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1. Full Text Vitamin C Promotes Maturation of T-Cells
by Manning, Jared and Mitchell, Birgitta and Appadurai, Daniel A and Shakya, Arvind and Pierce, Laura Jean and Wang, Hongfang and Nganga, Vincent and Swanson, Patrick C and May, James M and Tantin, Dean and Spangrude, Gerald J
Antioxidants & Redox Signaling, ISSN 1523-0864, 12/2013, Volume 19, Issue 17, pp. 254 - 2067
Aims: Vitamin C (ascorbic acid) is thought to enhance immune function, but the mechanisms involved are obscure. We utilized an in vitro model of T-cell... 
Forum Original Research Communications | LINEAGE COMMITMENT | PROGENITORS | IN-VITRO | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | ENDOCRINOLOGY & METABOLISM | DIFFERENTIATION | THYMOCYTES | ASCORBIC-ACID | TRANSCRIPTION FACTOR | REPERTOIRES | Gene Expression - drug effects | Phthalimides - pharmacology | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | T-Lymphocytes - metabolism | Culture Media | T-Lymphocytes - drug effects | Tryptophan - analogs & derivatives | Epigenesis, Genetic - drug effects | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cells, Cultured | Azepines - pharmacology | Animals | Histone-Lysine N-Methyltransferase - metabolism | Ascorbic Acid - pharmacology | T-Lymphocytes - immunology | Gene Rearrangement, T-Lymphocyte - drug effects | Mice | Protein Processing, Post-Translational | Receptors, Antigen, T-Cell - genetics | Tryptophan - pharmacology | Histones - metabolism | Methylation | Quinazolines - pharmacology | Immunologic Factors - pharmacology | Physiological aspects | Research | Cell development (Biology) | T cells | Health aspects | Vitamin C
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2. Full Text Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment
by De Smedt, Magda and Hoebeke, Inge and Reynvoet, Katia and Leclercq, Georges and Plum, Jean
Blood, ISSN 0006-4971, 11/2005, Volume 106, Issue 10, pp. 3498 - 3506
Notch receptors are involved in lineage decisions in multiple developmental scenarios, including hematopoiesis. Here, we treated hybrid human-mouse fetal... 
PROGENITOR CELLS | INACTIVATION | THYMOCYTE DEVELOPMENT | ALPHA-BETA | HEMATOPOIETIC STEM-CELLS | GENE-EXPRESSION | ORGAN-CULTURE | RECEPTOR | FATE | HEMATOLOGY | HUMAN CORD-BLOOD | Antigens, CD - immunology | Stem Cells - immunology | Dose-Response Relationship, Immunologic | Humans | Receptors, Antigen, T-Cell, alpha-beta - immunology | Stem Cells - cytology | Leukocytes - immunology | Signal Transduction - immunology | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Triglycerides - pharmacology | Organ Culture Techniques | Fetal Blood - immunology | Enzyme Inhibitors - pharmacology | Thymus Gland - cytology | gamma-Aminobutyric Acid - pharmacology | Fetal Blood - cytology | Endopeptidases - immunology | Animals | Gene Rearrangement, T-Lymphocyte - immunology | Signal Transduction - drug effects | Thymus Gland - immunology | Gene Rearrangement, T-Lymphocyte - drug effects | Mice | gamma-Aminobutyric Acid - analogs & derivatives | Receptors, Notch - immunology
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3. Full Text Effects of exogenous interleukin-7 on human thymus function
by Okamoto, Yukari and Douek, Daniel C and McFarland, Richard D and Koup, Richard A
Blood, ISSN 0006-4971, 04/2002, Volume 99, Issue 8, pp. 2851 - 2858
Immune reconstitution is a critical component of recovery after treatment of human immunodeficiency virus (HIV) infection, cancer chemotherapy, and... 
SEVERE COMBINED IMMUNODEFICIENCY | NATURAL-KILLER-CELLS | BONE-MARROW TRANSPLANTATION | DENDRITIC CELLS | IMMUNE RECONSTITUTION | IN-VIVO | DEFICIENT MICE | GROWTH-FACTOR | T-CELL DEVELOPMENT | HEMATOLOGY | RECEPTOR-GAMMA-CHAIN | Thymus Gland - physiology | Apoptosis - drug effects | Humans | Thymus Gland - cytology | Immunophenotyping | Infant | Interleukin-7 - pharmacology | Transplantation, Heterologous | Thymus Gland - drug effects | Mice, SCID | Cell Division - drug effects | Interleukin-7 - administration & dosage | Animals | Receptors, Interleukin-7 - analysis | Lymphocyte Subsets | Tissue Transplantation | Adult | Fetus | Gene Rearrangement, T-Lymphocyte - drug effects | Leukopoiesis - drug effects | Liver - cytology | Mice | Infant, Newborn
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4. Full Text The IgE repertoire in PBMCs of atopic patients is characterized by individual rearrangements without variable region of the heavy immunoglobulin chain bias
by Lim, Annick, MSci and Luderschmidt, Stephan, MD and Weidinger, Anke, MD and Schnopp, Christina, MD and Ring, Johannes, MD and Hein, Rüdiger, MD and Ollert, Markus, MD and Mempel, Martin, MD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2007, Volume 120, Issue 3, pp. 696 - 706
Background Patients with atopic diseases are characterized by high levels of specific IgE production. However, little is known about the composition of their... 
Allergy and Immunology | IgE repertoire | omalizumab | B cells | atopic eczema | NASAL-MUCOSA | CLASS SWITCH RECOMBINATION | SOMATIC HYPERMUTATION | DERMATITIS | ALLERGIC RHINITIS | PERIPHERAL-BLOOD | 3 UNRELATED PATIENTS | IMMUNOLOGY | EPSILON | B-CELLS | ALLERGY | GENE USAGE | Immunoglobulin G - blood | Humans | Middle Aged | Receptor-CD3 Complex, Antigen, T-Cell - genetics | Omalizumab | Antibodies, Monoclonal - therapeutic use | Male | Immunoglobulin Variable Region - immunology | Antibodies, Monoclonal, Humanized | Immunoglobulin E - immunology | Immunoglobulin E - genetics | Leukocytes, Mononuclear - immunology | Hypersensitivity, Immediate - immunology | Adult | Female | Transcription, Genetic | Immunoglobulin Heavy Chains - immunology | Immunoglobulin E - drug effects | Receptor-CD3 Complex, Antigen, T-Cell - drug effects | Hypersensitivity, Immediate - genetics | Hypersensitivity, Immediate - drug therapy | Immunoglobulin Heavy Chains - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Immunoglobulin Variable Region - drug effects | Anti-Allergic Agents - therapeutic use | Genes, Immunoglobulin | Immunoglobulin M - blood | Immunoglobulin Variable Region - genetics | Antibodies, Anti-Idiotypic | Receptor-CD3 Complex, Antigen, T-Cell - immunology | Gene Rearrangement, B-Lymphocyte - drug effects | Immunoglobulin Heavy Chains - genetics | Immunoglobulin E | Patients | Cloning | Allergies | Eczema | Immune system | Asthma
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5. Full Text Increased Peripheral Expansion of Naive CD4+ T Cells in vivo after IL-2 Treatment of Patients with HIV Infection
by Ven Natarajan and Richard A. Lempicki and Irini Sereti and Yunden Badralmaa and Joseph W. Adelsberger and Julia A. Metcalf and Darue A. Prieto and Randy Stevens and Michael W. Baseler and Joseph A. Kovacs and H. Clifford Lane
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2002, Volume 99, Issue 16, pp. 10712 - 10717
Intermittent interleukin-2 (IL-2) therapy has been shown to increase the number of CD4+ T cells, preferentially cells with a naive phenotype, in patients with... 
T lymphocytes | Telomeres | Biological Sciences | Cell growth | HIV infections | HIV | DNA | Stem cells | Cellular senescence | Viral load | Blood | INTERLEUKIN-2 | RECENT THYMIC EMIGRANTS | IMMUNE RECONSTITUTION | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | CD4(+) | INDEPENDENT ACTIVATION | HUMAN-IMMUNODEFICIENCY-VIRUS | T-CELLS | TELOMERE LENGTH | LYMPHOCYTES | HIV Infections - blood | CD4-Positive T-Lymphocytes - cytology | Humans | Interleukin-2 - therapeutic use | Treatment Outcome | CD4 Lymphocyte Count | Telomere - drug effects | Cell Division - drug effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Interleukin-2 - immunology | Interleukin-2 - administration & dosage | Adult | HIV Infections - drug therapy | Leukocytes, Mononuclear - cytology | Gene Rearrangement, T-Lymphocyte - drug effects | CD4-Positive T-Lymphocytes - drug effects | Cohort Studies | Interleukin-2 | CD4 lymphocytes | Research | Drug therapy | T cells | HIV infection | Health aspects
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6. Full Text An in vitro model of T cell receptor revision in mature human CD8+ T cells
by Lantelme, Erica and Orlando, Luca and Porcedda, Paola and Turinetto, Valentina and De Marchi, Mario and Amoroso, Antonio and Mantovani, Stefania and Giachino, Claudia
Molecular Immunology, ISSN 0161-5890, 01/2008, Volume 45, Issue 2, pp. 328 - 337
V(D)J recombination is a mechanism peculiar to the somatic rearrangement of antigen receptor genes. It requires both expression of the RAG-1 and RAG-2... 
Human | TCR revision | IL7 | T cells | RAG-1 | TCR/CD3 down-regulation | RAG-2 | RECOMBINATION-ACTIVATING GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | V(D)J RECOMBINATION | IMMUNOLOGY | SECONDARY REARRANGEMENT | CUTTING EDGE | SELECTIVE EXPRESSION | MESSENGER-RNA | TCR/CD3 down-re.gulation | IL-7 RECEPTOR | CENTRAL TOLERANCE | GERMINAL-CENTERS | human | ANTIGEN RECEPTOR | CD8-Positive T-Lymphocytes - cytology | Homeodomain Proteins - metabolism | Humans | Interleukin-7 - pharmacology | Receptors, Antigen, T-Cell, alpha-beta - immunology | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Receptors, Antigen, T-Cell - immunology | Clone Cells | Nuclear Proteins - genetics | Cell Line | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Down-Regulation - drug effects | Homeodomain Proteins - genetics | Antibodies - pharmacology | Models, Immunological | CD8-Positive T-Lymphocytes - drug effects | CD3 Complex - immunology | Fluorescent Antibody Technique | Gene Rearrangement, T-Lymphocyte - drug effects | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | Enterotoxins - pharmacology | Protein Isoforms - genetics
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7. Full Text Biomarker Correlations of Urinary 2,4-D Levels in Foresters: Genomic Instability and Endocrine Disruption
by Vincent F. Garry and Robert E. Tarone and Ilan R. Kirsch and Jorge M. Abdallah and Donald P. Lombardi and Leslie K. Long and Barbara L. Burroughs and Dana B. Barr and James S. Kesner
Environmental Health Perspectives, ISSN 0091-6765, 5/2001, Volume 109, Issue 5, pp. 495 - 500
Forest pesticide applicators constitute a unique pesticide use group. Aerial, mechanical-ground, and focal weed control by application of herbicides, in... 
Chemical hazards | Urine | Herbicides | Testosterone | Lymphocytes | Pesticides | Environmental health | Hormones | Research | Chromosomes | Backpacks | Foresters | Reproductive hormones | 2,4-D | V(D)J rearrangements | WORKERS | HERBICIDES | RISK | reproductive hormones | PESTICIDES | ENVIRONMENTAL SCIENCES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | DNA | ADJUVANTS | foresters | 2,4-DICHLOROPHENOXYACETIC ACID | LYMPHOMA | TOXICOLOGY | EXPOSURE
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8. Full Text Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis
by Nakamori, Yoshiki and Liu, Bing and Ohishi, Kohshi and Suzuki, Kei and Ino, Kazuko and Matsumoto, Takeshi and Masuya, Masahiro and Nishikawa, Hiroyoshi and Shiku, Hiroshi and Hamada, Hirofumi and Katayama, Naoyuki
British Journal of Haematology, ISSN 0007-1048, 06/2012, Volume 157, Issue 6, pp. 674 - 686
Summary The regulation of human early lymphopoiesis remains unclear. B‐ and T‐lineage cells cannot develop simultaneously with conventional stromal cultures.... 
haematopoietic progenitors | B lymphopoiesis | stromal cells | Flt3 ligand | T lymphopoiesis | Haematopoietic progenitors | Stromal cells | STEM-CELLS | IMMUNE RECONSTITUTION | CORD BLOOD | EX-VIVO EXPANSION | IN-VITRO | LARGE-SCALE GENERATION | LYMPHOID PROGENITOR | NOTCH SIGNALING PATHWAY | HEMATOLOGY | BLOOD CD34(+) CELLS | T-CELLS | Adjuvants, Immunologic - pharmacology | Antigens, CD - biosynthesis | Humans | Cell Communication - physiology | Gene Rearrangement, B-Lymphocyte, Heavy Chain - drug effects | Male | Membrane Proteins - pharmacology | Lymphopoiesis - physiology | T-Lymphocytes - metabolism | Female | B-Lymphocytes - metabolism | Lymphopoiesis - drug effects | B-Lymphocytes - cytology | Lymphoid Progenitor Cells - metabolism | Stromal Cells - metabolism | Cells, Cultured | Gene Expression Regulation - physiology | Gene Rearrangement, B-Lymphocyte, Heavy Chain - physiology | Lymphoid Progenitor Cells - cytology | Gene Expression Regulation - drug effects | Killer Cells, Natural - cytology | T-Lymphocytes - cytology | Cell Communication - drug effects | Killer Cells, Natural - metabolism | Stromal Cells - cytology
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9. Full Text Il-7 supports D-J but not V-DJ rearrangement of TCR-beta gene in fetal liver progenitor cells
by Tsuda, S and Rieke, S and Hashimoto, Y and Nakauchi, H and Takahama, Y
The Journal of Immunology, ISSN 0022-1767, 05/1996, Volume 156, Issue 9, pp. 3233 - 3242
The rearrangement of TCR-beta gene, one of the earliest events in T cell development, consists of two consecutive steps: D-J rearrangement and V-DJ... 
THYMOCYTE DEVELOPMENT | ALPHA-LOCUS | HEMATOPOIETIC STEM-CELLS | SURFACE EXPRESSION | RECEPTOR | T-CELL | DIFFERENTIATION | IMMUNOLOGY | CHAIN GENES | GAMMA-CHAIN | INTERLEUKIN-7 | Embryonic and Fetal Development - genetics | Molecular Sequence Data | Interleukin-7 - pharmacology | Stem Cells - metabolism | Interleukin-7 - genetics | Liver - immunology | T-Lymphocytes - metabolism | Base Sequence | Female | Cell Differentiation | Thymus Gland - metabolism | Mice, Inbred C57BL | Thymus Gland - drug effects | Receptors, Antigen, T-Cell, alpha-beta - genetics | Mice, Inbred ICR | Pregnancy | Animals | Gene Rearrangement, T-Lymphocyte - immunology | T-Lymphocytes - cytology | Interleukin-7 - biosynthesis | Stem Cells - drug effects | Embryonic and Fetal Development - immunology | Gene Rearrangement, T-Lymphocyte - drug effects | Liver - cytology | Mice | Deoxyguanosine - pharmacology
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10. Full Text Delayed expansion of a restricted T cell repertoire by low-density TCR ligands
by Lavoie, Pascal M and Dumont, Alain R and McGrath, Helen and Kernaleguen, Anne-Elen and Sékaly, Rafick-P
International Immunology, ISSN 0953-8178, 2005, Volume 17, Issue 7, pp. 931 - 941
The role of TCR ligand density (i.e. the number of antigen-MHC complexes) in modulating the diversity of a T cell response selected from a pool of naive... 
Antigen presentation | Avidity | Immune response | Staphylococcal A | T cell proliferation | IMMUNE-RESPONSE | antigen presentation | AFFINITY MATURATION | HIGH-AVIDITY | IMMUNOLOGY | LYMPHOCYTE RESPONSE | VIRAL-INFECTION | PRECURSOR FREQUENCY | avidity | PROTECTIVE IMMUNITY | staphylococcal enterotoxin A | immune response | IN-VIVO | RECEPTOR REPERTOIRE | MHC CLASS-II | Dose-Response Relationship, Immunologic | Humans | Cells, Cultured | Antigen Presentation - immunology | Lymphocyte Activation - immunology | Gene Rearrangement, T-Lymphocyte - immunology | Lymphocyte Activation - drug effects | Receptors, Antigen, T-Cell, alpha-beta | Ligands | T-Lymphocytes - immunology | Antigen Presentation - drug effects | Cell Proliferation - drug effects | Gene Rearrangement, T-Lymphocyte - drug effects | Enterotoxins - pharmacology | Interferon Inducers - pharmacology
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11. Full Text Epstein-Barr Virus LMP2A Drives B Cell Development and Survival in the Absence of Normal B Cell Receptor Signals
by Caldwell, Robert G and Wilson, Joanna B and Anderson, Steven J and Longnecker, Richard
Immunity, ISSN 1074-7613, 1998, Volume 9, Issue 3, pp. 405 - 411
Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and... 
LATENT MEMBRANE PROTEIN-2A | RAG-1-DEFICIENT MICE | REED-STERNBERG CELLS | HEALTHY SEROPOSITIVE INDIVIDUALS | GROWTH TRANSFORMATION INVITRO | SPONTANEOUS OUTGROWTH | TYROSINE KINASE | IN-VIVO | LYMPHOCYTE INFECTION | IMMUNOLOGY | SURFACE-IMMUNOGLOBULIN | Viral Matrix Proteins - genetics | Transgenes - physiology | Gene Rearrangement, B-Lymphocyte, Heavy Chain - drug effects | Interleukin-7 - pharmacology | Viral Matrix Proteins - physiology | Bone Marrow Cells - immunology | B-Lymphocytes - virology | Bone Marrow Cells - drug effects | Receptors, Antigen, B-Cell - physiology | Cell Differentiation | B-Lymphocytes - cytology | Genes, RAG-1 - physiology | Herpesvirus 4, Human - chemistry | Signal Transduction | Animals, Genetically Modified | Bone Marrow Cells - cytology | Cell Survival | Mice, Inbred C57BL | Cells, Cultured | Herpesvirus 4, Human - immunology | Mice, Transgenic | Gene Rearrangement, B-Lymphocyte, Heavy Chain - physiology | Animals | Lymphocyte Activation - drug effects | Mice
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12. Full Text A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines
by Muljo, Stefan A and Schlissel, Mark S
Nature Immunology, ISSN 1529-2908, 01/2003, Volume 4, Issue 1, pp. 31 - 37
Abelson murine leukemia virus-transformed cell lines have provided a critical model system for studying the regulation of B cell development. However,... 
C-ABL | LYMPHOCYTE DEVELOPMENT | IG-KAPPA | V(D)J RECOMBINASE ACTIVITY | TYROSINE KINASE | SPI-B | IN-VIVO | IMMUNOGLOBULIN GENE REARRANGEMENT | MURINE LEUKEMIA-VIRUS | IMMUNOLOGY | MICE LACKING | B-Lymphocytes - cytology | Piperazines | Gene Rearrangement, B-Lymphocyte, Light Chain - drug effects | Oligonucleotide Array Sequence Analysis | Oncogene Proteins v-abl - antagonists & inhibitors | Abelson murine leukemia virus - pathogenicity | Enzyme Inhibitors - pharmacology | Gene Expression Profiling | Pyrimidines - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Imatinib Mesylate | Abelson murine leukemia virus - genetics | DNA - genetics | B-Lymphocytes - drug effects | Animals | B-Lymphocytes - immunology | Cell Differentiation - drug effects | Base Sequence | B-Lymphocytes - virology | Mice | Benzamides | Cell Line, Transformed | Protein-Tyrosine Kinases - antagonists & inhibitors
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13. Effects of lead exposure on thymic output naive T cells function
by Liu, Wei-wei and Chen, Jia-yu and Yang, Zhi-qian and Chen, Shao-hua and Yang, Li-jian and Yu, Wei and Li, Yang-qiu
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, ISSN 1001-9391, 02/2007, Volume 25, Issue 2, p. 100
To investigate the levels of T cell receptor rearrangement excision DNA circles (TRECs) within peripheral blood from workers exposed to lead, and thereby to... 
Occupational Exposure - adverse effects | Humans | Male | Leukocytes, Mononuclear | T-Lymphocytes - drug effects | Adult | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Thymus Gland - immunology | Gene Rearrangement, T-Lymphocyte - drug effects | Receptors, Antigen, T-Cell - genetics | Lead - toxicity | DNA - drug effects
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