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Blood, ISSN 0006-4971, 06/2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | CLL | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | APOPTOTIC CELL-DEATH | RITUXIMAB | SURVIVAL SIGNALS | LYMPHOMA | DRUG-RESISTANCE | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
Neuron, ISSN 0896-6273, 04/2013, Volume 78, Issue 1, pp. 94 - 108
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2009, Volume 29, Issue 37, pp. 11451 - 11460
Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin... 
DEPRESSION | SOCIAL DEFEAT | MOUSE | GENE-EXPRESSION | DOPAMINE | INDUCED ANHEDONIA | MODEL | STRESS | SYNAPTIC PLASTICITY | NEUROSCIENCES | FAMILY | Gene Expression Regulation, Enzymologic - drug effects | Depression - pathology | Humans | Sucrose - pharmacology | Male | Gene Expression Regulation, Enzymologic - physiology | RNA, Messenger - metabolism | Repressor Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Depression - drug therapy | Dominance-Subordination | Nucleus Accumbens - enzymology | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Benzamides - pharmacology | Interpersonal Relations | Repressor Proteins - metabolism | Disease Models, Animal | Fluoxetine - pharmacology | Histone Deacetylases - genetics | Sweetening Agents - pharmacology | Food Preferences - drug effects | Oligonucleotide Array Sequence Analysis - methods | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Repressor Proteins - genetics | Gene Expression Profiling - methods | Histone Deacetylase 2 | Histone Deacetylases - metabolism | Depression - enzymology | Hydroxamic Acids | Animals | Histones - genetics | Analysis of Variance | Models, Biological | Histone Deacetylase Inhibitors | Mice | Pyridines - pharmacology | Histones - metabolism | Nucleus Accumbens - drug effects | Postmortem Changes | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 12, pp. 5021 - 5026
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 56, Issue 3, pp. 517 - 529
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 53, Issue 6, pp. 857 - 869
DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases (DNMTs). DNA methylation is associated with transcriptional... 
HUMDISEASE | MOLNEURO | SIGNALING | HIPPOCAMPAL SYNAPTIC PLASTICITY | METHYLTRANSFERASE GENE | ACETYLTRANSFERASE ACTIVITY | METHYLATION | LONG-TERM-MEMORY | NEURONAL GENES | GENE-EXPRESSION | QUANTITATIVE PCR | HISTONE ACETYLTRANSFERASE | NEUROSCIENCES | TRANSCRIPTIONAL REPRESSOR | Memory - drug effects | Gene Expression Regulation, Enzymologic - drug effects | Phosphoprotein Phosphatases - metabolism | Male | Gene Expression Regulation, Enzymologic - physiology | Hippocampus - drug effects | Behavior, Animal | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA - physiology | Reverse Transcriptase Polymerase Chain Reaction - methods | Serine Endopeptidases - genetics | Cell Adhesion Molecules, Neuronal - metabolism | Extracellular Matrix Proteins - metabolism | Extracellular Matrix Proteins - genetics | Enzyme Inhibitors - pharmacology | Rats | Azacitidine - analogs & derivatives | Conditioning, Classical - physiology | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Cell Adhesion Molecules, Neuronal - genetics | Nerve Tissue Proteins - metabolism | Azacitidine - pharmacology | DNA (Cytosine-5-)-Methyltransferases - genetics | Fear | Animals | Models, Biological | Serine Endopeptidases - metabolism | Hippocampus - physiology | DNA Methylation - drug effects | Memory - physiology | DNA | Studies | DNA methylation | Epigenetics | Chromatin | Kinases | Index Medicus
Journal Article
GLIA, ISSN 0894-1491, 02/2011, Volume 59, Issue 2, pp. 242 - 255
There is increasing evidence that astrocytes play important roles in immune regulation in the brain. Astrocytes express toll-like receptors (TLR) and build up... 
Brain | NFκB | Inflammation | Stat1 | Glia | Rodent | LPS | TOLL-LIKE-RECEPTORS | FOCAL CEREBRAL-ISCHEMIA | EXPERIMENTAL STROKE | brain | glia | NEUROSCIENCES | REGULATORY FACTOR-3 | inflammation | INNATE IMMUNE-RESPONSES | rodent | ENDOTHELIAL-CELLS | GENE-EXPRESSION | REACTIVE ASTROCYTES | SPINAL-CORD-INJURY | STAT1 ACTIVATION | NF kappa B | Enzyme-Linked Immunosorbent Assay - methods | Gene Expression Regulation, Enzymologic - drug effects | RNA, Small Interfering - genetics | Flow Cytometry - methods | STAT1 Transcription Factor - deficiency | NF-kappa B - metabolism | RNA, Messenger - metabolism | Cerebral Cortex - cytology | STAT1 Transcription Factor - metabolism | Drug Interactions | Transfection | Time Factors | Histone Acetyltransferases - metabolism | Phosphorylation - drug effects | Animals, Newborn | Astrocytes - drug effects | Microglia - drug effects | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - genetics | Rats | Signal Transduction - genetics | Enzyme Activation - drug effects | STAT1 Transcription Factor - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Tyrosine - metabolism | Animals | Myeloid Differentiation Factor 88 - deficiency | NF-kappa B - genetics | Signal Transduction - drug effects | Gene Expression Regulation, Enzymologic - genetics | Lipopolysaccharides - pharmacology | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Mice | Myeloid Differentiation Factor 88 - metabolism | Astrocytes - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 14, pp. 8885 - 8892
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 25, pp. 9157 - 9162
The transcription factor c-MYC is stabilized and activated by phosphorylation at serine 62 (S62) in breast cancer. Protein phosphatase 2A (PP2A) is a critical... 
Tumor cell line | Cell growth | Cell lines | Small interfering RNA | Breast cancer | Breast neoplasms | Heterologous transplantation | Tumors | Cancer | Apoptosis | Breast cancer therapy | Phosphatase activator | TUMOR-SUPPRESSOR PP2A | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PROTEIN PHOSPHATASE 2A | CIP2A | OVEREXPRESSION | phosphatase activator | CELL-TRANSFORMATION | GENE | breast cancer therapy | MYELOID-LEUKEMIA | DEGRADATION | SUBUNIT | Gene Expression Regulation, Enzymologic - drug effects | Autoantigens - biosynthesis | Histone Chaperones - genetics | Humans | Autoantigens - genetics | Breast Neoplasms - metabolism | Drug Delivery Systems | Gene Knockdown Techniques | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Protein Phosphatase 2 - antagonists & inhibitors | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Protein Phosphatase 2 - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Gene Expression Regulation, Enzymologic - genetics | Histone Chaperones - biosynthesis | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-myc - genetics | Physiological aspects | Tumor suppressor genes | Care and treatment | Transcription factors | Genetic aspects | Phosphorylation | Gene expression | Cells | Index Medicus | Biological Sciences
Journal Article