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Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 11, pp. 2563 - 2570
Summary BRAF mutation is seen in a variety of human neoplasms including cutaneous malignant melanoma, papillary thyroid carcinoma, colorectal carcinoma,... 
Pathology | Immunohistochemistry | Anti–B-Raf | BRAF V600E | VE1 | Glioma | Melanoma | Thyroid carcinoma | Anti-B-Raf | PROTEIN | IMPROVED SURVIVAL | PATHOLOGY | CANCER | TUMORS | HAIRY-CELL LEUKEMIA | THERAPY | MEK INHIBITION | GENE | MUTANT BRAF | VEMURAFENIB | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Mutation, Missense | Breast Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Ovarian Neoplasms - genetics | Gastrointestinal Neoplasms - pathology | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Glioma - pathology | Sensitivity and Specificity | Biomarkers, Tumor - metabolism | Female | Ovarian Neoplasms - metabolism | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Thyroid Neoplasms - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Neoplasms - pathology | Amino Acid Substitution | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Carcinoma | Gene mutations | Gliomas | Thyroid diseases | Monoclonal antibodies | Genetic aspects | Comparative analysis | Lung cancer, Non-small cell | Cancer | Breast cancer | Mutation | Tumors | Skin cancer | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 1976 - 1985.e10
Background & Aims MUTYH -associated polyposis (MAP) is characterized by a lifetime risk of colorectal cancer of up to 100%. However, no systematic evaluation... 
Gastroenterology and Hepatology | BASE-EXCISION-REPAIR | URINARY-TRACT CANCER | APC GENE MUTATION | MUIR-TORRE-SYNDROME | NONPOLYPOSIS COLORECTAL-CANCER | DUODENAL ADENOMATOSIS | FAMILIAL ADENOMATOUS POLYPOSIS | MYH-ASSOCIATED POLYPOSIS | LYNCH SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | MSH2 MUTATION CARRIERS | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Adenomatous Polyposis Coli - epidemiology | Ovarian Neoplasms - pathology | Male | Adenomatous Polyposis Coli - pathology | Incidence | Ovarian Neoplasms - genetics | Young Adult | Gastrointestinal Neoplasms - pathology | Gastrointestinal Neoplasms - epidemiology | Urinary Bladder Neoplasms - genetics | Urinary Bladder Neoplasms - pathology | Adult | Female | Retrospective Studies | Endoscopy | Adenomatous Polyposis Coli - genetics | Child | Urinary Bladder Neoplasms - epidemiology | Breast Neoplasms - epidemiology | Skin Neoplasms - pathology | Genetic Predisposition to Disease | Sebaceous Gland Neoplasms - epidemiology | Risk Assessment | Risk Factors | Sebaceous Gland Neoplasms - genetics | DNA Glycosylases - genetics | Kaplan-Meier Estimate | Europe - epidemiology | Skin Neoplasms - epidemiology | Ovarian Neoplasms - epidemiology | Phenotype | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Sebaceous Gland Neoplasms - pathology | Skin Neoplasms - genetics | Adolescent | Age of Onset | Aged | Medical colleges | Animal pigments | Genetic disorders | Oncology, Experimental | Colorectal cancer | Research | Cancer | Tumors | Medical informatics | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2017, Volume 116, Issue 6, pp. 802 - 810
When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%,... 
lung cancer | solid tumours | NGS | cfDNA | Melanoma - blood | Lung Neoplasms - drug therapy | Gastrointestinal Neoplasms - genetics | Prognosis | Prospective Studies | Follow-Up Studies | Gastrointestinal Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Gastrointestinal Neoplasms - pathology | DNA, Neoplasm - blood | Gastrointestinal Neoplasms - blood | DNA Mutational Analysis | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Gastrointestinal Stromal Tumors - pathology | Aged, 80 and over | Adult | Female | High-Throughput Nucleotide Sequencing - methods | Gastrointestinal Stromal Tumors - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Colorectal Neoplasms - blood | Melanoma - pathology | Mutation - genetics | Biomarkers, Tumor - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Gastrointestinal Stromal Tumors - drug therapy | Gastrointestinal Stromal Tumors - blood | Melanoma - drug therapy | Carcinoma, Non-Small-Cell Lung - blood | ROC Curve | Aged | Biomarkers, Tumor - genetics | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Neoplasm Staging | Index Medicus | Genetics & Genomics
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2015, Volume 33, Issue 34, pp. 4032 - 4038
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e90528 - e90528
We previously reported that the intronic tagSNP +357G/C in the metastasis suppressor HTPAP is associated with metastasis and prognosis of hepatocellular... 
CANCER-CELLS | SUPPRESSOR | VARIANTS | GENE | MULTIDISCIPLINARY SCIENCES | RISK | CHROMOSOME 8P DELETION | EXPRESSION | ASSOCIATION | Prognosis | Liver Neoplasms - genetics | Carcinoma, Hepatocellular - diagnosis | Neoplasm Invasiveness | Genomics | Humans | Middle Aged | Phosphatidate Phosphatase - metabolism | Male | Phosphatidate Phosphatase - genetics | Promoter Regions, Genetic - genetics | Haplotypes - genetics | Neoplasm Metastasis | Liver Neoplasms - diagnosis | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Female | Liver Neoplasms - pathology | Polymorphism, Single Nucleotide | Transcription, Genetic - genetics | Gene Expression Regulation, Neoplastic - genetics | Carcinoma, Hepatocellular - metabolism | Genetic aspects | Metastasis | Hepatoma | RNA | Luciferase | Cancer | Haplotypes | Transcription | Laboratories | Linkage disequilibrium | Science | Hepatocellular carcinoma | Genomes | Single-nucleotide polymorphism | Multivariate analysis | Western blotting | Metastases | Liver cancer | Education | Hepatology | Surgery | Deoxyribonucleic acid--DNA | Regression analysis | Gene expression | Patients | Promoters | Genetic variance | DNA microarrays | Plasmids | Medical prognosis | Cell lines | Mutation | Genetic testing | Aberration | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Modern Pathology, ISSN 0893-3952, 12/2011, Volume 24, Issue 12, pp. 1560 - 1570
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2013, Volume 31, Issue 26, pp. 3182 - 3190
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, pp. e0179501 - e0179501
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully... 
CD2 | THERAPY | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | GENES | IMMUNOMODULATORY ACTION | MECHANISMS | MOLECULES | SGI-110 | Colonic Neoplasms - genetics | DNA Methylation - immunology | DNA, Neoplasm - metabolism | Humans | Antigens, Neoplasm - biosynthesis | Ovarian Neoplasms - pathology | Male | Colonic Neoplasms - metabolism | Testicular Neoplasms - pathology | Ovarian Neoplasms - genetics | Colonic Neoplasms - immunology | Female | Ovarian Neoplasms - metabolism | Caco-2 Cells | Antigens, Neoplasm - genetics | Testicular Neoplasms - genetics | Antigens, Neoplasm - immunology | Testicular Neoplasms - metabolism | Antigen Presentation - genetics | DNA Methylation - genetics | Testicular Neoplasms - immunology | Animals | Colonic Neoplasms - pathology | DNA, Neoplasm - immunology | Mice | DNA, Neoplasm - genetics | Ovarian Neoplasms - immunology | Colon cancer | Tumor antigens | Physiological aspects | Development and progression | Genetic aspects | Research | Methylation | Ovarian cancer | Therapy | Biotechnology | Animal models | Ovarian carcinoma | CD58 antigen | Antigen processing | Genomes | Tissues | Cancer therapies | Immunotherapy | Surgery | Cell cycle | DNA methylation | Inhibition | Colon | Drug dosages | Deoxyribonucleic acid--DNA | Immune system | Antigen presentation | Antigens | Tumor cells | Melanoma | Tumor cell lines | Gene expression | Ribonucleic acid--RNA | Patients | Immune systems | Medicine | Inhibitors | Epigenetics | Solid tumors | Tumors | Cancer | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Gut, ISSN 0017-5749, 06/2013, Volume 62, Issue 6, pp. 812 - 823
Journal Article
Oncogene, ISSN 0950-9232, 04/2008, Volume 27, Issue 18, pp. 2635 - 2647
TMPRSS4 is a novel type II transmembrane serine protease found at the cell surface that is highly expressed in pancreatic, colon and gastric cancer tissues.... 
Serine protease | Metastasis | E-cadherin | EMT | Invasion | TMPRSS4 | PROSTATE | MATRIPTASE | SURFACE PROTEOLYTIC-ENZYMES | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | serine protease | CELL BIOLOGY | BREAST-CANCER CELLS | MATRIX METALLOPROTEINASES | invasion | PLASMINOGEN-ACTIVATOR | ONCOLOGY | metastasis | GENETICS & HEREDITY | TRANSMEMBRANE SERINE PROTEASES | EXPRESSION | RNA, Small Interfering - genetics | Cadherins - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | Cell Movement - genetics | Neoplasm Metastasis | Serine Endopeptidases - genetics | Liver Neoplasms - pathology | Cadherins - genetics | Liver Neoplasms - enzymology | Liver Neoplasms - secondary | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Lung Neoplasms - enzymology | Liver Neoplasms - genetics | Serine Endopeptidases - biosynthesis | Membrane Proteins - genetics | Epithelial Cells - pathology | Lung Neoplasms - therapy | Gastrointestinal Neoplasms - enzymology | Gastrointestinal Neoplasms - therapy | Cell Adhesion | Cell Movement - drug effects | Membrane Proteins - biosynthesis | Membrane Proteins - antagonists & inhibitors | Gene Expression Regulation, Enzymologic - genetics | Mice, Nude | Cell Communication - drug effects | Epithelial Cells - enzymology | Cell Line, Tumor | Biomarkers, Tumor - genetics | Cadherins - antagonists & inhibitors | Mice | RNA-Binding Proteins - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Neoplasm Transplantation | RNA-Binding Proteins - genetics | Gastrointestinal Neoplasms - genetics | Lung Neoplasms - pathology | Liver Neoplasms - therapy | Gastrointestinal Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Lung Neoplasms - genetics | Neoplasm Invasiveness | Neoplasm Proteins - biosynthesis | Cell Communication - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Biomarkers, Tumor - biosynthesis | Care and treatment | Control | Proteases | Cancer cells | Physiological aspects | Genetic aspects | Research | Risk factors | Oncology | Genetics | Cellular biology | Pancreatic cancer | Colorectal cancer | Index Medicus
Journal Article