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Oncogene, ISSN 0950-9232, 08/2017, Volume 36, Issue 34, pp. 4887 - 4900
Our recent perplexing findings that polyploid giant cancer cells (PGCCs) acquired embryonic-like stemness and were capable of tumor initiation raised two... 
OVARIAN TUMORIGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-CELLS | CELLULAR SENESCENCE | FAILURE | CLEAVAGE-STAGE EMBRYOS | ESCAPE | CELL BIOLOGY | IN-VITRO | CYTOKINESIS | THERAPY | ONCOLOGY | GENETICS & HEREDITY | DIFFERENTIATION | Embryonic Stem Cells - metabolism | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Giant Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Carcinogenesis - metabolism | Blastomeres - drug effects | Blastomeres - metabolism | Neoplastic Stem Cells - metabolism | Female | Ovarian Neoplasms - metabolism | Cell Differentiation - physiology | Ovarian Neoplasms - drug therapy | Neoplastic Stem Cells - physiology | Polyploidy | Giant Cells - metabolism | Blastomeres - pathology | Carcinogenesis - drug effects | Carcinogenesis - pathology | Drug Resistance, Neoplasm - genetics | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Embryonic Stem Cells - pathology | Cell Line, Tumor | Signal Transduction - physiology | Giant Cells - pathology | Cellular signal transduction | Research | Cell differentiation | Cancer cells | Blastomeres | Senescence | Carcinoma | Mesenchyme | Mitosis | Oct-4 protein | Embryo cells | Benign | Compaction | Cytokinesis | Embryos | Spheroids | Ovarian cancer | Yes-associated protein | Chemotherapy | Developmental stages | Somatic cells | Paclitaxel | Stem cells | Giant cells | Tumorigenesis | Budding | Cancer | Tumors | Original
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 01/2014, Volume 10, Issue 1, pp. 477 - 485
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64010
Lantibiotics are peptides, produced by bacteria, that contain the noncanonicalamino acid lanthionine and many of them exhibit antibacterial activities. The... 
TARGET | HERPES-SIMPLEX-VIRUS | IN-VITRO | ENTRY | MULTIDISCIPLINARY SCIENCES | GRIFFITHSIN | INFECTION | SYNERGISTIC ACTIVITY | SEXUAL TRANSMISSION | TENOFOVIR | GEL | Anti-HIV Agents - pharmacology | Leukocytes, Mononuclear - metabolism | Lactobacillus - growth & development | Simplexvirus - physiology | Bacteriocins - chemistry | Epithelial Cells - drug effects | Giant Cells - drug effects | Humans | Virus Internalization - drug effects | HIV Envelope Protein gp120 - metabolism | Leukocytes, Mononuclear - virology | Lectins, C-Type - metabolism | HIV-1 - physiology | HIV Infections - pathology | HIV-1 - isolation & purification | Lactobacillus - drug effects | Protein Binding - drug effects | Female | Vagina - pathology | Simplexvirus - drug effects | Virus Replication - drug effects | Leukocytes, Mononuclear - drug effects | Receptors, CXCR5 - metabolism | HIV-1 - drug effects | HIV Infections - virology | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Nisin - metabolism | Cell Adhesion Molecules - metabolism | Receptors, CXCR4 - metabolism | Leukocytes, Mononuclear - pathology | Nisin - pharmacology | Epithelial Cells - microbiology | Bacteriocins - pharmacology | Drug Resistance, Viral - drug effects | Vagina - microbiology | Kinetics | CD4 Antigens - metabolism | Prevention | Technology application | Disease transmission | Peptides | T cells | HIV (Viruses) | Acyclovir | Antibacterial agents | Drugs | Toxicity | Amino acids | Viruses | Lymphocytes T | Infections | Lantibiotics | Drug resistance | Proteins | Tenofovir | Synergistic effects | Saquinavir | CD69 antigen | Receptors | Sexually transmitted diseases | Microbicides | Enfuvirtide | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Antiviral activity | Lead | CD25 antigen | Bacteria | Inhibition | Pretreatment | Heparan sulfate | Medical research | Enzymes | Cytokines | Lactobacilli | Vagina | Envelope protein | Cultures | Inflammation | Virology | CD4 antigen | DC-SIGN protein | Studies | Glycoprotein gp120 | Chemokines | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
Bone, ISSN 8756-3282, 2016, Volume 93, pp. 43 - 54
Abstract Glucocorticoid (GC) therapy is the greatest risk factor for secondary osteoporosis. Pathogenic mechanisms involve an initial increase in bone... 
Orthopedics | Bone resorption | Osteoporosis | Osteoclast | Glucocorticoid | Glucocorticoid receptor | INDUCED OSTEOPOROSIS | RESORPTION | MOUSE CALVARIAL BONES | VERTEBRAL FRACTURE | OSTEOPROTEGERIN | OSTEOBLAST-LIKE CELLS | INHIBITION | CORTICOSTEROID-THERAPY | ENDOCRINOLOGY & METABOLISM | DIFFERENTIATION | NF-KAPPA-B | Giant Cells - drug effects | Protein Multimerization | Male | Receptors, Glucocorticoid - metabolism | Stem Cells - metabolism | RANK Ligand - pharmacology | Dexamethasone - pharmacology | Peptides - metabolism | Bone Resorption - metabolism | Bone Marrow Cells - drug effects | Osteogenesis - genetics | Biomarkers - metabolism | Osteoclasts - pathology | Collagen Type I - metabolism | Cell Size - drug effects | Giant Cells - metabolism | Osteogenesis - drug effects | Cells, Cultured | Osteoclasts - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Cell Differentiation - drug effects | Bone Resorption - pathology | Glucocorticoids - pharmacology | Stem Cells - drug effects | Macrophages - drug effects | Mice | Bone Marrow Cells - metabolism | Giant Cells - pathology | Osteoclasts - drug effects | Dexamethasone | Steroids | Bones | Corticosteroids | Density | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cell- och molekylärbiologi
Journal Article
Cancer Research, ISSN 0008-5472, 07/2009, Volume 69, Issue 14, pp. 5876 - 5884
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, p. e99143
The induction of polyploidy is considered the reproductive end of cells, but there is evidence that polyploid giant cancer cells (PGCCs) contribute to cell... 
OXYGEN | MAINTENANCE | MULTIDISCIPLINARY SCIENCES | EXPANSION | RESISTANCE | SELF-RENEWAL | SENESCENCE | HIF-1-ALPHA | CHALLENGES | DIVISION | CYCLE | Cyclin D1 - metabolism | Adenocarcinoma - pathology | Neoplastic Stem Cells - drug effects | Giant Cells - drug effects | Humans | Drug Resistance, Neoplasm | Neoplasm Proteins - metabolism | G2 Phase - drug effects | Organoplatinum Compounds - pharmacology | Cell Hypoxia | Protein Isoforms - metabolism | Cobalt - pharmacology | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | DNA, Neoplasm - analysis | Polyploidy | Tumor Suppressor Protein p53 - metabolism | In Situ Hybridization, Fluorescence | Cell Division - drug effects | Cell Shape - drug effects | Colonic Neoplasms - pathology | Cell Line, Tumor | Fluorouracil - pharmacology | Tumor Suppressor Protein p53 - chemistry | Giant Cells - ultrastructure | Hypoxia-inducible factor 1 | Senescence | Biomedical research | 5-Fluorouracil | Stabilization | p53 Protein | Cytology | Colorectal cancer | Chemoresistance | Oncology | Cyclin D1 | Cancer therapies | Oxaliplatin | Colon cancer | Cell cycle | Giant cells | Colon | Deoxyribonucleic acid--DNA | Repopulation | Cell division | Pharmacology | Gene expression | Molecular modelling | Stem cells | Hypoxia | Cell size | Cancer | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0158587
Reversine, an A3 adenosine receptor antagonist, has been shown to induce differentiated myogenic-lineage committed cells to become multipotent mesenchymal... 
OVEREXPRESSION | AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | RESISTANCE | MITOTIC KINASE | AURORA KINASE | ANTITUMOR-ACTIVITY | INHIBITOR | EXPRESSION | CARCINOMA | ERLOTINIB | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | A549 Cells | Polyploidy | Apoptosis - drug effects | Carcinoma, Non-Small-Cell Lung - genetics | Purines - pharmacology | Giant Cells - drug effects | Giant Cells - metabolism | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Morpholines - pharmacology | Lung Neoplasms - pathology | Autophagy - drug effects | Blotting, Western | Dose-Response Relationship, Drug | Autophagosomes - drug effects | Caspases - metabolism | Flow Cytometry | Time Factors | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Complications and side effects | Autophagy (Cytology) | Care and treatment | Analysis | Lung cancer | Research | Apoptosis | Cell proliferation | Mesenchyme | Leukemia | Dosage | Kinases | Autophagy | Anticancer properties | Cell growth | Medical laboratories | Cell cycle | Life sciences | Medical research | Medical technology | Non-small cell lung carcinoma | Caspase | Pharmacology | Breast cancer | Radiation therapy | Chemical compounds | Progenitor cells | Hospitals | Stem cells | Cells (biology) | Phagocytosis | Cancer | Tumors
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 01/2005, Volume 111, Issue 1, pp. 11 - 20
Background - Human embryonic stem cells (hESCs) derived from blastocysts can propagate indefinitely in culture while maintaining pluripotency, including the... 
Cardiac development | Viruses | Gene therapy | Pacemakers | Stem cells | pacemakers | stem cells | viruses | CARDIAC & CARDIOVASCULAR SYSTEMS | GENE DELIVERY | MYOCYTES | gene therapy | LENTIVIRAL VECTORS | BIOLOGICAL PACEMAKER | LIDOCAINE | IN-VIVO | CANINE HEART | CONDUCTION | PERIPHERAL VASCULAR DISEASE | DIFFERENTIATION | cardiac development | EXPRESSION | Lidocaine - pharmacology | Heart Ventricles - cytology | Cells, Cultured - cytology | Giant Cells - drug effects | Heart - physiology | Humans | Electrophysiology | Myocardial Contraction - drug effects | Green Fluorescent Proteins - genetics | Action Potentials | Cell Fusion | HIV-1 - physiology | Pericardium - physiology | Heart Conduction System - physiology | Female | Cell Differentiation | Genes, Reporter | Organ Culture Techniques | Heart Conduction System - cytology | Green Fluorescent Proteins - analysis | Guinea Pigs | Pluripotent Stem Cells - cytology | Transduction, Genetic | Myocytes, Cardiac - cytology | Pluripotent Stem Cells - physiology | Defective Viruses - genetics | Adrenergic beta-Agonists - pharmacology | Cells, Cultured - physiology | Rats | Giant Cells - cytology | Pyrimidines - pharmacology | HIV-1 - genetics | Defective Viruses - physiology | Myocytes, Cardiac - transplantation | Animals | Myocytes, Cardiac - drug effects | Genetic Vectors - pharmacology | Myocytes, Cardiac - physiology | Isoproterenol - pharmacology | Mice
Journal Article