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Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 05/2013, Volume 138, Issue 2, pp. 155 - 175
Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for... 
Parkinson's | GDNF | NGF | Trk | BDNF | Alzheimer's | FOREBRAIN CHOLINERGIC NEURONS | NERVE-GROWTH-FACTOR | AMYOTROPHIC-LATERAL-SCLEROSIS | NEUROTROPHIC FACTOR GDNF | NIGRAL DOPAMINERGIC-NEURONS | MOUSE MODEL | PHARMACOLOGY & PHARMACY | BASAL FOREBRAIN | LONG-TERM POTENTIATION | CONVECTION-ENHANCED DELIVERY | UP-REGULATES BDNF | Humans | Models, Molecular | Nerve Growth Factors - administration & dosage | Nerve Growth Factors - chemistry | Nerve Growth Factors - metabolism | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Glial Cell Line-Derived Neurotrophic Factor - administration & dosage | Nerve Growth Factors - therapeutic use | Brain-Derived Neurotrophic Factor - administration & dosage | Brain-Derived Neurotrophic Factor - chemistry | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Animals | Glial Cell Line-Derived Neurotrophic Factor - therapeutic use | Ligands | Brain-Derived Neurotrophic Factor - metabolism | Brain-Derived Neurotrophic Factor - therapeutic use | Glial Cell Line-Derived Neurotrophic Factor - chemistry | Brain | Enzymes | Care and treatment | Inositol | Glycogen | Tissue plasminogen activator | Amyloid beta-protein | Amyotrophic lateral sclerosis | Nerve growth factor | Superoxide | Apolipoproteins | Transforming growth factors | Synthesis | Choline | Bone morphogenetic proteins | Dopa | Alzheimer's disease | Intermediate filament proteins | Injuries | Protein binding
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2010, Volume 115, Issue 4, pp. 956 - 964
J. Neurochem. (2010) 115, 956–964. Neurogenesis, the birth of new neurons, continues throughout adulthood in the human subventricular zone (SVZ) and... 
neurogenesis | subventricular zone | hippocampus | human | age | transforming growth factor‐β1 | Human | Transforming growth factor-β1 | Neurogenesis | Subventricular zone | Age | Hippocampus | MESSENGER-RNA EXPRESSION | NEUROTROPHIC-FACTOR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | transforming growth factor-beta 1 | FACTOR-ALPHA | NEURAL STEM-CELLS | OLFACTORY-BULB | EPIDERMAL-GROWTH-FACTOR | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | Cell Proliferation | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | Neurogenesis - genetics | Young Adult | Interleukin-1beta - metabolism | Aged, 80 and over | Adult | Female | Brain-Derived Neurotrophic Factor - biosynthesis | Brain-Derived Neurotrophic Factor - metabolism | Interleukin-1beta - biosynthesis | Transforming Growth Factor alpha - metabolism | Interleukin-6 - metabolism | Transforming Growth Factor beta1 - biosynthesis | Transforming Growth Factor alpha - biosynthesis | Cellular Senescence - genetics | Insulin-Like Growth Factor I - biosynthesis | Epidermal Growth Factor - biosynthesis | Cellular Senescence - physiology | Epidermal Growth Factor - metabolism | Hippocampus - cytology | Hippocampus - metabolism | Neurogenesis - physiology | Adolescent | Interleukin-6 - biosynthesis | Aged | Hippocampus - physiology | Insulin-Like Growth Factor I - metabolism | Neurosciences | Fibroblast growth factors | Adults | Epidermal growth factor | Neurons | Neurochemistry | Brain | Cellular biology | Age differences | Fibroblast growth factor 2 | Transforming growth factor-b1 | Insulin-like growth factor I | Transforming growth factor-a | Neurotrophic factors | Neuronal-glial interactions | Interleukin 6 | Dentate gyrus | Brain-derived neurotrophic factor | Life span | Interleukin 1 | Enzyme-linked immunosorbent assay
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 03/2017, Volume 171, pp. 30 - 42
Pericytes are a heterogeneous population of cells located in the blood vessel wall. They were first identified in the 19th century by Rouget, however their... 
Pericytes | Perivascular stem cells | Diabetic retinopathy | Diabetic nephropathy | Pericyte fibrosis | Cancer stem cells | DIABETIC-RETINOPATHY | Cancer stern cells | VEGF-A | BLOOD-BRAIN-BARRIER | MESENCHYMAL STEM-CELLS | EPITHELIUM-DERIVED FACTOR | HIGH GLUCOSE | PHARMACOLOGY & PHARMACY | STROMAL CELLS | TUMOR-GROWTH | GLYCATION END-PRODUCTS | ENDOTHELIAL GROWTH-FACTOR | Neoplasms - therapy | Animals | Diabetes Mellitus - physiopathology | Vascular Diseases - therapy | Diabetes Mellitus - therapy | Humans | Pericytes - cytology | Ischemia - therapy | Vascular Diseases - physiopathology | Ischemia - physiopathology | Molecular Targeted Therapy | Neoplasms - pathology | Blood circulation disorders | Therapeutics | Homeopathy | Materia medica and therapeutics | Impotence | Diabetic nephropathies | T cells | Muscle proteins | Cardiovascular agents | Blood coagulation factor VIII | Interleukins | Chronic kidney failure | Type 1 diabetes | Stem cells | Vascular endothelial growth factor | Mitogens | Protein kinases | Growth factors | UUO, unilateral ureteric obstruction | EGFR, EGF receptor | EMT, epithelial-mesenchymal transition | SFT, solitary fibrous tumour | DAN, diabetic autonomous neuropathy | ECM, extracellular matrix | NRF2, nuclear factor (erythroid-derived 2)-like 2 | IL-6, interleukin 6 | PSC, perivascular stem cell | BBB, blood-brain barrier | SOD, super oxide dismutase | HIF, hypoxia inducible factor | ED, erectile dysfunction | SDF-1, stromal derived factor 1 | RAGE, receptors of AGEs | CKD, chronic kidney disease | MMP, matrix metalloproteinases | MDSC, myeloid-derived suppressor cells | DN, diabetic nephropathy | TGF β, transforming growth factor β | PDL-1, programmed death-ligand 1 | ANG2, angiopoietin-2 | Olmfl3, Olfactomedin-like 3 | VEGF, vascular endothelial growth factor | AGE, Advanced Glycation End-Products | EC, endothelial cells | NG2, neural | R, ischemia-reperfusion | MSC, mesenchymal stromal cell | MF-EGF8, milk fat globule epidermal growth factor VIII | IL-8, interleukin 8 | glial antigen 2 | T1D, type 1 diabetic | PDGFb, platelet-derived growth factor B | MAPK, mitogen-activated protein kinase | PDGFRβ, platelet derived growth factor receptor β | DR, diabetic retinopathy | CNS, blood-retinal barrier | HB-EGF, heparin-binding EGF-like growth factor | HPC, hemangiopericytoma | PDR, proliferative diabetic retinopathy | DME, diabetic macular oedema | GFR, glomerular filtration rate | MI, myocardial infarction | SMA, smooth muscle actin | CSC, cancer stem cell | NPDR, non-proliferative diabetic retinopathy | T2D, type 2 diabetic | ROS, reactive oxygen species | Treg, regulatory T cells | BRB, blood-retina barrier | PKC, protein kinase C | DPN, diabetic peripheral neuropathy | TME, tumour microenvironment | ANG1, angiopoietin-1 | GSC, glioblastoma CSC | iPS, induced pluripotent stem cells | GSI, g-secretase inhibitor | FGF-9, fibroblastic growth factor 9 | PEDF, Pigment Epithelium-Derived Factor
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19025
Bone marrow-derived human mesenchymal stem cells (hMSCs) have shown promise in in vitro neuronal differentiation and in cellular therapy for neurodegenerative... 
PROGENITOR CELLS | IN-VITRO | ADULT-RAT | OLFACTORY ENSHEATHING CELLS | MULTIDISCIPLINARY SCIENCES | NEUROECTODERMAL DIFFERENTIATION | CENTRAL-NERVOUS-SYSTEM | DOPAMINERGIC-NEURONS | STROMAL CELLS | RAT MODEL | PARKINSONS-DISEASE | Parkinson Disease - therapy | Rats, Wistar | Humans | Hedgehog Proteins - metabolism | Male | Neurons - cytology | Corpus Striatum - cytology | Corpus Striatum - metabolism | Platelet-Derived Growth Factor - genetics | Fibroblast Growth Factor 8 - metabolism | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Mesenchymal Stromal Cells - cytology | Hedgehog Proteins - genetics | Bone Marrow - metabolism | Fibroblast Growth Factor 2 - metabolism | Cell Differentiation | Neurons - metabolism | Fibroblast Growth Factor 8 - genetics | Disease Models, Animal | Bone Marrow - growth & development | Epidermal Growth Factor - genetics | RNA, Messenger - genetics | Cells, Cultured | Glial Cell Line-Derived Neurotrophic Factor - genetics | Mesenchymal Stromal Cells - metabolism | Rats | Epidermal Growth Factor - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Platelet-Derived Growth Factor - metabolism | Animals | Fibroblast Growth Factor 2 - genetics | Fluorescent Antibody Technique | Mesenchymal Stem Cell Transplantation | Fibronectins | Stem cell research | Nervous system diseases | Epidermal growth factor | Neurons | Stem cells | Bone marrow | Transplantation | Fibroblast growth factors | Cell differentiation | Mesenchyme | Syngeneic grafts | Cyclosporins | Cytology | Bone marrow transplantation | Macrophages | Grafting | Neurogenesis | Fibronectin | Cell morphology | Cell activation | Rodents | Neostriatum | Fibroblast growth factor 2 | Medical research | Glial cell line-derived neurotrophic factor | Cell survival | Neurodegenerative diseases | Glial fibrillary acidic protein | Priming | Fibroblast growth factor 8 | Inflammation | Gene expression | Survival | Olfactory ensheathing cells | Microglia | Studies | Regeneration | Immunosuppression | Grafts | Hedgehog protein | Differentiation
Journal Article
Brain Research, ISSN 0006-8993, 2015, Volume 1630, pp. 98 - 108
Abstract Central nervous system (CNS) pericytes have been recognized as an indispensable component of the neurovascular unit. The expression of... 
Neurology | Brain ischemia | Pericyte | Stroke | Basic fibroblast growth factor | Platelet-derived growth factor | Abbreviations CNS central nervous system | pMCAO permanent middle cerebral artery occlusion | VEGF vascular endothelial growth factor | bFGF basic fibroblast growth factor | CCA common carotid artery | PDGF platelet-derived growth factor | CBF cerebral blood flow | BBB blood-brain barrier | NGF nerve growth factor | MCA middle cerebral artery | FGFR fibroblast growth factor receptor | CREB cAMP responsive element binding protein | tMCAO transient middle cerebral artery occlusion | GFAP glial fibrillary acidic protein | PDGFRβ platelet-derived growth factor receptor β | ARTERY OCCLUSION | ANGIOGENESIS | FOCAL CEREBRAL-ISCHEMIA | RATS | FACTOR EXPRESSION | FIBROBLAST-GROWTH-FACTOR | CELL-PROLIFERATION | NEUROSCIENCES | EXPERIMENTAL BRAIN INFARCT | RECEPTOR-BETA | MICE | Cell Hypoxia - drug effects | Cell Hypoxia - physiology | Infarction, Middle Cerebral Artery | Brain - physiopathology | Humans | Mice, Inbred C57BL | Cell Proliferation - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Male | Brain Ischemia - physiopathology | Mice, 129 Strain | Pericytes - physiology | Stroke - physiopathology | Cell Movement - physiology | Pyrroles - pharmacology | Animals | Receptors, Fibroblast Growth Factor - metabolism | Up-Regulation - physiology | Fibroblast Growth Factor 2 - metabolism | Disease Models, Animal | Hydrogen-Ion Concentration | Receptor, Platelet-Derived Growth Factor beta - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e109305
We have investigated and compared the neurotrophic activity of human dental pulp stem cells (hDPSC), human bone marrow-derived mesenchymal stem cells (hBMSC)... 
SURVIVAL | OPTIC-NERVE | IN-VITRO | NEUROTROPHIC FACTOR | MULTIDISCIPLINARY SCIENCES | AXON REGENERATION | RATS | SPINAL-CORD | EXPERIMENTAL GLAUCOMA | BRAIN | TRANSPLANTATION | Nerve Growth Factor - secretion | Brain-Derived Neurotrophic Factor - secretion | Cell- and Tissue-Based Therapy - methods | Neuroprotection | Vascular Endothelial Growth Factor A - biosynthesis | Nerve Growth Factor - biosynthesis | Neurites - physiology | Coculture Techniques | Humans | Adipose Tissue - cytology | Male | Dental Pulp - metabolism | Retinal Ganglion Cells - metabolism | Vascular Endothelial Growth Factor A - secretion | Adipose Tissue - metabolism | Paracrine Communication - physiology | Retinal Ganglion Cells - cytology | Axotomy | Mesenchymal Stromal Cells - cytology | Brain-Derived Neurotrophic Factor - biosynthesis | Bone Marrow Cells - cytology | Dental Pulp - cytology | Mesenchymal Stromal Cells - metabolism | Rats | Rats, Sprague-Dawley | Animals | Primary Cell Culture | Bone Marrow Cells - metabolism | Fc receptors | Platelet-derived growth factor | Stem cells | Nerve growth factor | Comparative analysis | Ganglion | Vascular endothelial growth factor | Health aspects | Enzyme-linked immunosorbent assay | Neurosciences | Spinal cord | Mesenchyme | Neurobiology | Paracrine signalling | Stem cell transplantation | Retina | Nervous system | Neurotrophin 3 | Receptors | Rodents | Bone marrow | Conditioning | Ganglion cells | Growth factors | Glial cell line-derived neurotrophic factor | Optic nerve | Cytokines | Axonogenesis | Dentistry | Gene expression | Survival | Medicine | Retinal ganglion cells | Brain research | Brain-derived neurotrophic factor | Inhibitors | Apoptosis | Dental pulp
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, pp. e0213508 - e0213508
During experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis associated with blood-brain barrier (BBB) disruption, oligodendrocyte... 
PROGENITOR CELLS | PDGF ALPHA-RECEPTOR | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | FACTOR-BETA | VI COLLAGEN | OLIGODENDROCYTE PRECURSOR RESPONSE | MULTIDISCIPLINARY SCIENCES | PROTEOGLYCAN | UP-REGULATION | CEREBRAL-CORTEX | ENDOTHELIAL GROWTH-FACTOR | Oligodendroglia - metabolism | Cerebral Cortex - blood supply | Encephalomyelitis, Autoimmune, Experimental - metabolism | Tight Junctions - genetics | Cerebral Cortex - pathology | Claudin-5 - metabolism | Microvessels - metabolism | Microvessels - pathology | Vascular Endothelial Growth Factor A - metabolism | Stem Cells - metabolism | Vascular Endothelial Growth Factor A - genetics | Platelet-Derived Growth Factor - genetics | Cell Movement - genetics | Cerebral Cortex - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Disease Models, Animal | Tight Junctions - metabolism | Cell Proliferation - genetics | Encephalomyelitis, Autoimmune, Experimental - pathology | Proteoglycans - biosynthesis | Claudin-5 - genetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Oligodendroglia - pathology | Blood-Brain Barrier - pathology | Platelet-Derived Growth Factor - metabolism | Animals | Transforming Growth Factor beta - genetics | Stem Cells - pathology | Antigens - biosynthesis | Mice | Transforming Growth Factor beta - metabolism | Proteoglycans - genetics | Tight Junctions - pathology | Antigens - genetics | Cell proliferation | Multiple sclerosis | Care and treatment | Encephalomyelitis | Research | Risk factors | Cell migration | Immunohistochemistry | Neurosciences | Animal models | Cerebral cortex | Platelet-derived growth factor | Leukocyte migration | Transforming growth factor-b | Childrens health | Collagens | Nervous system | Hybridization | Glial stem cells | Cell adhesion & migration | Vascularization | Angiogenesis | Laminin | Blood platelets | Blood-brain barrier | Fibroblasts | Basal lamina | Collagen (type IV) | Chemical composition | Vascular endothelial growth factor | Growth factors | Fibroblast growth factor 2 | Proteoglycans | Cortex | Glycoproteins | Inflammation | Experimental allergic encephalomyelitis | Medicine | Brain research | Collagen | Pericytes | Chondroitin sulfate | Rehabilitation | Disruption | Morphometry | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79371
Antidepressants increase the proliferation of neural precursors in adult dentate gyrus (DG), which is considered to be involved in the therapeutic action of... 
DEPRESSION | PROTEIN | NEUROTROPHIC-FACTOR | MULTIDISCIPLINARY SCIENCES | KINASE | CYSTATIN-C | RECEPTOR | STEM-CELL PROLIFERATION | GROWTH-FACTOR | HIPPOCAMPAL NEUROGENESIS | BRAIN | Immunohistochemistry | Astrocytes - drug effects | Brain-Derived Neurotrophic Factor - genetics | Rats, Wistar | Cells, Cultured | Glial Cell Line-Derived Neurotrophic Factor - genetics | Rats | Male | Vascular Endothelial Growth Factor A - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Vascular Endothelial Growth Factor A - genetics | Rats, Sprague-Dawley | Dentate Gyrus - cytology | Glial Cell Line-Derived Neurotrophic Factor - metabolism | Animals | Fibroblast Growth Factor 2 - genetics | Antidepressive Agents, Tricyclic - pharmacology | Fibroblast Growth Factor 2 - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Cell Proliferation - drug effects | Amitriptyline - pharmacology | Astrocytes - metabolism | Amitriptyline | Fibroblast growth factors | Vascular endothelial growth factor | Health aspects | Brain | Fibroblast growth factor | Immunocytochemistry | Mental depression | Kinases | Neurogenesis | Proteins | Receptors | Cell growth | Antidepressants | Precursors | Rodents | Fibroblasts | Conditioning | Growth factors | University graduates | Fibroblast growth factor 2 | Glial cell line-derived neurotrophic factor | Neurons | Astrocytes | Gene expression | Medicine | Dentate gyrus | Brain-derived neurotrophic factor | Stem cells | Neural stem cells | Psychiatry | Niches | ADP
Journal Article