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Antioxidants & Redox Signaling, ISSN 1523-0864, 07/2016, Volume 25, Issue 2, pp. 61 - 77
Aims: This preclinical study was aimed at determining whether pharmacological targeting of transcription factor NRF2, a master controller of many homeostatic... 
Original Research Communications | OXIDATIVE STRESS | IN-VITRO | TRANSCRIPTION FACTOR NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | MPTP MOUSE MODEL | ALPHA-SYNUCLEIN | HEME OXYGENASE-1 | AUTOPHAGY | NF-KAPPA-B | EXPRESSION | NEUROPROTECTION | Immunohistochemistry | NF-E2-Related Factor 2 - agonists | Parkinson Disease - drug therapy | RNA, Messenger - metabolism | Autophagy | Brain - metabolism | Gliosis - pathology | Neuroprotective Agents - pharmacology | Dimethyl Fumarate - pharmacology | NF-E2-Related Factor 2 - genetics | Parkinson Disease - metabolism | Neuroprotective Agents - administration & dosage | Disease Models, Animal | Gene Expression | Gliosis - genetics | Parkinson Disease - pathology | Synucleins - genetics | Gliosis - metabolism | RNA, Messenger - genetics | Drug Repositioning | Synucleins - metabolism | Mice, Knockout | Phenotype | Animals | Mice | Dimethyl Fumarate - administration & dosage | Care and treatment | Parkinson's disease | Research | Gene expression | Dimethyl | Neuroprotection | Brain | Therapy | Oxidative stress | Basal ganglia | Multiple sclerosis | Mesencephalon | Toxicity | Substantia nigra | Parkinsons disease | Innovations | Synuclein | Proteins | Neurotoxicity | Autopsy | Movement disorders | Dopamine receptors | Recombinant | Phenotypes | Dopamine | Wound healing | Neurodegenerative diseases | Pharmacology | Inflammation | Disease control | Ganglia | Lewy bodies | Gliosis | Cell death | Phagocytosis | Index Medicus
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2017, Volume 23, Issue 33, pp. 4979 - 4989
Journal Article
Annals of Neurology, ISSN 0364-5134, 02/2017, Volume 81, Issue 2, pp. 212 - 226
Objectives Friedreich's ataxia is a devastating neurological disease currently lacking any proven treatment. We studied the neuroprotective effects of the... 
TRIPLET-REPEAT EXPANSION | SIGNALING PATHWAYS | COLONY-STIMULATING FACTOR | ADULT NEUROGENESIS | FRATAXIN DEFICIENCY LEADS | TAIL NERVES | STEM-CELL FACTOR | OPEN-LABEL | AMYOTROPHIC-LATERAL-SCLEROSIS | G-CSF | NEUROSCIENCES | CLINICAL NEUROLOGY | Friedreich Ataxia - metabolism | Friedreich Ataxia - drug therapy | Humans | Mice, Inbred C57BL | Mice, Transgenic | Peripheral Nerves - drug effects | Iron-Binding Proteins - metabolism | Stem Cell Factor - administration & dosage | Friedreich Ataxia - physiopathology | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Neuroprotective Agents - pharmacology | Stem Cell Factor - pharmacology | Behavior, Animal - drug effects | Mice | Neural Conduction - drug effects | Neuroprotective Agents - administration & dosage | Disease Models, Animal | Granulocyte Colony-Stimulating Factor - administration & dosage | Ataxia | Cytokines | Rodents | Stem cells | Cerebellum | Neuroprotection | Conduction | Spinal cord | Regulators | Performance tests | Animal models | Pathogenesis | mRNA | Cerebrospinal fluid | Motor task performance | Stem cell factor | Defects | Nerve conduction | Dorsal root ganglia | Frataxin | Granulocyte colony-stimulating factor | Colony-stimulating factor | Locomotor activity | Medical treatment | Ganglia | Friedreich's ataxia | Gliosis | Ribonucleic acids | Neural stem cells | Leukocytes (granulocytic)
Journal Article
Current Opinion in Psychiatry, ISSN 0951-7367, 03/2019, Volume 32, Issue 2, pp. 105 - 116
Journal Article
Molecular Therapy, ISSN 1525-0016, 12/2011, Volume 19, Issue 12, pp. 2152 - 2162
Journal Article
American Journal of Hematology, ISSN 0361-8609, 04/2018, Volume 93, Issue 4, pp. 590 - 594
Journal Article
CURRENT PHARMACEUTICAL DESIGN, ISSN 1381-6128, 2017, Volume 23, Issue 33, pp. 4979 - 4989
Alzheimer's disease (AD) is a devastating neurological illness with a heavy economic impact. Further comorbidities in combination with the social impact of... 
RECTIFYING POTASSIUM CHANNELS | NEURONAL-ACTIVITY | NADPH OXIDASE | genetic manipulation | reactive gliosis | Astrocytes | GLUTAMATE UPTAKE | METABOLIC PHENOTYPE | FACTOR-ALPHA | ATTENUATES SYNAPTIC DYSFUNCTION | pharmacotherapy | MOUSE MODEL | PHARMACOLOGY & PHARMACY | Alzheimer's disease | neurotrophins | CEREBRAL-ISCHEMIA | UP-REGULATION
Journal Article
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 6/2018, Volume 55, Issue 6, pp. 5299 - 5309
Journal Article
Experimental Neurology, ISSN 0014-4886, 09/2016, Volume 283, Issue Pt A, pp. 330 - 340
Used in combination with immunomodulatory therapies, remyelinating therapies are a viable therapeutic approach for treating individuals with multiple... 
Differential remyelination | Internodal length | Therapeutic | Mice | Myelin | Ultrastructure | CORTICAL DEMYELINATION | WHITE-MATTER | CNS REMYELINATION | THYROID-HORMONE | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | EXTENDS LIFE-SPAN | NEUROSCIENCES | MULTIPLE-SCLEROSIS | OLIGODENDROCYTE PROGENITOR MATURATION | CENTRAL-NERVOUS-SYSTEM | CUPRIZONE-INDUCED DEMYELINATION | Gliosis - chemically induced | Male | Glial Fibrillary Acidic Protein - metabolism | White Matter - ultrastructure | Triiodothyronine - therapeutic use | Time Factors | Axons - ultrastructure | Brain - ultrastructure | Myelin Proteolipid Protein - metabolism | Demyelinating Diseases - chemically induced | Microfilament Proteins - metabolism | Demyelinating Diseases - pathology | Sirolimus - adverse effects | Demyelinating Diseases - drug therapy | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cuprizone - toxicity | Mice, Inbred C57BL | White Matter - drug effects | Regeneration - physiology | White Matter - pathology | Monoamine Oxidase Inhibitors - toxicity | Regeneration - drug effects | Animals | Axons - pathology | Brain - pathology | Immunosuppressive Agents - adverse effects | In Vitro Techniques | Brain | Multiple sclerosis | Analysis | Therapeutics | Models | Thyroid hormones | Homeopathy | Materia medica and therapeutics | Neurosciences | myelin | therapeutic | ultra structure | internodal length | differential remyelination | mice
Journal Article