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index medicus (21) 21
oxidative stress (18) 18
animals (16) 16
biochemistry & molecular biology (16) 16
humans (16) 16
nrf2 (12) 12
mice (11) 11
glutamate-cysteine ligase - genetics (10) 10
glutathione (10) 10
are, antioxidant response element (9) 9
glutamate-cysteine ligase - metabolism (9) 9
nf-e2-related factor 2 - metabolism (9) 9
biology (8) 8
cysteine (8) 8
gclm (8) 8
glutamate (8) 8
ligases (8) 8
medicine (8) 8
cystine (7) 7
keap1, kelch-like ech-associated protein 1 (7) 7
ros, reactive oxygen species (7) 7
analysis (6) 6
article (6) 6
glutathione - metabolism (6) 6
male (6) 6
nf-e2-related factor 2 - genetics (6) 6
research paper (6) 6
activation (5) 5
antioxidants (5) 5
expression (5) 5
gclc, glutamate-cysteine ligase catalytic subunit (5) 5
genes (5) 5
glutamate-cysteine ligase (5) 5
gsh, glutathione (5) 5
nqo1, nadh:quinone oxidoreductase 1 (5) 5
antioxidants - pharmacology (4) 4
cell line, tumor (4) 4
cells (4) 4
er, endoplasmic reticulum (4) 4
gamma-glutamylcysteine synthetase (4) 4
gclc (4) 4
gene expression (4) 4
gene expression regulation - drug effects (4) 4
health aspects (4) 4
heme oxygenase-1 (4) 4
hmox1, heme oxygenase-1 (4) 4
modifier subunit (4) 4
oxidation-reduction (4) 4
protein binding (4) 4
reactive oxygen species - metabolism (4) 4
antioxidant response element (3) 3
atherosclerosis (3) 3
care and treatment (3) 3
cells, cultured (3) 3
dmso, dimethyl sulfoxide (3) 3
endocrinology & metabolism (3) 3
endoplasmic reticulum - metabolism (3) 3
female (3) 3
free radicals (3) 3
gapdh, glyceraldehyde-3-phosphate dehydrogenase (3) 3
gclm, glutamate-cysteine ligase modifier subunit (3) 3
gene-expression (3) 3
genetic research (3) 3
glutamate cysteine ligase (3) 3
gst, glutathione s-transferase (3) 3
heme (3) 3
heme oxygenase-1 - metabolism (3) 3
ho-1 (3) 3
ho-1, heme oxygenase-1 (3) 3
jnk, c-jun n-terminal kinase (3) 3
metabolism (3) 3
mice, inbred c57bl (3) 3
mice, knockout (3) 3
nac, n-acetylcysteine (3) 3
nrf2, nuclear factor erythroid 2-related factor 2 (3) 3
pharmacology & pharmacy (3) 3
protein (3) 3
respiratory system (3) 3
rna, messenger - metabolism (3) 3
ros (3) 3
sfn, sulforaphane (3) 3
subunit gene (3) 3
up-regulation (3) 3
upr, unfolded protein response (3) 3
ap-1, activator protein 1 (2) 2
are (2) 2
autophagy (2) 2
bh4, tetrahydrobiopterin (2) 2
carcinoma, hepatocellular - drug therapy (2) 2
cat, catalase (2) 2
catalysis (2) 2
chop, c (2) 2
deficiency (2) 2
degradation (2) 2
derivatives (2) 2
dietary supplements (2) 2
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disease models, animal (2) 2
electrophile response element (2) 2
endothelial cells - metabolism (2) 2
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Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 01/2015, Volume 78, pp. 202 - 212
The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules... 
Brusatol | Free radicals | Hepatocyte | Nrf2 | Toxicity | Keap1 | Chemical stress | Cell defense | OXIDATIVE STRESS | ACTIVATION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-SYNTHESIS INHIBITION | CANCER | TRANSCRIPTION FACTOR NRF2 | DEFENSE PATHWAY | ACETAMINOPHEN | ENDOCRINOLOGY & METABOLISM | DEGRADATION | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Oxidative Stress | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | Autophagy | Quassins - pharmacology | Hepatocytes - cytology | Carcinoma, Hepatocellular - drug therapy | Liver Neoplasms - pathology | NF-E2-Related Factor 2 - genetics | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | Oxidation-Reduction | RNA, Messenger - genetics | Cells, Cultured | Liver Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Brucea - chemistry | Blotting, Western | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Proliferation - drug effects | Mice | Carcinoma, Hepatocellular - metabolism | Chemical inhibitors | Metabolites | Proteolysis | Health aspects | Quinone | Cells | Index Medicus | Gclm, glutamate–cysteine ligase regulatory subunit | NEM, N-ethylmaleimide | NAPQI, N-acetyl-p-benzoquinone imine | IAA, iodoacetamide | Nrf2, nuclear factor erythroid 2-related factor 2 | Original Contribution | Keap1, Kelch-like ECH-associated protein 1 | DNCB, 2,4-dinitrochlorobenzene | Nqo1, NAD(P)H dehydrogenase quinone 1 | CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1, 9dien-28-oate | HIF-1α, hypoxia-inducible factor 1α | RT-qPCR, real-time quantitative PCR | AMC, 7-amino-4-methylcoumarin
Journal Article
Redox Biology, ISSN 2213-2317, 02/2019, Volume 21, p. 101068
Adropin, a secretory signal peptide, has shown beneficial effects on improving glucose homeostasis and dyslipidemia. However, whether this peptide affects... 
NASH | Lipotoxicity | Nrf2 | GSH | ROS | APOPTOSIS | OXIDATIVE STRESS | ACTIVATION | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | MECHANISMS | PATHOLOGY | METABOLISM | STEATOSIS | EXPRESSION
Journal Article
Molecular & Biochemical Parasitology, ISSN 0166-6851, 08/2014, Volume 196, Issue 1, pp. 12 - 20
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 05/2002, Volume 63, Issue 9, pp. 1739 - 1754
Glutamate-cysteine ligase is a heterodimer comprising a modifier (GCLM) and a catalytic (GCLC) subunit. In mouse Hepa-1c1c7 hepatoma cell cultures, we found... 
Oxidative stress | NRF2 | tert-Butylhydroquinone | Mouse Gclm gene regulation | Promoter analysis | Glutamate–cysteine ligase | Electrophile response element | Glutathione | Glutamate-cysteine ligase | tert-butylhydroquinone | LIGHT SUBUNIT | glutathione | HEPATOMA-CELLS | INDUCTION | METALLOTHIONEIN-I | MAMMALIAN-CELLS | electrophile response element | NAPHTHOFLAVONE-INDUCED EXPRESSION | GAMMA-GLUTAMYLCYSTEINE SYNTHETASE | ANTIOXIDANT RESPONSE ELEMENT | TRANSCRIPTION FACTOR NRF2 | START SITE | mouse Gclm gene regulation | promoter analysis | PHARMACOLOGY & PHARMACY | glutamate-cysteine ligase | oxidative stress | Protein Subunits | Transcription, Genetic - drug effects | Oxidative Stress | Glutathione - metabolism | Molecular Sequence Data | Hydroquinones - pharmacology | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | 5' Flanking Region - genetics | DNA - analysis | Base Sequence | Tumor Cells, Cultured | RNA, Messenger - drug effects | Hydrogen Peroxide - pharmacology | Cadmium - pharmacology | Antioxidants - pharmacology | Sequence Homology, Nucleic Acid | Gene Expression Regulation - drug effects | Vitamin K 3 - pharmacology | Animals | Transcription Initiation Site | TATA Box | Glutamate-Cysteine Ligase - genetics | Mice | Genome | Animal genetics | Cysteine | Genes | Ribonuclease | Genetic transcription | Glutamate | Cystine | Anopheles | Ligases | Analysis | Genetic research
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2006, Volume 399, Issue 3, pp. 373 - 385
Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) and Nrf2 regulate ARE (antioxidant response element)-driven genes. At its N-terminal end, Nrf1... 
Kelch-like ECH-associated protein 1 (Keap1) | Nuclear factor-erythroid 2 p45 subunit-related factor 2 (Nrf2) | Oxidative stress | Nuclear factor-erythroid 2 p45 subunit-related factor 1 (Nrf1) | Antioxidant response element | Endoplasmic reticulum | FACTOR TCF11 | nuclear factor-erythroid 2 p45 subunit-related factor 1 (Nrf1) | nuclear factor-erythroid 2 p45 subunit-related factor 2 (Nrf2) | DETOXIFYING ENZYMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | Kelch-like ECH-associated protein 1 (Keap 1) | MEDIATED EXPRESSION | NUCLEAR EXPORT | reticulum | CONSENSUS SEQUENCE | GENE-EXPRESSION | EMBRYONIC LETHALITY | endoplasmic | antioxidant response element | oxidative stress | INDUCIBLE EXPRESSION | Cytoskeletal Proteins - genetics | Humans | Transcriptional Activation | DNA, Complementary - genetics | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Protein Transport - physiology | Structure-Activity Relationship | Nuclear Respiratory Factor 1 - genetics | Recombinant Fusion Proteins - metabolism | Cytoskeletal Proteins - deficiency | Cell Nucleus - metabolism | Nuclear Respiratory Factor 1 - metabolism | Fibroblasts | NF-E2-Related Factor 2 - genetics | Cytoskeletal Proteins - physiology | Kelch-Like ECH-Associated Protein 1 | Genes, Reporter | Protein Structure, Tertiary | Amino Acid Sequence | Mutagenesis, Site-Directed | Cells, Cultured | Nuclear Respiratory Factor 1 - chemistry | Rats | Nuclear Proteins - metabolism | Epithelial Cells | Amino Acid Motifs | Mice, Knockout | Adaptor Proteins, Signal Transducing - physiology | Animals | Adaptor Proteins, Signal Transducing - deficiency | NF-E2-Related Factor 2 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mice | NF-E2-Related Factor 2 - chemistry | COS Cells | Neh2L, Nrf2-ECH homology 2-like | Nrf1, Nrf2, and Nrf3, nuclear factor-erythroid 2 p45 subunit-related factors 1, 2 and 3 | NuPAGE, Novex® PAGE | TCF11, transcription factor 11 | Gal4D, Gal4 DNA-binding domain | PBGD, porphobilinogen deaminase | SREBP, sterol-regulatory-element-binding protein | CNC, cap ‘n’ collar | Maf, musculoaponeurotic fibrosarcoma retrovirus transforming gene | NQO1, NAD(P)H:quinone oxidoreductase 1 | SV40, simian virus 40 | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | Luc, luciferase | nqo1-Luc | UAS, a Gal4-specific binding site | ARE, antioxidant response element | CREB, cyclic-AMP-response-element-binding protein | LDS, lithium dodecyl sulfate | bZIP, basic region-leucine zipper | FITC, fluorescein isothiocyanate | Keap1, Kelch-like ECH-associated protein 1 | DAPI, 4′,6-diamidino-2-phenylindole | P, promoter (as in P−1016 | TK, thymidine kinase promoter | β-gal, β-galactosidase | GCLM, glutamate cysteine ligase modifier | NTD, N-terminal domain | KO, knockout | MEF, mouse embryonic fibroblast | NHB, N-terminal homology box | endoplasmic reticulum
Journal Article