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1. Full Text Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism
by Suneil K. Koliwad and Taiyi Kuo and Lauren E. Shipp and Nora E. Gray and Fredrik Backhed and Alex Yick-Lun So and Robert V. Farese, Jr and Jen-Chywan Wang and Sahlgrenska akademin and Institute of Medicine, Department of Molecular and Clinical Medicine and Institutionen för medicin, avdelningen för molekylär och klinisk medicin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
The Journal of biological chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 38, pp. 25593 - 25601
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Transcription, Genetic - drug effects | Hypertriglyceridemia - genetics | Humans | Dexamethasone - adverse effects | Receptors, Glucocorticoid - metabolism | Hepatocytes - metabolism | Fatty Liver - chemically induced | Adipose Tissue - metabolism | Angiopoietin-like 4 Protein | Dexamethasone - pharmacology | Glucocorticoids - genetics | Glucocorticoids - metabolism | Response Elements - genetics | Lipoprotein Lipase - metabolism | Glucocorticoids - adverse effects | Fatty Liver - genetics | Angiopoietins - metabolism | Fatty Liver - metabolism | Lipoprotein Lipase - genetics | Liver - metabolism | Rats | Hypertriglyceridemia - metabolism | Mice, Knockout | Triglycerides - metabolism | Adipose Tissue, White | Hypertriglyceridemia - chemically induced | Animals | Receptors, Glucocorticoid - genetics | Cell Line, Tumor | Dexamethasone - metabolism | Glucocorticoids - pharmacology | Mice | Transcription, Genetic - genetics | Triglycerides - genetics | Angiopoietins - genetics | Index Medicus | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling | Transcription | Dermatologi och venereologi | Dermatology and Venereal Diseases | Dexamethasone/adverse effects/metabolism/pharmacology | Hypertriglyceridemia/chemically induced/genetics/metabolism | Receptors | Adipose Tissue/metabolism | Liver/metabolism | Tumor | Adipose Tissue | Cell Line | Fatty Liver/chemically induced/genetics/metabolism | Triglycerides/genetics/ metabolism | Response Elements/genetics | Angiopoietins/genetics/ metabolism | Knockout | Lipoprotein Lipase/genetics/metabolism | White | Hepatocytes/metabolism | Genetic/drug effects/genetics | Glucocorticoids/adverse effects/genetics/ metabolism/pharmacology | Glucocorticoid/genetics/ metabolism
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2. Full Text PGC-1α, glucose metabolism and type 2 diabetes mellitus
by Wu, Haijiang and Deng, Xinna and Shi, Yonghong and Su, Ye and Wei, Jinying and Duan, Huijun
Journal of endocrinology, ISSN 0022-0795, 06/2016, Volume 229, Issue 3, pp. R99 - R115
Review | Glucose metabolism | PGC-1α | Type 2 diabetes mellitus | Polymorphism | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Hepatocyte Nuclear Factor 4 - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | AMP-Activated Protein Kinases - metabolism | Receptors, Estrogen - metabolism | Oxidative Stress | Signal Transduction | Diabetes Mellitus, Type 2 - genetics | Diabetic Nephropathies - metabolism | Humans | Liver - metabolism | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Polymorphism, Genetic | Insulin - metabolism | Insulin-Secreting Cells - metabolism | Glucocorticoids - metabolism | Glucose - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism | Diabetes Mellitus, Type 2 - etiology | Hepatitis C - complications | p38 Mitogen-Activated Protein Kinases - metabolism | Insulin-Secreting Cells - pathology | Insulin Secretion | Sirtuins - metabolism | Index Medicus
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3. Full Text Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation
by Pariante, Carmine M
European neuropsychopharmacology, ISSN 0924-977X, 2017, Volume 27, Issue 6, pp. 554 - 559
Internal Medicine | Psychiatry | Immunopsychiatry | Antidepressants | Glucocorticoid receptor | HPA | mRNA | Psychoneuroimmunology | Childhood trauma | Neurosciences | Clinical Neurology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Science & Technology | Receptors, Glucocorticoid - deficiency | Glucocorticoids - therapeutic use | Inflammation - psychology | Pituitary-Adrenal System - metabolism | Humans | Metabolism, Inborn Errors - metabolism | Hydrocortisone - metabolism | Biomedical Research - trends | Receptors, Glucocorticoid - metabolism | Anti-Inflammatory Agents - metabolism | Hypothalamo-Hypophyseal System - metabolism | Depression - drug therapy | Depression - metabolism | Inflammation - metabolism | Time Factors | Glucocorticoids - metabolism | Inflammation - drug therapy | Inflammation Mediators - metabolism | Anti-Inflammatory Agents - therapeutic use | Depression - psychology | Metabolism, Inborn Errors - psychology | Metabolism, Inborn Errors - drug therapy | Inflammation | Corticosteroids | Depression, Mental | Steroids | RNA | Index Medicus
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4. Full Text The obesity-associated transcription factor ETV5 modulates circulating glucocorticoids
by Gutierrez-Aguilar, Ruth and Thompson, Abigail and Marchand, Nathalie and Dumont, Patrick and Woods, Stephen C and de Launoit, Yvan and Seeley, Randy J and Ulrich-Lai, Yvonne M
Physiology & behavior, ISSN 0031-9384, 2015, Volume 150, pp. 38 - 42
Psychiatry | Glucocorticoids | Metabolism | Hypothalamic–pituitary–adrenocortical (HPA) axis | ETV5 | Stress | Hypothalamic-pituitary-adrenocortical (HPA) axis | Adrenal Glands - pathology | Blood Glucose - physiology | Receptors, Mineralocorticoid - genetics | Glucocorticoids - administration & dosage | Receptors, Mineralocorticoid - metabolism | Receptors, Vasopressin - metabolism | Pituitary-Adrenal System - pathology | Receptors, Glucocorticoid - metabolism | Insulin - blood | DNA-Binding Proteins - metabolism | Dexamethasone - pharmacology | Stress, Psychological - metabolism | Thymus Gland - pathology | Anti-Inflammatory Agents - pharmacology | Gene Expression Regulation - genetics | Glucocorticoids - blood | Corticotropin-Releasing Hormone - blood | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Hypothalamo-Hypophyseal System - metabolism | Mice, Knockout | Stress, Psychological - pathology | Transcription Factors - metabolism | Animals | Receptors, Glucocorticoid - genetics | Receptors, Vasopressin - genetics | Mice | Corticotropin releasing hormone | Obesity | Dexamethasone | RNA | Corticosterone | Body weight | Genomics | Physiological aspects | Genetic research | ACTH | Steroids | Index Medicus | Receptors, Glucocorticoid/metabolism | Insulin/blood | Pituitary-Adrenal System/pathology | DNA-Binding Proteins/metabolism | Life Sciences | Transcription Factors/metabolism | Receptors, Vasopressin/genetics | Hypothalamo-Hypophyseal System/metabolism | Corticotropin-Releasing Hormone/blood | Gene Expression Regulation/genetics | Stress, Psychological/metabolism | Anti-Inflammatory Agents/pharmacology | Transcription Factors/genetics | Stress, Psychological/pathology | Glucocorticoids/blood | Receptors, Mineralocorticoid/genetics | Adrenal Glands/pathology | Thymus Gland/pathology | Receptors, Mineralocorticoid/metabolism | DNA-Binding Proteins/genetics | Dexamethasone/pharmacology | Receptors, Vasopressin/metabolism | Receptors, Glucocorticoid/genetics | Blood Glucose/physiology | Glucocorticoids/administration & dosage | stress | metabolism | hypothalamic-pituitary-adrenocortical (HPA) axis | glucocorticoids
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5. Full Text Metabolic gatekeeper function of B-lymphoid transcription factors
by Chan, Lai N and Chen, Zhengshan and Braas, Daniel and Lee, Jae-Woong and Xiao, Gang and Geng, Huimin and Cosgun, Kadriye Nehir and Hurtz, Christian and Shojaee, Seyedmehdi and Cazzaniga, Valeria and Schjerven, Hilde and Ernst, Thomas and Hochhaus, Andreas and Kornblau, Steven M and Konopleva, Marina and Pufall, Miles A and Cazzaniga, Giovanni and Liu, Grace J and Milne, Thomas A and Koeffler, H. Phillip and Ross, Theodora S and Sánchez-García, Isidro and Borkhardt, Arndt and Yamamoto, Keith R and Dickins, Ross A and Graeber, Thomas G and Müschen, Markus
Nature (London), ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 479 - 483
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Glucocorticoids - therapeutic use | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Receptor, Cannabinoid, CB2 - agonists | Humans | Gene Expression Regulation, Neoplastic | Receptors, Glucocorticoid - metabolism | PAX5 Transcription Factor - deficiency | Carrier Proteins - agonists | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Chromatin Immunoprecipitation | Adenosine Triphosphate - metabolism | Cell Death | Pyruvic Acid - metabolism | Female | Ikaros Transcription Factor - metabolism | Energy Metabolism - genetics | B-Lymphocytes - metabolism | PAX5 Transcription Factor - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | AMP-Activated Protein Kinases - antagonists & inhibitors | Carcinogenesis - genetics | PAX5 Transcription Factor - genetics | Mice, Transgenic | Citric Acid Cycle | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Transcription Factors - metabolism | B-Lymphocytes - drug effects | Receptor, Cannabinoid, CB2 - metabolism | Animals | Carrier Proteins - metabolism | Sequence Analysis, RNA | Glucocorticoids - pharmacology | Glucose - metabolism | Mice | Physiological aspects | Transcription factors | B cells | Proteins | Metabolites | Rodents | Cloning | Leukemia | Glucose | Kinases | Metabolism | Gene expression | Apoptosis | Index Medicus
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6. Full Text Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism
by Eloranta, Jyrki J and Kullak-Ublick, Gerd A
Archives of biochemistry and biophysics, ISSN 0003-9861, 2005, Volume 433, Issue 2, pp. 397 - 412
Coactivators and corepressors | Gene regulation | Drug metabolism | Xenobiotics | Nuclear receptors | Bile acids and salts | Hepatocyte nuclear factors | Steroid 12-alpha-Hydroxylase - metabolism | Steroid Hydroxylases - metabolism | Histone Acetyltransferases | Receptors, Steroid - metabolism | Receptors, Virus - metabolism | Humans | Cytochrome P-450 Enzyme System - metabolism | Homeostasis | Receptors, Glucocorticoid - metabolism | Coxsackie and Adenovirus Receptor-Like Membrane Protein | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Transcription, Genetic | Heat-Shock Proteins - metabolism | Bile Acids and Salts - metabolism | Receptors, Calcitriol - metabolism | Forecasting | Transcription Factors - metabolism | Feedback, Physiological | Pharmaceutical Preparations - metabolism | Animals | Cholesterol 7-alpha-Hydroxylase - metabolism | Models, Biological | Nuclear Receptor Coactivator 1 | Ligands | Trans-Activators - metabolism | Cholestanetriol 26-Monooxygenase | Hepatocyte Nuclear Factor 4 | Multidrug Resistance-Associated Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
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7. Full Text FGF21 regulates metabolism and circadian behavior by acting on the nervous system
by Bookout, Angie L and De Groot, Marleen H M and Owen, Bryn M and Lee, Syann and Gautron, Laurent and Lawrence, Heather L and Ding, Xunshan and Elmquist, Joel K and Takahashi, Joseph S and Mangelsdorf, David J and Kliewer, Steven A
Nature medicine, ISSN 1078-8956, 09/2013, Volume 19, Issue 9, pp. 1147 - 1152
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Starvation | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Nervous System - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Circadian Rhythm - physiology | Motor Activity | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Animals | Hypothalamus - metabolism | Energy Metabolism | Glucocorticoids - metabolism | Suprachiasmatic Nucleus - metabolism | Membrane Proteins - metabolism | Mice | Circadian rhythms | Physiological aspects | Metabolic regulation | Nervous system | Research | Metabolism | Neurophysiology | Fibroblast growth factor receptors | Proteins | Circadian rhythm | Gene expression | Index Medicus
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8. Full Text Differential impact of stress on hypothalamic–pituitary–adrenal axis: Gene expression changes in Lewis and Fisher rats
by Ergang, Peter and Vodička, Martin and Soták, Matúš and Klusoňová, Petra and Behuliak, Michal and Řeháková, Lenka and Zach, Petr and Pácha, Jiří
Psychoneuroendocrinology, ISSN 0306-4530, 2014, Volume 53, pp. 49 - 59
Endocrinology & Metabolism | Psychiatry | 11β-Hydroxysteroid dehydrogenase type 1 | Brain | Neuropeptides | Lewis rat | Stress | Fisher rat | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Pituitary Gland - metabolism | Rats, Inbred F344 | Adrenal Cortex - metabolism | Rats, Inbred Lew | Urocortins - genetics | Gene Expression Profiling | Receptors, Glucocorticoid - metabolism | RNA, Messenger - metabolism | Oxytocin - metabolism | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics | Brain - metabolism | Urocortins - metabolism | Stress, Psychological - metabolism | Arginine Vasopressin - genetics | Corticotropin-Releasing Hormone - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Pituitary-Adrenal System - metabolism | Amygdala - metabolism | Rats | Corticotropin-Releasing Hormone - metabolism | Hypothalamo-Hypophyseal System - metabolism | Hippocampus - metabolism | Stress, Psychological - genetics | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Animals | Arginine Vasopressin - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Paraventricular Hypothalamic Nucleus - metabolism | Prefrontal Cortex - metabolism | Receptors, Glucocorticoid - genetics | Oxytocin - genetics | Gene expression | Index Medicus
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