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Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects... 
INSULIN | HYPERGLUCAGONEMIA | ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | RECEPTOR GENE | SECRETION | DIFFERENTIATION | HYPERPLASIA | ISLET CELLS | EXPRESSION | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Islet Studies
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7657, pp. 248 - 253
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2012, Volume 32, Issue 14, pp. 4812 - 4820
Journal Article
Journal Article
Journal Article
Peptides (New York, N.Y. : 1980), ISSN 0196-9781, 2018, Volume 100, pp. 190 - 201
[Display omitted] •Unimolecular agonists targeting the receptors for GLP-1, GIP and Glucagon offer therapeutic value for the treatment of the metabolic... 
Type 2 diabetes | GLP-1/Glucagon Co-agonism | Polypharmacology | Gip | GLP-1 RECEPTOR AGONISTS | PROHORMONE CONVERTASE PC2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BODY-WEIGHT | TERM WEIGHT CONTROL | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELLS | PHARMACOLOGY & PHARMACY | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | GIP RECEPTOR | FED HIGH-FAT | Glucagon-Like Peptide-1 Receptor - antagonists & inhibitors | Receptors, Glucagon - genetics | Receptors, Glucagon - antagonists & inhibitors | Gastric Inhibitory Polypeptide - antagonists & inhibitors | Obesity - drug therapy | Glucagon-Like Peptide 1 - analogs & derivatives | Gastric Inhibitory Polypeptide - therapeutic use | Humans | Incretins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Gastrointestinal Hormones - antagonists & inhibitors | Obesity - metabolism | Obesity - pathology | Receptors, Gastrointestinal Hormone - antagonists & inhibitors | Gastrointestinal Hormones - therapeutic use | Glucagon-Like Peptide-1 Receptor - genetics | Insulin - metabolism | Receptors, Gastrointestinal Hormone - genetics | Gastrointestinal Hormones - genetics | Diabetes Mellitus, Type 2 - pathology | Glucagon-Like Peptide 1 - antagonists & inhibitors | Diabetes Mellitus, Type 2 - drug therapy | Insulin - genetics | Glucagon-Like Peptide 1 - therapeutic use | Hormones | Peptides | Drug therapy | Diabetes therapy | GLP-1 | Glucagon Co-agonism
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 29, pp. 15119 - 15130
Journal Article
Diabetologia, ISSN 1432-0428, 2015, Volume 59, Issue 2, pp. 363 - 370
Normal glucose metabolism depends on pancreatic secretion of insulin and glucagon. The bihormonal hypothesis states that while lack of insulin leads to glucose... 
Medicine & Public Health | Human Physiology | Glucagon | Glucose homeostasis | Type 1 diabetes | Metabolic Diseases | Internal Medicine | Streptozotocin | Endocrine pancreas | ENDOGENOUS GLUCAGON | GLP-1 | BLOOD-GLUCOSE | ENDOCRINOLOGY & METABOLISM | RECEPTOR | ANTIBODY | IMMUNONEUTRALIZATION | Receptors, Glucagon - antagonists & inhibitors | Streptozocin | Diabetes Mellitus, Experimental - genetics | Male | Glucagon - antagonists & inhibitors | Glucose Intolerance - blood | Glucose Intolerance - drug therapy | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Receptors, Glucagon - genetics | Glucose Intolerance - genetics | Glucose Tolerance Test | Glucagon-Like Peptide 1 - metabolism | Glucagon-Secreting Cells - pathology | Mice, Inbred C57BL | Glucagon - physiology | Mice, Knockout | Blood Glucose - drug effects | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Diabetes Mellitus, Experimental - pathology | Insulin - deficiency | Diphtheria Toxin | Mice | Glucagon - secretion | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Glucose metabolism | Hyperglycemia | Analysis | Genetic engineering | Glucose | Glucose tolerance tests | Insulin | Dextrose
Journal Article
Diabetes, obesity & metabolism, ISSN 1462-8902, 2016, Volume 18, Issue 5, pp. 475 - 482
Aims To evaluate the safety and efficacy of once‐weekly dulaglutide 1.5 mg, a long‐acting glucagon‐like peptide‐1 receptor agonist, compared with placebo in... 
glucagon‐like peptide‐1 | type 2 diabetes | dulaglutide | Type 2 diabetes | Dulaglutide | Glucagon-like peptide-1 | METFORMIN | GLYCEMIC CONTROL | SULFONYLUREA | glucagon-like peptide-1 | EXENATIDE | SITAGLIPTIN | OPEN-LABEL | TREATED PATIENTS | LIRAGLUTIDE | PARALLEL-GROUP | ENDOCRINOLOGY & METABOLISM | ASSOCIATION | Glycated Hemoglobin A - analysis | Recombinant Fusion Proteins - adverse effects | Glucagon-Like Peptides - administration & dosage | Humans | Middle Aged | Recombinant Fusion Proteins - therapeutic use | Male | Diabetes Mellitus, Type 2 - metabolism | Patient Dropouts | Immunoglobulin Fc Fragments - administration & dosage | Hypoglycemia - prevention & control | Drug Therapy, Combination - adverse effects | Glucagon-Like Peptide-1 Receptor - metabolism | Hypoglycemic Agents - administration & dosage | Injections, Subcutaneous | Female | Immunoglobulin Fc Fragments - therapeutic use | Hypoglycemia - chemically induced | Glucagon-Like Peptides - analogs & derivatives | Drug Resistance | Immunoglobulin Fc Fragments - adverse effects | Recombinant Fusion Proteins - administration & dosage | Hypoglycemic Agents - therapeutic use | Hyperglycemia - prevention & control | Double-Blind Method | Drug Administration Schedule | Sulfonylurea Compounds - therapeutic use | Sulfonylurea Compounds - adverse effects | Glucagon-Like Peptides - adverse effects | Diabetes Mellitus, Type 2 - blood | Intention to Treat Analysis | Aged | Glucagon-Like Peptides - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Glucagon-Like Peptide-1 Receptor - agonists | Glycosylated hemoglobin | Glimepiride | Glucose | Glucagon | Dextrose | Confidence intervals | Hypoglycemia | Diabetes | Motivation | Diabetes mellitus | Hemoglobin | Diarrhea | Nausea | Safety | Glucagon-like peptide 1 | Original
Journal Article