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Diabetes (New York, N.Y.), ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects beta-cell function and blood glucose homeostasis... 
INSULIN | HYPERGLUCAGONEMIA | ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | RECEPTOR GENE | SECRETION | DIFFERENTIATION | HYPERPLASIA | ISLET CELLS | EXPRESSION | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Islet Studies
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 464, Issue 7292, pp. 1149 - 1154
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 567, Issue 7746, pp. 43 - 48
Cell-identity switches, in which terminally differentiated cells are converted into different cell types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals... 
SURVIVAL | THERAPY | ISLETS | DECOY SEARCH STRATEGY | CONVERSION | MULTIDISCIPLINARY SCIENCES | TISSUE | PANCREATIC BETA-CELLS | PROTEIN-PHOSPHORYLATION | EXPRESSION | EXOCRINE | Diabetes Mellitus - pathology | Organ Specificity - drug effects | Islets of Langerhans - drug effects | Homeodomain Proteins - metabolism | Humans | Transcriptome | Male | Cell Lineage - drug effects | Pancreatic Polypeptide-Secreting Cells - metabolism | Pancreatic Polypeptide-Secreting Cells - cytology | Maf Transcription Factors, Large - metabolism | Glucagon-Secreting Cells - drug effects | Maf Transcription Factors, Large - genetics | Islets of Langerhans - metabolism | Glucagon-Secreting Cells - metabolism | Trans-Activators - genetics | Female | Disease Models, Animal | Glucagon-Secreting Cells - cytology | Pancreatic Polypeptide - metabolism | Transduction, Genetic | Islets of Langerhans - pathology | Biomarkers - analysis | Diabetes Mellitus - metabolism | Islets of Langerhans - immunology | Glucose - pharmacology | Pancreatic Polypeptide-Secreting Cells - drug effects | Homeodomain Proteins - genetics | Cellular Reprogramming - drug effects | Insulin - metabolism | Animals | Sequence Analysis, RNA | Diabetes Mellitus - immunology | Diabetes Mellitus - therapy | Glucagon-Secreting Cells - transplantation | Proteomics | Glucose - metabolism | Glucagon - metabolism | Trans-Activators - metabolism | Mice
Journal Article
PloS one, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144597
The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs... 
IDENTITY | ALPHA-CELLS | MOUSE PANCREAS | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | INSULIN-SECRETION | 7B2 | MICE | ENZYMATIC-ACTIVITY | DIFFERENTIATION | EXPRESSION | Paired Box Transcription Factors - genetics | Homeodomain Proteins - metabolism | Somatostatin-Secreting Cells - cytology | Male | Cell Lineage - drug effects | Pancreatic Polypeptide-Secreting Cells - metabolism | Pancreatic Polypeptide-Secreting Cells - cytology | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Gene Expression Regulation, Developmental | Glucagon-Secreting Cells - metabolism | Somatostatin-Secreting Cells - drug effects | Female | Integrases - metabolism | Cell Differentiation | Insulin-Secreting Cells - cytology | Eye Proteins - genetics | Insulin - genetics | Cell Lineage - genetics | Genes, Reporter | Repressor Proteins - metabolism | Glucagon-Secreting Cells - cytology | Signal Transduction | Bacterial Proteins - genetics | Ghrelin - genetics | Repressor Proteins - genetics | PAX6 Transcription Factor | Pancreatic Polypeptide-Secreting Cells - drug effects | Homeodomain Proteins - genetics | Mice, Knockout | Ghrelin - metabolism | Insulin - metabolism | Animals | Eye Proteins - metabolism | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Integrases - genetics | Somatostatin-Secreting Cells - metabolism | Paired Box Transcription Factors - metabolism | Crosses, Genetic | Luminescent Proteins - metabolism | Care and treatment | Research | Glucagon | Pancreas | Ghrelin | Risk factors | Spinal cord | Cerebral cortex | Transcription factors | Deactivation | Maturation | Developmental biology | Genes | Organs | Glucose | Kinases | Cell differentiation | Inactivation | Insulin | Proteins | Pax6 protein | Rodents | Diabetes | Alzheimers disease | Life Sciences | Development Biology
Journal Article
Diabetes (New York, N.Y.), ISSN 0012-1797, 2013, Volume 62, Issue 7, pp. 2471 - 2480
Conversion of one terminally differentiated cell type into another (or transdifferentiation... 
HUMAN PANCREATIC-ISLETS | IN-VITRO | HYPERGLYCEMIA | THERAPY | LIVER | TISSUE | ENDOCRINOLOGY & METABOLISM | DIFFERENTIATION | MICROSCOPY | EXPRESSION | CONTEXT | Original Research
Journal Article
Nature medicine, ISSN 1546-170X, 2011, Volume 17, Issue 11, pp. 1481 - 1489
Journal Article
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 138, Issue 5, pp. 1954 - 1965.e8
Journal Article
Journal Article
American journal of physiology: endocrinology and metabolism, ISSN 0193-1849, 2012, Volume 303, Issue 9, pp. E1107 - E1116
.... SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells... 
Electrophysiology | Glucagon | Exocytosis | Somatostatin receptor 2 | Insulin | ACTIVATION | PHYSIOLOGY | insulin | INHIBITS GLUCAGON-SECRETION | INSULIN-SECRETION | ENDOCRINE PANCREAS | HUMAN ISLETS | IN-VITRO | electrophysiology | GLUCOSE-TRANSPORTER | ENDOCRINOLOGY & METABOLISM | somatostatin receptor 2 | glucagon | exocytosis | GATED ION CHANNELS | K+ CHANNEL | SUBTYPE 2 | Immunohistochemistry | Islets of Langerhans - drug effects | Insulin-Secreting Cells - secretion | Humans | RNA, Messenger - metabolism | Islets of Langerhans - secretion | Exocytosis - drug effects | Protein Subunits - metabolism | Receptors, Somatostatin - genetics | Receptors, Somatostatin - agonists | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Protein Isoforms - metabolism | Protein Isoforms - agonists | Islets of Langerhans - metabolism | Glucagon-Secreting Cells - metabolism | Islets of Langerhans - cytology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Insulin-Secreting Cells - cytology | Receptors, Somatostatin - metabolism | Glucagon-Secreting Cells - secretion | Somatostatin - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Potassium Channel Blockers - pharmacology | Protein Subunits - genetics | Membrane Potentials - drug effects | Recombinant Proteins - metabolism | Glucagon-Secreting Cells - cytology | Somatostatin - agonists | Cells, Cultured | Gene Expression Regulation | Recombinant Proteins - agonists | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Patch-Clamp Techniques | Insulin-Secreting Cells - drug effects | Calcium Signaling - drug effects | Kinetics | Protein Isoforms - genetics
Journal Article
eLife, ISSN 2050-084X, 2014, Volume 3, Issue 3, p. e01846
Direct lineage conversion of adult cells is a promising approach for regenerative medicine... 
MAFB | HORMONE | TRANSCRIPTION | MOUSE | BIOLOGY | DIRECT CONVERSION | NEURONS | HUMAN FIBROBLASTS | GENERATION | PAX6 | Homeodomain Proteins - metabolism | Humans | Cellular Reprogramming | Luminescent Proteins - biosynthesis | Maf Transcription Factors, Large - metabolism | Insulin-Secreting Cells - metabolism | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | Maf Transcription Factors, Large - genetics | Pancreas, Exocrine - cytology | Time Factors | Gene Expression Regulation, Developmental | Glucagon-Secreting Cells - metabolism | HEK293 Cells | Trans-Activators - genetics | Glucagon-Secreting Cells - physiology | Cell Transdifferentiation | Genes, Reporter | Insulin-Secreting Cells - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Mice, Knockout | Pancreas, Exocrine - physiology | Nerve Tissue Proteins - metabolism | Cell Lineage | Animals | Somatostatin-Secreting Cells - physiology | Luminescent Proteins - genetics | Trans-Activators - metabolism | Pancreas, Exocrine - metabolism | Somatostatin-Secreting Cells - metabolism | Acinar cells | Transcription factors | Glucagon | Insulin | Studies | Polymerase chain reaction | Regeneration | Rodents | Stem cells | DNA methylation | Fibroblasts | Somatostatin | Islets of Langerhans | Pancreas | Deoxyribonucleic acid--DNA
Journal Article