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Cell Metabolism, ISSN 1550-4131, 06/2012, Volume 15, Issue 6, pp. 827 - 837
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2012, Volume 48, Issue 5, pp. 771 - 784
Many types of human tumor cells have overexpressed pyruvate kinase M2 (PKM2). However, the mechanism underlying this increased PKM2 expression remains to be... 
GROWTH-FACTOR RECEPTOR | PROTEIN-KINASE-C | PYRUVATE-KINASE | UBIQUITIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA | BETA-CATENIN | TUMOR-GROWTH | TRANSCRIPTIONAL REGULATION | CANCER | CELL BIOLOGY | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Glioblastoma - enzymology | Humans | NF-kappa B - metabolism | Ubiquitination | Glioblastoma - genetics | RNA Interference | Cell Transformation, Neoplastic - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Signal Transduction | Membrane Proteins - genetics | Lactic Acid - metabolism | Protein Kinase C-epsilon - genetics | Brain Neoplasms - genetics | Polypyrimidine Tract-Binding Protein - metabolism | Mice, Nude | Glioblastoma - pathology | Protein Kinase C-epsilon - metabolism | Cell Line, Tumor | Glucose - metabolism | Mice | Enzyme Activation | Mutation | Neoplasm Transplantation | Phosphorylation | Prognosis | Serine | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Receptor, Epidermal Growth Factor - metabolism | Neoplasm Grading | Transfection | I-kappa B Kinase - metabolism | HEK293 Cells | Female | Membrane Proteins - metabolism | Genes, Reporter | Promoter Regions, Genetic | Brain Neoplasms - enzymology | Phospholipase C gamma - metabolism | Mutagenesis, Site-Directed | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Epidermal Growth Factor - metabolism | Thyroid Hormones - genetics | Cell Transformation, Neoplastic - metabolism | Gene Expression Regulation, Enzymologic | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | NF-kappa B - genetics | Transcription Factor RelA - metabolism | Thyroid Hormones - metabolism | Glycolysis | Cell Transformation, Neoplastic - pathology | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 1, pp. 12 - 21
Journal Article
Cell Metabolism, ISSN 1550-4131, 11/2013, Volume 18, Issue 5, pp. 726 - 739
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, pp. e112945 - e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
OXIDATIVE STRESS | QUINOLINIC ACID | MAMMALIAN BRAIN | POOR-PROGNOSIS | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | TRYPTOPHAN 2,3-DIOXYGENASE | TUMORAL IMMUNE RESISTANCE | T-CELLS | IDO EXPRESSION | BRAIN-TUMORS | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 16062 - 16067
Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is thought that tumor regrowth originates from GSCs, thus rendering GSCs... 
Lactates | Cellular metabolism | Glioma | Stem cells | Cell lines | Glycolysis | Progenitor cells | Cellular differentiation | Tumors | Cancer | INITIATING CELLS | PYRUVATE-KINASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ISOFORM | IDENTIFICATION | TUMOR-GROWTH | CANCER | RADIATION | GLIOBLASTOMA PATIENTS | Immunohistochemistry | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Neoplastic Stem Cells - drug effects | Tissue Array Analysis | Humans | Stem Cells - metabolism | Glycolysis - drug effects | Glioma - metabolism | Oligomycins - pharmacology | Neoplastic Stem Cells - metabolism | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Glioma - pathology | Oxygen Consumption | Positron-Emission Tomography - methods | Clone Cells - metabolism | Blotting, Western | Lactates - metabolism | Energy Metabolism | Glucose - pharmacokinetics | Cell Line, Tumor | Glucose - metabolism | Stem Cells - drug effects | Proteasome Endopeptidase Complex - metabolism | Physiological aspects | Cell metabolism | Research | Diagnosis | Gliomas | Glucose | Metabolism | Pyruvate kinase | Brain tumors | Acidification | Oxygen consumption | imaging | Emissions | Glucose metabolism | Progeny | Mitochondria | Oxidative phosphorylation | Glioma cells | Cell cycle | Metabolic pathways | Lactic acid | ATP | Positron emission tomography | Index Medicus | Biological Sciences
Journal Article
Journal Article
BBA - Bioenergetics, ISSN 0005-2728, 08/2016, Volume 1857, Issue 8, pp. 1228 - 1242
Proteins initially identified as essential for apoptosis also mediate a wide range of non-apoptotic functions that include cell cycle progression,... 
Mitochondria | VDAC1 | Cell differentiation | Metabolism | Glioblastoma | Apoptosis | DEPENDENT ANION CHANNEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | DEATH | KAPPA-B | BENZODIAZEPINE-RECEPTOR | 18 KDA | CYTOCHROME-C | BREAST-CANCER | BIOPHYSICS | CASPASE ACTIVATION | TUMOR-GROWTH | Neurons - pathology | RNA, Small Interfering - genetics | Cell Proliferation | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | NF-kappa B - metabolism | Cytochromes c - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Brain Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Caspases - metabolism | Glioblastoma - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mitochondrial Proteins - metabolism | Voltage-Dependent Anion Channel 1 - antagonists & inhibitors | Glioblastoma - metabolism | Cell Differentiation | Neurons - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Apoptosis Inducing Factor - metabolism | Receptors, GABA - genetics | Signal Transduction | Caspases - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cytochromes c - metabolism | Tumor Suppressor Protein p53 - metabolism | Voltage-Dependent Anion Channel 1 - metabolism | Brain Neoplasms - genetics | Mitochondria - metabolism | Mitochondria - pathology | Proto-Oncogene Proteins c-myc - metabolism | Apoptosis Inducing Factor - genetics | Glioblastoma - therapy | Xenograft Model Antitumor Assays | Animals | NF-kappa B - genetics | Mice, Nude | Glioblastoma - pathology | Brain Neoplasms - therapy | Receptors, GABA - metabolism | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | Voltage-Dependent Anion Channel 1 - genetics | RNA, Small Interfering - metabolism | Cytochrome c | Physiological aspects | DNA binding proteins | Tumor proteins | Cancer | Gliomas
Journal Article
journal of histochemistry and cytochemistry, ISSN 0022-1554, 2015, Volume 63, Issue 7, pp. 481 - 493
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2454 - 2468
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed.... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIPLE-SCLEROSIS | NEURITE OUTGROWTH | NITRIC-OXIDE SYNTHASE | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | VASCULAR-PERMEABILITY | ENDOTHELIAL GROWTH-FACTOR | HUMAN GLIOBLASTOMA-MULTIFORME | Membrane Glycoproteins - metabolism | Humans | Male | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Occludin | Brain - metabolism | Inflammation - metabolism | Nitric Oxide Synthase Type III - metabolism | Demyelinating Diseases | Multiple Sclerosis - metabolism | Interleukin-1beta - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Nuclear Proteins - metabolism | Permeability | Blood-Brain Barrier - metabolism | Membrane Glycoproteins - genetics | Membrane Proteins | Nerve Tissue Proteins - metabolism | Blood-Brain Barrier - pathology | Lymphocytes - pathology | Animals | Brain - pathology | Multiple Sclerosis - pathology | Mice | Primary Cell Culture | Vascular Endothelial Growth Factor A - physiology | Astrocytes - metabolism | Physiological aspects | Central nervous system diseases | Research | Blood-brain barrier | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus
Journal Article