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Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 601 - 613
The proto-oncogene is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we... 
PROGENITORS | SOX9 EXPRESSION | ONCOLOGY | SONIC HEDGEHOG | MOUSE MODEL | EMBRYONIC LETHALITY | PROLIFERATION | GENERATION | MUTATIONS | PEDIATRIC MEDULLOBLASTOMA | ASTROCYTES | CELL BIOLOGY | Oncogene Proteins - genetics | Cell Proliferation | Humans | Zinc Finger Protein Gli2 | Brain Stem - metabolism | Hedgehog Proteins - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | Glioma - pathology | Medulloblastoma - pathology | Cell Differentiation | N-Myc Proto-Oncogene Protein | Cerebellar Neoplasms - pathology | Prosencephalon - metabolism | Cerebellar Neoplasms - metabolism | Biomarkers - metabolism | Neuroectodermal Tumors, Primitive - metabolism | SOX9 Transcription Factor - metabolism | Transduction, Genetic | Signal Transduction | Oncogene Proteins - metabolism | Brain Neoplasms - genetics | Mice, Transgenic | Medulloblastoma - metabolism | Gestational Age | Cell Lineage | Mice, Nude | Brain Stem - embryology | Mice | Mutation | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Glioma - metabolism | Cerebellum - embryology | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Female | Nuclear Proteins - genetics | Spheroids, Cellular | Proto-Oncogene Proteins - metabolism | Cerebellum - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Neural Stem Cells - pathology | Animals | Cell Transformation, Neoplastic - pathology | Prosencephalon - embryology | Neural Stem Cells - metabolism | SOX9 Transcription Factor - genetics | Neuroectodermal Tumors, Primitive - pathology | Gliomas | Children's hospitals | Oncology, Experimental | Brain tumors | Stem cells | Transplantation | Universities and colleges | Research | Statistics | Tumors | Cancer | Index Medicus | N-MYC | glioma | SOX9 | medulloblastoma | neural stem cells | GFAP | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, pp. e112945 - e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 16062 - 16067
Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is thought that tumor regrowth originates from GSCs, thus rendering GSCs... 
Lactates | Cellular metabolism | Glioma | Stem cells | Cell lines | Glycolysis | Progenitor cells | Cellular differentiation | Tumors | Cancer | INITIATING CELLS | PYRUVATE-KINASE | PATHWAY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ISOFORM | IDENTIFICATION | TUMOR-GROWTH | CANCER | RADIATION | GLIOBLASTOMA PATIENTS | Immunohistochemistry | Reactive Oxygen Species - metabolism | Uncoupling Agents - pharmacology | Neoplastic Stem Cells - drug effects | Tissue Array Analysis | Humans | Stem Cells - metabolism | Glycolysis - drug effects | Glioma - metabolism | Oligomycins - pharmacology | Neoplastic Stem Cells - metabolism | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Glioma - pathology | Oxygen Consumption | Positron-Emission Tomography - methods | Clone Cells - metabolism | Blotting, Western | Lactates - metabolism | Energy Metabolism | Glucose - pharmacokinetics | Cell Line, Tumor | Glucose - metabolism | Stem Cells - drug effects | Proteasome Endopeptidase Complex - metabolism | Physiological aspects | Cell metabolism | Research | Diagnosis | Gliomas | Glucose | Metabolism | Pyruvate kinase | Brain tumors | Acidification | Oxygen consumption | imaging | Emissions | Glucose metabolism | Progeny | Mitochondria | Oxidative phosphorylation | Glioma cells | Cell cycle | Metabolic pathways | Lactic acid | ATP | Positron emission tomography | Index Medicus | Biological Sciences
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2012, Volume 15, Issue 6, pp. 827 - 837
Journal Article
journal of histochemistry and cytochemistry, ISSN 0022-1554, 2015, Volume 63, Issue 7, pp. 481 - 493
Journal Article
Oncogene, ISSN 0950-9232, 01/2016, Volume 35, Issue 1, pp. 12 - 21
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2166 - 2166
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and... 
DNA METHYLATION | MAMMALIAN DNA | 5-METHYLCYTOSINE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHENOTYPE | RETINOIC ACID RECEPTORS | ACUTE MYELOID-LEUKEMIA | MUTATIONS | 5-CARBOXYLCYTOSINE | DISCOVERY | Neoplasms - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Gene Expression Regulation, Neoplastic | Cholangiocarcinoma - metabolism | Bone Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Bone Neoplasms - metabolism | Glioma - metabolism | DNA-Binding Proteins - metabolism | Glioma - genetics | DNA Methylation | Neoplasms - genetics | Glioma - pathology | Trans-Activators - genetics | Chondrosarcoma - genetics | Chondrosarcoma - pathology | Bone Neoplasms - genetics | Bile Duct Neoplasms - genetics | Proto-Oncogene Proteins - metabolism | Central Nervous System Neoplasms - metabolism | Bile Duct Neoplasms - metabolism | Signal Transduction | Leukemia, Myeloid, Acute - pathology | Central Nervous System Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Proto-Oncogene Proteins - genetics | Receptors, Retinoic Acid - metabolism | DNA-Binding Proteins - genetics | Central Nervous System Neoplasms - pathology | Cholangiocarcinoma - pathology | Chondrosarcoma - metabolism | Cholangiocarcinoma - genetics | Isocitrate Dehydrogenase - metabolism | Trans-Activators - metabolism | Glutarates - metabolism | Bile Duct Neoplasms - pathology | Mutation | Neoplasms - pathology | Leukemia, Myeloid, Acute - genetics | Index Medicus
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2014, Volume 5, Issue 5, pp. e1212 - e1212
Oxidative stress serves as an important regulator of both apoptosis and metabolic reprogramming in tumor cells. Chaetocin, a histone methyltransferase... 
YAP | ATM | Metabolism | JNK | Glioblastoma | ROS | YES-ASSOCIATED PROTEIN | GLIOMA-CELLS | ACTIVATION | DNA-DAMAGE | CANCER | CELL BIOLOGY | GROWTH | KAPPA-B AXIS | metabolism | UP-REGULATION | GLIOBLASTOMA CELLS | Reactive Oxygen Species - metabolism | Ataxia Telangiectasia Mutated Proteins - metabolism | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Glioma - genetics | Transfection | RNA Interference | Time Factors | Adenosine Triphosphate - metabolism | Glioma - pathology | Antineoplastic Agents - pharmacology | Brain Neoplasms - enzymology | Tumor Suppressor Proteins - metabolism | Glioma - enzymology | Pyruvate Kinase - metabolism | Lactic Acid - metabolism | Brain Neoplasms - genetics | Nuclear Proteins - metabolism | Phosphoproteins - genetics | Brain Neoplasms - drug therapy | Piperazines - pharmacology | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Tumor Protein p73 | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Glucose - metabolism | Cell Proliferation - drug effects | Mice | Enzyme Activation | Oxidative Stress - drug effects | Adaptor Proteins, Signal Transducing - metabolism | Hexokinase - metabolism | Glioma - drug therapy | Index Medicus | Original
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