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Nature (London), ISSN 1476-4687, 02/2017, Volume 542, Issue 7642, pp. 489 - 493
...). In addition, through off-target activity, AID has a much broader effect on genomic instability by initiating oncogenic chromosomal translocations and mutations involved in the development and progression of lymphoma(2... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Isoquinolines - adverse effects | Class I Phosphatidylinositol 3-Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Phosphatidylinositol 3-Kinases - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Translocation, Genetic - drug effects | Isoquinolines - pharmacology | Antineoplastic Agents - adverse effects | Genomic Instability - drug effects | Female | Antineoplastic Agents - pharmacology | Purines - adverse effects | B-Lymphocytes - pathology | Immunoglobulin Class Switching - drug effects | Somatic Hypermutation, Immunoglobulin - drug effects | Lymphoma, Mantle-Cell - genetics | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Enzyme Inhibitors - adverse effects | B-Lymphocytes - enzymology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | B-Lymphocytes - drug effects | Animals | Agammaglobulinaemia Tyrosine Kinase | Cytidine Deaminase - metabolism | Pyrimidines - adverse effects | Cell Line, Tumor | Mice | Immunoglobulin Heavy Chains - genetics | Quinazolinones - adverse effects | Recombination, Genetic - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 06/2018, Volume 559, Issue 7713, pp. 279 - 284
...). Replication stress induces fork stalling and fuels genome instability(2). The mechanistic basis of replication stress remains poorly understood despite its emerging role in promoting cancer(2... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | DNA Damage - drug effects | DNA Replication - drug effects | Humans | Tumor Suppressor Protein p53 - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Chromosome Structures - drug effects | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | DNA Replication - physiology | Time Factors | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Genomic Instability - drug effects | Genetic research | DNA replication | Research | DNA damage | Oncology, Experimental | Cancer | Analysis | Genomics | DNA | Development and progression | Genomes | Tumor proteins | DNA repair | Cells | Phosphorylation | p53 Protein | Poly(ADP-ribose) | Kinases | Modulators | Replication forks | Genomic instability | Damage tolerance | Proteins | Ribose | Proliferating cell nuclear antigen | Cell cycle | Inhibition | Speed control | Lesions | Stalling | Deoxyribonucleic acid--DNA | Elongation | ADP-ribosylation | Stresses | Stability | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Gene expression | Velocity | Suppressors | Stress | DNA biosynthesis | Cyclin-dependent kinase inhibitor p21 | Replication origins | S phase | Replication | Instability | Control stability | Index Medicus | Medicin och hälsovetenskap
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 5/2009, Volume 106, Issue 21, pp. 8671 - 8676
Journal Article
Mutation research, ISSN 0027-5107, 05/2012, Volume 733, Issue 1-2, pp. 69 - 77
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 02/2010, Volume 285, Issue 7, pp. 4931 - 4940
.... Compelling evidence has determined the chromosomal aneuploidy to be one of the hallmarks of cancer cells, indicating genome instability plays an important role in tumorigenesis, for which CSCs... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Immunohistochemistry | Nasopharyngeal Neoplasms - genetics | Nasopharyngeal Neoplasms - metabolism | Neoplastic Stem Cells - cytology | Cadherins - metabolism | Humans | Glycoproteins - metabolism | Genomic Instability - physiology | Neoplasm Proteins - metabolism | Antigens, CD - metabolism | Aurora Kinase B | Flow Cytometry | Peptides - metabolism | Neoplastic Stem Cells - metabolism | RNA Interference | Karyotyping | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Mad2 Proteins | Cadherins - genetics | Genomic Instability - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | DNA Damage - drug effects | Cell Line | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Aurora Kinases | AC133 Antigen | Blotting, Western | Ultraviolet Rays - adverse effects | Cell Line, Tumor | Mitomycin - toxicity | In Vitro Techniques | DNA Damage - radiation effects | Calcium-Binding Proteins - genetics | Index Medicus | Cycle | Cell Biology | Cancer Stem Cells | Stem Cells | Gene |