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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7370 - 7380
Journal Article
Diabetes, ISSN 0012-1797, 10/2014, Volume 63, Issue 10, pp. 3346 - 3358
GLP-1 receptor (GLP-1R) is widely located throughout the brain, but the precise molecular mechanisms mediating the actions of GLP-1 and its long-acting analogs... 
NERVOUS-SYSTEM | GLUCOSE-HOMEOSTASIS | ENERGY-EXPENDITURE | GLUCAGON-LIKE PEPTIDE-1 | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | RAT-BRAIN | DIET-INDUCED OBESITY | RECEPTORS | TYPE-2 DIABETES-MELLITUS | Protein Kinases - metabolism | Metformin - therapeutic use | Obesity - drug therapy | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Eating - physiology | Young Adult | Glucagon-Like Peptide 1 - agonists | Aged, 80 and over | Adult | Female | Hypothalamus - drug effects | Drug Therapy, Combination | Energy Metabolism - physiology | Hypoglycemic Agents - therapeutic use | Glucagon-Like Peptide 1 - analogs & derivatives | Metformin - pharmacology | Glucagon-Like Peptide 1 - pharmacology | Rats | Hypoglycemic Agents - pharmacology | Obesity - metabolism | Peptides - pharmacology | Eating - drug effects | Animals | Hypothalamus - metabolism | Venoms - therapeutic use | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Aged | Mice | Venoms - pharmacology | Thermogenesis - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Energy Metabolism - drug effects | Liraglutide | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Type 2 diabetes | Complications and side effects | Thermogenesis | Body weight | Brown adipose tissue | Development and progression | Research | Risk factors
Journal Article
Diabetes, ISSN 0012-1797, 04/2012, Volume 61, Issue 4, pp. 888 - 896
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2014, Volume 124, Issue 10, pp. 4473 - 4488
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 209, pp. 209ra151 - 209ra151
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones... 
MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | GLYCEMIC CONTROL | HIGH-FAT DIET | GLUCOSE-INTOLERANCE | ENTEROINSULAR AXIS | PANCREATIC BETA-CELLS | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | LIPOPROTEIN-LIPASE | PEPTIDE YY3-36 | CELL BIOLOGY | Acylation - drug effects | Glucagon-Like Peptide 1 - administration & dosage | Humans | Middle Aged | Male | Rodentia - metabolism | Weight Loss - drug effects | Hyperglycemia - drug therapy | Young Adult | Incretins - pharmacology | Adult | Female | Gastric Inhibitory Polypeptide - pharmacology | Receptors, Glucagon - agonists | Glucose Tolerance Test | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Rats | Receptors, Glucagon - metabolism | Treatment Outcome | Haplorhini - metabolism | Gastric Inhibitory Polypeptide - administration & dosage | Peptides - pharmacology | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Adolescent | Aged | Mice | Venoms - pharmacology | Incretins - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Gastrointestinal Hormone | Incretins - administration & dosage | Liraglutide | Medicin och hälsovetenskap | Medicinsk bioteknologi (inriktn. mot cellbiologi (inkl. stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi
Journal Article
Atherosclerosis, ISSN 0021-9150, 2012, Volume 221, Issue 2, pp. 375 - 382
Highlights ► Liraglutide can normalize TNF-α-induced pro-oxidant production in HUVEC probably through reduced expression of NADPH oxidase subunit gp91phox and... 
Cardiovascular | Oxidative stress | NF-κB | Endothelial cell | Inflammation | Apoptosis | CHRONIC HEART-FAILURE | TRANSLOCATION | PROTEIN-KINASE-C | PENTRAXIN 3 | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | IN-VITRO | NF-kappa B | ACUTE MYOCARDIAL-INFARCTION | DEGRADATION | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | VASCULAR NAD(P)H OXIDASE | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Membrane Glycoproteins - metabolism | Protein Kinase C-alpha - metabolism | Apoptosis - drug effects | Humans | NADPH Oxidases - metabolism | Human Umbilical Vein Endothelial Cells - immunology | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Dose-Response Relationship, Drug | C-Reactive Protein - metabolism | Transfection | I-kappa B Kinase - metabolism | Time Factors | Inflammation Mediators - metabolism | Superoxide Dismutase - metabolism | Recombinant Proteins - metabolism | Glutathione Peroxidase - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Anti-Inflammatory Agents - pharmacology | Glucagon-Like Peptide 1 - analogs & derivatives | Cells, Cultured | Glucagon-Like Peptide 1 - pharmacology | Antioxidants - pharmacology | NADPH Oxidase 2 | Protein Transport | Catalase - metabolism | NF-kappa B - genetics | Signal Transduction - drug effects | Serum Amyloid P-Component - metabolism | Oxidative Stress - drug effects | Liraglutide
Journal Article