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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 06/2014, Volume 111, Issue 25, pp. 9157 - 9162
The transcription factor c-MYC is stabilized and activated by phosphorylation at serine 62 (S62) in breast cancer. Protein phosphatase 2A (PP2A) is a critical... 
Tumor cell line | Cell growth | Cell lines | Small interfering RNA | Breast cancer | Breast neoplasms | Heterologous transplantation | Tumors | Cancer | Apoptosis | Breast cancer therapy | Phosphatase activator | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Gene Expression Regulation, Enzymologic - drug effects | Autoantigens - biosynthesis | Histone Chaperones - genetics | Humans | Autoantigens - genetics | Breast Neoplasms - metabolism | Drug Delivery Systems | Gene Knockdown Techniques | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Protein Phosphatase 2 - antagonists & inhibitors | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | Protein Phosphatase 2 - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | Breast Neoplasms - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Gene Expression Regulation, Enzymologic - genetics | Histone Chaperones - biosynthesis | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Proto-Oncogene Proteins c-myc - genetics | Physiological aspects | Tumor suppressor genes | Care and treatment | Transcription factors | Genetic aspects | Phosphorylation | Gene expression | Cells | Index Medicus | Biological Sciences | phosphatase activator | breast cancer therapy
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 09/2013, Volume 288, Issue 36, pp. 25938 - 25949
NAD(+) is mainly synthesized in human cells via the "salvage" pathways starting from nicotinamide, nicotinic acid, or nicotinamide riboside (NR). The... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | 5'-Nucleotidase - genetics | Gene Expression Regulation, Enzymologic - drug effects | Humans | Membrane Glycoproteins - biosynthesis | GPI-Linked Proteins - biosynthesis | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Neoplasms - genetics | Nicotinamide Phosphoribosyltransferase - metabolism | Piperidines - pharmacology | NAD - biosynthesis | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Acrylamides - pharmacology | Cytokines - genetics | Gene Expression Regulation, Neoplastic - genetics | 5'-Nucleotidase - biosynthesis | NAD - genetics | ADP-ribosyl Cyclase 1 - genetics | Cytokines - metabolism | Gene Silencing | Neoplasms - enzymology | Down-Regulation - drug effects | Down-Regulation - genetics | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Nicotinamide Phosphoribosyltransferase - genetics | Gene Expression Regulation, Enzymologic - genetics | ADP-ribosyl Cyclase 1 - biosynthesis | Cell Line, Tumor | Cytokines - antagonists & inhibitors | Nicotinamide Mononucleotide - biosynthesis | Nicotinamide Mononucleotide - genetics | GPI-Linked Proteins - genetics | Index Medicus | NAD | Cancer Therapy | CD73 | Nicotinamide Riboside | NAD Biosynthesis | Signal Transduction | Cell Death | Nicotinamide Mononucleotide | Nicotinamide
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 2, pp. e16724 - e16724
...: A fry1 mutant was identified in a genetic screen for Arabidopsis mutants deregulated in the expression of Pi High affinity Transporter 1;4 (PHT1;4... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Exoribonucleases - genetics | Arabidopsis - enzymology | Starvation - pathology | Phosphate Transport Proteins - metabolism | Plant Roots - genetics | Green Fluorescent Proteins - genetics | Gene Expression Regulation, Enzymologic - physiology | Recombinant Fusion Proteins - metabolism | Arabidopsis Proteins - metabolism | Mutation - physiology | Plants, Genetically Modified | Phosphate Transport Proteins - genetics | Starvation - genetics | Green Fluorescent Proteins - metabolism | Arabidopsis Proteins - genetics | Phosphoric Monoester Hydrolases - genetics | Plant Roots - metabolism | Genes, Plant - physiology | Arabidopsis - metabolism | Arabidopsis - genetics | Phenotype | Gene Expression Regulation, Plant - physiology | Alleles | Plant Roots - enzymology | Recombinant Fusion Proteins - genetics | Exoribonucleases - metabolism | Phosphates | Arabidopsis thaliana | Inositol | Phosphatases | Analysis | Genetic aspects | Genetic transcription | Genetic screening | Deregulation | Transcription | Genes | Gene regulation | Roots | Genomics | Inositol polyphosphate | Biology | Phosphatase | Grafting | Meristems | Signal transduction | Drought resistance | Trends | Drought | Enzymes | Starvation | AMP | Architecture | Abiotic stress | Cloning | Gene expression | Immunological tolerance | Mutants | Depletion | Rosette | Mutation | Transporter | Leaves | inositol polyphosphate | Nucleotides | Index Medicus | Green Fluorescent Proteins | Exoribonucleases | Arabidopsis | Genes, Plant | Recombinant Fusion Proteins | Gene Expression Regulation, Enzymologic | Life Sciences | Phosphoric Monoester Hydrolases | Arabidopsis Proteins | Plant Roots | Phosphate Transport Proteins | Gene Expression Regulation, Plant | Vegetal Biology
Journal Article
Oncotarget, ISSN 1949-2553, 2012, Volume 3, Issue 1, pp. 84 - 97
.... Pharmacologic interference of CAIX catalytic activity using monoclonal antibodies or CAIX-specific small molecule inhibitors, consequently disrupting pH regulation by cancer cells, has been shown... 
Hypoxia | Targeted therapeutics | Carbonic anhydrase IX | Metastasis |