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1. Full Text Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) – A review
by Miettinen, Markku and Lasota, Jerzy
The international journal of biochemistry & cell biology, ISSN 1357-2725, 08/2014, Volume 53, pp. 514 - 519
SDH-complex | GIST | SDHA | SDHB | Gastrointestinal stromal tumor | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gastrointestinal Stromal Tumors - enzymology | Genetic Predisposition to Disease | Electron Transport Complex II - genetics | Gastrointestinal Stromal Tumors - epidemiology | Membrane Proteins - genetics | Humans | DNA Methylation - genetics | Succinate Dehydrogenase - deficiency | Membrane Proteins - deficiency | Succinate Dehydrogenase - genetics | Gastrointestinal Stromal Tumors - pathology | Electron Transport Complex II - deficiency | Mutation | Energy Metabolism - genetics | Gastrointestinal Stromal Tumors - genetics | Somatomedins - metabolism | Proteins | Immunohistochemistry | Epigenetic inheritance | Analysis | Physiological aspects | Methylation | Tumors | Index Medicus | mutation | pseudohypoxia | SDHC | SDHD
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2. Full Text Current management of succinate dehydrogenase–deficient gastrointestinal stromal tumors
by Neppala, Pushpa and Banerjee, Sudeep and Fanta, Paul T and Yerba, Mayra and Porras, Kevin A and Burgoyne, Adam M and Sicklick, Jason K
Cancer and metastasis reviews, ISSN 0167-7659, 09/2019, Volume 38, Issue 3, pp. 525 - 535
Gastrointestinal stromal tumors | GIST | Succinate dehydrogenase | SDH | Tyrosine kinase inhibitors | Life Sciences & Biomedicine | Oncology | Science & Technology | Gastrointestinal Stromal Tumors - enzymology | Gastrointestinal Stromal Tumors - therapy | Succinate Dehydrogenase - genetics | Animals | Gastrointestinal Neoplasms - genetics | Humans | Succinate Dehydrogenase - metabolism | Gastrointestinal Neoplasms - enzymology | Gastrointestinal Neoplasms - therapy | Mutation | Gastrointestinal Stromal Tumors - genetics | Succinate Dehydrogenase - deficiency | Tyrosine | Dehydrogenases | Medical treatment | Clinical trials | Paraganglioma | Biology | Kinases | Dehydrogenase | Metastases | Inhibitors | Biological warfare | Tumorigenesis | Protein-tyrosine kinase | Tumors | Index Medicus | tyrosine kinase inhibitors | succinate dehydrogenase
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3. Full Text Conventional Risk Stratification Fails to Predict Progression of Succinate Dehydrogenase–deficient Gastrointestinal Stromal Tumors: A Clinicopathologic Study of 76 Cases
by Mason, Emily F and Hornick, Jason L
The American journal of surgical pathology, ISSN 0147-5185, 12/2016, Volume 40, Issue 12, pp. 1616 - 1621
Succinate dehydrogenase | Prognosis | Risk stratification | Gastrointestinal stromal tumor | Pathology | Life Sciences & Biomedicine | Surgery | Science & Technology | Gastrointestinal Stromal Tumors - enzymology | Follow-Up Studies | Biomarkers, Tumor - deficiency | Humans | Middle Aged | Male | Stomach Neoplasms - pathology | Young Adult | Neoplasm Metastasis | Gastrointestinal Stromal Tumors - diagnosis | Gastrointestinal Stromal Tumors - pathology | Adult | Female | Gastrointestinal Stromal Tumors - mortality | Child | Stomach Neoplasms - enzymology | Stomach Neoplasms - diagnosis | Risk Assessment | Disease Progression | Succinate Dehydrogenase - deficiency | Succinate Dehydrogenase - genetics | Adolescent | Aged | Biomarkers, Tumor - genetics | Mutation | Stomach Neoplasms - mortality | Index Medicus
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4. Full Text Succinate dehydrogenase-deficient GISTs: A clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age
by Miettinen, Markku and Wang, Zeng-Feng and Sarlomo-Rikala, Maarit and Osuch, Czeslaw and Rutkowski, Piotr and Lasota, Jerzy
The American journal of surgical pathology, ISSN 0147-5185, 11/2011, Volume 35, Issue 11, pp. 1712 - 1721
gastrointestinal stromal tumor | prognosis | SDHB | succinate dehydrogenase subunit B | succinate dehydrogenase | Pathology | Life Sciences & Biomedicine | Surgery | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Investigative techniques, diagnostic techniques (general aspects) | Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques | Biological and medical sciences | Medical sciences | Tumors | Gastrointestinal Stromal Tumors - enzymology | Immunohistochemistry | Prognosis | Age Factors | Gastrointestinal Stromal Tumors - secondary | Humans | Middle Aged | Male | Stomach Neoplasms - pathology | Young Adult | Gastrointestinal Stromal Tumors - diagnosis | Time Factors | DNA Mutational Analysis | Aged, 80 and over | Poland | Adult | Female | Stomach Neoplasms - chemistry | Gastrointestinal Stromal Tumors - mortality | Child | Gastrointestinal Stromal Tumors - genetics | Stomach Neoplasms - enzymology | Stomach Neoplasms - genetics | Stomach Neoplasms - diagnosis | Biomarkers, Tumor - analysis | Neoplasm Invasiveness | Tumor Burden | Succinate Dehydrogenase - deficiency | Mitotic Index | Succinate Dehydrogenase - genetics | Gastrointestinal Stromal Tumors - chemistry | Adolescent | Finland | Aged | Biomarkers, Tumor - genetics | Maryland | Stomach Neoplasms - mortality | Index Medicus
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5. Full Text Recurrent epimutation of SDHC in gastrointestinal stromal tumors
by Killian, J. Keith and Miettinen, Markku and Walker, Robert L and Wang, Yonghong and Zhu, Yuelin Jack and Waterfall, Joshua J and Noyes, Natalia and Retnakumar, Parvathy and Yang, Zhiming and Smith, William I and Killian, M. Scott and Lau, C. Christopher and Pineda, Marbin and Walling, Jennifer and Stevenson, Holly and Smith, Carly and Wang, Zengfeng and Lasota, Jerzy and Kim, Su Young and Boikos, Sosipatros A and Helman, Lee J and Meltzer, Paul S
Science translational medicine, ISSN 1946-6234, 12/2014, Volume 6, Issue 268, pp. 268ra177 - ra177
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Gastrointestinal Stromal Tumors - enzymology | Membrane Proteins - genetics | Humans | Middle Aged | Gene Silencing | Male | DNA Methylation - genetics | Mutation - genetics | Promoter Regions, Genetic - genetics | Young Adult | Membrane Proteins - deficiency | Gastrointestinal Stromal Tumors - blood | Adolescent | Adult | Female | Mosaicism | Enzyme Activation | Child | Gastrointestinal Stromal Tumors - genetics | Index Medicus
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6. Full Text Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors
by Maynard, Michelle A and Marino-Enriquez, Adrian and Fletcher, Jonathan A and Dorfman, David M and Dorfman, Clara and Raut, Chandrajit P and Yassa, Leila and Guo, Cuicui and Wang, Yuexiang and Feldman, Henry A and Frates, Mary C and Song, Huaidong and Jugo, Rebecca H and Taguchi, Takahiro and Hershman, Jerome M and Larsen, P. Reed and Huang, Stephen A
The New England journal of medicine, ISSN 0028-4793, 04/2014, Volume 370, Issue 14, pp. 1327 - 1334
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | General aspects | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Gastrointestinal Stromal Tumors - enzymology | Thyroid Hormones - deficiency | Humans | Middle Aged | Gastrointestinal Stromal Tumors - diagnostic imaging | Gastrointestinal Neoplasms - complications | Male | Gastrointestinal Neoplasms - enzymology | Hypothyroidism - etiology | Gastrointestinal Neoplasms - diagnostic imaging | Iodide Peroxidase - metabolism | Gastrointestinal Stromal Tumors - complications | Hypothyroidism - enzymology | Iodide Peroxidase - genetics | Radiography, Abdominal | Physiological aspects | Thyroid hormones | Research | Gastrointestinal tumors | Risk factors | Tyrosine | Imatinib | Iodide peroxidase | Hypothyroidism | Side effects | Chemotherapy | Thyroxine deiodinase | Supplementation | Protein-tyrosine kinase | Cancer | Thyroid | Iodine | Index Medicus | Abridged Index Medicus
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7. Full Text Loss of SDHA expression identifies SDHA mutations in succinate dehydrogenase-deficient gastrointestinal stromal tumors
by Dwight, Trisha and Benn, Diana E and Clarkson, Adele and Vilain, Ricardo and Lipton, Lara and Robinson, Bruce G and Clifton-Bligh, Roderick J and Gill, Anthony J
The American journal of surgical pathology, ISSN 0147-5185, 02/2013, Volume 37, Issue 2, pp. 226 - 233
gastrointestinal stromal tumor | SDHA | SDHB | succinate dehydrogenase | Pathology | Life Sciences & Biomedicine | Surgery | Science & Technology | Gastrointestinal Stromal Tumors - enzymology | Triage - methods | Electron Transport Complex II - genetics | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Male | Gastrointestinal Neoplasms - enzymology | Succinate Dehydrogenase - deficiency | Young Adult | DNA Mutational Analysis | Adolescent | Germ-Line Mutation | Adult | Female | DNA, Neoplasm - analysis | Gastrointestinal Stromal Tumors - genetics | Index Medicus
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8. Full Text KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence
by Joensuu, Heikki and Rutkowski, Piotr and Nishida, Toshirou and Steigen, Sonja E and Brabec, Peter and Plank, Lukas and Nilsson, Bengt and Braconi, Chiara and Bordoni, Andrea and Magnusson, Magnus K and Sufliarsky, Jozef and Federico, Massimo and Jonasson, Jon G and Hostein, Isabelle and Bringuier, Pierre-Paul and Emile, Jean-Francois
Journal of clinical oncology, ISSN 0732-183X, 02/2015, Volume 33, Issue 6, pp. 634 - 642
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastrointestinal Stromal Tumors - enzymology | Genetic Predisposition to Disease | Gastrointestinal Neoplasms - genetics | Gastrointestinal Stromal Tumors - surgery | Humans | Middle Aged | Gastrointestinal Neoplasms - surgery | Male | Gastrointestinal Neoplasms - enzymology | Neoplasm Recurrence, Local - enzymology | Young Adult | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adolescent | Aged, 80 and over | Adult | Female | Neoplasm Recurrence, Local - genetics | Proto-Oncogene Proteins c-kit - genetics | Aged | Child | Gastrointestinal Stromal Tumors - genetics | Index Medicus
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9. Full Text Gastrointestinal stromal tumors: What do we know now?
by Corless, Christopher L
Modern pathology, ISSN 0893-3952, 01/2014, Volume 27, Issue 1, pp. S1 - S16
PDGFRA | GIST | KIT | Life Sciences & Biomedicine | Pathology | Science & Technology | Gastrointestinal Stromal Tumors - enzymology | Predictive Value of Tests | Genetic Predisposition to Disease | Genetic Testing | Humans | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Patient Selection | Phenotype | Gastrointestinal Stromal Tumors - drug therapy | Protein Kinase Inhibitors - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - antagonists & inhibitors | Receptor, Platelet-Derived Growth Factor alpha - genetics | Gastrointestinal Stromal Tumors - pathology | Proto-Oncogene Proteins c-kit - genetics | Biomarkers, Tumor - genetics | Mutation | Gastrointestinal Stromal Tumors - genetics | Precision Medicine | Index Medicus
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10. Full Text Pediatric KIT-wild-type and platelet-derived growth factor receptor α-wild-type gastrointestinal stromal tumors share KIT activation but not mechanisms of genetic progression with adult gastrointestinal stromal tumors
by Janeway, Katherine A and Liegl, Bernadette and Harlow, Amy and Le, Claudia and Perez-Atayde, Antonio and Kozakewich, Harry and Corless, Christopher L and Heinrich, Michael C and Fletcher, Jonathan A
Cancer research (Chicago, Ill.), ISSN 0008-5472, 10/2007, Volume 67, Issue 19, pp. 9084 - 9088
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Gastrointestinal Stromal Tumors - enzymology | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Signal Transduction | Humans | Male | Proto-Oncogene Proteins c-kit - metabolism | Disease Progression | Receptor, Platelet-Derived Growth Factor alpha - genetics | Gastrointestinal Stromal Tumors - pathology | Adolescent | Adult | Female |