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Science, ISSN 0036-8075, 01/2018, Volume 359, Issue 6371, pp. 91 - 97
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that... 
CELL LUNG-CANCER | MELANOMA | MICROENVIRONMENT | INTESTINAL MICROBIOTA | CYCLOPHOSPHAMIDE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | GENES | RESISTANCE | ANTITUMOR IMMUNITY | NIVOLUMAB | CD4 Antigens - immunology | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Gastrointestinal Microbiome - genetics | Fecal Microbiota Transplantation | Anti-Bacterial Agents - therapeutic use | Feces - microbiology | Metagenome - genetics | Neoplasms - therapy | Animals | Receptors, CCR - immunology | Interleukin-12 - immunology | Receptors, CXCR3 - immunology | T-Lymphocytes - immunology | Mice | Gastrointestinal Microbiome - immunology | Verrucomicrobia - genetics | Verrucomicrobia - immunology | Care and treatment | Cell receptors | Microbiota (Symbiotic organisms) | Immunotherapy | Epithelial tumors | Physiological aspects | Health aspects | Methods | Apoptosis | PD-1 protein | Lung | Interleukin | Microbiomes | Transplantation | Lymphocytes T | Anticancer properties | Microbiota | Lymphocytes | Bacteria | Feces | Supplementation | Gnotobiotics | Kidneys | Melanoma | Dietary supplements | Interleukin 12 | Abundance | CXCR3 protein | Patients | CD4 antigen | Immune checkpoint | Antibiotics | Flora | PD-L1 protein | Relative abundance | Antitumor activity | CCR9 protein | Tumors | Kidney transplantation | Cancer | Index Medicus | Life Sciences
Journal Article
Nature immunology, ISSN 1529-2908, 05/2016, Volume 17, Issue 5, pp. 505 - 513
The effect of alterations in intestinal microbiota on microbial metabolites and on disease processes such as graft-versus-host disease (GVHD) is not known.... 
Butyrates - metabolism | Epithelial Cells - metabolism | Gas Chromatography-Mass Spectrometry | Butyrates - pharmacology | Histone Acetyltransferases - genetics | Immunoblotting | Gastrointestinal Microbiome - physiology | Histone Deacetylases - immunology | Bone Marrow Transplantation - methods | Graft vs Host Disease - immunology | Graft vs Host Disease - microbiology | Fatty Acids, Volatile - metabolism | Intestines - immunology | Transplantation, Homologous | Fatty Acids, Volatile - immunology | T-Lymphocytes - metabolism | Butyrates - immunology | Histone Acetyltransferases - metabolism | Gene Expression - immunology | Female | Graft vs Host Disease - etiology | Histone Deacetylases - genetics | Histones - immunology | Mice, Inbred C57BL | Cells, Cultured | Histone Deacetylases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Acetylation - drug effects | Animals | Intestines - microbiology | Epithelial Cells - immunology | Epithelial Cells - microbiology | Bone Marrow Transplantation - adverse effects | Metabolome - immunology | Histone Acetyltransferases - immunology | T-Lymphocytes - immunology | Mice, Inbred BALB C | Gastrointestinal Microbiome - immunology | Histones - metabolism | Intestines - cytology | Microbiota (Symbiotic organisms) | Graft versus host reaction | Development and progression | Genetic aspects | Properties | Health aspects | Fatty acids | Index Medicus
Journal Article
Science, ISSN 0036-8075, 01/2018, Volume 359, Issue 6371, pp. 97 - 103
Journal Article
Science, ISSN 0036-8075, 01/2018, Volume 359, Issue 6371, pp. 104 - 108
Anti-PD-1-based immunotherapy has had a major impact on cancer treatment but has only benefited a subset of patients. Among the variables that could contribute... 
MULTIDISCIPLINARY SCIENCES | Immunotherapy - methods | Enterococcus faecium - immunology | Skin Neoplasms - immunology | Skin Neoplasms - therapy | Humans | Antibodies, Monoclonal - therapeutic use | Bifidobacterium longum - immunology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Enterococcus faecium - genetics | Gastrointestinal Microbiome - genetics | Enterococcus faecium - isolation & purification | Bifidobacterium longum - genetics | Enterococcus faecium - classification | Feces - microbiology | Bifidobacterium longum - isolation & purification | Animals | Melanoma - immunology | Bifidobacterium longum - classification | RNA, Ribosomal, 16S - genetics | T-Lymphocytes - immunology | Mice | Gastrointestinal Microbiome - immunology | Melanoma - therapy | Care and treatment | Cell receptors | Microbiota (Symbiotic organisms) | Immunotherapy | Melanoma | Physiological aspects | Metastasis | Health aspects | Methods | Apoptosis | Animal models | rRNA 16S | PD-1 protein | Lung | Microbiomes | Lymphocytes T | Immunity | Metastases | Gene sequencing | Anticancer properties | Microorganisms | Bacteria | Supplementation | Gnotobiotics | Effectiveness | Kidneys | Dietary supplements | Ribonucleic acid--RNA | Patients | Polymerase chain reaction | Antibiotics | Flora | PD-L1 protein | Antitumor activity | Cancer | Kidney transplantation | Index Medicus
Journal Article
Science, ISSN 0036-8075, 05/2018, Volume 360, Issue 6391, p. eaan5931
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7654, pp. 305 - 310
Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an... 
BACTERIA | ANGIOGENESIS | INTERFACE | STABILITY | MULTIDISCIPLINARY SCIENCES | GENES | LIPOPOLYSACCHARIDE | RECEPTOR | HOST | LPS | INSIGHTS | Injections, Intravenous | Humans | Lipopolysaccharides - administration & dosage | Male | Hemangioma, Cavernous, Central Nervous System - immunology | Gram-Negative Bacteria - immunology | Lipopolysaccharides - immunology | Lipopolysaccharide Receptors - metabolism | Toll-Like Receptor 4 - deficiency | Female | Toll-Like Receptor 4 - antagonists & inhibitors | Disease Susceptibility | Hemangioma, Cavernous, Central Nervous System - microbiology | Signal Transduction | Endothelial Cells - metabolism | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Immunity, Innate | Animals | Hemangioma, Cavernous, Central Nervous System - pathology | Germ-Free Life | Lipopolysaccharide Receptors - genetics | Anti-Bacterial Agents - pharmacology | Mice | Gastrointestinal Microbiome - immunology | Anti-Bacterial Agents - administration & dosage | Toll-like receptors | Physiological aspects | Health aspects | Hemangioma, Cavernous | Brain | Stroke | Gnotobiotics | Pathogenesis | Pharmacology | TLR4 protein | Gene expression | CD14 antigen | Endothelial cells | Immune systems | Proteins | Signal transduction | Signaling | Stimulants | Antibiotics | Bacteria | Gram-negative bacteria | Lung Kruppel-like factor | Brain diseases | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2017, Volume 198, Issue 2, pp. 553 - 554
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 2017, Volume 215, Issue 1, pp. 34 - 41
Journal Article
Mucosal Immunology, ISSN 1933-0219, 01/2016, Volume 9, Issue 1, pp. 24 - 37
HIV-1-associated disruption of intestinal homeostasis is a major factor contributing to chronic immune activation and inflammation. Dendritic cells (DCs) are... 
TRANSLOCATION | RESPONSES | LYMPHOID-TISSUE | INFLAMMATION | PREDICT MORTALITY | IMMUNE ACTIVATION | ANTIRETROVIRAL THERAPY | INTESTINAL LAMINA PROPRIA | IMMUNOLOGY | VIRUS TYPE-1 INFECTION | SIV INFECTION | Antigens, CD - immunology | Immunoglobulins - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Colon - immunology | Male | Immunoglobulins - genetics | Antigens, CD - genetics | Case-Control Studies | Viral Load | Ruminococcus - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV Infections - microbiology | Prevotella - immunology | HIV Infections - pathology | Prevotella - growth & development | Adult | Female | CD40 Antigens - genetics | Interferon-gamma - genetics | Membrane Glycoproteins - immunology | Ruminococcus - growth & development | Glycoproteins - genetics | Antigens, CD1 - immunology | CD4-Positive T-Lymphocytes - microbiology | CD8-Positive T-Lymphocytes - microbiology | Signal Transduction | Lymphocyte Activation | Gene Expression Regulation | Membrane Glycoproteins - genetics | Glycoproteins - immunology | HIV-1 - immunology | Mucous Membrane - immunology | Interferon-gamma - immunology | Dendritic Cells - microbiology | Colon - microbiology | Antigens, CD1 - genetics | Gastrointestinal Microbiome - immunology | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology | Mucous Membrane - microbiology | Cell Lineage - immunology | Index Medicus | mucosal immunology | HIV-1 pathogenesis | microbiome | Human intestinal dendritic cells
Journal Article