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Annals of the New York Academy of Sciences, ISSN 0077-8923, 04/2018, Volume 1417, Issue 1, pp. 104 - 115
Cancer immunotherapy involving blockade of immune checkpoint molecules, such as CTLA‐4 and PD‐1, has shown remarkable clinical success across several types of... 
regulatory T cells | OX40 | CTLA‐4 | PD‐1 | PD‐L1 | PD-l1 | CTLA-4 | Regulatory T cells | PD-1 | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | INDUCTION | SUPPRESSION | TUMOR-IMMUNITY | GROWTH-FACTOR-BETA | MELANOMA | PD-L1 | IMMUNE TOLERANCE | NIVOLUMAB | CARCINOMA | SELF-TOLERANCE | Glucocorticoid-Induced TNFR-Related Protein - antagonists & inhibitors | Immunotherapy - methods | T-Lymphocytes, Regulatory - classification | Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors | Receptors, CCR4 - immunology | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Humans | Antibodies, Monoclonal - therapeutic use | Vascular Endothelial Growth Factor A - immunology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | CTLA-4 Antigen - immunology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, OX40 - immunology | Receptors, CCR4 - antagonists & inhibitors | T-Lymphocytes, Regulatory - immunology | Models, Immunological | Neoplasms - therapy | Neoplasms - immunology | Transforming Growth Factor beta - antagonists & inhibitors | Glucocorticoid-Induced TNFR-Related Protein - immunology | CTLA-4 Antigen - antagonists & inhibitors | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Interleukin-2 Receptor alpha Subunit - immunology | Receptors, OX40 - antagonists & inhibitors | Development and progression | Care and treatment | Drug therapy | T cells | Immunotherapy | Cancer | Immunoregulation | Medical treatment | Medical services | Homeostasis | Immunosurveillance | Lymphocytes T | Immunity | Patients | Molecular chains | Anticancer properties | CD4 antigen | Inhibitors | Immune checkpoint | Lymphocytes | Foxp3 protein | Antitumor activity | Tumors
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 9, pp. 1685 - 1693
Fc gamma receptor (Fc gamma R) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPONSES | MELANOMA | ANTI-GITR MAB | REGULATORY T-CELLS | COSTIMULATION | IGG1 | CANCER-IMMUNOTHERAPY | IMMUNOLOGY | BLOCKADE | BINDING | TUMOR-IMMUNITY | Brief Definitive Report
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2019, Volume 25, Issue 5, pp. 759 - 766
Journal Article
Immunological Reviews, ISSN 0105-2896, 11/2011, Volume 244, Issue 1, pp. 197 - 217
GITR [glucocorticoid inducible tumor necrosis factor receptor (TNFR)‐related protein] and 4‐1BB are costimulatory TNFR family members that are expressed on... 
influenza | GITR | adoptive therapy | 4‐1BB | T cell | vaccination | 4-1BB | Adoptive therapy | Influenza | Vaccination | DENDRITIC CELLS | INDUCED TNF RECEPTOR | GLUCOCORTICOID-INDUCED TNFR | IMMUNOLOGY | CD28 COSTIMULATORY PATHWAY | CUTTING EDGE | EX-VIVO EXPANSION | TUMOR-NECROSIS-FACTOR | HERPESVIRUS ENTRY MEDIATOR | IN-VIVO | NF-KAPPA-B | Neoplasms - metabolism | Immunotherapy - methods | Humans | Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics | Signal Transduction - immunology | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Gene Expression - immunology | Antibodies - immunology | Influenza A virus - immunology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Glucocorticoid-Induced TNFR-Related Protein - antagonists & inhibitors | Immunity, Innate - drug effects | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Glucocorticoid-Induced TNFR-Related Protein - metabolism | Glucocorticoid-Induced TNFR-Related Protein - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism | Mice, Knockout | Neoplasms - drug therapy | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Antibodies - administration & dosage | Animals | Signal Transduction - drug effects | Neoplasms - immunology | T-Lymphocytes - immunology | Cell Proliferation - drug effects | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | Orthomyxoviridae Infections - virology | Autoimmunity - drug effects | Orthomyxoviridae Infections - immunology | Care and treatment | Corticosteroids | Analysis | Respiratory agents | Drug therapy | T cells | Health aspects | Cancer | Index Medicus
Journal Article
Journal of Translational Medicine, ISSN 1479-5876, 02/2014, Volume 12, Issue 1, pp. 36 - 36
Background: The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer... 
GITR | Monoclonal antibody | PD-1 | Immunotherapy | REGRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | EFFECTOR T-CELLS | MECHANISM | ANTIBODY | OVARIAN-CANCER | FAMILY | TUMOR-INFILTRATING LYMPHOCYTES | PERIPHERAL-BLOOD LYMPHOCYTES | Ovarian Neoplasms - pathology | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunity | CD4-Positive T-Lymphocytes - immunology | Female | Ovarian Neoplasms - drug therapy | Antibodies, Monoclonal - immunology | Disease Models, Animal | Mice, Inbred C57BL | Glucocorticoid-Induced TNFR-Related Protein - metabolism | Glucocorticoid-Induced TNFR-Related Protein - agonists | Programmed Cell Death 1 Receptor - metabolism | Remission Induction | Drug Synergism | Tumor Microenvironment - immunology | Immunosuppression | Animals | Cell Line, Tumor | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Interferon-gamma - biosynthesis | Cytotoxicity, Immunologic | Immunomodulation - immunology | Ovarian Neoplasms - immunology | Chemotherapy | Immune response | Analysis | Interferon | B cells | Cancer | Cell culture | Cloning | Clinical trials | Experiments | Cancer therapies | Ovarian cancer | Proteins | Studies | Hospitals | Lymphocytes | Hepatology | Ligands | Immune system | Tumors
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 13, pp. 3416 - 3427
Purpose: To generate and characterize a murine GITR ligand fusion protein (mGITRL-FP) designed to maximize valency and the potential to agonize the GITR... 
EFFECTOR | RESPONSES | ACTIVATION | FC-GAMMA RECEPTORS | ONCOLOGY | IN-VIVO | REGULATORY T-CELLS | CANCER-IMMUNOTHERAPY | SUPPRESSION | TNF | TUMOR-IMMUNITY | Tumor Necrosis Factors - agonists | Tumor Necrosis Factors - genetics | Humans | Melanoma, Experimental - therapy | Membrane Glycoproteins - agonists | Glucocorticoid-Induced TNFR-Related Protein - administration & dosage | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Oncogene Proteins, Fusion - administration & dosage | CTLA-4 Antigen - immunology | Tumor Necrosis Factors - immunology | B7-H1 Antigen - immunology | Oncogene Proteins, Fusion - immunology | Animals | B7-H1 Antigen - antagonists & inhibitors | Melanoma, Experimental - genetics | Melanoma, Experimental - immunology | CD8-Positive T-Lymphocytes - drug effects | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice | Membrane Glycoproteins - immunology | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Disease Models, Animal | Cell proliferation | Animal models | PD-1 protein | CD8 antigen | Antibodies | Antagonists | Lymphocytes T | Immunity | Anticancer properties | Proteins | CTLA-4 protein | Lymphocytes | Immunotherapy | Fusion protein | Valency | CD4 antigen | Ox40L protein | Immune checkpoint | Experimental design | Tumor necrosis factor | PD-L1 protein | Antitumor activity | Ligands | Cancer | Tumors
Journal Article
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2017, Volume 74, pp. 55 - 72
Abstract Recent success in cancer immunotherapy (anti-CTLA-4, anti-PD1/PD-L1) has confirmed the hypothesis that the immune system can control many cancers... 
Hematology, Oncology and Palliative Medicine | Molecular biology | Clinical development | Immuno-oncology | Novel antibodies | OX40 | NATURAL-KILLER-CELLS | SOLID TUMORS | CD4(+) T-CELLS | CANCER-IMMUNOTHERAPY | LUNG-CANCER | THERAPY | NK CELLS | ONCOLOGY | PHASE-I TRIAL | MONOCLONAL-ANTIBODIES | T-Lymphocyte Subsets - immunology | Immunotherapy - methods | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | B7 Antigens - immunology | Inducible T-Cell Co-Stimulator Protein - agonists | Glucocorticoid-Induced TNFR-Related Protein - drug effects | OX40 Ligand - agonists | Hepatitis A Virus Cellular Receptor 2 - antagonists & inhibitors | Lymphocyte Activation - immunology | Neoplasms - therapy | Immunity, Cellular - physiology | Killer Cells, Natural - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 9 - agonists | Cytokines - immunology | T-Lymphocytes, Cytotoxic - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | CD40 Antigens - agonists | Antigens, CD - drug effects | B7 Antigens - antagonists & inhibitors | B-Lymphocytes - immunology | Neoplasms - immunology | Major Histocompatibility Complex - immunology | CTLA-4 Antigen - antagonists & inhibitors | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Receptors, KIR - antagonists & inhibitors | Drugs | Chemotherapy | Cell death | Immunotherapy | Monoclonal antibodies | Control systems | T cells | Cancer
Journal Article
Immunology, ISSN 0019-2805, 02/2016, Volume 147, Issue 2, pp. 190 - 203
Summary Lymphatic filariasis leads to profound impairment of parasite‐specific T helper type 1 (Th1) and Th2 immune responses and significantly increases the... 
lymphatic filariasis | immunosuppression | anti‐CD25 | anti‐glucocorticoid‐induced tumour necrosis factor receptor | Wolbachia surface protein | Immunosuppression | Anti-CD25 | Lymphatic filariasis | Anti-glucocorticoid-induced tumour necrosis factor receptor | GITR | DENDRITIC CELLS | anti-CD25 | MONOCYTES | RECEPTOR | IMMUNOLOGY | HELMINTH-PARASITES | anti-glucocorticoid-induced tumour necrosis factor receptor | IMMUNE-RESPONSES | NEMATODES | CD4(+) | INFECTION | Elephantiasis, Filarial - metabolism | T-Lymphocytes, Regulatory - metabolism | Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors | Eosinophils - drug effects | Eosinophils - parasitology | Dendritic Cells - immunology | Interferon-gamma - metabolism | Eosinophils - immunology | T-Lymphocytes, Regulatory - immunology | Th17 Cells - drug effects | CD40 Antigens - metabolism | Elephantiasis, Filarial - immunology | Th17 Cells - metabolism | Time Factors | Inflammation Mediators - metabolism | Interleukin-10 - metabolism | Dendritic Cells - drug effects | Host-Parasite Interactions | T-Lymphocytes, Regulatory - parasitology | Disease Models, Animal | Interleukin-2 Receptor alpha Subunit - immunology | Inflammation Mediators - immunology | Dendritic Cells - parasitology | Glucocorticoid-Induced TNFR-Related Protein - antagonists & inhibitors | Immunization | Bacterial Outer Membrane Proteins - immunology | Elephantiasis, Filarial - parasitology | Cells, Cultured | Glucocorticoid-Induced TNFR-Related Protein - metabolism | Th17 Cells - parasitology | Antibodies, Neutralizing - pharmacology | T-Lymphocytes, Regulatory - drug effects | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Interferon-gamma - immunology | Th17 Cells - immunology | Glucocorticoid-Induced TNFR-Related Protein - immunology | Mice, Inbred BALB C | Macrophage Activation - drug effects | Interleukin-10 - immunology | CD40 Antigens - immunology | Elephantiasis, Filarial - drug therapy | Corticosteroids | Filariasis | Dendritic cells | Nitric oxide | Immunotherapy | Bone morphogenetic proteins | Biological response modifiers | T cells | Antigens | Immunoglobulins | T cell receptors | Parasites | Rodents | Original
Journal Article