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1. Full Text A conditional knockout resource for the genome-wide study of mouse gene function
by Skarnes, William C and Rosen, Barry and West, Anthony P and Koutsourakis, Manousos and Bushell, Wendy and Iyer, Vivek and Mujica, Alejandro O and Thomas, Mark and Harrow, Jennifer and Cox, Tony and Jackson, David and Severin, Jessica and Biggs, Patrick and Fu, Jun and Nefedov, Michael and De Jong, Pieter J and Stewart, A. Francis and Bradley, Allan
Nature (London), ISSN 0028-0836, 06/2011, Volume 474, Issue 7351, pp. 337 - 344
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Classical genetics, quantitative genetics, hybrids | Biological and medical sciences | Vertebrata | Animals | Genetics of eukaryotes. Biological and molecular evolution | Mice, Knockout - genetics | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Mutagenesis, Insertional - methods | Genomics | Humans | Mice, Inbred C57BL | Computational Biology | Genome - genetics | Genes - genetics | Genetic Association Studies - methods | Rats | Genotype | Gene Knockout Techniques - methods | Genetic Vectors - genetics | Phenotype | Gene Deletion | Genes, Lethal - genetics | Alleles | Polymerase Chain Reaction | Mice | Proteins | Genetics | Mutation | Genes | Index Medicus
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2. Full Text The Knockout Mouse Project
by Austin, Christopher P and Battey, James F and Bradley, Allan and Bucan, Maja and Capecchi, Mario and Collins, Francis S and Dove, William F and Duyk, Geoffrey and Dymecki, Susan and Eppig, Janan T and Grieder, Franziska B and Heintz, Nathaniel and Hicks, Geoff and Insel, Thomas R and Joyner, Alexandra and Koller, Beverly H and Lloyd, K. C. Kent and Magnuson, Terry and Moore, Mark W and Nagy, Andras and Pollock, Jonathan D and Roses, Allen D and Sands, Arthur T and Seed, Brian and Skarnes, William C and Snoddy, Jay and Soriano, Philippe and Stewart, David J and Stewart, Francis and Stillman, Bruce and Varmus, Harold and Varticovski, Lyuba and Verma, Inder M and Vogt, Thomas F and Von Melchner, Harald and Witkowski, Jan and Woychik, Richard P and Wurst, Wolfgang and Yancopoulos, George D and Young, Stephen G and Zambrowicz, Brian and Comprehensive Knockout Mouse Proje and The Comprehensive Knockout Mouse Project Consortium
Nature genetics, ISSN 1061-4036, 09/2004, Volume 36, Issue 9, pp. 921 - 924
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Research Embryo Creation - economics | Phenotype | Animals | Genetic Research | Alleles | Mice | Mice, Knockout | Usage | Gene mutations | Physiological aspects | Genetic aspects | Nucleotide sequencing | Research | Identification and classification | Methods | Index Medicus
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3. Full Text Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
by Ophir Shalem and Neville E. Sanjana and Ella Hartenian and Xi Shi and David A. Scott and Tarjei S. Mikkelsen and Dirk Heckl and Benjamin L. Ebert and David E. Root and John G. Doench and Feng Zhang
Science (American Association for the Advancement of Science), ISSN 0036-8075, 1/2014, Volume 343, Issue 6166, pp. 84 - 87
T lymphocytes | HEK293 cells | Genetic vectors | Genomics | REPORTS | Cell lines | Stem cells | Melanoma | Genetic loci | Genetic mutation | Genetic screening | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genome-Wide Association Study | Gene Library | raf Kinases - antagonists & inhibitors | Humans | Selection, Genetic | Cell Survival - genetics | Mediator Complex - genetics | Genetic Loci | Transcription Factors - genetics | Gene Knockout Techniques | Genes, Neurofibromatosis 1 | Genes, Neurofibromatosis 2 | Genetic Testing - methods | Lentivirus | Cullin Proteins - genetics | Pluripotent Stem Cells - metabolism | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Melanoma - genetics | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Adaptor Proteins, Signal Transducing - genetics | Clustered Regularly Interspaced Short Palindromic Repeats | Indoles - therapeutic use | RNA sequencing | Genome-wide association studies | Research | Studies | Genetic engineering | Pharmaceutical sciences | Index Medicus
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4. Full Text Double knockout pigs deficient in N‐glycolylneuraminic acid and Galactose α‐1,3‐Galactose reduce the humoral barrier to xenotransplantation
by Lutz, Andrew J and Li, Ping and Estrada, Jose L and Sidner, Richard A and Chihara, Ray K and Downey, Susan M and Burlak, Christopher and Wang, Zheng‐Yu and Reyes, Luz M and Ivary, Bess and Yin, Fuqin and Blankenship, Ross L and Paris, Leela L and Tector, A. Joseph
Xenotransplantation (Københaven), ISSN 0908-665X, 01/2013, Volume 20, Issue 1, pp. 27 - 35
xenotransplantation | Neu5Gc | humoral | zinc‐finger nuclease | pig | zinc-finger nuclease | Transplantation | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Galactosyltransferases - deficiency | Mixed Function Oxygenases - deficiency | Transplantation, Heterologous - immunology | Antibody-Dependent Cell Cytotoxicity | Humans | Antigens, Heterophile - immunology | Cells, Cultured | Antibodies, Heterophile - metabolism | Antigens, Heterophile - metabolism | Galactosyltransferases - genetics | Gene Knockout Techniques - methods | DNA - genetics | Sus scrofa - genetics | Animals | Disaccharides - immunology | Sus scrofa - metabolism | Neuraminic Acids - metabolism | Base Sequence | Leukocytes, Mononuclear - immunology | Female | Mixed Function Oxygenases - genetics | Sus scrofa - immunology | Neuraminic Acids - immunology | Disaccharides - deficiency | Index Medicus | GGTA1 gene | somatic cell nuclear transfer | Hepatocytes | Breeding | Hydroxylase | Xenografts | xenoantigens | Antibodies | Cytotoxicity | Immunoreactivity | Nuclease | Galactose
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5. Full Text Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
by Joung, Julia and Konermann, Silvana and Gootenberg, Jonathan S and Abudayyeh, Omar O and Platt, Randall J and Brigham, Mark D and Sanjana, Neville E and Zhang, Feng
Nature protocols, ISSN 1754-2189, 04/2017, Volume 12, Issue 4, pp. 828 - 863
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Phenotype | Animals | Gene Library | Humans | Transcriptional Activation | Lentivirus - genetics | Mice | Genomics - methods | CRISPR-Cas Systems - genetics | Gene Knockout Techniques - methods | Genetic Vectors - genetics | Genetic engineering | Models | Genetic transcription | Analysis | Innovations | Index Medicus
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6. Full Text Characterization of Dopaminergic System in the Striatum of Young Adult Park2 -/- Knockout Rats
by Gemechu, Jickssa M and Sharma, Akhil and Yu, Dongyue and Xie, Yuran and Merkel, Olivia M and Moszczynska, Anna
Scientific reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 1517 - 19
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Monoamine Oxidase - analysis | Serotonin - analysis | Animals | Dopaminergic Neurons - pathology | Rats | Ubiquitin-Protein Ligases - deficiency | Gene Knockout Techniques | Corpus Striatum - pathology | Phenethylamines - analysis | Parkinson's disease | Neurodegenerative diseases | Serotonin | Methamphetamine | Phenylethylamine | Amine oxidase (flavin-containing) | Neurodegeneration | Rodents | Neostriatum | Parkin protein | Mutation | Dopamine D2 receptors | Movement disorders | Neurotransmission | Locomotor activity | Age | Index Medicus
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7. Full Text Oral benzo[a]pyrene: Understanding pharmacokinetics, detoxication, and consequences - Cyp1 knockout mouse lines as a paradigm
by Nebert, Daniel W and Shi, Zhanquan and Gálvez-Peralta, Marina and Uno, Shigeyuki and Dragin, Nadine
Molecular pharmacology, ISSN 0026-895X, 09/2013, Volume 84, Issue 3, pp. 304 - 313
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cytochrome P-450 CYP1A1 - genetics | Species Specificity | Aryl Hydrocarbon Hydroxylases - genetics | Neoplasms, Experimental - enzymology | Benzo(a)pyrene - administration & dosage | Neoplasms, Experimental - chemically induced | Carcinogens, Environmental - toxicity | Gene-Environment Interaction | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Carcinogens, Environmental - administration & dosage | Cytochrome P-450 CYP1A2 - genetics | Carcinogens, Environmental - pharmacokinetics | Benzo(a)pyrene - toxicity | Metabolic Detoxication, Phase II | Administration, Oral | Scent Glands - enzymology | Cytochrome P-450 CYP1A1 - metabolism | Organ Specificity | Cytochrome P-450 CYP1A2 - metabolism | Aryl Hydrocarbon Hydroxylases - metabolism | Benzo(a)pyrene - pharmacokinetics | Intestinal Neoplasms - pathology | Mice, Knockout | Intestinal Neoplasms - enzymology | Animals | Intestinal Neoplasms - chemically induced | Cytochrome P-450 CYP1B1 | Scent Glands - pathology | Mice | Index Medicus | Minireview
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