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Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 11, pp. 2563 - 2570
Summary BRAF mutation is seen in a variety of human neoplasms including cutaneous malignant melanoma, papillary thyroid carcinoma, colorectal carcinoma,... 
Pathology | Immunohistochemistry | Anti–B-Raf | BRAF V600E | VE1 | Glioma | Melanoma | Thyroid carcinoma | Anti-B-Raf | PROTEIN | IMPROVED SURVIVAL | PATHOLOGY | CANCER | TUMORS | HAIRY-CELL LEUKEMIA | THERAPY | MEK INHIBITION | GENE | MUTANT BRAF | VEMURAFENIB | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Humans | Lung Neoplasms - metabolism | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Mutation, Missense | Breast Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Ovarian Neoplasms - genetics | Gastrointestinal Neoplasms - pathology | Neoplasms - genetics | DNA Mutational Analysis | Melanoma - genetics | Glioma - pathology | Sensitivity and Specificity | Biomarkers, Tumor - metabolism | Female | Ovarian Neoplasms - metabolism | Carcinoma - pathology | Antibodies, Monoclonal - immunology | Proto-Oncogene Proteins B-raf - metabolism | Gastrointestinal Neoplasms - metabolism | Lung Neoplasms - genetics | Melanoma - metabolism | Mutant Proteins - genetics | Mutant Proteins - metabolism | Melanoma - pathology | Thyroid Neoplasms - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Carcinoma - genetics | Biomarkers, Tumor - genetics | Carcinoma - metabolism | Neoplasms - pathology | Amino Acid Substitution | Thyroid Neoplasms - metabolism | Thyroid Neoplasms - pathology | Carcinoma | Gene mutations | Gliomas | Thyroid diseases | Monoclonal antibodies | Genetic aspects | Comparative analysis | Lung cancer, Non-small cell | Cancer | Breast cancer | Mutation | Tumors | Skin cancer | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 6, pp. 1976 - 1985.e10
Background & Aims MUTYH -associated polyposis (MAP) is characterized by a lifetime risk of colorectal cancer of up to 100%. However, no systematic evaluation... 
Gastroenterology and Hepatology | BASE-EXCISION-REPAIR | URINARY-TRACT CANCER | APC GENE MUTATION | MUIR-TORRE-SYNDROME | NONPOLYPOSIS COLORECTAL-CANCER | DUODENAL ADENOMATOSIS | FAMILIAL ADENOMATOUS POLYPOSIS | MYH-ASSOCIATED POLYPOSIS | LYNCH SYNDROME | GASTROENTEROLOGY & HEPATOLOGY | MSH2 MUTATION CARRIERS | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Adenomatous Polyposis Coli - epidemiology | Ovarian Neoplasms - pathology | Male | Adenomatous Polyposis Coli - pathology | Incidence | Ovarian Neoplasms - genetics | Young Adult | Gastrointestinal Neoplasms - pathology | Gastrointestinal Neoplasms - epidemiology | Urinary Bladder Neoplasms - genetics | Urinary Bladder Neoplasms - pathology | Adult | Female | Retrospective Studies | Endoscopy | Adenomatous Polyposis Coli - genetics | Child | Urinary Bladder Neoplasms - epidemiology | Breast Neoplasms - epidemiology | Skin Neoplasms - pathology | Genetic Predisposition to Disease | Sebaceous Gland Neoplasms - epidemiology | Risk Assessment | Risk Factors | Sebaceous Gland Neoplasms - genetics | DNA Glycosylases - genetics | Kaplan-Meier Estimate | Europe - epidemiology | Skin Neoplasms - epidemiology | Ovarian Neoplasms - epidemiology | Phenotype | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Sebaceous Gland Neoplasms - pathology | Skin Neoplasms - genetics | Adolescent | Age of Onset | Aged | Medical colleges | Animal pigments | Genetic disorders | Oncology, Experimental | Colorectal cancer | Research | Cancer | Tumors | Medical informatics | Index Medicus | Abridged Index Medicus
Journal Article
2012, 2nd ed., Foundations in diagnostic pathology., ISBN 9781437709254, xvi, 713
Book
Journal Article
British Journal of Cancer, ISSN 0007-0920, 02/2018, Volume 118, Issue 3, pp. 428 - 434
Background: Periodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown.... 
chymotrypsin-like proteinase | Treponema denticola | periodontopathogen | COLLAGENASE-2 MMP-8 | PORPHYROMONAS-GINGIVALIS | PANCREATIC-CANCER | TISSUE INHIBITORS | PERIODONTAL-DISEASE | METALLOPROTEINASES | ONCOLOGY | gastrointestinal cancer | ALPHA-1-ANTITRYPSIN | EXPRESSION | oral cancer | HUMAN NEUTROPHIL | PROGRESSION | Digestive System Neoplasms - metabolism | Pancreatic Neoplasms - chemistry | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Treponema denticola - enzymology | Mouth Neoplasms - metabolism | Stomach Neoplasms - pathology | Tonsillar Neoplasms - chemistry | Complement C1q - metabolism | Colonic Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Esophageal Neoplasms - pathology | Tonsillar Neoplasms - metabolism | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Head and Neck Neoplasms - chemistry | Matrix Metalloproteinase 9 - metabolism | Adenocarcinoma - metabolism | Matrix Metalloproteinase 8 - metabolism | Esophageal Neoplasms - metabolism | Digestive System Neoplasms - pathology | Colonic Neoplasms - chemistry | Stomach Neoplasms - chemistry | Adenocarcinoma - chemistry | Esophageal Neoplasms - chemistry | Tonsillar Neoplasms - pathology | Pancreatic Neoplasms - pathology | Carcinoma, Squamous Cell - chemistry | Mouth Neoplasms - chemistry | Head and Neck Neoplasms - pathology | Cell Transformation, Neoplastic - immunology | Digestive System Neoplasms - chemistry | alpha 1-Antichymotrypsin - metabolism | Colonic Neoplasms - pathology | Chymases - analysis | Mouth Neoplasms - pathology | Immunohistochemistry | Proteinase | Virulence | Tissue inhibitor of metalloproteinase 2 | Tissues | Tissue inhibitor of metalloproteinase 1 | Carcinogenesis | Proteins | Carcinogens | Pancreatic carcinoma | Bacteria | Colon | Pancreas | Gastric cancer | Squamous cell carcinoma | Tonsil | Immunomodulation | Teeth | Proteinase inhibitors | Esophagus | Complement component C1q | Chymotrypsin | Periodontitis | Neutrophil collagenase | Tumors | Index Medicus | Molecular Diagnostics
Journal Article
British Journal of Cancer, ISSN 0007-0920, 03/2017, Volume 116, Issue 6, pp. 802 - 810
When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%,... 
lung cancer | solid tumours | NGS | cfDNA | Melanoma - blood | Lung Neoplasms - drug therapy | Gastrointestinal Neoplasms - genetics | Prognosis | Prospective Studies | Follow-Up Studies | Gastrointestinal Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Gastrointestinal Neoplasms - pathology | DNA, Neoplasm - blood | Gastrointestinal Neoplasms - blood | DNA Mutational Analysis | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Gastrointestinal Stromal Tumors - pathology | Aged, 80 and over | Adult | Female | High-Throughput Nucleotide Sequencing - methods | Gastrointestinal Stromal Tumors - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Colorectal Neoplasms - blood | Melanoma - pathology | Mutation - genetics | Biomarkers, Tumor - blood | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Gastrointestinal Stromal Tumors - drug therapy | Gastrointestinal Stromal Tumors - blood | Melanoma - drug therapy | Carcinoma, Non-Small-Cell Lung - blood | ROC Curve | Aged | Biomarkers, Tumor - genetics | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Neoplasm Staging | Index Medicus | Genetics & Genomics
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2008, Volume 60, Issue 3, pp. 379 - 387
Background Previous reports regarding the rates at which various internal tumors metastasize to the skin have been limited and have only included the Caucasian... 
Dermatology | LUNG-CANCER | PROGNOSTIC-FACTORS | ASIAN ETHNICITY | BREAST-CANCER METASTASIS | SKIN-ASSOCIATED CHEMOKINE | BASAL-CELL CARCINOMA | WHITE WOMEN | DRINKING-WATER | AFRICAN-AMERICAN | CHINESE WOMEN | DERMATOLOGY | Immunohistochemistry | Lung Neoplasms - ethnology | Academic Medical Centers - statistics & numerical data | Carcinoma, Squamous Cell - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Transitional Cell - secondary | Lung Neoplasms - pathology | Mouth Neoplasms - metabolism | Carcinoma, Hepatocellular - secondary | Carcinoma, Transitional Cell - ethnology | Breast Neoplasms - metabolism | Carcinoma, Squamous Cell - ethnology | Gastrointestinal Neoplasms - pathology | Mouth Neoplasms - ethnology | Adenocarcinoma - metabolism | Urinary Bladder Neoplasms - pathology | Liver Neoplasms - pathology | Retrospective Studies | Adenocarcinoma - ethnology | Breast Neoplasms - ethnology | Urinary Bladder Neoplasms - metabolism | Carcinoma, Hepatocellular - ethnology | Gastrointestinal Neoplasms - metabolism | Receptors, CCR10 - metabolism | Skin Neoplasms - ethnology | Carcinoma, Transitional Cell - metabolism | Adenocarcinoma - secondary | Receptors, CXCR4 - metabolism | Skin Neoplasms - metabolism | Liver Neoplasms - ethnology | Breast Neoplasms - pathology | Taiwan - epidemiology | Liver Neoplasms - metabolism | Skin Neoplasms - secondary | Mouth Neoplasms - pathology | Carcinoma, Squamous Cell - secondary | Gastrointestinal Neoplasms - ethnology | Asian Continental Ancestry Group - statistics & numerical data | Carcinoma, Hepatocellular - metabolism | Urinary Bladder Neoplasms - ethnology | Medical colleges | Hospitals | Metastasis | Medical centers | Cancer | Index Medicus
Journal Article
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 09/2009, Volume 33, Issue 9, pp. 1401 - 1408
Gastrointestinal stromal tumors (GISTs), KIT or platelet derived growth factor receptor alpha (PDGFRA) signaling driven mesenchymal tumors of the... 
PDGFRA | Chloride channel protein | Sarcoma | DOG1 | KIT | Mutation | Gastrointestinal stromal tumor | PDGFRA MUTATIONS | GASTRIC TUMORS | SURGERY | sarcoma | MARKER | KINASE-C-THETA | MONOCLONAL-ANTIBODY | PATHOLOGY | mutation | chloride channel protein | gastrointestinal stromal tumor | TERM-FOLLOW-UP | EXPRESSION | PKC-THETA | MORPHOLOGY | Immunohistochemistry | Myenteric Plexus - pathology | Predictive Value of Tests | Anoctamin-1 | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Stomach Neoplasms - metabolism | Leiomyoma - metabolism | Myenteric Plexus - metabolism | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Esophageal Neoplasms - pathology | Leiomyoma - pathology | Chloride Channels | Gastrointestinal Stromal Tumors - diagnosis | Esophageal Neoplasms - metabolism | Mesenchymoma - diagnosis | Biomarkers, Tumor - metabolism | Membrane Proteins - metabolism | Intestinal Neoplasms - diagnosis | Colorectal Neoplasms - metabolism | Peritoneal Neoplasms - pathology | Mesenchymoma - metabolism | Diagnosis, Differential | Stomach Neoplasms - diagnosis | Intestinal Neoplasms - metabolism | Sarcoma, Synovial - metabolism | Peritoneal Neoplasms - metabolism | Gastrointestinal Stromal Tumors - metabolism | Mesenchymoma - secondary | Colorectal Neoplasms - pathology | Sarcoma, Synovial - pathology | Index Medicus
Journal Article
Modern Pathology, ISSN 0893-3952, 12/2011, Volume 24, Issue 12, pp. 1560 - 1570
Journal Article
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2015, Volume 33, Issue 34, pp. 4032 - 4038
Purpose BRAF V600E mutation is seen in 5% to 8% of patients with metastatic colorectal cancer (CRC) and is associated with poor prognosis. Vemurafenib, an oral... 
COLON-CANCER | SURVIVAL | INHIBITION | <