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1. Full Text Discovery of the Once-Weekly Glucagon-Like Peptide‑1 (GLP-1) Analogue Semaglutide
by Lau, Jesper and Bloch, Paw and Schäffer, Lauge and Pettersson, Ingrid and Spetzler, Jane and Kofoed, Jacob and Madsen, Kjeld and Knudsen, Lotte Bjerre and McGuire, James and Steensgaard, Dorte Bjerre and Strauss, Holger Martin and Gram, Dorte X and Knudsen, Sanne Møller and Nielsen, Flemming Seier and Thygesen, Peter and Reedtz-Runge, Steffen and Kruse, Thomas
Journal of medicinal chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7370 - 7380
Glucagon-Like Peptide 1 - administration & dosage | Glucagon-Like Peptides - administration & dosage | Humans | Half-Life | Crystallography, X-Ray | Male | Structure-Activity Relationship | Glucagon-Like Peptide-1 Receptor - metabolism | Glucagon-Like Peptides - pharmacology | Liraglutide - pharmacology | Swine | Injections, Subcutaneous | Glucagon-Like Peptides - chemistry | Swine, Miniature | Cell Line | Cricetinae | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Models, Molecular | Glucagon-Like Peptide 1 - chemistry | Rats, Sprague-Dawley | Administration, Intravenous | Animals | Mice, Obese | Glucagon-Like Peptide-1 Receptor - agonists | Index Medicus
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2. Full Text Glucagon‐like peptide analogues for type 2 diabetes mellitus
by Shyangdan, Deepson S and Royle, Pamela and Clar, Christine and Sharma, Pawana and Waugh, Norman and Snaith, Ailsa and Shyangdan, Deepson S
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 2011, Volume 2013, Issue 7, pp. CD006423 - CD006423
Endocrine & metabolic | Hypoglycemic Agents | Diabetes Type 2 | Diabetes mellitus | Glycated Hemoglobin A | Type 2 Diabetes mellitus (formerly: non‐insulin‐dependent) | Glucagon‐Like Peptide 1 | Diabetes Mellitus, Type 2 | Diabetes mellitus and Related Disorders | Diabetes | Medicine General & Introductory Medical Sciences | Randomized Controlled Trials as Topic | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Hypoglycemic Agents - therapeutic use | Diabetes Mellitus, Type 2 - blood | Glucagon-Like Peptide 1 - analogs & derivatives | Glycated Hemoglobin A - metabolism | Humans | Diabetes Mellitus, Type 2 - drug therapy | Index Medicus
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3. Full Text Glucagon-like Peptide-1 Analogues for Type 2 Diabetes Mellitus
: Current and Emerging Agents
by Gallwitz, Baptist
Drugs (New York, N.Y.), ISSN 0012-6667, 9/2011, Volume 71, Issue 13, pp. 1675 - 1688
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Hormones. Endocrine system | Diabetes. Impaired glucose tolerance | Pharmacology. Drug treatments | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Glucagon-Like Peptide-1 Receptor | Glucagon-Like Peptide 1 - analogs & derivatives | Humans | Venoms - therapeutic use | Incretins - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Liraglutide | Peptides - therapeutic use | Glucagon-Like Peptide 1 - therapeutic use | Type 2 diabetes | Complications and side effects | Glucagon | Physiological aspects | Hypoglycemic agents | Dosage and administration | Research | Drug therapy | Index Medicus
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4. Full Text Novel strategies in the oral delivery of antidiabetic peptide drugs – Insulin, GLP 1 and its analogs
by Ismail, Ruba and Csóka, Ildikó
European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, 06/2017, Volume 115, pp. 257 - 267
Antidiabetic peptides | GLP-1 | Polymeric nanoparticles | Nano-carriers | Quality by design | Micelles | Diabetes | Liposomes | Insulin | Solid lipid nanoparticles | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Glucagon-Like Peptide 1 - administration & dosage | Hypoglycemic Agents - administration & dosage | Administration, Oral | Humans | Insulin - administration & dosage | Drug Delivery Systems - methods | Peptides - administration & dosage | Peptides | Diabetes therapy | Glucagon | Proteases | Mortality | Index Medicus
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5. Full Text α‑Helix or β‑Turn? An Investigation into N‑Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin‑4
by Oddo, Alberto and Mortensen, Sofia and Thøgersen, Henning and De Maria, Leonardo and Hennen, Stephanie and McGuire, James N and Kofoed, Jacob and Linderoth, Lars and Reedtz-Runge, Steffen
Biochemistry (Easton), ISSN 0006-2960, 07/2018, Volume 57, Issue 28, pp. 4148 - 4154
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Exenatide - analogs & derivatives | Amino Acid Sequence | Cell Line | Protein Conformation, alpha-Helical | Glucagon-Like Peptide 1 - metabolism | Glucagon-Like Peptide 1 - analogs & derivatives | Humans | Glucagon-Like Peptide-1 Receptor - chemistry | Crystallography, X-Ray | Glucagon-Like Peptide 1 - chemistry | Exenatide - chemistry | Molecular Dynamics Simulation | Glucagon-Like Peptide-1 Receptor - metabolism | Animals | Protein Conformation, beta-Strand | Protein Domains | Exenatide - metabolism | Index Medicus
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6. Full Text Glucagon-like Peptide‑1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications
by Manandhar, Bikash and Ahn, Jung-Mo
Journal of medicinal chemistry, ISSN 0022-2623, 02/2015, Volume 58, Issue 3, pp. 1020 - 1037
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Insulin-Secreting Cells - metabolism | Animals | Glucagon-Like Peptide 1 - metabolism | Humans | Diabetes Mellitus - drug therapy | Diabetes Mellitus - metabolism | Molecular Imaging | Glucagon-Like Peptide 1 - therapeutic use | Index Medicus
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7. Full Text The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells
by Shiraki, Aya and Oyama, Jun-ichi and Komoda, Hiroshi and Asaka, Machiko and Komatsu, Aiko and Sakuma, Masashi and Kodama, Kazuhisa and Sakamoto, Yoshiko and Kotooka, Norihiko and Hirase, Tetsuaki and Node, Koichi
Atherosclerosis, ISSN 0021-9150, 2012, Volume 221, Issue 2, pp. 375 - 382
Cardiovascular | Oxidative stress | NF-κB | Endothelial cell | Inflammation | Apoptosis | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Cardiology. Vascular system | Blood vessels and receptors | Atherosclerosis (general aspects, experimental research) | Biological and medical sciences | Medical sciences | Vertebrates: cardiovascular system | Blood and lymphatic vessels | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Membrane Glycoproteins - metabolism | Protein Kinase C-alpha - metabolism | Apoptosis - drug effects | Humans | NADPH Oxidases - metabolism | Human Umbilical Vein Endothelial Cells - immunology | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Dose-Response Relationship, Drug | C-Reactive Protein - metabolism | Transfection | I-kappa B Kinase - metabolism | Time Factors | Inflammation Mediators - metabolism | Superoxide Dismutase - metabolism | Recombinant Proteins - metabolism | Glutathione Peroxidase - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Anti-Inflammatory Agents - pharmacology | Glucagon-Like Peptide 1 - analogs & derivatives | Cells, Cultured | Glucagon-Like Peptide 1 - pharmacology | Antioxidants - pharmacology | NADPH Oxidase 2 | Protein Transport | Catalase - metabolism | NF-kappa B - genetics | Signal Transduction - drug effects | Serum Amyloid P-Component - metabolism | Oxidative Stress - drug effects | Liraglutide | Index Medicus
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