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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 50, pp. 21824 - 21829
Journal Article
BMC Medical Genomics, ISSN 1755-8794, 2010, Volume 3, Issue 1, pp. 26 - 26
Background: Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies.... 
CELL LUNG-CANCER | CETUXIMAB | SIGNALING PATHWAYS | METAANALYSIS | GENOMIC STRATEGY | IN-VIVO | GROWTH | GENETICS & HEREDITY | MUTATIONS | IDENTIFICATION | METASTATIC COLORECTAL-CANCER | Neoplasms - metabolism | Lung Neoplasms - drug therapy | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Databases, Genetic | ras Proteins - metabolism | Antibodies, Monoclonal - therapeutic use | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antibodies, Monoclonal, Humanized | Mitogen-Activated Protein Kinase Kinases - metabolism | RNA Interference | Colorectal Neoplasms - drug therapy | Female | Cetuximab | Proto-Oncogene Proteins c-akt - metabolism | Lung Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Breast Neoplasms - drug therapy | Breast Neoplasms - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Mutation | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA, Small Interfering - metabolism | Ras genes | Physiological aspects | Genetic aspects | Research | Gene expression | Protein kinases | Risk factors | Cancer | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 20, pp. 8182 - 8187
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2013, Volume 369, Issue 11, pp. 1023 - 1034
Patients who have colorectal cancer with RAS mutations in exon 2 are unlikely to respond to EGFR blockers. A retrospective analysis of tumors containing other,... 
SURVIVAL | 1ST-LINE TREATMENT | LUNG-CANCER | MEDICINE, GENERAL & INTERNAL | LEUCOVORIN | RANDOMIZED PHASE-III | CETUXIMAB PLUS IRINOTECAN | BRAF | KRAS CODON 12 | FLUOROURACIL | CHEMOTHERAPY | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Membrane Proteins - genetics | Colorectal Neoplasms - genetics | Humans | Antibodies, Monoclonal - therapeutic use | Proto-Oncogene Proteins - genetics | Disease-Free Survival | Fluorouracil - therapeutic use | Neoplasm Metastasis | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Leucovorin - therapeutic use | Mutation | Colorectal Neoplasms - pathology | Genes, ras | Organoplatinum Compounds - therapeutic use | Care and treatment | Dosage and administration | Research | Gene mutations | Panitumumab | Colorectal cancer | Hypothesis testing | Medical research | Statistical analysis | Epidermal growth factor receptors | Colorectal carcinoma | Metastasis | Cancer therapies | Survival | Patients | Metastases | Studies | Hypotheses | Chemotherapy | Epidermal growth factor | Oxaliplatin | Testing laboratories | Medical prognosis | Biomarkers | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 1/2002, Volume 156, Issue 2, pp. 299 - 313
Multistep carcinogenesis involves more than six discrete events also important in normal development and cell behavior. Of these, local invasion and metastasis... 
Gels | Hepatocytes | Epithelial cells | Collagens | Cell lines | Cadherins | Metastasis | Cells | Tumors | Apoptosis | TGFβ | PI3K | MAPK | EMT | PHOSPHATIDYLINOSITOL 3-KINASE | E-CADHERIN EXPRESSION | TUMOR-SUPPRESSOR GENE | CELL BIOLOGY | GROWTH-FACTOR-BETA | ONCOGENIC RAS | metastasis | MESENCHYMAL TRANSITIONS | MOUSE EMBRYOS LACKING | MICE | TGF beta | MESODERM INDUCTION | N-CADHERIN | PI3K; MAPK; TGFβ; EMT; metastasis
Journal Article
Cell, ISSN 0092-8674, 04/2016, Volume 165, Issue 3, pp. 643 - 655
Oncogenic activation of genes via point mutations occurs in 20%–30% of human cancers. The development of effective RAS inhibitors has been challenging,... 
rigosertib | RAS-binding domain | PI3K | MAPK | RAS | RAF | POINT MUTATIONS | BLADDER-CARCINOMA ONCOGENE | MUTANT | SELECTIVE INHIBITOR | ACTIVATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | KINASE | BINDING | TRANSFORMING PROPERTIES | CELL BIOLOGY | Glycine - analogs & derivatives | Phosphorylation | Humans | Molecular Sequence Data | ras Proteins - metabolism | Crystallography, X-Ray | Proto-Oncogene Proteins - chemistry | Sulfones - pharmacology | MAP Kinase Signaling System | Cell Cycle Proteins - chemistry | Pancreatic Neoplasms - drug therapy | Glycine - chemistry | Sulfones - chemistry | Nuclear Magnetic Resonance, Biomolecular | Dimerization | Glycine - administration & dosage | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | RNA-Binding Proteins - chemistry | Cell Cycle Proteins - metabolism | Models, Molecular | Sequence Alignment | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Mice, Nude | Mice | Protein-Serine-Threonine Kinases - chemistry | Cell Transformation, Neoplastic - drug effects | RNA-Binding Proteins - metabolism | Sulfones - administration & dosage | Proteins | Medical colleges | Gene mutations | Protein binding | Jewish schools | Phosphotransferases | Index Medicus
Journal Article
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