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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 35, pp. 12823 - 12828
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2010, Volume 12, Issue 11, pp. 1113 - 1125
Macrophages (MΦs)/microglia that constitute the dominant tumor-infiltrating immune cells in glioblastoma are recruited by tumor-secreted factors and are... 
Immune suppression | Innate immunity | Cancer stem cells | Macrophages | Signal transducer and activator of transcription 3 | Microglia | ACTIVATION | TOLL-LIKE RECEPTOR | TGF-BETA SUPERFAMILY | signal transducer and activator of transcription 3 | FACTOR-KAPPA-B | CLINICAL NEUROLOGY | macrophages | GLIOBLASTOMA | innate immunity | ONCOLOGY | TUMOR-ASSOCIATED MACROPHAGES | cancer stem cells | ANTITUMOR IMMUNITY | SUPPRESSOR-CELLS | immune suppression | microglia | T-CELLS | Microglia - metabolism | Phosphorylation | Humans | Brain Neoplasms - pathology | Neoplastic Stem Cells - immunology | Brain Neoplasms - metabolism | Glioma - metabolism | Cell Movement - immunology | Signal Transduction - immunology | Brain Neoplasms - immunology | Flow Cytometry | Microglia - immunology | Transfection | Chemotactic Factors - metabolism | Neoplastic Stem Cells - metabolism | Glioma - pathology | Neoplastic Stem Cells - pathology | Macrophages - immunology | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Chemotactic Factors - immunology | Enzyme-Linked Immunosorbent Assay | Cell Separation | Cells, Cultured | Glioma - immunology | Blotting, Western | Immunity, Innate - immunology | Macrophages - metabolism | STAT3 Transcription Factor - immunology | Chemotaxis, Leukocyte - immunology | Cytokines - biosynthesis | Basic and Translational Investigations
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 1, pp. 367 - 376
Dendritic cells (DCs) are professional APCs that are traditionally divided into two distinct subsets, myeloid DC (mDCs) and plasmacytoid DC (pDCs). pDCs are... 
ANTIGEN-PRESENTATION | IFN-GAMMA | IN-VIVO | INDOLEAMINE 2,3-DIOXYGENASE | REGULATORY T-CELLS | INFLUENZA-VIRUS | MELANOMA PATIENTS | OVARIAN-CANCER | IMMUNOLOGY | DRAINING LYMPH-NODES | BRAIN-TUMORS | Immunodominant Epitopes - immunology | Th1 Cells - pathology | Lymph Nodes - pathology | Ovalbumin - immunology | Cell Count | Dendritic Cells - immunology | Vaccination | Brain Neoplasms - pathology | Dendritic Cells - pathology | Th1 Cells - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Brain Neoplasms - immunology | Myeloid Cells - immunology | Glioma - pathology | Peptide Fragments - immunology | Glioma - therapy | Brain Neoplasms - mortality | Ovalbumin - chemistry | Adaptive Immunity | Glioma - mortality | Immunodominant Epitopes - chemistry | Interferon-alpha - biosynthesis | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Glioma - immunology | Mice, Transgenic | Lymph Nodes - immunology | Cancer Vaccines - immunology | Dendritic Cells - classification | Peptide Fragments - chemistry | Animals | Brain Neoplasms - therapy | Survival Analysis | Brain - pathology | Mice | Myeloid Cells - pathology | Brain - immunology | Dendritic Cells - transplantation | Cell Lineage - immunology | Cell Movement | regulatory T cells | plasmacytoid dendritic cells | vaccine | Glioma | immunization | brain tumor | myeloid dendritic cells
Journal Article
Clinical and Developmental Immunology, ISSN 1740-2522, 2013, Volume 2013, pp. 264124 - 5
Journal Article
Brain, ISSN 0006-8950, 2012, Volume 135, Issue 4, pp. 1042 - 1054
Peptides presented at the cell surface reflect the protein content of the cell; those on HLA class I molecules comprise the critical peptidome elements... 
peptidome | glioblastoma | tumour-infiltrating lymphocytes | tumour antigen | immunotherapy | AVIDITY | IDENTIFICATION | NEUROSCIENCES | CLINICAL NEUROLOGY | GLIOMA-CELL | GROWTH | CHONDROITIN SULFATE PROTEOGLYCAN | SELECTION | EXPRESSION | T-CELLS | PROGRESSION | TENASCIN-C | Oligonucleotide Array Sequence Analysis | Humans | Brain Neoplasms - pathology | Gene Expression Profiling | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Antigens, Neoplasm - chemistry | HLA-A Antigens - analysis | Antigens, CD - metabolism | Sequence Analysis, Protein | Brain Neoplasms - immunology | Flow Cytometry | Antigens, Neoplasm - therapeutic use | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Mass Spectrometry | Chromatography, Liquid | Cytokines - metabolism | Antigens, Neoplasm - immunology | Peptides - immunology | Glioblastoma - therapy | HLA-A Antigens - immunology | Glioblastoma - immunology | Glioblastoma - pathology | Brain Neoplasms - therapy | HLA-A Antigens - chemistry | CD8-Positive T-Lymphocytes - immunology | Antigen Presentation - physiology | Peptides - analysis | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - metabolism | Immunogenicity | CD8 antigen | Immunotherapy | Glioblastoma | Data processing | Histocompatibility antigen HLA | Lymphocytes T | Vaccines | Cell surface | Immunological tolerance
Journal Article
Nature Communications, ISSN 2041-1723, 01/2019, Volume 10, Issue 1, pp. 448 - 15
Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2... 
ACTIVATION | HOMEOSTASIS | COLONY-STIMULATING FACTOR | MICROENVIRONMENT | GM-CSF | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | ANTIGEN-PRESENTING CELLS | ANTITUMOR-ACTIVITY | T-CELLS | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - pathology | Neuroglia - pathology | Dendritic Cells - immunology | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | NF-kappa B - immunology | Dendritic Cells - pathology | Neoplastic Stem Cells - immunology | STAT Transcription Factors - immunology | CD4-Positive T-Lymphocytes - pathology | Antigens, CD - genetics | CD4-Positive T-Lymphocytes - immunology | Brain Neoplasms - immunology | Heterografts | Glioblastoma - genetics | Integrin alpha Chains - immunology | Neuroglia - immunology | Neoplastic Stem Cells - pathology | Cell Differentiation | Brain Neoplasms - mortality | Fibrinogen - immunology | Brain Neoplasms - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Mice, Transgenic | p38 Mitogen-Activated Protein Kinases - immunology | Tumor Burden | Fibrinogen - genetics | Disease Progression | STAT Transcription Factors - genetics | Animals | Glioblastoma - immunology | NF-kappa B - genetics | Glioblastoma - pathology | Survival Analysis | Cell Line, Tumor | Mice | CD8-Positive T-Lymphocytes - immunology | Glioblastoma - mortality | Integrin alpha Chains - genetics | Cell proliferation | Brain | Brain tumors | Brain cancer | Glioblastoma | Differentiation (biology) | Stem cell transplantation | Cerebrospinal fluid | Kinases | Granulocyte-macrophage colony stimulating factor | Lymph nodes | Proteins | Cell activation | CD103 antigen | Glioma cells | Fibrinogen | Colony-stimulating factor | Inhibition | Stat1 protein | Fgl2 protein | NF-κB protein | Arbitration | Dendritic cells | Immunoregulation | Granulocyte-macrophage colony-stimulating factor | Tumor cells | Immunodeficiency | Cell differentiation | Gene expression | Low level | Drainage | Stem cells | Tumors
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 07/2014, Volume 32, Issue 19, pp. 2050 - 2058
Journal Article
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7543, pp. 366 - 369
After stimulation, dendritic cells(DCs) mature andmigrate to draining lymph nodes to induce immune responses(1). As such, autologous DCs generated ex vivo have... 
MALIGNANT GLIOMA | RESPONSES | IMMUNITY | MULTIDISCIPLINARY SCIENCES | HUMAN CYTOMEGALOVIRUS | VACCINATION | PERIPHERAL-BLOOD | MELANOMA-CELLS | MIP-1-ALPHA | TUMORS | T-CELLS | Phosphoproteins - immunology | Immunotherapy - methods | Viral Matrix Proteins - genetics | Chemokine CCL3 - immunology | Dendritic Cells - immunology | Humans | Substrate Specificity | Phosphoproteins - chemistry | CD4-Positive T-Lymphocytes - immunology | Cancer Vaccines - therapeutic use | Dendritic Cells - drug effects | Female | Lymph Nodes - drug effects | Tetanus Toxoid - pharmacology | Antigens, Neoplasm - immunology | Cancer Vaccines - administration & dosage | Mice, Inbred C57BL | Tetanus Toxoid - therapeutic use | Survival Rate | Treatment Outcome | Lymph Nodes - immunology | Phosphoproteins - genetics | Lymph Nodes - cytology | Tetanus Toxoid - administration & dosage | Glioblastoma - therapy | Cancer Vaccines - immunology | Cell Movement - drug effects | Animals | Glioblastoma - immunology | Viral Matrix Proteins - chemistry | Glioblastoma - pathology | Dendritic Cells - cytology | Mice | Viral Matrix Proteins - immunology | Glioblastoma - drug therapy | CD4-Positive T-Lymphocytes - drug effects | Medical research | Dendritic cells | Physiological aspects | Medicine, Experimental | Vaccines | Research | Glioblastoma multiforme | Immunization | Lymphocytes | Medical prognosis | Clinical trials | Tetanus | Chemokines
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 1/2013, Volume 62, Issue 1, pp. 125 - 135
This study evaluated the safety and immune responses to an autologous dendritic cell vaccine pulsed with class I peptides from tumor-associated antigens (TAA)... 
Cancer vaccine | Immunology | Medicine & Public Health | Glioblastoma | Oncology | Cancer Research | CTL | Epitopes | Cancer stem cells | Dendritic cell immunotherapy | GP100 | MARKER CD133 | IMMUNOLOGY | IDENTIFICATION | CANCER STEM-CELLS | MALIGNANT GLIOMA | CYTOTOXIC T-CELLS | ONCOLOGY | IMMUNOTHERAPY | GENE-EXPRESSION | PCR | ANTIGEN | Antigens, Neoplasm - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Brain Neoplasms - pathology | Histocompatibility Antigens Class I - immunology | Kaplan-Meier Estimate | Neoplastic Stem Cells - immunology | Male | Reverse Transcriptase Polymerase Chain Reaction | Epitopes - immunology | Glioblastoma - therapy | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Brain Neoplasms - immunology | Glioblastoma - immunology | Glioblastoma - pathology | Brain Neoplasms - therapy | Adult | Female | Aged | Brain Neoplasms - mortality | Dendritic Cells - transplantation | Glioblastoma - mortality | Rare earth metals | Care and treatment | Peptides | Dendritic cells | Immunotherapy | Stem cells | Clinical trials | Product development | Vaccines | T cells | Glioblastoma multiforme | Autografts | Brain stem | Brain tumors | Data processing | Leukocytes (mononuclear) | ErbB-2 protein | Survival | Leukapheresis | Glioma | Antigen (tumor-associated) | Interleukin 1 | Histocompatibility antigen HLA | Glycoprotein gp100 | Tumors | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 9, pp. 1 - 12
Background: Studies of patients with paraneoplastic neurologic disorders (PND) have revealed that apoptotic tumor serves as a potential potent trigger for the... 
MALIGNANT GLIOMA | METASTATIC MELANOMA | PULSED DENDRITIC CELLS | PARANEOPLASTIC CEREBELLAR DEGENERATION | EFFICIENT PRESENTATION | MULTIDISCIPLINARY SCIENCES | APOPTOTIC CELLS | NECROSIS-FACTOR-ALPHA | T-CELLS | CROSS-PRESENTATION | ANTIGEN | Dendritic Cells - immunology | Humans | Middle Aged | Vaccination | Male | Cell- and Tissue-Based Therapy | Prostatic Neoplasms - immunology | Cancer Vaccines - immunology | Cancer Vaccines - therapeutic use | Aged, 80 and over | Cell Line, Tumor | Female | Aged | Dendritic Cells - cytology | Prostate-Specific Antigen - immunology | Dendritic Cells - transplantation | Prostatic Neoplasms - drug therapy | Apoptosis | Medical research | Nervous system diseases | Dendritic cells | Prostate-specific antigen | Clinical trials | Vaccines | T cells | Medicine, Experimental | Product development | Prostate cancer | Tumors | Cell proliferation | Peptides | Laboratories | Hypersensitivity (delayed) | CD8 antigen | Oncology | Lymphocytes T | Metastasis | Immunity | Cancer therapies | Cancer vaccines | Granulocytes | Lymphocytes | Rodents | Immunotherapy | Tumor necrosis factor-TNF | Foxp3 protein | Safety | Antigens | Immunization | Immune response | Statistical analysis | Cytokines | Immunoregulation | Tumor cells | Hypersensitivity | Feasibility studies | Melanoma | T cell receptors | Patients | CD4 antigen | Studies | Immunogenicity | Prostate | Cancer | Prostate-Specific Antigen/immunology | Dendritic Cells/cytology | Cancer Vaccines/therapeutic use | Life Sciences | Prostatic Neoplasms/immunology | Immunology | Cancer Vaccines/immunology | Dendritic Cells/transplantation | Prostatic Neoplasms/drug therapy | Dendritic Cells/immunology
Journal Article
Psychological Medicine, ISSN 0033-2917, 12/2016, Volume 46, Issue 16, pp. 3303 - 3313
Background. Autoimmune encephalitis associated with anti-neuronal antibodies may be challenging to distinguish from primary psychiatric disorders. The... 
Antibodies | psychiatry | autoimmunity | N-methyl D-aspartate (NMDA) receptor | LIMBIC ENCEPHALITIS | NMDA-RECEPTOR ENCEPHALITIS | SCHIZOPHRENIA | PSYCHOLOGY, CLINICAL | PSYCHOLOGY | NEUROPSYCHIATRIC DISORDERS | IMPORTANT DIFFERENTIAL-DIAGNOSIS | DISEASE | ACUTE-PSYCHOSIS | CASE SERIES | EARLY RECOGNITION | Cross-Sectional Studies | Nerve Tissue Proteins - immunology | Psychotic Disorders - immunology | Humans | Middle Aged | Depressive Disorder - immunology | Male | Membrane Proteins - immunology | Hospitalization | Mental Disorders - immunology | Proteins - immunology | Autoantibodies - immunology | Bipolar Disorder - immunology | Schizophrenia - immunology | Receptors, GABA-B - immunology | Norway | Adult | Female | Receptors, AMPA - immunology | Glutamate Decarboxylase - immunology | Receptors, N-Methyl-D-Aspartate - immunology | Immunoglobulin M | Glutamic acid | Mentally ill people | Mental disorders | Immunoglobulin G | Patient care | LGI1 protein | Immunoglobulin | Clinical inferences | Glutamic acid receptors | Forensic evidence | Leucine | Immunoglobulin A | Psychosis | Mental health care | Psychoses | Contactin | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Classification | Serum | Mental health services | Diagnosis | γ-Aminobutyric acid B receptors | Encephalitis | Autoantibodies | Acute | Clinical research | N-Methyl-D-aspartic acid receptors | Glutamate decarboxylase | Acids | Glioma | Monoclonal antibodies | Autoimmune diseases | Immunofluorescence | Psychiatric disorders | Psychiatric symptoms | Psychiatry | Laboratories | Schizophrenia | Bipolar disorder | Medical diagnosis | γ-Aminobutyric acid | Antigens | Immunoglobulins | Blood & organ donations | Patient admissions | Psychologists | Patients | Studies | Inpatient care | Methods
Journal Article