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Oncogene, ISSN 0950-9232, 08/2017, Volume 36, Issue 34, pp. 4887 - 4900
Our recent perplexing findings that polyploid giant cancer cells (PGCCs) acquired embryonic-like stemness and were capable of tumor initiation raised two... 
OVARIAN TUMORIGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-CELLS | CELLULAR SENESCENCE | FAILURE | CLEAVAGE-STAGE EMBRYOS | ESCAPE | CELL BIOLOGY | IN-VITRO | CYTOKINESIS | THERAPY | ONCOLOGY | GENETICS & HEREDITY | DIFFERENTIATION | Embryonic Stem Cells - metabolism | Paclitaxel - pharmacology | Neoplastic Stem Cells - drug effects | Giant Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Carcinogenesis - metabolism | Blastomeres - drug effects | Blastomeres - metabolism | Neoplastic Stem Cells - metabolism | Female | Ovarian Neoplasms - metabolism | Cell Differentiation - physiology | Ovarian Neoplasms - drug therapy | Neoplastic Stem Cells - physiology | Polyploidy | Giant Cells - metabolism | Blastomeres - pathology | Carcinogenesis - drug effects | Carcinogenesis - pathology | Drug Resistance, Neoplasm - genetics | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Embryonic Stem Cells - pathology | Cell Line, Tumor | Signal Transduction - physiology | Giant Cells - pathology | Cellular signal transduction | Research | Cell differentiation | Cancer cells | Blastomeres | Senescence | Carcinoma | Mesenchyme | Mitosis | Oct-4 protein | Embryo cells | Benign | Compaction | Cytokinesis | Embryos | Spheroids | Ovarian cancer | Yes-associated protein | Chemotherapy | Developmental stages | Somatic cells | Paclitaxel | Stem cells | Giant cells | Tumorigenesis | Budding | Cancer | Tumors | Original
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2012, Volume 109, Issue 8, pp. 2772 - 2777
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0125316
Missense mutations of the GJA1 gene encoding the gap junction channel protein connexin43 (Cx43) cause bone malformations resulting in oculodentodigital... 
CORNEAL FIBROBLASTS | MARROW | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TISSUE | GENE-EXPRESSION | MYOFIBROBLASTS | GROWTH-FACTOR | CX43 | DIFFERENTIATION | COMMUNICATION | Bone and Bones - pathology | Gap Junctions - metabolism | Humans | Middle Aged | Actins - metabolism | Gene Expression Regulation, Neoplastic | Child, Preschool | Hematopoietic Stem Cells - pathology | Monocytes - metabolism | Antigens, CD - genetics | Bone Neoplasms - pathology | Actins - genetics | Antigens, CD - metabolism | Bone Neoplasms - metabolism | Giant Cell Tumor of Bone - pathology | Neoplastic Stem Cells - metabolism | Bone and Bones - metabolism | Monocytes - pathology | Neoplastic Stem Cells - pathology | Adult | Bone Neoplasms - genetics | Giant Cell Tumor of Bone - diagnosis | Child | Giant Cell Tumor of Bone - genetics | Connexin 43 - genetics | Gap Junctions - pathology | Alkaline Phosphatase - genetics | Bone Neoplasms - diagnosis | Connexin 43 - metabolism | Macrophages - pathology | Signal Transduction | Giant Cells - metabolism | Bone Marrow Cells - pathology | Receptors, Cell Surface - metabolism | Hematopoietic Stem Cells - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Macrophages - metabolism | Giant Cell Tumor of Bone - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Adolescent | Survival Analysis | Aged | Primary Cell Culture | Alkaline Phosphatase - deficiency | Bone Marrow Cells - metabolism | Giant Cells - pathology | Receptors, Cell Surface - genetics | Immunohistochemistry | Dysplasia | Muscle proteins | Tumors | Nests | Smooth muscle | Osteolysis | Proteins | Animal tissues | Bone marrow | Fibroblasts | Bone dysplasia | Biocompatibility | Growth factors | Medical research | Gap junctions | Cultures | Survival | Golgi apparatus | CD163 antigen | Pathology | DNA microarrays | Stem cells | Mutation | Binding sites | Alkaline phosphatase | Phosphorylation | Membranes | Oculodentodigital dysplasia | Laboratories | Oncology | Connexin 43 | Macrophages | Western blotting | Defects | Biomedical materials | Missense mutation | Actin | Rodents | Giant cells | Coupling | Localization | Calcein | Communication | Cell survival | Muscles | Cell membranes | Monocytes | Bone | Cancer
Journal Article
The Plant Cell, ISSN 1040-4651, 12/2011, Volume 23, Issue 12, pp. 4382 - 4393
Increased cellular ploidy is widespread during developmental processes of multicellular organisms, especially in plants. Elevated ploidy levels are typically... 
Cotyledons | Phenotypes | Mother cells | Epidermal cells | Cell nucleus | Stem cells | Cell cycle | Guard cells | Giant cells | Plant cells | ENDOREDUPLICATION | PLANT CYTOKINESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | ENDOREPLICATION | DROSOPHILA ENDOCYCLE | PLANT SCIENCES | CELL BIOLOGY | APC/C | GENE | THALIANA | DIFFERENTIATION | EXPRESSION | Anaphase-Promoting Complex-Cyclosome | Pollen - metabolism | Plants, Genetically Modified - growth & development | Transcriptional Activation | Ubiquitin-Protein Ligase Complexes - genetics | Plant Epidermis - genetics | Plant Stomata - metabolism | Genetic Complementation Test | Arabidopsis Proteins - metabolism | Cell Nucleus - metabolism | Cyclin B - genetics | Plant Stomata - cytology | Gene Expression Regulation, Plant | Cdc20 Proteins | Plant Epidermis - growth & development | Arabidopsis Proteins - genetics | Plant Cells - metabolism | Enzyme Inhibitors - metabolism | Arabidopsis - cytology | Cell Cycle Proteins - metabolism | Plant Stomata - growth & development | Chromosomes, Plant - metabolism | Cytokinesis | Plasmids - metabolism | Plants, Genetically Modified - metabolism | Ubiquitin-Protein Ligase Complexes - metabolism | Cell Nucleus - genetics | Ploidies | Plants, Genetically Modified - cytology | Mutation | Chromosomes, Plant - genetics | Arabidopsis - growth & development | Genes, Plant | Mitosis | Plant Epidermis - metabolism | Cloning, Molecular | Plasmids - genetics | Cell Cycle Proteins - genetics | Plant Epidermis - cytology | Pollen - growth & development | Plants, Genetically Modified - genetics | Transcription Factors - genetics | Cotyledon - genetics | Cotyledon - metabolism | Arabidopsis - metabolism | Protein Interaction Mapping | Arabidopsis - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Alleles | Cyclin B - metabolism | Plant Stomata - genetics | Arabidopsis thaliana | Ubiquitin | Plant genetics | Physiological aspects | Genetic aspects | Research
Journal Article
Plant Physiology, ISSN 0032-0889, 5/2012, Volume 159, Issue 1, pp. 321 - 335
The syncytium is a unique plant root organ whose differentiation is induced by plant-parasitic cyst nematodes to create a source of nourishment. Syncytium... 
MicroRNA | Plant parasitic nematodes | Developmental biology | Genes | Plant roots | Nematodes | Giant cells | Infections | Plants | Transgenic plants | PLANTS INTERACTING WITH OTHER ORGANISMS | LEAF GROWTH | SMALL RNAS | TRANSCRIPTOME | THALIANA | MIRNA | GENE-EXPRESSION | TARGETS | HETERODERA-SCHACHTII | MICRORNAS | IDENTIFICATION | PLANT SCIENCES | Genes, Plant | Plant Diseases - immunology | Arabidopsis - immunology | Plant Roots - genetics | MicroRNAs - metabolism | Gene Expression Profiling | RNA, Plant - metabolism | Arabidopsis Proteins - metabolism | Gene Expression Regulation, Plant | Plasmids - genetics | Nematoda - pathogenicity | Transgenes | Arabidopsis Proteins - genetics | Disease Resistance | Plant Cells - metabolism | Plant Roots - metabolism | Plants, Genetically Modified - genetics | Giant Cells - metabolism | Plant Cells - parasitology | RNA, Plant - genetics | Arabidopsis Proteins - immunology | Plasmids - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Animals | Plants, Genetically Modified - metabolism | Nematoda - growth & development | Plants, Genetically Modified - parasitology | Arabidopsis - parasitology | MicroRNAs - genetics | Plant Diseases - parasitology | Giant Cells - pathology | Plant Roots - parasitology | Arabidopsis thaliana | Roundworm infections | Diseases and pests | Development and progression | Genetic aspects | Research | Properties | Genetic regulation
Journal Article
Bone, ISSN 8756-3282, 2016, Volume 93, pp. 43 - 54
Abstract Glucocorticoid (GC) therapy is the greatest risk factor for secondary osteoporosis. Pathogenic mechanisms involve an initial increase in bone... 
Orthopedics | Bone resorption | Osteoporosis | Osteoclast | Glucocorticoid | Glucocorticoid receptor | INDUCED OSTEOPOROSIS | RESORPTION | MOUSE CALVARIAL BONES | VERTEBRAL FRACTURE | OSTEOPROTEGERIN | OSTEOBLAST-LIKE CELLS | INHIBITION | CORTICOSTEROID-THERAPY | ENDOCRINOLOGY & METABOLISM | DIFFERENTIATION | NF-KAPPA-B | Giant Cells - drug effects | Protein Multimerization | Male | Receptors, Glucocorticoid - metabolism | Stem Cells - metabolism | RANK Ligand - pharmacology | Dexamethasone - pharmacology | Peptides - metabolism | Bone Resorption - metabolism | Bone Marrow Cells - drug effects | Osteogenesis - genetics | Biomarkers - metabolism | Osteoclasts - pathology | Collagen Type I - metabolism | Cell Size - drug effects | Giant Cells - metabolism | Osteogenesis - drug effects | Cells, Cultured | Osteoclasts - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Cell Differentiation - drug effects | Bone Resorption - pathology | Glucocorticoids - pharmacology | Stem Cells - drug effects | Macrophages - drug effects | Mice | Bone Marrow Cells - metabolism | Giant Cells - pathology | Osteoclasts - drug effects | Dexamethasone | Steroids | Bones | Corticosteroids | Density | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Cell- och molekylärbiologi
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2010, Volume 18, Issue 1, pp. 77 - 89
Journal Article
Nature Cell Biology, ISSN 1465-7392, 11/2012, Volume 14, Issue 11, pp. 1192 - 1202
The endocycle is a variant cell cycle consisting of successive DNA synthesis and gap phases that yield highly polyploid cells. Although essential formetazoan... 
CELLS | REPRESSION | LIVER | GROWTH | S-PHASE | PATTERNS | MICE | POLYPLOIDY | ACTIVATORS | ENDOREPLICATION | CELL BIOLOGY |