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Journal Article
Expert Review of Gastroenterology and Hepatology, ISSN 1747-4124, 2013, Volume 7, Issue 3, pp. 197 - 199
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 01/2014, Volume 16, Issue 1, pp. 75 - 85
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 10/2018, Volume 123, pp. 111 - 123
The main disadvantages of glucagon-like peptide 1 (GLP-1) are its rapid degradation and excretion. These bottlenecks can be overcome by lipidation or other... 
Type 2 diabetes | Conformational constrain | Lipidation | Glucagon-like peptide 1 | DESIGN | GLP-1 RECEPTOR AGONISTS | EFFICACY | SAFETY | PLASMA STABILITY | DISCOVERY | OBESITY | DISEASE | PHARMACOLOGY & PHARMACY | TYPE-2 DIABETES-MELLITUS | DERIVATIVES | Glycosylated hemoglobin | Glucagon | Analysis | Body weight
Journal Article
Psychopharmacology, ISSN 0033-3158, 2/2019, Volume 236, Issue 2, pp. 603 - 611
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2018, Volume 157, pp. 177 - 187
Dimerization is viewed as an effective means to enhance the binding affinity and therapeutic potency of peptides. Both dimerization and lipidation effectively... 
Type 2 diabetes | Lipidization | Dimerization | Glucagon-like peptide 1 | HALF-LIFE | CHEMISTRY, MEDICINAL | GLP-1 RECEPTOR AGONISTS | EXENDIN-4 | PROLONGS | BIOLOGICAL EVALUATION | DISCOVERY | THERAPEUTIC UTILITIES | Albumin | Hypoglycemic agents | Glucagon | Fatty acids | Analysis | Index Medicus
Journal Article
Diabetes Care, ISSN 0149-5992, 2014, Volume 37, Issue 8, pp. 2159 - 2167
OBJECTIVE To compare the efficacy and safety of dulaglutide, a once-weekly GLP-1 receptor agonist, with placebo and exenatide in type 2 diabetic patients. The... 
GLYCEMIC CONTROL | GLUCAGON-LIKE PEPTIDE-1 | EXENDIN-4 | SITAGLIPTIN | ENDOCRINOLOGY & METABOLISM | ANALOG LIRAGLUTIDE | OPEN-LABEL | LY2189265 | TREATED PATIENTS | Recombinant Fusion Proteins - adverse effects | Glucagon-Like Peptides - administration & dosage | Humans | Middle Aged | Male | Immunoglobulin Fc Fragments - administration & dosage | Thiazolidinediones - administration & dosage | Metformin - adverse effects | Peptides - administration & dosage | Hypoglycemic Agents - administration & dosage | Venoms - administration & dosage | Female | Metformin - administration & dosage | Drug Therapy, Combination | Glucagon-Like Peptides - analogs & derivatives | Immunoglobulin Fc Fragments - adverse effects | Recombinant Fusion Proteins - administration & dosage | Drug Administration Schedule | Venoms - adverse effects | Hypoglycemia - drug therapy | Thiazolidinediones - adverse effects | Blood Glucose - drug effects | Glucagon-Like Peptides - adverse effects | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Peptides - adverse effects | Type 2 diabetes | Care and treatment | Safety and security measures | Dosage and administration | Metformin | Comparative analysis | Exenatide | Clinical trials | Hemoglobin | Diabetes | Product safety | Drug dosages | Placebo effect | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 2012, Volume 221, Issue 2, pp. 375 - 382
Highlights ► Liraglutide can normalize TNF-α-induced pro-oxidant production in HUVEC probably through reduced expression of NADPH oxidase subunit gp91phox and... 
Cardiovascular | Oxidative stress | NF-κB | Endothelial cell | Inflammation | Apoptosis | CHRONIC HEART-FAILURE | TRANSLOCATION | PROTEIN-KINASE-C | PENTRAXIN 3 | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | IN-VITRO | NF-kappa B | ACUTE MYOCARDIAL-INFARCTION | DEGRADATION | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | VASCULAR NAD(P)H OXIDASE | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Membrane Glycoproteins - metabolism | Protein Kinase C-alpha - metabolism | Apoptosis - drug effects | Humans | NADPH Oxidases - metabolism | Human Umbilical Vein Endothelial Cells - immunology | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Dose-Response Relationship, Drug | C-Reactive Protein - metabolism | Transfection | I-kappa B Kinase - metabolism | Time Factors | Inflammation Mediators - metabolism | Superoxide Dismutase - metabolism | Recombinant Proteins - metabolism | Glutathione Peroxidase - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Anti-Inflammatory Agents - pharmacology | Glucagon-Like Peptide 1 - analogs & derivatives | Cells, Cultured | Glucagon-Like Peptide 1 - pharmacology | Antioxidants - pharmacology | NADPH Oxidase 2 | Protein Transport | Catalase - metabolism | NF-kappa B - genetics | Signal Transduction - drug effects | Serum Amyloid P-Component - metabolism | Oxidative Stress - drug effects | Liraglutide | Index Medicus
Journal Article