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Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 614 - 625
Rescuing the function of mutant p53 protein is an attractive cancer therapeutic strategy. Using the National Cancer Institute's anticancer drug screen data, we... 
WILD-TYPE CONFORMATION | DNA-BINDING DOMAIN | RESCUE | ONCOLOGY | IRON CHELATORS | MUTATION | REDOX ACTIVITY | TUMOR-SUPPRESSOR | CANCER MUTANTS | RESTORATION | ANTITUMOR-ACTIVITY | CELL BIOLOGY | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Zinc - metabolism | Humans | Transcriptional Activation - drug effects | Structure-Activity Relationship | Mutation, Missense | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Binding Sites | Cell Line | Cell Survival - drug effects | Oxidation-Reduction | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Mice, Transgenic | Chelating Agents - pharmacology | DNA - metabolism | Tumor Suppressor Protein p53 - drug effects | Gene Knock-In Techniques | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | Mice, Nude | Alleles | Protein Conformation | Mice | Mice, Inbred BALB C | Tumor Suppressor Protein p53 - chemistry | Oxidative Stress - drug effects | Neoplasms - pathology | Care and treatment | Nuclear radiation | Oncology, Experimental | Research | Tumor proteins | Health aspects | Cancer | Antitumor agents | Lymphocytes B | Xenografts | Data processing | Drug development | Zinc | p53 protein | Apoptosis | Structure-function relationships | Tumors
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2012, Volume 30, Issue 29, pp. 3633 - 3639
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 07/2014, Volume 73, Issue 7, pp. 1405 - 1413
Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration. Objective To determine whether... 
MAMMALIAN TARGET | ARREST | CELLS | MESSENGER-RNA | GENE-EXPRESSION | PHENOTYPE | RHEUMATOLOGY | TRANSLATION | CELLULAR SENESCENCE | CULTURE | P53 | Sirtuin 1 - metabolism | Glucocorticoids - therapeutic use | Cyclin-Dependent Kinase Inhibitor p21 - drug effects | TOR Serine-Threonine Kinases - metabolism | Tendons - drug effects | Humans | Middle Aged | Cellular Senescence - drug effects | Rotator Cuff | Male | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Tendons - cytology | Dexamethasone - pharmacology | beta-Galactosidase - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Adult | Female | TOR Serine-Threonine Kinases - drug effects | Tendons - metabolism | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Tumor Suppressor Protein p53 - drug effects | Dexamethasone - therapeutic use | Signal Transduction - drug effects | beta-Galactosidase - drug effects | Glucocorticoids - pharmacology | Sirtuin 1 - drug effects | Aged | Cell Cycle - drug effects | In Vitro Techniques | Tendinopathy - drug therapy | Aging | Care and treatment | Corticosteroids | Health aspects | Analysis | Cell cycle | Polymerase chain reaction | Cell culture | Cell growth | Senescence | Pain | Biopsy | Shoulder | Kinases | Tendinitis | Chondrocytes | Basic and Translational Research | Fibroblasts | Inflammation | 1506
Journal Article