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1. Full Text Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
by Katherine A. Janeway and Su Young Kim and Maya Lodish and Vânia Nosé and Pierre Rustin and José Gaal and Patricia L. M. Dahia and Bernadette Liegl and Evan R. Ball and Margarita Raygada and Angela H. Lai and Lorna Kelly and Jason L. Hornick and NIH Pediatric and Wild-Type GIST Clinic and Maureen O'Sullivan and Ronald R. de Krijger and Winand N. M. Dinjens and George D. Demetri and Cristina R. Antonescu and Jonathan A. Fletcher and Lee Helman and Constantine A. Stratakis and Stuart H. Orkin and NIH Pediat Wild Type GIST Clinic and NIH Pediatric and Wild-Type GIST Clinic
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 1, pp. 314 - 318
Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by... 
Pediatrics | Gastrointestinal stromal tumors | Germ cells | Dehydrogenases | Medical genetics | Paraganglioma | Germline mutation | Genetic mutation | Summarization | Tumors | Genetic predisposition | Sarcoma | Pediatric | RESPIRATORY-CHAIN | GIST | sarcoma | VARIANTS | SDHD GENE | MULTIDISCIPLINARY SCIENCES | PHENOTYPE | PARAGANGLIOMA | MECHANISMS | APPARENTLY SPORADIC PHEOCHROMOCYTOMAS | pediatric | COMPLEX-II | genetic predisposition | GERMLINE MUTATIONS | Gastrointestinal Stromal Tumors - enzymology | Immunohistochemistry | Genetic Predisposition to Disease - genetics | Paraganglioma - enzymology | Electron Transport Complex II - genetics | Humans | Germ-Line Mutation - genetics | Blotting, Western | Syndrome | Succinate Dehydrogenase - genetics | Cell Respiration - genetics | DNA Mutational Analysis | Electron Transport Complex II - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adolescent | Cell Respiration - physiology | Proto-Oncogene Proteins c-kit - genetics | Succinate Dehydrogenase - metabolism | Polymorphism, Single Nucleotide | Protein Subunits - genetics | Physiological aspects | Succinate dehydrogenase complex | Platelet-derived growth factor | Gene mutations | Biological Sciences
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2. Full Text Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) – A review
by Miettinen, Markku and Lasota, Jerzy
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 08/2014, Volume 53, pp. 514 - 519
Loss of function of the succinate dehydrogenase complex characterizes a rare group of human tumors including some gastrointestinal stromal tumors,... 
SDH-complex | GIST | SDHA | SDHB | Gastrointestinal stromal tumor | PDGFRA MUTATIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SDHA MUTATIONS | PARAGANGLIOMA | IGF1R | CELL BIOLOGY | CARNEY TRIAD | GENE | THERAPEUTIC TARGET | GERMLINE MUTATIONS | COMPLEX II | EXPRESSION | Gastrointestinal Stromal Tumors - enzymology | Genetic Predisposition to Disease | Electron Transport Complex II - genetics | Gastrointestinal Stromal Tumors - epidemiology | Membrane Proteins - genetics | Humans | DNA Methylation - genetics | Succinate Dehydrogenase - deficiency | Membrane Proteins - deficiency | Succinate Dehydrogenase - genetics | Gastrointestinal Stromal Tumors - pathology | Electron Transport Complex II - deficiency | Mutation | Energy Metabolism - genetics | Gastrointestinal Stromal Tumors - genetics | Somatomedins - metabolism | Proteins | Immunohistochemistry | Epigenetic inheritance | Analysis | Physiological aspects | Methylation | Tumors | mutation | pseudohypoxia | SDHC | SDHD
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3. Full Text Succinate dehydrogenase-deficient GISTs: A clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age
by Miettinen, Markku and Wang, Zeng-Feng and Sarlomo-Rikala, Maarit and Osuch, Czeslaw and Rutkowski, Piotr and Lasota, Jerzy
American Journal of Surgical Pathology, ISSN 0147-5185, 11/2011, Volume 35, Issue 11, pp. 1712 - 1721
Most gastrointestinal stromal tumors (GISTs) are driven by KIT or PDGFRA-activating mutations, but a small subset is associated with loss of function of the... 
gastrointestinal stromal tumor | prognosis | SDHB | succinate dehydrogenase subunit B | succinate dehydrogenase | SURGERY | CARNEY-STRATAKIS-SYNDROME | SDHD GENE | TRIAD | C-KIT | PARAGANGLIOMA | PATHOLOGY | HIF1-ALPHA | PHEOCHROMOCYTOMA | GERMLINE MUTATIONS | GASTROINTESTINAL STROMAL TUMORS | EXPRESSION | Gastrointestinal Stromal Tumors - enzymology | Immunohistochemistry | Prognosis | Age Factors | Gastrointestinal Stromal Tumors - secondary | Humans | Middle Aged | Male | Stomach Neoplasms - pathology | Young Adult | Gastrointestinal Stromal Tumors - diagnosis | Time Factors | DNA Mutational Analysis | Aged, 80 and over | Poland | Adult | Female | Stomach Neoplasms - chemistry | Gastrointestinal Stromal Tumors - mortality | Child | Gastrointestinal Stromal Tumors - genetics | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Stomach Neoplasms - diagnosis | Biomarkers, Tumor - analysis | Neoplasm Invasiveness | Tumor Burden | Succinate Dehydrogenase - deficiency | Mitotic Index | Succinate Dehydrogenase - genetics | Gastrointestinal Stromal Tumors - chemistry | Adolescent | Finland | Aged | Biomarkers, Tumor - genetics | Maryland | Stomach Neoplasms - mortality
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4. Full Text Recurrent epimutation of SDHC in gastrointestinal stromal tumors
by Killian, J. Keith and Miettinen, Markku and Walker, Robert L and Wang, Yonghong and Zhu, Yuelin Jack and Waterfall, Joshua J and Noyes, Natalia and Retnakumar, Parvathy and Yang, Zhiming and Smith, William I and Killian, M. Scott and Lau, C. Christopher and Pineda, Marbin and Walling, Jennifer and Stevenson, Holly and Smith, Carly and Wang, Zengfeng and Lasota, Jerzy and Kim, Su Young and Boikos, Sosipatros A and Helman, Lee J and Meltzer, Paul S
Science Translational Medicine, ISSN 1946-6234, 12/2014, Volume 6, Issue 268, pp. 268ra177 - ra177
Succinate dehydrogenase (SDH) is a conserved effector of cellular metabolism and energy production, and loss of SDH function is a driver mechanism in several... 
CARNEY TRIAD | MEDICINE, RESEARCH & EXPERIMENTAL | IDH2 MUTATIONS | HYPERMETHYLATION | INHIBITION | SUCCINATE | PHENOTYPE | PARAGANGLIOMA | RECEPTOR | EXPRESSION | HISTONE | CELL BIOLOGY | Gastrointestinal Stromal Tumors - enzymology | Membrane Proteins - genetics | Humans | Middle Aged | Gene Silencing | Male | DNA Methylation - genetics | Mutation - genetics | Promoter Regions, Genetic - genetics | Young Adult | Membrane Proteins - deficiency | Gastrointestinal Stromal Tumors - blood | Adolescent | Adult | Female | Mosaicism | Enzyme Activation | Child | Gastrointestinal Stromal Tumors - genetics
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5. Full Text Conventional Risk Stratification Fails to Predict Progression of Succinate Dehydrogenase–deficient Gastrointestinal Stromal Tumors: A Clinicopathologic Study of 76 Cases
by Mason, Emily F and Hornick, Jason L
The American Journal of Surgical Pathology, ISSN 0147-5185, 12/2016, Volume 40, Issue 12, pp. 1616 - 1621
Gastrointestinal stromal tumors (GISTs) that lack kinase mutations often show loss of function of the succinate dehydrogenase (SDH) complex, due to germline... 
Succinate dehydrogenase | Prognosis | Risk stratification | Gastrointestinal stromal tumor | CARNEY TRIAD | SURGERY | DEFECTS | risk stratification | gastrointestinal stromal tumor | MUTATIONS | PATHOLOGY | prognosis | EXPRESSION | succinate dehydrogenase | Gastrointestinal Stromal Tumors - enzymology | Follow-Up Studies | Biomarkers, Tumor - deficiency | Humans | Middle Aged | Male | Stomach Neoplasms - pathology | Young Adult | Neoplasm Metastasis | Gastrointestinal Stromal Tumors - diagnosis | Gastrointestinal Stromal Tumors - pathology | Adult | Female | Gastrointestinal Stromal Tumors - mortality | Child | Stomach Neoplasms - enzymology | Stomach Neoplasms - diagnosis | Risk Assessment | Disease Progression | Succinate Dehydrogenase - deficiency | Succinate Dehydrogenase - genetics | Adolescent | Aged | Biomarkers, Tumor - genetics | Mutation | Stomach Neoplasms - mortality
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6. Full Text Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor
by Killian, J. Keith and Kim, Su Young and Miettinen, Markku and Smith, Carly and Merino, Maria and Tsokos, Maria and Quezado, Martha and Smith Jr, William I and Jahromi, Mona S and Xekouki, Paraskevi and Szarek, Eva and Walker, Robert L and Lasota, Jerzy and Raffeld, Mark and Klotzle, Brandy and Wang, Zengfeng and Jones, Laura and Zhu, Yuelin and Wang, Yonghong and Waterfall, Joshua J and O'Sullivan, Maureen J and Bibikova, Marina and Pacak, Karel and Stratakis, Constantine and Janeway, Katherine A and Schiffman, Joshua D and Fan, Jian-Bing and Helman, Lee and Meltzer, Paul S
Cancer Discovery, ISSN 2159-8274, 2013, Volume 3, Issue 6, pp. 648 - 657
Gastrointestinal stromal tumors (GIST) harbor driver mutations of signal transduction kinases such as KIT, or, alternatively, manifest loss-of-function defects... 
IDH2 MUTATIONS | INHIBITION | ASSAY | SUPPRESSORS | ONCOLOGY | COPY-NUMBER | KIT | UPDATE | OF-FUNCTION MUTATIONS | SDHA | HISTONE | Gastrointestinal Stromal Tumors - enzymology | Genomic Instability | DNA Methylation | Succinate Dehydrogenase - genetics | Epigenomics | Signal Transduction | Gastrointestinal Stromal Tumors - pathology | Humans | Gene Expression Regulation, Neoplastic | Germ-Line Mutation | Gastrointestinal Stromal Tumors - genetics
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7. Full Text KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence
by Joensuu, Heikki and Rutkowski, Piotr and Nishida, Toshirou and Steigen, Sonja E and Brabec, Peter and Plank, Lukas and Nilsson, Bengt and Braconi, Chiara and Bordoni, Andrea and Magnusson, Magnus K and Sufliarsky, Jozef and Federico, Massimo and Jonasson, Jon G and Hostein, Isabelle and Bringuier, Pierre-Paul and Emile, Jean-Francois
Journal of Clinical Oncology, ISSN 0732-183X, 02/2015, Volume 33, Issue 6, pp. 634 - 642
Purpose Mutated KIT and platelet-derived growth factor alpha gene (PDGFRA) drive GI stromal tumor (GIST) oncogenesis, but the clinical significance of their... 
MESYLATE | ONCOLOGY | RESECTION | GISTS | PROGNOSTIC VALUE | ADJUVANT IMATINIB | STRATIFICATION | KIT/PDGFRA MUTATIONS | FEATURES | Gastrointestinal Stromal Tumors - enzymology | Genetic Predisposition to Disease | Gastrointestinal Neoplasms - genetics | Gastrointestinal Stromal Tumors - surgery | Humans | Middle Aged | Gastrointestinal Neoplasms - surgery | Male | Gastrointestinal Neoplasms - enzymology | Neoplasm Recurrence, Local - enzymology | Young Adult | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adolescent | Aged, 80 and over | Adult | Female | Neoplasm Recurrence, Local - genetics | Proto-Oncogene Proteins c-kit - genetics | Aged | Child | Gastrointestinal Stromal Tumors - genetics
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8. Full Text Immunohistochemical loss of succinate dehydrogenase subunit a (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation
by Miettinen, Markku and Killian, Jonathan Keith and Wang, Zeng-Feng and Lasota, Jerzy and Lau, Christopher and Jones, Laura and Walker, Robert and Pineda, Marbin and Zhu, Yuelin Jack and Kim, Su Y and Helman, Lee and Meltzer, Paul
American Journal of Surgical Pathology, ISSN 0147-5185, 02/2013, Volume 37, Issue 2, pp. 234 - 240
A subset (7% to 10%) of gastric gastrointestinal stromal tumors (GISTs) is notable for the immunohistochemical loss of succinate dehydrogenase (SDH) subunit B... 
GIST | mutation analysis | immunohistochemistry | SDHA | prognosis | SDHB | pediatric GIST | paraganglioma | succinate dehydrogenase | SURGERY | MOLECULAR-GENETICS | CARNEY-STRATAKIS-SYNDROME | TRIAD | PATHOLOGY | MISSENSE MUTATIONS | Gastrointestinal Stromal Tumors - enzymology | Electron Transport Complex II - genetics | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Male | Gastrointestinal Neoplasms - enzymology | Succinate Dehydrogenase - deficiency | Immunohistochemistry - methods | Young Adult | DNA Mutational Analysis | Adolescent | Aged, 80 and over | Germ-Line Mutation | Adult | Female | Aged | DNA, Neoplasm - analysis | Child | Gastrointestinal Stromal Tumors - genetics
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9. Full Text Pediatric KIT-wild-type and platelet-derived growth factor receptor α-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors
by Janeway, Katherine A and Liegl, Bernadette and Harlow, Amy and Le, Claudia and Perez-Atayde, Antonio and Kozakewich, Harry and Corless, Christopher L and Heinrich, Michael C and Fletcher, Jonathan A
Cancer Research, ISSN 0008-5472, 10/2007, Volume 67, Issue 19, pp. 9084 - 9088
Fewer than 15% of gastrointestinal stromal tumors (GIST) in pediatric patients harbor JUT or platelet-derived growl factor receptor alpha (PDGFRA) mutations in... 
YOUNG-ADULTS | PDGFRA | ONCOLOGY | IMATINIB | DEREGULATION | BIOLOGY | MUTATIONS | OF-THE-LITERATURE | 12-YEAR-OLD GIRL | STOMACH | CHILDREN | Gastrointestinal Stromal Tumors - enzymology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | Humans | Male | Proto-Oncogene Proteins c-kit - metabolism | Disease Progression | Receptor, Platelet-Derived Growth Factor alpha - genetics | Gastrointestinal Stromal Tumors - pathology | Adolescent | Adult | Female | Proto-Oncogene Proteins c-kit - genetics | Polymorphism, Single Nucleotide | Enzyme Activation | Child | Gastrointestinal Stromal Tumors - genetics
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10. Full Text Gastrointestinal stromal tumors: What do we know now?
by Corless, Christopher L
Modern Pathology, ISSN 0893-3952, 01/2014, Volume 27, Issue 1, pp. S1 - S16
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the GI tract, arising from the interstitial cells of Cajal, primarily in the... 
PDGFRA | GIST | KIT | PDGFRA MUTATIONS | WILD-TYPE | GERMLINE MUTATION | OF-FUNCTION MUTATIONS | PATHOLOGY | V600E BRAF MUTATIONS | FACTOR-RECEPTOR-ALPHA | C-KIT GENE | POOR-PROGNOSIS | TYROSINE KINASE INHIBITOR | TERM-FOLLOW-UP | Gastrointestinal Stromal Tumors - enzymology | Predictive Value of Tests | Genetic Predisposition to Disease | Genetic Testing | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Patient Selection | Phenotype | Gastrointestinal Stromal Tumors - drug therapy | Protein Kinase Inhibitors - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - antagonists & inhibitors | Receptor, Platelet-Derived Growth Factor alpha - genetics | Gastrointestinal Stromal Tumors - pathology | Proto-Oncogene Proteins c-kit - genetics | Biomarkers, Tumor - genetics | Mutation | Gastrointestinal Stromal Tumors - genetics | Precision Medicine
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11. Full Text Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal stromal tumors
by Dwight, Trisha and Benn, Diana E and Clarkson, Adele and Vilain, Ricardo and Lipton, Lara and Robinson, Bruce G and Clifton-Bligh, Roderick J and Gill, Anthony J
American Journal of Surgical Pathology, ISSN 0147-5185, 02/2013, Volume 37, Issue 2, pp. 226 - 233
Succinate dehydrogenase-deficient gastrointestinal stromal tumors (SDH-deficient GISTs) are a unique class of GIST defined by negative immunohistochemical... 
gastrointestinal stromal tumor | SDHA | SDHB | succinate dehydrogenase | GENE-MUTATIONS | SURGERY | PARAGANGLIOMA | RENAL TUMORS | PATHOLOGY | CARNEY TRIAD | PHEOCHROMOCYTOMA | KIT | GISTS | GERMLINE SDHB | IMMUNOHISTOCHEMISTRY | Gastrointestinal Stromal Tumors - enzymology | Triage - methods | Electron Transport Complex II - genetics | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Male | Gastrointestinal Neoplasms - enzymology | Succinate Dehydrogenase - deficiency | Young Adult | DNA Mutational Analysis | Adolescent | Germ-Line Mutation | Adult | Female | DNA, Neoplasm - analysis | Gastrointestinal Stromal Tumors - genetics
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12. Full Text KIT Kinase Mutants Show Unique Mechanisms of Drug Resistance to Imatinib and Sunitinib in Gastrointestinal Stromal Tumor Patients
by Ketan S. Gajiwala and Joe C. Wu and James Christensen and Gayatri D. Deshmukh and Wade Diehl and Jonathan P. DiNitto and Jessie M. English and Michael J. Greig and You-Ai He and Suzanne L. Jacques and Elizabeth A. Lunney and Michele McTigue and David Molina and Terri Quenzer and Peter A. Wells and Xiu Yu and Yan Zhang and Aihua Zou and Mark R. Emmett and Alan G. Marshall and Hui-Min Zhang and George D. Demetri
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2009, Volume 106, Issue 5, pp. 1542 - 1547
Most gastrointestinal stromal tumors (GISTs) exhibit aberrant activation of the receptor tyrosine kinase (RTK) KIT. The efficacy of the inhibitors imatinib... 
Enzymes | Gastrointestinal stromal tumors | Fluorescence | Mass spectroscopy | Biochemistry | Drug resistance | Genetic mutation | Summarization | Mutant proteins | Resistance mechanisms | Signal transduction | Targeted therapy resistance mechanism | Kinase inhibitor | Cancer | ION-CYCLOTRON RESONANCE | kinase inhibitor | targeted therapy | signal transduction | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | resistance mechanism | cancer | STI-571 INHIBITION | GENE MUTATION | ATP | MASS-SPECTROMETRY | Gastrointestinal Stromal Tumors - enzymology | Pyrroles - metabolism | Phosphorylation | Humans | Spectrometry, Fluorescence | Piperazines - metabolism | Antineoplastic Agents - therapeutic use | Piperazines - therapeutic use | Receptor Protein-Tyrosine Kinases - metabolism | Imatinib Mesylate | Pyrimidines - metabolism | Antineoplastic Agents - metabolism | Drug Resistance, Neoplasm - genetics | Indoles - metabolism | Receptor Protein-Tyrosine Kinases - genetics | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Indoles - therapeutic use | Benzamides | Mutation | Pyrroles - therapeutic use | Gastrointestinal Stromal Tumors - genetics | Research | Drug therapy | Gastrointestinal tumors | Phosphotransferases | Health aspects | Biological Sciences
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13. Full Text Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors
by Boikos, SA and Helman, LJ and Stratakis, CA and Natl Inst Hlth and Pediatric and Wildtype GIST Clinic at the National Institutes of Health
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 07/2014, Volume 371, Issue 1, pp. 85 - 86
MEDICINE, GENERAL & INTERNAL | MUTATIONS | Gastrointestinal Stromal Tumors - enzymology | Thyroid Hormones - deficiency | Humans | Iodide Peroxidase - metabolism | Hypothyroidism - enzymology | Male | Gastrointestinal Neoplasms - enzymology | Hypothyroidism - etiology
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14. Full Text Resumption of imatinib to control metastatic or unresectable gastrointestinal stromal tumours after failure of imatinib and sunitinib (RIGHT): a randomised, placebo-controlled, phase 3 trial
by Kang, Yoon-Koo, Prof and Ryu, Min-Hee, MD and Yoo, Changhoon, MD and Ryoo, Baek-Yeol, Prof and Kim, Hyun Jin, MD and Lee, Jong Jin, MD and Nam, Byung-Ho, PhD and Ramaiya, Nikhil, MBBS and Jagannathan, Jyothi, MD and Demetri, George D, Prof
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 12, pp. 1175 - 1182
Summary Background Few treatment options remain for patients with metastatic or unresectable gastrointestinal stromal tumours (GIST) after objective... 
Hematology, Oncology and Palliative Medicine | MESYLATE | SOLID TUMORS | EFFICACY | ONCOLOGY | SAFETY | KIT | MUTATIONS | GUIDELINE | Gastrointestinal Stromal Tumors - enzymology | Piperazines - administration & dosage | Prospective Studies | Gastrointestinal Stromal Tumors - secondary | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Indoles - administration & dosage | Benzamides - administration & dosage | Time Factors | Antineoplastic Agents - adverse effects | Pyrroles - administration & dosage | Pyrroles - adverse effects | Female | Gastrointestinal Stromal Tumors - mortality | Benzamides - adverse effects | Republic of Korea | Double-Blind Method | Drug Administration Schedule | Pyrimidines - administration & dosage | Kaplan-Meier Estimate | Proportional Hazards Models | Treatment Outcome | Imatinib Mesylate | Piperazines - adverse effects | Disease Progression | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Indoles - adverse effects | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - adverse effects | Aged | Antimitotic agents | Clinical trials | Product development | Metastasis | Antineoplastic agents
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15. Full Text Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors
by Maynard, Michelle A and Marino-Enriquez, Adrian and Fletcher, Jonathan A and Dorfman, David M and Dorfman, Clara and Raut, Chandrajit P and Yassa, Leila and Guo, Cuicui and Wang, Yuexiang and Feldman, Henry A and Frates, Mary C and Song, Huaidong and Jugo, Rebecca H and Taguchi, Takahiro and Hershman, Jerome M and Larsen, P. Reed and Huang, Stephen A
The New England Journal of Medicine, ISSN 0028-4793, 04/2014, Volume 370, Issue 14, pp. 1327 - 1334
A case of hypothyroidism with a very high requirement for thyroxine replacement was found to be due to production of type 3 iodothyronine deiodinase (D3) by a... 
CONSUMPTIVE HYPOTHYROIDISM | MEDICINE, GENERAL & INTERNAL | KIT | SUNITINIB | SERUM | TYPE-3 IODOTHYRONINE DEIODINASE | MUTATIONS | Gastrointestinal Stromal Tumors - enzymology | Thyroid Hormones - deficiency | Humans | Middle Aged | Gastrointestinal Stromal Tumors - diagnostic imaging | Gastrointestinal Neoplasms - complications | Male | Gastrointestinal Neoplasms - enzymology | Hypothyroidism - etiology | Gastrointestinal Neoplasms - diagnostic imaging | Iodide Peroxidase - metabolism | Gastrointestinal Stromal Tumors - complications | Hypothyroidism - enzymology | Iodide Peroxidase - genetics | Radiography, Abdominal | Physiological aspects | Thyroid hormones | Research | Gastrointestinal tumors | Risk factors | Tyrosine | Imatinib | Iodide peroxidase | Hypothyroidism | Side effects | Chemotherapy | Thyroxine deiodinase | Supplementation | Protein-tyrosine kinase | Cancer | Thyroid | Iodine | Tumors
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