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GLIA, ISSN 0894-1491, 04/2010, Volume 58, Issue 5, pp. 588 - 598
Neural injury leads to inflammation and activation of microglia that in turn may participate in progression of neurodegeneration. The mechanisms involved in... 
Neurodegenerative diseases | Innate immune system | Heme oxygenase-1 | OXIDATIVE STRESS | ACTIVATION | LEWY BODY DISEASE | heme oxygenase-1 | NEUROSCIENCES | innate immune system | CELL-DEATH | neurodegenerative diseases | TRANSCRIPTION FACTOR NRF2 | BRAIN INFLAMMATION | MOUSE MODEL | THERAPEUTIC TARGET | ENHANCES SUSCEPTIBILITY | Dopamine Plasma Membrane Transport Proteins - metabolism | Tyrosine 3-Monooxygenase - metabolism | Flow Cytometry - methods | Leukocyte Common Antigens - metabolism | Reactive Oxygen Species - metabolism | Culture Media, Conditioned - pharmacology | Male | Glial Fibrillary Acidic Protein - metabolism | Brain - metabolism | MPTP Poisoning - complications | Inflammation - metabolism | Microglia - physiology | MPTP Poisoning - pathology | Antigens, Differentiation - metabolism | Neurons - metabolism | Neurons - drug effects | Dopamine - metabolism | Gliosis - etiology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Neurons - chemistry | Mice, Inbred C57BL | Gene Expression Regulation - physiology | NF-E2-Related Factor 2 - deficiency | Inflammation - etiology | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Analysis of Variance | Microfilament Proteins | NF-E2-Related Factor 2 - metabolism | Cyclooxygenase 2 - metabolism | Brain - pathology | Mice | CD11b Antigen - metabolism | Cell Line, Transformed | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 02/2012, Volume 73, Issue 4, pp. 685 - 697
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2008, Volume 31, Issue 4, pp. 578 - 590
Abstract Astrocyte pathology occurs in association with Alzheimer's disease (AD) and in brain ageing, but is poorly characterised. We sought to define the... 
Neurology | Internal Medicine | Aging | Alzheimer's type pathology | Excitatory amino acid transporter | Temporal cortex | Astrocyte | Glial fibrillary acidic protein | OXIDATIVE STRESS | AMYLOID PLAQUES | FIBROUS ASTROCYTES | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | COGNITIVE FUNCTION | GERIATRICS & GERONTOLOGY | IN-VITRO | CEREBROSPINAL-FLUID S100B | SENILE-DEMENTIA | FIBRILLARY ACIDIC PROTEIN | GLUTAMATE TRANSPORTER | Immunohistochemistry | Predictive Value of Tests | Prospective Studies | Humans | Astrocytes - pathology | Nerve Tissue Proteins - analysis | tau Proteins - metabolism | Male | Gliosis - physiopathology | Nerve Growth Factors - metabolism | Glial Fibrillary Acidic Protein - metabolism | Alzheimer Disease - pathology | Brain - metabolism | Gliosis - pathology | Amyloid beta-Peptides - metabolism | Aged, 80 and over | Female | Biomarkers - metabolism | Severity of Illness Index | Alzheimer Disease - physiopathology | Plaque, Amyloid - pathology | S100 Calcium Binding Protein beta Subunit | Brain - physiopathology | Glial Fibrillary Acidic Protein - analysis | Gliosis - metabolism | Biomarkers - analysis | S100 Proteins - metabolism | Excitatory Amino Acid Transporter 1 - metabolism | Excitatory Amino Acid Transporter 2 - analysis | Excitatory Amino Acid Transporter 2 - metabolism | S100 Proteins - analysis | Nerve Growth Factors - analysis | Nerve Tissue Proteins - metabolism | Phenotype | Alzheimer Disease - metabolism | Amyloid beta-Peptides - analysis | Brain - pathology | Plaque, Amyloid - metabolism | Aged | tau Proteins - analysis | Excitatory Amino Acid Transporter 1 - analysis | Longitudinal Studies | Astrocytes - metabolism | Cohort Studies | Amino acids | Genetic aspects | Alzheimer's disease | Intermediate filament proteins | Public health | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, pp. e0145467 - e0145467
Alzheimer's disease (AD) is the major cause of dementia worldwide. The pharmacological activation of nuclear receptors (Liver X receptors: LXRs or Retinoid X... 
WILD-TYPE | AMYLOID BETA-PEPTIDE | ADULT NEUROGENESIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | SUBVENTRICULAR ZONE | TRANSGENIC MODEL | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | APOLIPOPROTEIN-E | Benzoates - therapeutic use | Cerebral Cortex - pathology | tau Proteins - metabolism | Cognition Disorders - metabolism | Male | Hippocampus - drug effects | Orphan Nuclear Receptors - metabolism | Apolipoproteins E - metabolism | Excitatory Postsynaptic Potentials - drug effects | ATP Binding Cassette Transporter 1 - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Gliosis - pathology | Dentate Gyrus - drug effects | Long-Term Potentiation - drug effects | Liver X Receptors | Amyloid beta-Peptides - metabolism | Female | Cerebral Cortex - drug effects | Biomarkers - metabolism | Alzheimer Disease - physiopathology | Cognition Disorders - physiopathology | Dentate Gyrus - metabolism | Orphan Nuclear Receptors - agonists | Neural Stem Cells - drug effects | Alzheimer Disease - drug therapy | Mice, Transgenic | Nuclear Proteins - metabolism | Hippocampus - pathology | Cognition Disorders - drug therapy | Gliosis - complications | Nerve Tissue Proteins - metabolism | Nestin - metabolism | Up-Regulation - drug effects | Hippocampus - metabolism | Cognition Disorders - complications | Animals | Alzheimer Disease - metabolism | Fluorescent Antibody Technique | Benzoates - pharmacology | Protein Biosynthesis - drug effects | Cell Proliferation - drug effects | Benzylamines - pharmacology | Benzylamines - therapeutic use | Dentate Gyrus - pathology | Neural Stem Cells - metabolism | Brain | Advertising executives | Cognition | Apolipoproteins | Alzheimer's disease | Liver | Amyloidogenesis | Peptides | Cognitive ability | Proteins | Receptors | Neurodegeneration | Physiology | Chemical synthesis | Neurodegenerative diseases | Cortex | Protein biosynthesis | Behavioral sciences | Metabolism | Retinoid X receptors | Nuclear receptors | Dentate gyrus | Gliosis | Molecular modelling | Tau protein | Protein synthesis | Stem cells | Ligands | ATP-binding protein | Hippocampus | Animal models | Cerebral cortex | Lipids | Kinases | Neurogenesis | ABCA1 protein | Reduction | Metabolites | Apolipoprotein E | Rodents | Dementia disorders | Liver X receptors | Neurons | Pharmacology | Cholesterol | Cortex (entorhinal) | Plasticity (synaptic) | Presenilin 1 | Laboratory animals | Alzheimers disease | Animal cognition | Index Medicus
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2014, Volume 44, pp. 221 - 234
Journal Article
Neuropathology and Applied Neurobiology, ISSN 0305-1846, 06/2009, Volume 35, Issue 3, pp. 306 - 328
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2014, Volume 45, pp. 80 - 97
Highlights • Transgenic IL-10 production in the CNS induces a specific activated microglial phenotype. • IL-10-induced microglia shows increased Iba1, CD11b,... 
Psychiatry | Allergy and Immunology | CD150 | Transgenic mice | Cytokine | Neuroinflammation | LTP | Iba1 | F4/80 | CD11b | GFAP | Microglial plasticity | Gliosis | IL-10R | CD16/32 | TGF-BETA | DEVELOPING RAT-BRAIN | IMMUNOLOGY | EXPRESSION PATTERNS | TUMOR-NECROSIS-FACTOR | MULTIPLE-SCLEROSIS | CENTRAL-NERVOUS-SYSTEM | PRO-INFLAMMATORY CYTOKINES | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | NEUROSCIENCES | TRAUMATIC BRAIN-INJURY | TRANSCRIPTION FACTOR | Glial Fibrillary Acidic Protein - genetics | Microglia - metabolism | CA1 Region, Hippocampal - cytology | Neurons - cytology | RNA, Messenger - metabolism | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Receptors, IgG - metabolism | Synapses - metabolism | CA3 Region, Hippocampal - metabolism | Antigens, Differentiation - metabolism | CA1 Region, Hippocampal - metabolism | Microfilament Proteins - metabolism | Neurons - metabolism | Astrocytes - cytology | Calcium-Binding Proteins - metabolism | Microglia - cytology | Dendrites - metabolism | CA3 Region, Hippocampal - cytology | Cerebellum - metabolism | Mice, Transgenic | Long-Term Potentiation - genetics | Hippocampus - cytology | Hippocampus - metabolism | Phenotype | Animals | Interleukin-10 - genetics | Cerebellum - cytology | Neural Pathways - metabolism | Mice | CD11b Antigen - metabolism | Astrocytes - metabolism | Animal genetic engineering | Genetic aspects | Interleukins | Neurons | Index Medicus
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2006, Volume 99, Issue 4, pp. 1263 - 1272
It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin‐1β... 
interleukin‐1β | interferon‐γ | long‐term potentiation | age | interleukin‐18 | microglial activation | Interleukin-18 | Interferon-γ | Interleukin-1β | Long-term potentiation | Age | Microglial activation | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | NEUROSCIENCES | PROTEIN-KINASES | CELL-DEATH | IN-VITRO | interleukin-1 beta | interleukin-18 | MOUSE MODEL | AGING HUMAN BRAIN | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | interferon-gamma | long-term potentiation | Memory Disorders - physiopathology | Microglia - metabolism | Interleukin-18 - immunology | Interleukin-1alpha - immunology | Rats, Wistar | Minocycline - pharmacology | Memory Disorders - metabolism | Interleukin-1alpha - metabolism | Male | Gliosis - physiopathology | Interferon-gamma - metabolism | Dentate Gyrus - physiopathology | CD40 Antigens - metabolism | Encephalitis - physiopathology | Microglia - immunology | Long-Term Potentiation - drug effects | Encephalitis - metabolism | Long-Term Potentiation - physiology | Gliosis - immunology | B7-2 Antigen - immunology | Cytokines - immunology | Biomarkers - metabolism | Dentate Gyrus - metabolism | Cytokines - metabolism | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Intercellular Adhesion Molecule-1 - immunology | Gliosis - metabolism | Rats | Encephalitis - immunology | Memory Disorders - immunology | B7-2 Antigen - metabolism | Hippocampus - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Aging - physiology | Interferon-gamma - immunology | Hippocampus - physiopathology | CD40 Antigens - immunology | Interleukin-18 - metabolism | Brain | Neurology | Cytokines | Long term | Rodents | Index Medicus
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 04/2008, Volume 86, Issue 5, pp. 1125 - 1131
Journal Article