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Nature (London), ISSN 1476-4687, 2011, Volume 471, Issue 7336, pp. 119 - 123
... are not lymphoma-prone. We reasoned that[ Rag2.sup.c/c] [p53.sup.-/-] double-mutant mice might display genomic instability and lymphomagenesis, even in the context of intact... 
THYMIC LYMPHOMA | REPAIR | LYMPHOCYTE DEVELOPMENT | B-CELL | ROLES | TRANSLOCATIONS | MULTIDISCIPLINARY SCIENCES | V(D)J RECOMBINATION | DOUBLE-STRAND BREAKS | GENE AMPLIFICATION | ATM-DEFICIENT MICE | Genomic Instability | Protein-Serine-Threonine Kinases - deficiency | Gene Rearrangement, T-Lymphocyte - genetics | Chromosomes, Mammalian - genetics | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Recombination, Genetic - genetics | Lymphoma - pathology | Chromosome Deletion | Tumor Suppressor Proteins - metabolism | Kaplan-Meier Estimate | Protein-Serine-Threonine Kinases - genetics | Thymus Gland - cytology | Lymphoma - genetics | In Situ Hybridization, Fluorescence | Ataxia Telangiectasia Mutated Proteins | Genes, p53 - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Disease Progression | Animals | Genes, Immunoglobulin Heavy Chain - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Translocation, Genetic - genetics | Causes of | Tumor suppressor genes | Lymphomas | Genetic aspects | Abnormalities | Software | Chromosomes | Deoxyribonucleic acid--DNA | Cell cycle | Apoptosis | Tumors | Thymus Gland | Translocation, Genetic | Protein-Serine-Threonine Kinases | Gene Rearrangement, T-Lymphocyte | Receptors, Antigen, T-Cell | Lymphoma | Chromosomes, Mammalian | Genes, Immunoglobulin Heavy Chain | Life Sciences | Genes, p53 | Immunology | Recombination, Genetic | Cell Cycle Proteins | Tumor Suppressor Proteins | DNA-Binding Proteins
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 467, Issue 7319, pp. 1109 - 1113
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 03/2008, Volume 8, Issue 3, pp. 180 - 192
.... There are several reasons why this might be, including the capacity of hypoxia to drive genomic instability and alter DNA damage repair pathways... 
Genomic Instability | Protein Biosynthesis | Humans | Gene Expression Regulation, Neoplastic | Disease Progression | Neoplasm Metastasis | Phenotype | Animals | Neoplasms - genetics | Models, Biological | DNA Repair | Hypoxia | Transcription, Genetic | DNA Damage | Neoplasms - pathology
Journal Article
Journal Article
PLoS genetics, ISSN 1553-7404, 2012, Volume 8, Issue 7, p. e1002772
Journal Article
Journal Article
Nature medicine, ISSN 1546-170X, 2005, Volume 11, Issue 7, pp. 780 - 785
... aging is attributable to genomic instability in progeroid syndromes caused by mutations that compromise DNA repair or genome maintenance, we asked whether defective... 
MEDICINE, RESEARCH & EXPERIMENTAL | RECOMBINATION | LAMIN-A | METALLOPROTEINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | DOUBLE-STRAND BREAKS | HUTCHINSON-GILFORD PROGERIA | MICE | CELLULAR SENESCENCE | ZMPSTE24 | CELL BIOLOGY | Metalloendopeptidases - genetics | Gamma Rays | Genomic Instability | Humans | DNA Repair - physiology | Bone Marrow Cells - physiology | Metalloendopeptidases - metabolism | Aging, Premature - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Histones - radiation effects | Mice, Mutant Strains | DNA Damage - genetics | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Cellular Senescence - genetics | Protein Precursors - genetics | Rad51 Recombinase | Membrane Proteins - genetics | Chromosomal Proteins, Non-Histone | Nuclear Proteins - metabolism | Bone Marrow Cells - radiation effects | Lamin Type A - metabolism | Phosphoproteins - genetics | DNA-Binding Proteins - genetics | Fibroblasts - pathology | Protein Precursors - metabolism | DNA - genetics | Animals | Histones - genetics | Fibroblasts - radiation effects | Chromosome Aberrations | Lamin Type A - genetics | Mice | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1
Journal Article