phosphorylation | Ribonucleic acids | MicroRNAs | Regulatory mechanisms (biology) | Stem cells | Metabolic pathways | Lactic acid | Cancer | Index Medicus
Journal Article
Journal Article