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1. Full Text Characterization of immunoglobulin heavy chain knockout rats
by Ménoret, Séverine and Iscache, Anne-L and Tesson, Laurent and Rémy, Séverine and Usal, Claire and Osborn, Michel J and Cost, Gregory J and Brüggemann, Marianne and Buelow, Roland and Anegon, Ignacio
European Journal of Immunology, ISSN 0014-2980, 10/2010, Volume 40, Issue 10, pp. 2932 - 2941
The rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene-specific mutations. In a recent study,... 
Transgenic rat | B-cell deficient | Zinc-finger nucleases | Knockout rat | IMMUNOLOGY | B-CELLS | DISRUPTION | MU-CHAIN | GENE | EMBRYONIC STEM-CELLS | GENERATION | DIFFERENTIATION | BLASTOCYSTS | EXPRESSION | Graft Survival - immunology | Rats, Inbred Lew | Molecular Sequence Data | Immunoglobulin Constant Regions - immunology | Lymphoid Tissue - immunology | RNA - genetics | Immunoglobulin Constant Regions - genetics | Immunoglobulin Joining Region - immunology | Rats, Mutant Strains | Embryonic Stem Cells - immunology | Immunoglobulin Heavy Chains - immunology | Amino Acid Sequence | B-Lymphocytes - cytology | Specific Pathogen-Free Organisms | Heart Transplantation - immunology | Animals, Genetically Modified | Rats | Immunoglobulin Joining Region - genetics | RNA - chemistry | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Cell Differentiation - immunology | Immunoglobulin Isotypes - blood | Animals | B-Lymphocytes - immunology | Zinc Fingers - genetics | Immunoglobulin Heavy Chains - genetics | Index Medicus
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2. Full Text T cells in swine completely rearrange immunoglobulin heavy chain genes
by Sinkorova, Jana and Stepanova, Katerina and Butler, John E and Sinkora, Marek
Developmental and Comparative Immunology, ISSN 0145-305X, 10/2019, Volume 99, pp. 103396 - 103396
Porcine thymus contains three independent populations of cells that have rearranged immunoglobulin heavy chain VDJ genes. The first population can be found... 
B cell receptors | Lymphocyte subpopulations | Porcine immune system | Gene rearrangement | Lymphocyte repertoire development | Thymus | ANTIBODY REPERTOIRE DEVELOPMENT | TRANSCRIPTION | ILEAL PEYERS-PATCHES | GERM-FREE | IMMUNOLOGY | B-CELLS | FISHERIES | ZOOLOGY | LYMPHOGENESIS | FETAL | EXPRESSION | NEONATAL PIGLETS | Immunoglobulins | Transcription | Genes | Chains | Medulla | Lymphocytes T | Lymphocytes B | Lymphocytes | Swine | Bone marrow | Plasma cells | Livestock
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3. Full Text The 3D Structure of the Immunoglobulin Heavy-Chain Locus: Implications for Long-Range Genomic Interactions
by Jhunjhunwala, Suchit and van Zelm, Menno C and Peak, Mandy M and Cutchin, Steve and Riblet, Roy and van Dongen, Jacques J.M and Grosveld, Frank G and Knoch, Tobias A and Murre, Cornelis
Cell, ISSN 0092-8674, 2008, Volume 133, Issue 2, pp. 265 - 279
The immunoglobulin heavy-chain ( ) locus is organized into distinct regions that contain multiple variable (V ), diversity (D ), joining (J ) and constant (C )... 
CELLBIO | MOLIMMUNO | DNA | B-CELLS | REARRANGEMENT | DNA-SEQUENCES | GENE | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-SITU HYBRIDIZATION | V(D)J RECOMBINATION | ENHANCER | CHROMOSOMES | REGION | CELL BIOLOGY | Genes, Immunoglobulin Heavy Chain | Cell Lineage | Animals | VDJ Exons | Mice, Inbred C57BL | Cells, Cultured | Models, Molecular | Mice | Nucleic Acid Conformation | B-Lymphocytes - chemistry | B-Lymphocytes - metabolism | Immunoglobulins | Computer-generated environments | Computer simulation | Analysis | Cells | Index Medicus
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4. Full Text Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros
by Winandy, Susan and Bertolino, Eric and Singh, Harinder and L Reddy, Karen and Schjerven, Hilde and A Demarco, Ignacio and Chen, Zhengshan and Smale, Stephen T and Reynaud, Damien
Nature Immunology, ISSN 1529-2908, 08/2008, Volume 9, Issue 8, pp. 927 - 936
The transcription factor Ikaros is essential for B cell development. However, its molecular functions in B cell fate specification and commitment have remained... 
TRANSCRIPTION FACTOR PAX5 | LYMPHOCYTE DEVELOPMENT | RECOMBINATION ACTIVATING GENE-2 | HETEROCHROMATIN | DNA-BINDING PROTEINS | V(D)J RECOMBINATION | COORDINATE REGULATION | DIFFERENTIATION | IMMUNOLOGY | LOCUS | INTERLEUKIN-7 RECEPTOR | Cell Line | Genes, Immunoglobulin - genetics | B-Lymphocytes - physiology | Ikaros Transcription Factor - genetics | Cell Lineage | Animals | Cell Differentiation | Mice | Gene Rearrangement - genetics | Ikaros Transcription Factor - metabolism | Gene Rearrangement - immunology | Binding Sites | VDJ Recombinases - genetics | Immunoglobulin Heavy Chains - genetics | Antibody diversity | Immunoglobulins | Physiological aspects | Genetic aspects | Research | B cells | DNA binding proteins | Index Medicus
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5. Full Text Artificial immunoglobulin light chain with potential to associate with a wide variety of immunoglobulin heavy chains
by Xue, Hanbing and Sun, Lin and Fujimoto, Hirofumi and Suzuki, Tadaki and Takahashi, Yoshimasa and Ohnishi, Kazuo
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2019, Volume 515, Issue 3, pp. 481 - 486
Immunoglobulins play important roles in antigen recognition during the immune response, and the complementarity-determining region (CDR) 3 of the heavy chain... 
Genetically engineered antibody | Antibody repertoire | Pre-B cell receptor | Recombinant antibody expression | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SPECIFIC GENES | LEVEL | REARRANGEMENTS | V-H | BIOPHYSICS | VPREB | LAMBDA-5 | GENERATION | ANTIBODY REPERTOIRES | Viral antibodies | Antibodies | Antigens | Genetic engineering | Analysis | Genetically modified organisms
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6. Full Text Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
by Gawad, Charles and Pepin, Francois and Carlton, Victoria E. H and Klinger, Mark and Logan, Aaron C and Miklos, David B and Faham, Malek and Dahl, Gary and Lacayo, Norman
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 22, pp. 4407 - 4417
The ability to distinguish clonal B-cell populations based on the sequence of their rearranged immunoglobulin heavy chain (IgH) locus is an important tool for... 
V-H | RELAPSE | DIAGNOSIS | RECEPTOR GENE REARRANGEMENTS | SOMATIC HYPERMUTATION | QUANTIFICATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | CLONAL EVOLUTION | HEMATOLOGY | MINIMAL RESIDUAL DISEASE | Recurrence | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Age Factors | Humans | Genetic Loci - genetics | Child, Preschool | Infant | Clonal Evolution - genetics | Case-Control Studies | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Algorithms | Clonal Evolution - physiology | Validation Studies as Topic | DNA Mutational Analysis | Bone Marrow - pathology | Genes, Immunoglobulin Heavy Chain - genetics | Child | Infant, Newborn | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
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7. Full Text Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania
by Parks, Tom and Mirabel, Mariana M and Kado, Joseph and Auckland, Kathryn and Nowak, Jaroslaw and Rautanen, Anna and Mentzer, Alexander J and Marijon, Eloi and Jouven, Xavier and Perman, Mai Ling and Cua, Tuliana and Kauwe, John K and Allen, John B and Taylor, Henry and Robson, Kathryn J and Deane, Charlotte M and Steer, Andrew C and Hil, Adrian V.S and Pacific Isl Rheumatic Heart Dis Ge and Pacific Islands Rheumatic Heart Disease Genetics Network
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 14946 - 14946
The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study... 
ANTIBODIES | POPULATION | GENOMES | ORIENTATION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MUTATIONS | REGION | FEVER | PREDICTION | TOOL | Haplotypes | Rheumatic Heart Disease - genetics | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Male | Risk | Rheumatic Heart Disease - pathology | Case-Control Studies | Oceania | Rheumatic Heart Disease - immunology | Asian Continental Ancestry Group | Rheumatic Heart Disease - ethnology | Alleles | Adult | Female | Odds Ratio | Child | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Heavy Chains - genetics | Oceanic Ancestry Group | Index Medicus
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8. Full Text ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia
by Rassenti, Laura Z and Huynh, Lang and Toy, Tracy L and Chen, Liguang and Keating, Michael J and Gribben, John G and Neuberg, Donna S and Flinn, Ian W and Rai, Kanti R and Byrd, John C and Kay, Neil E and Greaves, Andrew and Weiss, Arthur and Kipps, Thomas J
The New England Journal of Medicine, ISSN 0028-4793, 08/2004, Volume 351, Issue 9, pp. 893 - 901
Variations in the clinical course of chronic lymphocytic leukemia (CLL) make decisions about treatment difficult. In more than 300 patients with the disease,... 
B-CELLS | PHENOTYPE | MEDICINE, GENERAL & INTERNAL | V-H GENES | CD38 EXPRESSION | VARIABLE-REGION MUTATIONS | Protein-Tyrosine Kinases - metabolism | Humans | Proportional Hazards Models | ZAP-70 Protein-Tyrosine Kinase | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, T-Cell | Sequence Analysis, DNA | Disease Progression | Genes, Immunoglobulin | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Flow Cytometry | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Mutation | Tumor Cells, Cultured | B-Lymphocytes - metabolism | Immunoglobulin Heavy Chains - genetics | DNA, Complementary | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Chronic lymphocytic leukemia | Diagnosis | Research | Gene mutations | Immunoglobulin allotypes | Health Insurance Portability & Accountability Act 1996-US | Information management | Patients | Leukemia | Index Medicus | Abridged Index Medicus
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9. Full Text Immunoglobulin heavy chain variable region analysis in dairy goats
by Du, Lijuan and Wang, Shuhui and Zhu, Yanjiao and Zhao, Haidong and Basit, Abdul and Yu, Xiaohui and Li, Qingwang and Sun, Xiuzhu
Immunobiology, ISSN 0171-2985, 11/2018, Volume 223, Issue 11, pp. 599 - 607
Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is... 
Somatic hypermutation | Goat | Immunoglobulin heavy chain | Complementarity-Determining region 3 | Genomic organization | V(D)J recombination | ANTIBODY REPERTOIRE DEVELOPMENT | IMMUNOLOGY | LOCUS | FAMILY | B-CELLS | EVOLUTION | SEQUENCE | CHICKEN | V-H GENES | D SEGMENTS | DIVERSITY | Animals | Horses - immunology | Humans | DNA, Complementary - genetics | Genome - genetics | Immunoglobulin Variable Region - genetics | Mutation - genetics | Goats - immunology | Immunoglobulin Heavy Chains - genetics | Evolution, Molecular | Immunoglobulins | Immunogenetics | Anopheles | Goats | Gene mutations | Analysis | Genes | Genomics | Genomes
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10. Full Text The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z
by Danilova, Nadia and Steiner, Lisa A and Jekosch, Kerstin and Bussmann, Jeroen
Nature Immunology, ISSN 1529-2908, 03/2005, Volume 6, Issue 3, pp. 295 - 302
The only immunoglobulin heavy-chain classes known so far in teleosts have been mu and delta. We identify here a previously unknown class, immunoglobulin zeta,... 
JAPANESE FLOUNDER | CHANNEL CATFISH | CONSTANT-REGION GENE | GADUS-MORHUA L | GENOMIC ORGANIZATION | V(D)J RECOMBINATION | ICTALURUS-PUNCTATUS | PARALICHTHYS-OLIVACEUS | IMMUNOLOGY | ATLANTIC SALMON | NUCLEOTIDE-SEQUENCES | Fishes - genetics | Zebrafish - immunology | Zebrafish Proteins - metabolism | Immunoglobulin Isotypes - metabolism | Molecular Sequence Data | Phylogeny | Zebrafish - genetics | Immunoglobulin Isotypes - genetics | Immunoglobulin delta-Chains - genetics | Genes, Immunoglobulin | Immunoglobulin mu-Chains - genetics | Animals | Base Sequence | Gene Rearrangement | Immunoglobulin Heavy Chains - metabolism | Zebrafish Proteins - genetics | Immunoglobulin Heavy Chains - genetics | Index Medicus
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11. Full Text Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity, and Joining Genes and Characterization of Allelic and Copy-Number Variation
by Watson, Corey T and Steinberg, Karyn M and Huddleston, John and Warren, Rene L and Malig, Maika and Schein, Jacqueline and Willsey, A. Jeremy and Joy, Jeffrey B and Scott, Jamie K and Graves, Tina A and Wilson, Richard K and Holt, Robert A and Eichler, Evan E and Breden, Felix
The American Journal of Human Genetics, ISSN 0002-9297, 04/2013, Volume 92, Issue 4, pp. 530 - 546
The immunoglobulin heavy-chain locus (IGH) encodes variable (IGHV), diversity (IGHD), joining (IGHJ), and constant (IGHC) genes and is responsible for antibody... 
HOMOZYGOUS DELETION | CELL-RECEPTORS REPORT | IUIS NOMENCLATURE SUBCOMMITTEE | AUTOIMMUNE-DISEASES | REGION GENE | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | V-H GENES | SEGMENTAL DUPLICATIONS | HUMAN-GENOME | STRUCTURAL VARIATION | Genetics, Population | Humans | V(D)J Recombination | Molecular Sequence Data | Genotype | DNA Copy Number Variations - genetics | Sequence Analysis, DNA | Hydatidiform Mole - genetics | Genes, Immunoglobulin Heavy Chain | Pregnancy | Gene Fusion - genetics | Haplotypes - genetics | Alleles | Chromosomes, Artificial, Bacterial | Female | Immunoglobulin Variable Region - genetics | Immunoglobulin Heavy Chains - genetics | Linkage (Genetics) | Research | Nucleotide sequencing | Gene expression | Genetic variation | DNA sequencing | Genetic research | Immunoglobulins | Genetic aspects | Chemical properties | Genes | Genomics | Genotype & phenotype | Biosynthesis | Lymphocytes | Biological diversity | Index Medicus
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