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Blood, ISSN 1528-0020, 2011, Volume 117, Issue 23, pp. 6287 - 6296
B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and... 
B-CELLS | SURVIVAL | APOPTOSIS | ACTIVATION | FLUDARABINE PLUS CYCLOPHOSPHAMIDE | RITUXIMAB | LYMPHOMA | PROLIFERATION | INHIBITOR | HEMATOLOGY | EXPRESSION | T-Lymphocytes - enzymology | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cell Survival - genetics | Apoptosis - genetics | Male | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Receptors, Antigen, B-Cell - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Cell Survival - drug effects | Drug Screening Assays, Antitumor - methods | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | B-Cell Activating Factor - metabolism | CD40 Ligand - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Receptors, Antigen, B-Cell - genetics | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Mitogen-Activated Protein Kinase 1 - metabolism | Protein-Tyrosine Kinases - antagonists & inhibitors | Tumor Necrosis Factor-alpha - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Gene Expression Regulation, Leukemic - genetics | Protein-Tyrosine Kinases - genetics | CD40 Ligand - metabolism | MAP Kinase Signaling System - genetics | Female | Interleukin-4 - genetics | Protein-Tyrosine Kinases - biosynthesis | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Neoplasm Proteins - biosynthesis | Interleukin-4 - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | MAP Kinase Signaling System - drug effects | NF-kappa B - genetics | B-Cell Activating Factor - genetics | Cell Proliferation - drug effects | Lymphoid Neoplasia
Journal Article
BMC cancer, ISSN 1471-2407, 2015, Volume 15, Issue 1, p. 672
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 406, Issue 1, pp. 105 - 114
NOX4 is an enigmatic member of the NOX (NADPH oxidase) family of ROS (reactive oxygen species)-generating NADPH oxidases. NOX4 has a wide tissue distribution,... 
NOX4 | NADPH oxidase (NOX) | Superoxide | Hydrogen peroxide | NOX4 inhibitor | Reactive oxygen species (ROS) | APOPTOSIS | OXYGEN SPECIES PRODUCTION | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | hydrogen peroxide | TRANSCRIPTION | reactive oxygen species (ROS) | NADPH OXIDASE ACTIVITY | NAD(P)H OXIDASE | INHIBITION | DIFFERENTIATION | superoxide | EXPRESSION | DIPHENYLENEIODONIUM | Gene Expression Regulation, Enzymologic - drug effects | Reactive Oxygen Species - metabolism | Humans | Cytosol - drug effects | RNA, Messenger - metabolism | Cytosol - enzymology | Time Factors | Superoxides - metabolism | Enzyme Induction - drug effects | NADPH Oxidases - genetics | NADP - metabolism | Ethidium - analogs & derivatives | Cell Membrane - drug effects | NAD - metabolism | Cell Line | Electron Spin Resonance Spectroscopy | RNA, Messenger - genetics | Tetracycline - pharmacology | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Nitroblue Tetrazolium - pharmacology | Mitochondria - drug effects | NADPH Oxidase 4 | Cell Membrane - enzymology | Animals | Ethidium - pharmacology | Mice | Cell Membrane | Enzyme Inhibitors | Reactive Oxygen Species | Hydrogen Peroxide | Cytosol | Life Sciences | Mitochondria | Biomolecules | NADP | Ethidium | Biochemistry, Molecular Biology | Enzyme Induction | Nitroblue Tetrazolium | Tetracycline | NAD | Gene Expression Regulation, Enzymologic | Superoxides | RNA, Messenger | NADPH Oxidase | tet, tetracycline | PKC, protein kinase C | NOX, NADPH oxidase | HEK-293, human embryonic kidney | ACP, 1-acetoxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine | HRP, horseradish peroxidase | HBSS, Hanks balanced salt solution | DMEM, Dulbecco's modified Eagle's medium | TGF, transforming growth factor | DHE, dihydroethidium | CMV, cytomegalovirus | NBT, Nitro Blue Tetrazolium | ROS, reactive oxygen species | DPI, diphenyleneiodonium chloride
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2013, Volume 78, Issue 1, pp. 94 - 108
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2008, Volume 283, Issue 2, pp. 774 - 783
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2009, Volume 29, Issue 37, pp. 11451 - 11460
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2011, Volume 286, Issue 21, pp. 19127 - 19137
...) therapy for breast cancers. Here, we demonstrated that miR-21 expression was up-regulated and its function was elevated in HER2... 
CELLS | OVEREXPRESSION | INVASION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TUMOR-SUPPRESSOR GENE | DOWN-REGULATION | PTEN | MICRORNA-21 TARGETS | EXPRESSION | PROMOTES | Carcinoma, Ductal, Breast - genetics | Gene Silencing - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | G1 Phase - drug effects | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Carcinoma, Ductal, Breast - drug therapy | Female | Antineoplastic Agents - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | G1 Phase - genetics | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Antibodies, Monoclonal - pharmacology | PTEN Phosphohydrolase - biosynthesis | MicroRNAs - biosynthesis | Up-Regulation - genetics | Breast Neoplasms - drug therapy | S Phase - genetics | Gene Expression Regulation, Enzymologic | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | RNA, Neoplasm - genetics | MicroRNAs - genetics | S Phase - drug effects | Trastuzumab | Drug Resistance, Neoplasm - drug effects | Gene Regulation | RNA Silencing | MicroRNA | Gene Therapy | Tumor Therapy | Breast Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2009, Volume 284, Issue 51, pp. 35412 - 35424
Heavy metals are known to generate reactive oxygen species that lead to the oxidation and fragmentation of proteins, which become toxic when accumulated in the... 
20S PROTEASOME | DEPENDENT PROTEOLYSIS | OXIDATIVE STRESS | PEA-PLANTS | UBIQUITIN-CONJUGATING ENZYMES | LENS EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | OXIDIZED PROTEINS | 26S PROTEASOME | IMMUNOLOGICAL CHARACTERIZATION | LEUCINE AMINOPEPTIDASE | Gene Expression Regulation, Enzymologic - drug effects | Arabidopsis - enzymology | Serine Endopeptidases - biosynthesis | Muramidase - chemistry | Cadmium - pharmacology | Proteasome Endopeptidase Complex - chemistry | Serine Endopeptidases - chemistry | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - chemistry | Enzyme Activation - drug effects | Proteasome Endopeptidase Complex - biosynthesis | Up-Regulation - drug effects | Gene Expression Regulation, Plant - drug effects | Animals | Arabidopsis Proteins - chemistry | Cattle | Arabidopsis Proteins - biosynthesis | Aminopeptidases - chemistry | Serum Albumin, Bovine - chemistry | Stress, Physiological - drug effects | Plant Leaves - enzymology | Aminopeptidases - biosynthesis | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - biosynthesis | Index Medicus | Up-Regulation | Cadmium | Arabidopsis | Aminopeptidases | Plant Leaves | Biochemistry, Molecular Biology | Stress, Physiological | Proteasome Endopeptidase Complex | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases | Gene Expression Regulation, Enzymologic | Life Sciences | Arabidopsis Proteins | Muramidase | Serum Albumin, Bovine | Gene Expression Regulation, Plant | Serine Endopeptidases | Enzyme Activation | Protein Synthesis, Post-Translational Modification, and Degradation
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 25, pp. 9157 - 9162
The transcription factor c-MYC is stabilized and activated by phosphorylation at serine 62 (S62) in breast cancer. Protein phosphatase 2A (PP2A) is a critical... 
Tumor cell line | Cell growth | Cell lines | Small interfering RNA | Breast cancer | Breast neoplasms | Heterologous transplantation | Tumors | Cancer | Apoptosis | Breast cancer therapy | Phosphatase activator | TUMOR-SUPPRESSOR PP2A | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | PROTEIN PHOSPHATASE 2A | CIP2A | OVEREXPRESSION | phosphatase activator | CELL-TRANSFORMATION | GENE | breast cancer therapy | MYELOID-LEUKEMIA | DEGRADATION | SUBUNIT | Gene Expression Regulation, Enzymologic - drug effects | Autoantigens - biosynthesis | Histone Chaperones - genetics | Humans | Autoantigens - genetics | Breast Neoplasms - metabolism | Drug Delivery Systems | Gene Knockdown Techniques | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Protein Phosphatase 2 - antagonists & inhibitors | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Protein Phosphatase 2 - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Gene Expression Regulation, Enzymologic - genetics | Histone Chaperones - biosynthesis | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-myc - genetics | Physiological aspects | Tumor suppressor genes | Care and treatment | Transcription factors | Genetic aspects | Biological Sciences
Journal Article