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The New England Journal of Medicine, ISSN 0028-4793, 12/2007, Volume 357, Issue 24, pp. 2426 - 2429
Journal Article
Nature communications, ISSN 2041-1723, 2016, Volume 7, Issue 1, p. 10548
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 12, p. e49838
... have been generated to study disease pathogenesis and evaluate potential therapeutic approaches. Of these, knock-in models best mimic the human condition from a genetic... 
PRECISION GRIP | MESSENGER-RNA | REPEAT | MULTIDISCIPLINARY SCIENCES | MUTANT HUNTINGTIN | LENGTH | GENE-EXPRESSION | STRIATAL NEURONS | EARLY MOTOR | ONSET | TRANSGENIC MICE | Darkness | RNA, Messenger - genetics | Male | RNA, Messenger - metabolism | Body Weight - genetics | Nerve Tissue Proteins - genetics | Behavior, Animal - radiation effects | Gene Knock-In Techniques | Homozygote | Rotarod Performance Test | Animals | Genetic Markers - genetics | Survival Analysis | Cognition - physiology | Huntington Disease - genetics | Repetitive Sequences, Nucleic Acid | Female | Heterozygote | Neostriatum - metabolism | Mice | Transcription, Genetic - genetics | Hand Strength - physiology | Huntington Disease - physiopathology | Disease Models, Animal | Genetic markers | Nervous system diseases | Genetic aspects | Health aspects | Analysis | Huntingtons disease | Neurosciences | Animal models | Huntingtin | Copy number | Pathogenesis | Body weight | Cognitive ability | Heterozygotes | Proteins | Transgenic animals | Rodents | Neostriatum | Diurnal cycle | Grip strength | Trinucleotide repeat diseases | Age | Dopamine | Polyglutamine | Neurodegenerative diseases | Abnormalities | Trinucleotide repeats | Huntington's disease | Gene expression | Diurnal | Hereditary diseases | Homozygotes | Diurnal variations | Weight reduction | Mutation
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 33, pp. 10437 - 10442
Journal Article
Nature protocols, ISSN 1750-2799, 2017, Volume 13, Issue 1, pp. 195 - 215
Journal Article
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2015, Volume 78, pp. 172 - 195
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 08/2012, Volume 27, Issue 8, pp. 1746 - 1756
...) in the gene encoding ACVR1/ALK2, a bone morphogenetic protein (BMP) type I receptor. Gene targeting was used to develop an Acvr1 knock‐in model for FOP (Acvr1R206H... 
ACVR1 | ALK2 | HETEROTOPIC OSSIFICATION | ENDOCHONDRAL BONE | FIBRODYSPLASIA OSSIFICANS PROGRESSIVA | CELLS | NOGGIN | MUTATION | ENDOCRINOLOGY & METABOLISM | MECHANISMS | BMP RECEPTOR | CHONDROGENESIS | Myositis Ossificans - diagnostic imaging | Inflammation - pathology | Receptor, TIE-2 | Humans | Molecular Sequence Data | Muscle, Skeletal - injuries | Stem Cells - metabolism | Inflammation - complications | Base Sequence | Myositis Ossificans - pathology | Chondrogenesis | Ossification, Heterotopic - complications | Gene Targeting | Myositis Ossificans - complications | Connective Tissue - pathology | Ossification, Heterotopic - pathology | Mice, Inbred C57BL | Activin Receptors, Type I - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Activin Receptors, Type I - genetics | Gene Knock-In Techniques | Radiography | Lymphocytes - pathology | Ossification, Heterotopic - physiopathology | Animals | Myositis Ossificans - physiopathology | Alleles | Amino Acid Substitution - genetics | Mice | Muscle, Skeletal - pathology | Osteogenesis | Apoptosis | Cell Movement | Medical colleges | Embryonic development | Genetic disorders | Analysis | Genes | Muscles | Bone morphogenetic proteins | Limbs | Animal models | Inflammation | Myositis ossificans | Nucleotides | Skeletal muscle | Ossification | Cartilage | Bone growth | Embryogenesis | Gene targeting | Stem cells | Mutation | Differentiation | Bone (endochondral) | Ossification (ectopic) | heterotopic ossification | endochondral bone | fibrodysplasia ossificans progressiva | FOP
Journal Article