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1. Full Text Gastrointestinal stromal tumour
by Joensuu, Heikki, Prof and Hohenberger, Peter, MD and Corless, Christopher L, MD
Lancet, The, ISSN 0140-6736, 2013, Volume 382, Issue 9896, pp. 973 - 983
Summary Gastrointestinal stromal tumours (GISTs) are mesenchymal neoplasms that arise in the gastrointestinal tract, usually in the stomach or the small... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | PHASE-II TRIAL | SUCCINATE-DEHYDROGENASE | POSITRON-EMISSION-TOMOGRAPHY | GERMLINE MUTATION | TERM-FOLLOW-UP | C-KIT | OF-FUNCTION MUTATIONS | RECEPTOR TYROSINE KINASE | IMATINIB MESYLATE | ADJUVANT IMATINIB | Lung Neoplasms - genetics | Stomach Neoplasms - genetics | Gastrointestinal Neoplasms - genetics | Humans | Chondroma - genetics | Antineoplastic Agents - therapeutic use | Piperazines - therapeutic use | Gastrointestinal Neoplasms - therapy | Mutation - genetics | Imatinib Mesylate | Preoperative Care | Gastrointestinal Neoplasms - pathology | Gastrointestinal Stromal Tumors - therapy | Benzamides - therapeutic use | Pyrimidines - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Gastrointestinal Stromal Tumors - pathology | Paraganglioma, Extra-Adrenal - genetics | Leiomyosarcoma - genetics | Proto-Oncogene Proteins c-kit - genetics | Neurofibromatosis 1 - genetics | Gastrointestinal Stromal Tumors - genetics | Gastrointestinal tumors | Clinical trials | Dehydrogenases | Mutation | Surgery | Colorectal cancer | Abdomen
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2. Full Text Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
by Casali, P.G and Blay, J.Y and Bertuzzi, A and Bielack, S and Bjerkehagen, B and Bonvalot, S and Boukovinas, I and Bruzzi, P and Dei Tos, A.P and Dileo, P and Eriksson, M and Fedenko, A and Ferrari, A and Ferrari, S and Gelderblom, H and Grimer, R and Gronchi, A and Haas, R and Hall, K.S and Hohenberger, P and Issels, R and Joensuu, H and Judson, I and Cesne, A. le and Litiere, S and Martin-Broto, J and Merimsky, O and Montemurro, M and Morosi, C and Picci, P and Ray-Coquard, I and Reichardt, P and Rutkowski, P and Schlemmer, M and Stacchiotti, S and Torri, V and Trama, A and Coevorden, F. van and Graaf, W.T. van der and Vanel, D and Wardelmann, E and ESMO European Sarcoma and ESMO/European Sarcoma Network Working Group and The ESMO/European Sarcoma Network Working Group
Annals of Oncology, ISSN 0923-7534, 2014, Volume 25 Suppl 3, Issue suppl 3, pp. iii21 - 6
SURGERY | PHASE-II TRIAL | NEOADJUVANT/ADJUVANT IMATINIB MESYLATE | ONCOLOGY | CARNEY-STRATAKIS | RANDOMIZED-TRIAL | DOSE IMATINIB | RECURRENCE | MUTATIONS | ADJUVANT IMATINIB | PROGRESSION | Gastrointestinal Stromal Tumors - therapy | Prognosis | Follow-Up Studies | Gastrointestinal Stromal Tumors - diagnosis | Humans | Health Planning Guidelines | Combined Modality Therapy | Neoplasm Staging | Societies, Medical - standards
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3. Full Text Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era - A population-based study in western Sweden
by Nilsson, Bengt and Bümming, Per and Meis-Kindblom, Jeanne M and Odén, Anders and Dortok, Aydin and Gustavsson, Bengt and Sablinska, Katarzyna and Kindblom, Lars-Gunnar
Cancer, ISSN 0008-543X, 02/2005, Volume 103, Issue 4, pp. 821 - 829
BACKGROUND. Recent breakthroughs regarding gastrointestinal stromal tumors (GIST) and their pathogenesis have redefined diagnostic criteria and have led to the... 
Prevalence | Prognosis | Gastrointestinal stromal tumor | Incidence | DIAGNOSIS | MANAGEMENT | EFFICACY | STI571 | SAFETY | C-KIT | PROLIFERATION | prognosis | prevalence | gastrointestinal stromal tumor | ONCOLOGY | TYROSINE KINASE INHIBITOR | MUTATIONS | incidence | Gastrointestinal Stromal Tumors - epidemiology | Age Factors | Humans | Risk Factors | Ki-67 Antigen - metabolism | Antineoplastic Agents - therapeutic use | Piperazines - therapeutic use | Imatinib Mesylate | Gastrointestinal Stromal Tumors - therapy | Sweden | Digestive System Surgical Procedures | Pyrimidines - therapeutic use | Gastrointestinal Stromal Tumors - pathology | Survival Analysis | Retrospective Studies | Benzamides | Measurement | Gastrointestinal tumors | Oncology, Experimental | Diagnosis | Research | Cancer
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4. Full Text Gastrointestinal stromal tumor (GIST)
by Joensuu, H
Annals of Oncology, ISSN 0923-7534, 09/2006, Volume 17, Issue 10, pp. x280 - x286
Gastrointestinal stromal tumors (GISTs) may be defined as morphologically spindle cell, epithelioid, or occasionally pleomorphic mesenchymal tumours of the... 
MESYLATE | SURVIVAL | DIAGNOSIS | EFFICACY | ONCOLOGY | SAFETY | IMATINIB | KIT | MUTATIONS | THETA | Gastrointestinal Stromal Tumors - therapy | Gastrointestinal Stromal Tumors - diagnosis | Gastrointestinal Stromal Tumors - genetics | Humans
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5. Gastrointestinal Stromal Tumors
by Miettinen, Markku and Lasota, Jerzy
Gastroenterology Clinics of North America, ISSN 0889-8553, 06/2013, Volume 42, Issue 2, pp. 399 - 415
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. Soon after GIST was recognized as a tumor driven... 
Leiomyoma | GIST | Stromal tumors mesenchymal neoplasm | Leiomyosarcoma | Leiomyoblastoma | PDGFRA MUTATIONS | MOLECULAR-GENETICS | CARNEY-STRATAKIS-SYNDROME | C-KIT | INTERSTITIAL-CELLS | V600E BRAF MUTATIONS | SUCCINATE-DEHYDROGENASE | JUXTAMEMBRANE DOMAIN | GASTROENTEROLOGY & HEPATOLOGY | ACTIVATING MUTATIONS | ADJUVANT IMATINIB | Abdominal Pain - etiology | Gastrointestinal Neoplasms - genetics | Gastrointestinal Stromal Tumors - epidemiology | Prognosis | Humans | Gastrointestinal Neoplasms - complications | Gastrointestinal Neoplasms - diagnosis | Gastrointestinal Neoplasms - therapy | Platelet-Derived Growth Factor - genetics | Succinate Dehydrogenase - deficiency | Gastrointestinal Stromal Tumors - therapy | Gastrointestinal Neoplasms - epidemiology | Gastrointestinal Stromal Tumors - diagnosis | Gastrointestinal Hemorrhage - etiology | Neurofibromatosis 1 - complications | Gastrointestinal Stromal Tumors - complications | Proto-Oncogene Proteins c-kit - genetics | Gastrointestinal Stromal Tumors - genetics
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6. Full Text Diagnostic and treatment strategy for small gastrointestinal stromal tumors
by Nishida, Toshirou and Goto, Osamu and Raut, Chandrajit Premanand and Yahagi, Naohisa
Cancer, ISSN 0008-543X, 10/2016, Volume 122, Issue 20, pp. 3110 - 3118
Gastrointestinal stromal tumors (GISTs) are considered to be potentially malignant mesenchymal tumors of the gastrointestinal tract. Clinically relevant GISTs... 
submucosal tumor (SMT) | high‐risk features | gastrointestinal stromal tumor (GIST) | endoscopic ultrasonography (EUS) | laparoscopic surgery | Submucosal tumor (SMT) | High-risk features | Laparoscopic surgery | Endoscopic ultrasonography (EUS) | Gastrointestinal stromal tumor (GIST) | high-risk features | GIST | ENDOSCOPIC SUBMUCOSAL DISSECTION | LONG-TERM OUTCOMES | LAPAROSCOPIC RESECTION | COOPERATIVE SURGERY | MESENCHYMAL TUMORS | SUBEPITHELIAL LESIONS | FINE-NEEDLE-ASPIRATION | ONCOLOGY | ESOPHAGOGASTRIC JUNCTION | MUSCULARIS PROPRIA | Carcinoma, Small Cell - therapy | Gastrointestinal Stromal Tumors - therapy | Prognosis | Gastrointestinal Stromal Tumors - diagnosis | Humans | Gastrointestinal Neoplasms - diagnosis | Gastrointestinal Neoplasms - therapy | Carcinoma, Small Cell - diagnosis | CT imaging | Usage | Care and treatment | Gastrointestinal tumors | Development and progression | Metastasis | Diagnosis | Risk factors | Review
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7. Combined Therapy of Gastrointestinal Stromal Tumors
by Rutkowski, Piotr and Hompes, Daphne
Surgical Oncology Clinics of North America, ISSN 1055-3207, 10/2016, Volume 25, Issue 4, pp. 735 - 759
Radical surgery is the mainstay of therapy for primary resectable, localized gastrointestinal stromal tumors (GIST). Nevertheless, approximately 40% to 50% of... 
Neoadjuvant therapy | Imatinib | Surgery | Adjuvant therapy | Gastrointestinal stromal tumor | PDGFRA MUTATIONS | TYROSINE-KINASE | PROGNOSTIC-FACTORS | CLINICAL-PRACTICE GUIDELINES | PHASE-II TRIAL | NEOADJUVANT/ADJUVANT IMATINIB MESYLATE | ONCOLOGY | HIGH-RISK | TERM-FOLLOW-UP | SURGICAL RESECTION | ADJUVANT IMATINIB | Gastrointestinal Neoplasms - secondary | Piperazines | Gastrointestinal Neoplasms - drug therapy | Gastrointestinal Stromal Tumors - secondary | Humans | Neoplasm Recurrence, Local | Treatment Outcome | Antineoplastic Agents - therapeutic use | Imatinib Mesylate - therapeutic use | Pyrimidines | Gastrointestinal Stromal Tumors - drug therapy | Neoadjuvant Therapy | Disease Management | Benzamides | Chemotherapy, Adjuvant
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8. Full Text Gastrointestinal stromal tumors: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
by Blay, JY and Blomqvist, C and Bonvalot, S and Boukovinas, I and Casali, PG and De Alava, E and Dei Tos, AP and Dirksen, U and Duffaud, F and Eriksson, M and Fedenko, A and Ferrari, A and Ferrari, S and Garcia del Muro, X and Gelderblom, H and Grimer, R and Gronchi, A and Hall, KS and Hassan, B and Hogendoorn, P and Hohenberger, P and Issels, R and Joensuu, H and Jost, L and Jurgens, H and Kager, L and Le Cesne, A and Leyvraz, S and Martin, J and Merimsky, O and Nishida, O and Picci, P and Reichardt, P and Rutkowski, P and Schlemmer, M and Sleijfer, S and Stacchiotti, S and Taminiau, A and Wardelmann, E and ESMO European Sarcoma Network Work and ESMO / European Sarcoma Network Working Group and The ESMO / European Sarcoma Network Working Group
Annals of Oncology, ISSN 0923-7534, 10/2012, Volume 23, Issue 7, pp. vii49 - vii55
SURGERY | PHASE-II TRIAL | ONCOLOGY | ADVANCED/METASTATIC GIST | KINASE | CARNEY-STRATAKIS | RANDOMIZED-TRIAL | DOSE IMATINIB | MUTATIONS | IMATINIB MESYLATE | ADJUVANT IMATINIB | Gastrointestinal Neoplasms - genetics | Prognosis | Risk Assessment | Humans | Treatment Outcome | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Piperazines - therapeutic use | Gastrointestinal Neoplasms - diagnosis | Gastrointestinal Neoplasms - therapy | Imatinib Mesylate | Gastrointestinal Stromal Tumors - therapy | Gastrointestinal Stromal Tumors - diagnosis | DNA Mutational Analysis | Pyrimidines - therapeutic use | Disease Management | Benzamides | Neoplasm Staging | Gastrointestinal Stromal Tumors - genetics
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9. Full Text Current management of gastrointestinal stromal tumors: Surgery, current biomarkers, mutations, and therapy
by Valsangkar, Nakul, MD and Sehdev, Amikar, MD, MPH and Misra, Subhasis, MD, MS, FACS and Zimmers, Teresa A., PhD and O'Neil, Bert H., MD and Koniaris, Leonidas G., MD, MBA, FACS
Surgery: Official Journal of the Society of University Surgeons, Central Surgical Association, and the American Association of Endocrine Surgeons, ISSN 0039-6060, 2015, Volume 158, Issue 5, pp. 1149 - 1164
In the past decade, the addition of molecular diagnosis of mutations and use of tyrosine kinase inhibitors (TKIs), either as neoadjuvant/adjuvant therapy with... 
Surgery | SURGERY | TYROSINE-KINASE | PROGNOSTIC-FACTORS | RESECTION | TERM-FOLLOW-UP | DOSE IMATINIB | PHASE-II | SURGICAL-MANAGEMENT | INHIBITOR | IMATINIB MESYLATE | ADJUVANT IMATINIB | Gastrointestinal Stromal Tumors - therapy | Gastrointestinal Neoplasms - genetics | Gastrointestinal Stromal Tumors - diagnosis | Protein Kinase Inhibitors - therapeutic use | Humans | Biomarkers | Antineoplastic Agents - therapeutic use | Combined Modality Therapy | Gastrointestinal Neoplasms - diagnosis | Gastrointestinal Neoplasms - therapy | Mutation | Gastrointestinal Stromal Tumors - genetics | Medical colleges | Therapeutics | Forecasts and trends | Genetic aspects | Biological markers | Tumors | Homeopathy | Materia medica and therapeutics
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10. Full Text Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
by DeMatteo, Ronald P, Prof and Ballman, Karla V, PhD and Antonescu, Cristina R, MD and Maki, Robert G, MD and Pisters, Peter WT, Prof and Demetri, George D, MD and Blackstein, Martin E, MD and Blanke, Charles D, Prof and von Mehren, Margaret, MD and Brennan, Murray F, Prof and Patel, Shreyaskumar, Prof and McCarter, Martin D, MD and Polikoff, Jonathan A, MD and Tan, Benjamin R, MD and Owzar, Kouros, PhD and ACOSOG Intergrp Adjuvant GIST Stud and American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team
Lancet, The, ISSN 0140-6736, 2009, Volume 373, Issue 9669, pp. 1097 - 1104
Summary Background Gastrointestinal stromal tumour is the most common sarcoma of the intestinal tract. Imatinib mesylate is a small molecule that inhibits... 
Internal Medicine | SURVIVAL | MEDICINE, GENERAL & INTERNAL | PROGNOSTIC-FACTORS | TYROSINE KINASE | PHASE-III | KIT | RESISTANCE | DOSE IMATINIB | MUTATIONS | INHIBITOR | PROGRESSION | Piperazines - administration & dosage | Gastrointestinal Stromal Tumors - surgery | Double-Blind Method | Pyrimidines - administration & dosage | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Imatinib Mesylate | Piperazines - adverse effects | Gastrointestinal Stromal Tumors - therapy | Antineoplastic Agents - adverse effects | Gastrointestinal Stromal Tumors - pathology | Adolescent | Pyrimidines - adverse effects | Aged, 80 and over | Adult | Female | Aged | Benzamides | Chemotherapy, Adjuvant | Gastrointestinal Stromal Tumors - mortality | Care and treatment | Research | Gastrointestinal tumors | Patient outcomes | Studies | Physical examinations | Chemotherapy | Health services | Medical treatment | Patient care planning | Oncology | Mutation | Small intestine | Patients | Cancer | Index Medicus | Abridged Index Medicus
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11. Full Text Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
by Balachandran, Vinod P and Cavnar, Michael J and Zeng, Shan and Bamboat, Zubin M and Ocuin, Lee M and Obaid, Hebroon and Sorenson, Eric C and Popow, Rachel and Ariyan, Charlotte and Rossi, Ferdinand and Besmer, Peter and Guo, Tianhua and Antonescu, Cristina R and Taguchi, Takahiro and Yuan, Jianda and Wolchok, Jedd D and Allison, James P and Dematteo, Ronald P
Nature Medicine, ISSN 1078-8956, 09/2011, Volume 17, Issue 9, pp. 1094 - 1100
Imatinib mesylate targets mutated KIT oncoproteins in gastrointestinal stromal tumor (GIST) and produces a clinical response in 80% of patients. The mechanism... 
MEDICINE, RESEARCH & EXPERIMENTAL | CTLA-4 BLOCKADE | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMBINATION IMMUNOTHERAPY | INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION | C-KIT | OVARIAN-CANCER | TRYPTOPHAN CATABOLISM | CELL BIOLOGY | REGULATORY CELLS | MOUSE MODEL | RECEPTOR TYROSINE KINASE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Immunotherapy - methods | Humans | Proto-Oncogene Proteins c-kit - metabolism | T-Lymphocytes, Regulatory - immunology | Flow Cytometry | Chromatin Immunoprecipitation | Microarray Analysis | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - physiology | Gastrointestinal Stromal Tumors - immunology | Mice, Inbred C57BL | Piperazines - therapeutic use | Pyrimidines - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Piperazines - pharmacology | Blotting, Western | Gastrointestinal Stromal Tumors - therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | CD8-Positive T-Lymphocytes - drug effects | Mice | Benzamides | CD8-Positive T-Lymphocytes - immunology | Cellular biology | Lymphocytes | Gastrointestinal diseases | Pharmacology | Gene expression | Cancer | Immune system
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