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Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 11, pp. 2563 - 2570
Summary BRAF mutation is seen in a variety of human neoplasms including cutaneous malignant melanoma, papillary thyroid carcinoma, colorectal carcinoma,... 
Pathology | Immunohistochemistry | Anti–B-Raf | BRAF V600E | VE1 | Glioma | Melanoma | Thyroid carcinoma | Anti-B-Raf | PROTEIN | IMPROVED SURVIVAL | PATHOLOGY | CANCER | TUMORS | HAIRY-CELL LEUKEMIA | THERAPY | MEK INHIBITION | GENE | MUTANT BRAF | VEMURAFENIB | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Mutation, Missense | Breast Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Ovarian Neoplasms - genetics | Gastrointestinal Neoplasms - pathology | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Glioma - pathology | Sensitivity and Specificity | Biomarkers, Tumor - metabolism | Female | Ovarian Neoplasms - metabolism | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Thyroid Neoplasms - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Neoplasms - pathology | Amino Acid Substitution | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Carcinoma | Gene mutations | Gliomas | Thyroid diseases | Monoclonal antibodies | Genetic aspects | Comparative analysis | Lung cancer, Non-small cell | Cancer | Breast cancer | Mutation | Tumors | Skin cancer
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2008, Volume 60, Issue 3, pp. 379 - 387
Background Previous reports regarding the rates at which various internal tumors metastasize to the skin have been limited and have only included the Caucasian... 
Dermatology | LUNG-CANCER | PROGNOSTIC-FACTORS | ASIAN ETHNICITY | BREAST-CANCER METASTASIS | SKIN-ASSOCIATED CHEMOKINE | BASAL-CELL CARCINOMA | WHITE WOMEN | DRINKING-WATER | AFRICAN-AMERICAN | CHINESE WOMEN | DERMATOLOGY | Immunohistochemistry | Lung Neoplasms - ethnology | Academic Medical Centers - statistics & numerical data | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Transitional Cell - secondary | Lung Neoplasms - pathology | Mouth Neoplasms - metabolism | Carcinoma, Hepatocellular - secondary | Carcinoma, Transitional Cell - ethnology | Breast Neoplasms - metabolism | Carcinoma, Squamous Cell - ethnology | Gastrointestinal Neoplasms - pathology | Mouth Neoplasms - ethnology | Adenocarcinoma - metabolism | Urinary Bladder Neoplasms - pathology | Liver Neoplasms - pathology | Retrospective Studies | Adenocarcinoma - ethnology | Breast Neoplasms - ethnology | Urinary Bladder Neoplasms - metabolism | Carcinoma, Hepatocellular - ethnology | Gastrointestinal Neoplasms - metabolism | Receptors, CCR10 - metabolism | Skin Neoplasms - ethnology | Carcinoma, Transitional Cell - metabolism | Adenocarcinoma - secondary | Receptors, CXCR4 - metabolism | Skin Neoplasms - metabolism | Liver Neoplasms - ethnology | Breast Neoplasms - pathology | Taiwan - epidemiology | Liver Neoplasms - metabolism | Skin Neoplasms - secondary | Mouth Neoplasms - pathology | Carcinoma, Squamous Cell - secondary | Gastrointestinal Neoplasms - ethnology | Asian Continental Ancestry Group - statistics & numerical data | Carcinoma, Hepatocellular - metabolism | Urinary Bladder Neoplasms - ethnology | Medical colleges | Hospitals | Metastasis | Medical centers | Cancer
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 428 - 434
Background: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown.... 
chymotrypsin-like proteinase | Treponema denticola | periodontopathogen | COLLAGENASE-2 MMP-8 | PORPHYROMONAS-GINGIVALIS | PANCREATIC-CANCER | TISSUE INHIBITORS | PERIODONTAL-DISEASE | METALLOPROTEINASES | ONCOLOGY | gastrointestinal cancer | ALPHA-1-ANTITRYPSIN | EXPRESSION | oral cancer | HUMAN NEUTROPHIL | PROGRESSION | Digestive System Neoplasms - metabolism | Pancreatic Neoplasms - chemistry | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Treponema denticola - enzymology | Mouth Neoplasms - metabolism | Stomach Neoplasms - pathology | Tonsillar Neoplasms - chemistry | Complement C1q - metabolism | Colonic Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Esophageal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Head and Neck Neoplasms - chemistry | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Matrix Metalloproteinase 8 - metabolism | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Colonic Neoplasms - chemistry | Stomach Neoplasms - chemistry | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Tonsillar Neoplasms - pathology | Pancreatic Neoplasms - pathology | Carcinoma, Squamous Cell - chemistry | Mouth Neoplasms - chemistry | Head and Neck Neoplasms - pathology | Cell Transformation, Neoplastic - immunology | Digestive System Neoplasms - chemistry | alpha 1-Antichymotrypsin - metabolism | Colonic Neoplasms - pathology | Chymases - analysis | Mouth Neoplasms - pathology | Immunohistochemistry | Proteinase | Virulence | Tissue inhibitor of metalloproteinase 2 | Tissues | Tissue inhibitor of metalloproteinase 1 | Carcinogenesis | Proteins | Carcinogens | Pancreatic carcinoma | Bacteria | Colon | Pancreas | Gastric cancer | Squamous cell carcinoma | Tonsil | Immunomodulation | Teeth | Proteinase inhibitors | Esophagus | Complement component C1q | Chymotrypsin | Periodontitis | Neutrophil collagenase | Tumors | Molecular Diagnostics
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 09/2009, Volume 33, Issue 9, pp. 1401 - 1408
Gastrointestinal stromal tumors (GISTs), KIT or platelet derived growth factor receptor alpha (PDGFRA) signaling driven mesenchymal tumors of the... 
PDGFRA | Chloride channel protein | Sarcoma | DOG1 | KIT | Mutation | Gastrointestinal stromal tumor | PDGFRA MUTATIONS | GASTRIC TUMORS | SURGERY | sarcoma | MARKER | KINASE-C-THETA | MONOCLONAL-ANTIBODY | PATHOLOGY | mutation | chloride channel protein | gastrointestinal stromal tumor | TERM-FOLLOW-UP | EXPRESSION | PKC-THETA | MORPHOLOGY | Immunohistochemistry | Myenteric Plexus - pathology | Predictive Value of Tests | Anoctamin-1 | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Stomach Neoplasms - metabolism | Leiomyoma - metabolism | Myenteric Plexus - metabolism | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Esophageal Neoplasms - pathology | Leiomyoma - pathology | Chloride Channels | Gastrointestinal Stromal Tumors - diagnosis | Esophageal Neoplasms - metabolism | Mesenchymoma - diagnosis | Biomarkers, Tumor - metabolism | Membrane Proteins - metabolism | Intestinal Neoplasms - diagnosis | Colorectal Neoplasms - metabolism | Peritoneal Neoplasms - pathology | Mesenchymoma - metabolism | Diagnosis, Differential | Stomach Neoplasms - diagnosis | Intestinal Neoplasms - metabolism | Sarcoma, Synovial - metabolism | Peritoneal Neoplasms - metabolism | Gastrointestinal Stromal Tumors - metabolism | Mesenchymoma - secondary | Colorectal Neoplasms - pathology | Sarcoma, Synovial - pathology
Journal Article
Seminars in Oncology, ISSN 0093-7754, 2015, Volume 42, Issue 6, pp. 801 - 819
The fibroblast growth factor receptor (FGFR) pathway plays a major role in several biological processes, from organogenesis to metabolism homeostasis and... 
BREAST-CANCER | LUNG-CANCER | IN-VITRO | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | RESISTANCE | GENE AMPLIFICATION | POTENTIAL THERAPEUTIC TARGET | PROGNOSTIC-SIGNIFICANCE | ANTITUMOR-ACTIVITY | EXPRESSION | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Gastrointestinal Neoplasms - drug therapy | Humans | Brain Neoplasms - pathology | Fibroblast Growth Factors - genetics | Brain Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Breast Neoplasms - metabolism | Fibroblast Growth Factors - metabolism | Gastrointestinal Neoplasms - pathology | Glioblastoma - genetics | Receptors, Fibroblast Growth Factor - genetics | Female | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Molecular Targeted Therapy - methods | Gastrointestinal Neoplasms - metabolism | Biomarkers, Tumor - analysis | Head and Neck Neoplasms - drug therapy | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Thoracic Neoplasms - pathology | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Thoracic Neoplasms - metabolism | Head and Neck Neoplasms - pathology | Neoplasms - drug therapy | Breast Neoplasms - genetics | Thoracic Neoplasms - genetics | Breast Neoplasms - pathology | Glioblastoma - pathology | Receptors, Fibroblast Growth Factor - metabolism | Head and Neck Neoplasms - genetics | Fibroblast Growth Factors - antagonists & inhibitors | Thoracic Neoplasms - drug therapy | Glioblastoma - drug therapy | Neoplasms - pathology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Breast cancer research, ISSN 1465-5411, 2010, Volume 12, Issue 5, pp. R75 - R75
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2013, Volume 19, Issue 9, pp. 1114 - 1123
Although angiogenesis inhibitors have provided substantial clinical benefit as cancer therapeutics, their use is limited by resistance to their therapeutic... 
CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | MYELOID CELLS | REFRACTORINESS | CELL BIOLOGY | MICROENVIRONMENT | IL-17 | GROWTH | VEGF TREATMENT | SUPPRESSOR-CELLS | T-CELLS | Neoplasms - metabolism | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Male | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Lymphoma - metabolism | Myeloid Cells - immunology | Gastrointestinal Hormones - metabolism | Antibodies - immunology | Female | Neovascularization, Pathologic - immunology | Granulocytes - metabolism | Colorectal Neoplasms - metabolism | Fibroblasts - metabolism | Paracrine Communication | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Neuropeptides - metabolism | Vascular Endothelial Growth Factor A - immunology | Mice, Knockout | Neoplasms - drug therapy | Tumor Microenvironment - immunology | Interleukin-17 - metabolism | Animals | Granulocyte Colony-Stimulating Factor - biosynthesis | Neoplasms - immunology | Th17 Cells - immunology | Mice | CD11b Antigen - metabolism | Immunohistochemistry | Physiological aspects | Angiogenesis inhibitors | Research | Interleukins | Health aspects | Angiogenesis | Inhibitor drugs | Cytokines | Pharmacology | Vascular endothelial growth factor | Immune system | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7456, pp. 97 - 101
Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several... 
HEPATOCELLULAR-CARCINOMA | HEPATIC STELLATE CELLS | ACID | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | PHENOTYPE | BACTERIUM | MECHANISMS | STRESS | EXPRESSION | CLOSTRIDIUM | Fatty Liver - pathology | Carcinoma, Hepatocellular - prevention & control | Humans | Fatty Liver - complications | Cellular Senescence - drug effects | Hepatic Stellate Cells - metabolism | Liver Neoplasms - complications | Male | Hepatic Stellate Cells - cytology | Interleukin-1beta - deficiency | Liver Neoplasms - etiology | Carcinoma, Hepatocellular - complications | Dietary Fats - pharmacology | Non-alcoholic Fatty Liver Disease | Carcinoma, Hepatocellular - etiology | Disease Models, Animal | Hepatic Stellate Cells - drug effects | DNA Damage - drug effects | Hepatic Stellate Cells - secretion | Liver Neoplasms - prevention & control | Bacteria - metabolism | Dietary Fats - adverse effects | Obesity - chemically induced | Cytokines - metabolism | Deoxycholic Acid - blood | Mice, Inbred C57BL | Risk Factors | Cells, Cultured | Cytokines - secretion | Gastrointestinal Tract - microbiology | Bile Acids and Salts - metabolism | Gastrointestinal Tract - drug effects | Gastrointestinal Tract - metabolism | Obesity - metabolism | Phenotype | Animals | Deoxycholic Acid - metabolism | Liver Neoplasms - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Carcinoma, Hepatocellular - metabolism | Liver cancer | Obesity | Microbial metabolism | Development and progression | Genetic aspects | Research | Health aspects | Proteins | Cell growth | Weight control | Rodents | Index Medicus
Journal Article
Seminars in Immunopathology, ISSN 1863-2297, 3/2013, Volume 35, Issue 2, pp. 229 - 244
Connection between inflammation and cancer is a rapidly developing field. Epidemiological data suggests that inflammation along with distinct arms of host... 
Inflammatory bowel disease | Biomedicine | Immunology | Colon cancer | Cytokines | Internal Medicine | Bacteria | Inflammation | INDUCED CYTIDINE DEAMINASE | SPONTANEOUS INTESTINAL TUMORIGENESIS | IMMUNOLOGY | PATHOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | DEXTRAN SODIUM-SULFATE | TUMOR-NECROSIS-FACTOR | MURINE ULCERATIVE-COLITIS | BETA-CATENIN ACTIVATION | PROMOTES COLON TUMORIGENESIS | NF-KAPPA-B | GENOME-WIDE ASSOCIATION | Colonic Neoplasms - prevention & control | Humans | Risk Factors | Colitis - complications | Colitis - pathology | Inflammatory Bowel Diseases - metabolism | Colonic Neoplasms - metabolism | Rectal Neoplasms - prevention & control | Rectal Neoplasms - microbiology | Animals | Colitis - microbiology | Colitis - therapy | Colonic Neoplasms - pathology | Inflammatory Bowel Diseases - pathology | Colitis - metabolism | Inflammatory Bowel Diseases - microbiology | Rectal Neoplasms - metabolism | Rectal Neoplasms - pathology | Inflammatory Bowel Diseases - complications | Rectal Neoplasms - etiology | Colonic Neoplasms - etiology | Inflammatory Bowel Diseases - therapy | Colonic Neoplasms - microbiology | Prevention | Gastrointestinal diseases | Colorectal cancer | Development and progression | Colitis | Risk factors | Tumors | Inflammatory bowel diseases | Molecular modelling | Intestine | Data processing | Tumorigenesis | Neoplasia | Immune system | Metastases | cytokines | bacteria | inflammation | colon cancer | inflammatory bowel disease
Journal Article