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1. Full Text Ejaculate economics: Testing the effects of male sexual history on the trade-off between sperm and immune function in Australian crickets
by Dowling, Damian K and Simmons, Leigh W
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e30172
Trade-offs between investment into male sexual traits and immune function provide the foundation for some of the most prominent models of sexual selection.... 
TELEOGRYLLUS-OCEANICUS | SEED BEETLES | QUALITY | MATING STATUS | MULTIDISCIPLINARY SCIENCES | VIABILITY | FERTILIZATION SUCCESS | FIELD CRICKET | COMPETITION GAMES | FEMALE CHOICE | REPRODUCTION | Ejaculation - physiology | Sexual Behavior, Animal - physiology | Gryllidae - immunology | Animals | Gryllidae - physiology | Humans | Female | Linear Models | Male | Spermatozoa - physiology | Australia | Spermatozoa - immunology | Spermatozoa | Analysis | Bacterial infections | Competition | Costs | Sperm | Crickets | Parasites | Males | Immunity | Success | Animal reproduction | Immunology | Investments | Quality | Population | Trends | Immune system | Copulation | Sexual selection | Immune response | Ecology | Quantitative genetics | Insects | Animal behavior | Tradeoffs | Economic impact | Females | Viability | Investment
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2. Full Text Cost-effectiveness of population screening for BRCA mutations in Ashkenazi Jewish women compared with family history-based testing
by Manchanda, Ranjit and Legood, Rosa and Burnell, Matthew and McGuire, Alistair and Raikou, Maria and Loggenberg, Kelly and Wardle, Jane and Sanderson, Saskia and Gessler, Sue and Side, Lucy and Balogun, Nyala and Desai, Rakshit and Kumar, Ajith and Dorkins, Huw and Wallis, Yvonne and Chapman, Cyril and Taylor, Rohan and Jacobs, Chris and Tomlinson, Ian and Beller, Uziel and Menon, Usha and Jacobs, Ian
Journal of the National Cancer Institute, ISSN 0027-8874, 01/2015, Volume 107, Issue 1, p. 380
Population-based testing for BRCA1/2 mutations detects the high proportion of carriers not identified by cancer family history (FH)-based testing. We compared... 
IMMEDIATE BREAST RECONSTRUCTION | BILATERAL PROPHYLACTIC MASTECTOMY | SURGICAL ADJUVANT BREAST | ECONOMIC-EVALUATION | ONCOLOGY | HIGH-RISK | REDUCING SALPINGO-OOPHORECTOMY | QUALITY-OF-LIFE | HORMONE REPLACEMENT THERAPY | EPITHELIAL OVARIAN-CANCER | PROSE-STUDY-GROUP | Breast Neoplasms - economics | Early Detection of Cancer - methods | Humans | Middle Aged | Genetic Testing - methods | Mass Screening - methods | Jews - genetics | Ovarian Neoplasms - genetics | Sensitivity and Specificity | Adult | Female | Early Detection of Cancer - economics | Quality-Adjusted Life Years | Ovarian Neoplasms - prevention & control | Mass Screening - economics | United Kingdom | Breast Neoplasms - prevention & control | BRCA1 Protein - genetics | Breast Neoplasms - genetics | Ovarian Neoplasms - economics | Cost-Benefit Analysis | Quality of Life | Aged | Genetic Testing - economics | Mutation | BRCA2 Protein - genetics | Usage | Care and treatment | Genetic aspects | Women, Jewish | Medical screening | Health aspects | Cancer
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3. Full Text Molecular genetic testing and the future of clinical genomics
by Katsanis, Sara Huston and Katsanis, Nicholas
Nature Reviews Genetics, ISSN 1471-0056, 06/2013, Volume 14, Issue 6, pp. 415 - 426
Genomic technologies are reaching the point of being able to detect genetic variation in patients at high accuracy and reduced cost, offering the promise of... 
INFORMED-CONSENT | EMERGE NETWORK | EXOME CAPTURE | OF-FUNCTION VARIANTS | GENETICS & HEREDITY | FACTOR-H POLYMORPHISM | ELECTRONIC MEDICAL-RECORDS | MODEL ORGANISM | HEALTH-CARE PROFESSIONALS | PROTEIN FUNCTION | WHOLE EXOME | Molecular Diagnostic Techniques - ethics | Genome-Wide Association Study | Oligonucleotide Array Sequence Analysis | Genetic Testing - standards | United States | Genetic Testing - legislation & jurisprudence | Genomics | Humans | Genetic Testing - ethics | Molecular Diagnostic Techniques - economics | Sequence Analysis, DNA | Animals | Karyotyping | Molecular Diagnostic Techniques - standards | Polymorphism, Single Nucleotide | Genetic Testing - economics | Evaluation Studies as Topic | Molecular genetics | Medical genetics | Molecular diagnostic techniques | Forecasts and trends | Research | Genetic screening | Methods
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4. Full Text Carrier testing for severe childhood recessive diseases by next-generation sequencing
by Bell, Callum J and Dinwiddie, Darrell L and Miller, Neil A and Hateley, Shannon L and Ganusova, Elena E and Mudge, Joann and Langley, Ray J and Zhang, Lu and Lee, Clarence C and Schilkey, Faye D and Sheth, Vrunda and Woodward, Jimmy E and Peckham, Heather E and Schroth, Gary P and Kim, Ryan W and Kingsmore, Stephen F
Science Translational Medicine, ISSN 1946-6234, 01/2011, Volume 3, Issue 65, pp. 65ra4 - 65ra4
Of 7028 disorders with suspected Mendelian inheritance, 1139 are recessive and have an established molecular basis. Although individually uncommon, Mendelian... 
POPULATION | GENETIC SCREENING-PROGRAM | GENOME SEQUENCE | AMPLIFICATION | PELIZAEUS-MERZBACHER-DISEASE | MISSENSE MUTATION | CYSTIC-FIBROSIS | MENDELIAN DISEASE | IDENTIFICATION | TAY-SACHS-DISEASE | CELL BIOLOGY | Genes, Recessive - genetics | Humans | Prenatal Diagnosis | Databases, Genetic | Molecular Sequence Data | Genetic Testing - methods | Genetic Carrier Screening - methods | Pregnancy | Sequence Alignment | Base Sequence | Female | Heterozygote | Genetic Testing - economics | Mutation | Sequence Analysis, DNA - economics | Genome, Human | Child | Sequence Analysis, DNA - methods
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5. Full Text Cost Impact of Molecular Testing for Indeterminate Thyroid Nodule Fine-Needle Aspiration Biopsies
by Yip, Linwah and Farris, Coreen and Kabaker, Adam S and Hodak, Steven P and Nikiforova, Marina N and McCoy, Kelly L and Stang, Michael T and Smith, Kenneth J and Nikiforov, Yuri E and Carty, Sally E
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2012, Volume 97, Issue 6, pp. 1905 - 1912
Introduction: Molecular testing of fine-needle aspiration (FNA) results helps diagnose thyroid cancer, although the additional cost of this adjunct has not... 
DIAGNOSIS | MANAGEMENT | BRAF(V600E) MUTATION | SCIENCE CONFERENCE | INCREASED RISK | RECOMMENDATIONS | ENDOCRINOLOGY & METABOLISM | REQUIRING REOPERATIVE SURGERY | BETHESDA SYSTEM | CANCER | LESIONS | Thyroid Neoplasms - surgery | Adenoma, Oxyphilic - surgery | Unnecessary Procedures - economics | Adenoma, Oxyphilic - pathology | Humans | Thyroid Nodule - economics | Preoperative Care - economics | Thyroidectomy - methods | Thyroid Neoplasms - economics | Algorithms | Thyroid Nodule - pathology | Biopsy, Fine-Needle - economics | Cost-Benefit Analysis | Adenoma, Oxyphilic - economics | Thyroidectomy - economics | Decision Trees | Genetic Testing - economics | Thyroid Nodule - surgery | Thyroid Neoplasms - pathology | Endocrine Care
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6. Full Text Does pharmacogenomic testing improve clinical outcomes for major depressive disorder?: A systematic review of clinical trials and cost-effectiveness studies
by Rosenblat, Joshua D and Lee, Yena and McIntyre, Roger S
Journal of Clinical Psychiatry, ISSN 0160-6689, 06/2017, Volume 78, Issue 6, pp. 720 - 729
Objective: Pharmacogenomic testing has become scalable and available to the general public. Pharmacogenomics has shown promise for predicting antidepressant... 
STAR-ASTERISK-D | VARIANTS | MOOD DISORDERS | PSYCHIATRY | GUIDELINES | ANTIDEPRESSANT TREATMENT | ECONOMIC EVALUATIONS | PSYCHOLOGY, CLINICAL | BURDEN | PHARMACOTHERAPY | VALIDITY | CARE | Outcome and Process Assessment (Health Care) | Depressive Disorder, Major - genetics | Cost-Benefit Analysis | Humans | Clinical Trials as Topic | Pharmacogenomic Testing - economics | Pharmacogenomic Testing - methods | Pharmacogenomic Testing - utilization | Depressive Disorder, Major - drug therapy
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7. Full Text Testing HLA-B15: 02: Is it worth it?
by Marson, Anthony and Guerrini, Renzo
Neurology, ISSN 0028-3878, 03/2016, Volume 86, Issue 12, pp. 1080 - 1081
Persons carrying the HLA-B*15:02 allele (predominantly those of Asian descent) are at high risk of hypersensitivity reactions to carbamazepine, including... 
CLINICAL NEUROLOGY | Pharmacogenetics - economics | Cost-Benefit Analysis | Humans | Epilepsy - genetics | Female | Male | Genetic Testing - economics | Epilepsy - economics
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8. Full Text Cost-effectiveness of population-based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 mutation testing in unselected general population women
by Manchanda, Ranjit and Patel, Shreeya and Gordeev, Vladimir S and Antoniou, Antonis C and Smith, Shantel and Lee, Andrew and Hopper, John L and MacInnis, Robert J and Turnbull, Clare and Ramus, Susan J and Gayther, Simon A and Pharoah, Paul D.P and Menon, Usha and Jacobs, Ian and Legood, Rosa
Journal of the National Cancer Institute, ISSN 0027-8874, 2018, Volume 110, Issue 7, pp. 714 - 725
Background: The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is... 
BILATERAL PROPHYLACTIC MASTECTOMY | ONCOLOGY | BREAST-CANCER RISK | GERMLINE MUTATIONS | HEREDITARY BREAST | CONFER SUSCEPTIBILITY | REDUCING SALPINGO-OOPHORECTOMY | QUALITY-OF-LIFE | OVARIAN-CANCER | HORMONE REPLACEMENT THERAPY | HEALTH OUTCOMES | DNA Mutational Analysis - economics | United States - epidemiology | Breast Neoplasms - economics | Humans | Middle Aged | DNA Mutational Analysis - methods | Genetic Testing - methods | Incidence | Ovarian Neoplasms - genetics | Aged, 80 and over | Adult | Female | RNA Helicases - genetics | Mammography - methods | Breast Neoplasms - epidemiology | Fanconi Anemia Complementation Group N Protein - genetics | Ovarian Neoplasms - diagnosis | Decision Support Techniques | Fanconi Anemia Complementation Group Proteins - genetics | Ovarian Neoplasms - epidemiology | BRCA1 Protein - genetics | Breast Neoplasms - genetics | Ovarian Neoplasms - economics | Mammography - economics | Cost-Benefit Analysis | Aged | Breast Neoplasms - diagnosis | Genetic Testing - economics | Mutation | United Kingdom - epidemiology | BRCA2 Protein - genetics
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9. Full Text Effect of Enhanced Information, Values Clarification, and Removal of Financial Barriers on Use of Prenatal Genetic Testing: A Randomized Clinical Trial
by Kuppermann, Miriam and Pena, Sherri and Bishop, Judith T and Nakagawa, Sanae and Gregorich, Steven E and Sit, Anita and Vargas, Juan and Caughey, Aaron B and Sykes, Susan and Pierce, Lasha and Norton, Mary E
JAMA, ISSN 0098-7484, 09/2014, Volume 312, Issue 12, pp. 1210 - 1217
IMPORTANCE: Prenatal genetic testing guidelines recommend providing patients with detailed information to allow informed, preference-based screening and... 
AMNIOCENTESIS | VALIDATION | DIAGNOSIS | MEDICINE, GENERAL & INTERNAL | SCALE | DOWN-SYNDROME | Prenatal Diagnosis - utilization | Humans | Patient Participation | Decision Support Techniques | Health Literacy | Risk | Pregnancy | Guideline Adherence | Genetic Testing - utilization | Prenatal Diagnosis - economics | Adult | Female | Genetic Testing - economics | Practice Guidelines as Topic | Genetic testing | Medical diagnosis | Decision making | Prenatal care
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10. Full Text Implementation of TPMT testing
by Lennard, Lynne
British Journal of Clinical Pharmacology, ISSN 0306-5251, 04/2014, Volume 77, Issue 4, pp. 704 - 714
The activity of the enzyme thiopurine methyltransferase ( TPMT ) is regulated by a common genetic polymorphism. One in 300 individuals lack enzyme activity and... 
childhood leukaemia | thiopurine methyltransferase | azathioprine | mercaptopurine | thioguanine nucleotides | TPMT | LIQUID-CHROMATOGRAPHIC ASSAY | COST-EFFECTIVENESS | THIOPURINE S-METHYLTRANSFERASE | CROHNS-DISEASE | BRITISH-ASSOCIATION | ERYTHROCYTE CORRELATION | INFLAMMATORY-BOWEL-DISEASE | MERCAPTOPURINE METABOLISM | ACUTE LYMPHOBLASTIC-LEUKEMIA | PHARMACOLOGY & PHARMACY | CONSORTIUM GUIDELINES | Cost-Benefit Analysis - economics | Antimetabolites, Antineoplastic - pharmacokinetics | Azathioprine - pharmacokinetics | Humans | Methyltransferases - metabolism | Mercaptopurine - adverse effects | Methyltransferases - genetics | Genotype | Drug Labeling - standards | Purine-Pyrimidine Metabolism, Inborn Errors - diagnosis | Thioguanine - adverse effects | Phenotype | Thioguanine - pharmacokinetics | Antimetabolites, Antineoplastic - adverse effects | Drug Hypersensitivity - diagnosis | Genetic Testing - economics | Azathioprine - adverse effects | Mercaptopurine - pharmacokinetics | Index Medicus | Translation Into Clinical Application
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