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Journal Article
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, pp. e0170327 - e0170327
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, pp. e20164 - e20164
Background: Diosgenin, a steroidal saponin obtained from fenugreek (Trigonella foenum graecum), was found to exert anti-carcinogenic properties, such as... 
APOPTOSIS | SIGNALING PATHWAYS | ACTIVATION | METASTASIS | ANGIOGENESIS | COLORECTAL-CANCER | KINASE | BIOLOGY | CYCLE ARREST | OSTEOSARCOMA CELLS | PROGRESSION | Prostatic Neoplasms - metabolism | Humans | Immunoblotting | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Tissue Inhibitor of Metalloproteinase-2 - genetics | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 7 - metabolism | Basigin - genetics | Matrix Metalloproteinase 9 - genetics | Polymerase Chain Reaction | JNK Mitogen-Activated Protein Kinases - genetics | Phosphatidylinositol 3-Kinase - metabolism | Diosgenin - pharmacology | Matrix Metalloproteinase 2 - metabolism | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Matrix Metalloproteinase 7 - genetics | NF-kappa B - genetics | Phosphatidylinositol 3-Kinase - genetics | Basigin - metabolism | Cell Line, Tumor | Progesterone | Metastasis | Vascular endothelial growth factor | Health aspects | Prostate cancer | Apoptosis | Transcription factors | Boyden chamber | Matrix metalloproteinases | Leukocyte migration | AKT protein | Assaying | Metastases | Proteins | Angiogenesis | Cell growth | Gelatin | Inhibition | Enzymes | NF-κB protein | Medical technology | Wound healing | Gene expression | 1-Phosphatidylinositol 3-kinase | Pharmacy | Cell migration | Cell proliferation | Biotechnology | Tissue inhibitor of metalloproteinases | Phosphorylation | Colorectal cancer | Science | mRNA | Matrix metalloproteinase | Kinases | Cell adhesion & migration | Carcinogens | Cell cycle | Fenugreek | Metalloproteinase | Tumor cells | Extracellular signal-regulated kinase | c-Jun protein | Breast cancer | Endothelial cells | Gelatinase B | Gelatinase A | Signaling | Collagen | Prostate | Tumors | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e42714 - e42714
The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-beta 1/Smad2 axis, via its cognate... 
RENAL FIBROSIS | LUNG FIBROSIS | COLLAGEN | MULTIDISCIPLINARY SCIENCES | GROWTH | INTERSTITIAL FIBROSIS | TISSUE INHIBITORS | SMOOTH-MUSCLE-CELLS | NITRIC-OXIDE PATHWAY | HORMONE RELAXIN | FIBROBLASTS | Relaxin - metabolism | Matrix Metalloproteinases - genetics | Receptors, G-Protein-Coupled - metabolism | Humans | Male | Receptors, Peptide - genetics | Matrix Metalloproteinase 9 - metabolism | Relaxin - genetics | Matrix Metalloproteinase 9 - genetics | Fibroblasts - metabolism | Cell Line | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 13 - genetics | Cells, Cultured | Rats | Kidney - cytology | Signal Transduction - genetics | Extracellular Signal-Regulated MAP Kinases | Rats, Sprague-Dawley | Matrix Metalloproteinase 13 - metabolism | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Animals | Cyclic GMP - metabolism | Nitric Oxide Synthase Type I - metabolism | Signal Transduction - physiology | Fibroblasts - cytology | Mice | Nitric Oxide Synthase Type I - genetics | Receptors, G-Protein-Coupled - genetics | Matrix Metalloproteinases - metabolism | Nitric Oxide - metabolism | Receptors, Peptide - metabolism | Physiological aspects | Genetic aspects | Research | Transforming growth factors | Metalloenzymes | Nitric oxide | Neurosciences | Phosphorylation | Matrix metalloproteinases | Guanosine | Smooth muscle | Genomes | Arthritis | Biochemistry | Matrix metalloproteinase | Guanylate cyclase | Western blotting | Signal transduction | Arginine | Gelatin | Rodents | Cyclic GMP | Fibroblasts | Metalloproteinase | Interstitial collagenase | Kidneys | Extracellular signal-regulated kinase | Collagenase 3 | Nitric-oxide synthase | Gelatinase B | NG-Nitroarginine methyl ester | Gelatinase A | Signaling | Inhibitors | Human performance | Collagen | Isoforms | Fibrosis | Skin | Aberration | Molecular biology | Ornithine | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0129013 - e0129013
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e56587 - e56587
EMT (epithelial-mesenchymal transition) is crucial for cancer cells to acquire invasive phenotypes. In A549 lung adenocarcinoma cells, TGF-beta elicited EMT in... 
EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | CARCINOMA CELLS | MULTIDISCIPLINARY SCIENCES | ADENOCARCINOMA CELLS | E-CADHERIN | NF-KAPPA-B | UP-REGULATION | DIFFERENTIAL REGULATION | PROMOTES | PROGRESSION | Lung Neoplasms - genetics | Tumor Necrosis Factor-alpha - metabolism | HMGN2 Protein - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | HMGN2 Protein - metabolism | Signal Transduction | Humans | Lung Neoplasms - metabolism | Tumor Necrosis Factor-alpha - genetics | Gene Expression Regulation, Neoplastic | Smad2 Protein - metabolism | Lung Neoplasms - pathology | MicroRNAs - metabolism | Epithelial-Mesenchymal Transition - genetics | Adenocarcinoma - metabolism | Transforming Growth Factor beta - genetics | Computer Simulation | Cell Line, Tumor | Adenocarcinoma - genetics | MicroRNAs - genetics | Transforming Growth Factor beta - metabolism | Adenocarcinoma | Phosphorylation | Smad protein | Profiling | Mesenchyme | Epithelial cells | Genes | Lung cancer | Lung | Cytology | Paracrine signalling | Biochemistry | Metastasis | Kinases | Cell morphology | Genotype & phenotype | Gelatin | Smad2 protein | Extracellular matrix | Tumor necrosis factor-TNF | Autocrine signalling | Growth factors | Cytokines | Invasiveness | MiRNA | JNK protein | Tumor necrosis factor-α | Gene expression | Medicine | Ribonucleic acids | MicroRNAs | Cell lines | Lysis | TNF inhibitors | Chemokines | Cancer | Index Medicus
Journal Article
Journal of Dental Research, ISSN 0022-0345, 9/2008, Volume 87, Issue 9, pp. 845 - 849
BMP2/7 heterodimer expression by adenovirus can stimulate bone formation at subcutaneous sites. In the present study, we evaluate whether this approach will... 
Bone morphogenetic proteins | Cranial defect | Gene therapy | Adenovirus | Bone regeneration | Heterodimer | DEFECTS | gene therapy | INDUCTION | IDENTIFICATION | DELIVERY | cranial defect | heterodimer | DENTISTRY, ORAL SURGERY & MEDICINE | adenovirus | IN-VIVO | bone regeneration | OSTEOGENIC PROTEIN-1 | RECEPTORS | MARROW STROMAL CELLS | bone morphogenetic proteins | MORPHOGENETIC PROTEIN-2 | GROWTH/DIFFERENTIATION FACTOR-5 | Bone Regeneration - physiology | Osteogenesis - physiology | Bone Regeneration - genetics | Tissue Scaffolds | Cell Differentiation - genetics | Bone Morphogenetic Proteins - metabolism | Myoblasts - metabolism | Gelatin Sponge, Absorbable - metabolism | Guided Tissue Regeneration - methods | Myoblasts - cytology | Adenoviridae - genetics | Wound Healing - genetics | Transgenes | Bone Morphogenetic Proteins - genetics | Cell Differentiation - physiology | Osteogenesis - genetics | Fibroblasts - metabolism | Gene Transfer Techniques | Bone Morphogenetic Proteins - administration & dosage | Bone Morphogenetic Protein 2 | Mice, Inbred C57BL | Cells, Cultured | Genetic Vectors - genetics | Absorbable Implants | Animals | Transforming Growth Factor beta - genetics | Transforming Growth Factor beta - administration & dosage | Craniotomy | Fibroblasts - cytology | Mice | Wound Healing - physiology | Transforming Growth Factor beta - metabolism | Bone Morphogenetic Protein 7 | Genetic Therapy - methods | Index Medicus | Dentistry
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e112186 - e112186
We previously showed that [Pt(O,O'-acac)(gamma-acac)(DMS)] ([Pt(acac)(2)(DMS)]) exerted substantial cytotoxic effects in SH-SY5Y neuroblastoma cells, and... 
BREAST-CANCER CELLS | TUMOR INVASION | ACTIVATION | NHE1 | PLATINUM(II) COMPLEXES | CARCINOMA CELLS | MULTIDISCIPLINARY SCIENCES | GROWTH | INTRACELLULAR PH | S6 KINASE | INDEPENDENT PATHWAY | TOR Serine-Threonine Kinases - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Neoplasm Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Sodium-Hydrogen Exchangers - metabolism | MAP Kinase Signaling System - genetics | Protein Isoforms - metabolism | TOR Serine-Threonine Kinases - genetics | Cation Transport Proteins - metabolism | Neoplasm Invasiveness - pathology | Cation Transport Proteins - genetics | Sodium-Hydrogen Exchangers - genetics | Neoplasm Proteins - genetics | Neuroblastoma - pathology | Neuroblastoma - genetics | Protein Kinase C-epsilon - genetics | Cell Movement - drug effects | MAP Kinase Signaling System - drug effects | Protein Kinase C-epsilon - metabolism | Cell Line, Tumor | Neuroblastoma - metabolism | Neoplasm Invasiveness - genetics | Platinum Compounds - pharmacology | Sodium-Hydrogen Exchanger 1 | Protein Isoforms - genetics | TOR protein | Protein kinase C | Hydrogen | Cytotoxicity | Activation | mRNA | Metastasis | Neuroblastoma | Kinases | pH effects | NAD(P)H oxidase | Neuroblastoma cells | Cell adhesion & migration | Proteins | Gelatin | Platinum | Cell cycle | Physiology | Inhibition | Sulfur | Secretion | Na+/H+-exchanging ATPase | Extracellular signal-regulated kinase | MAP kinase | Breast cancer | Gene expression | Gelatinase A | Wounding | Sodium | Inorganic chemistry | Ligands | Solid tumors | Cell migration | Tumors | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e56241 - e56241
RUNX3 (runt-related transcription factor-3) is a known tumor suppressor gene which exhibits potent antitumor activity in several carcinomas. However, little is... 
MATRIX METALLOPROTEINASES | METHYLATION | METASTASIS | GENE | GASTRIC-CANCER | MULTIDISCIPLINARY SCIENCES | TRANSFORMING-GROWTH-FACTOR | EXPRESSION | PROGRESSION | Human Umbilical Vein Endothelial Cells | Core Binding Factor Alpha 3 Subunit - metabolism | Kidney Neoplasms - genetics | Kidney - blood supply | Kidney - pathology | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Kidney Neoplasms - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Kidney - metabolism | Matrix Metalloproteinase 9 - metabolism | Core Binding Factor Alpha 3 Subunit - analysis | Matrix Metalloproteinase 9 - genetics | Neoplasm Invasiveness - pathology | Carcinoma, Renal Cell - blood supply | Carcinoma, Renal Cell - pathology | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Core Binding Factor Alpha 3 Subunit - genetics | Kidney Neoplasms - pathology | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - metabolism | Neoplasm Invasiveness - genetics | Kidney Neoplasms - blood supply | Cell Movement | Vascular endothelial growth factor | Enzyme-linked immunosorbent assay | Carcinoma, Renal cell | Cell proliferation | Immunohistochemistry | Biotechnology | Enzyme activity | Laboratories | Metastasis | Matrix metalloproteinase | Tissues | Cancer therapies | Stomach cancer | Anticancer properties | Angiogenesis | Restoration | Enzymatic activity | Gelatin | Metalloproteinase | Secretion | Melanoma | Endothelial cells | Gelatinase B | Pathology | Hospitals | DNA microarrays | Plasmids | Medical prognosis | Tumor suppressor genes | Antitumor activity | Cell migration | Clear cell-type renal cell carcinoma | Runx3 protein | Kidney transplantation | Tumors | Index Medicus
Journal Article