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1. Full Text Mutational analysis of allosteric activation and inhibition of glucokinase
by Zelent, Bogumil and Odili, Stella and Buettger, Carol and Zelent, Dorothy K and Chen, Pan and Fenner, Deborah and Bass, Joseph and Stanley, Charles and Laberge, Monique and Vanderkooi, Jane M and Sarabu, Ramakanth and Grimsby, Joseph and Matschinsky, Franz M
Biochemical journal, ISSN 0264-6021, 12/2011, Volume 440, Issue 2, pp. 203 - 215
Glucokinase regulatory protein (GKRP) | Glucokinase activator drug (GKA) | Glucokinase mutant (GK mutant) | Fluorescence quantum yield | Tryptophan fluorescence (TF) | Glucose | Enzyme kinetics | Glucokinase (GK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Point Mutation | Glucokinase - antagonists & inhibitors | Allosteric Regulation | Humans | Fluorescence | Tryptophan - chemistry | Glucokinase - genetics | Protein Conformation | Glucose - pharmacology | Kinetics | Glucokinase - metabolism | Carrier Proteins | Index Medicus | GKRP | Glucokinase Mutants | Tryptophan Fluorescence | Fluorescence Quantum Yield | Glucokinase | Enzyme Kinetics | GKA
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2. Full Text Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence
by Zelent, Bogumil and Raimondo, Anne and Barrett, Amy and Buettger, Carol W and Chen, Pan and Gloyn, Anna L and Matschinsky, Franz M
Biochemical journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 551 - 564
Allosteric regulation | Fructose phosphate ester | Glucokinase regulatory protein | Glucokinase | Metabolic regulation | Diabetes | Co-operativity | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Adaptor Proteins, Signal Transducing - chemistry | Protein Unfolding | Allosteric Regulation | Humans | Protein Multimerization | Tryptophan - chemistry | Fructosephosphates - metabolism | Protein Interaction Domains and Motifs | Protein Stability | Glucokinase - chemistry | Recombinant Proteins - metabolism | Protein Refolding | Models, Molecular | Recombinant Proteins - chemistry | Spectrometry, Fluorescence | Glucokinase - genetics | Mutant Proteins - metabolism | Glucokinase - metabolism | Protein Transport | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Ligands | Protein Conformation | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Index Medicus | T2D, Type 2 diabetes | WT, wild-type | rGKRP, rat GKRP | allosteric regulation | NPC, nuclear pore complex | PPI, protein–protein interaction | co-operativity | NATA, N-acetyl-L-tryptophanamide | xGKRP, Xenopus GKRP | MH, D-mannoheptulose | GKA, GK activator | hGK, human GK | F6P, fructose 6-phosphate | metabolic regulation | hGKRP, human GKRP | GCKR | xGK, Xenopus GK | fructose phosphate ester | GKRPI, GKRP inhibitor | GK, glucokinase | TF, tryptophan fluorescence | GCK | glucokinase regulatory protein | GKRP, GK regulatory protein | SIS, sugar isomerase | diabetes | glucokinase | F1P, fructose 1-phosphate
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3. Full Text α-cell glucokinase suppresses glucose-regulated glucagon secretion
by Basco, Davide and Zhang, Quan and Salehi, Albert and Tarasov, Andrei and Dolci, Wanda and Herrera, Pedro and Spiliotis, Ioannis and Berney, Xavier and Tarussio, David and Rorsman, Patrik and Thorens, Bernard
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 546 - 9
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Glucose Intolerance - metabolism | KATP Channels - genetics | Male | Glucose Intolerance - pathology | Hypoglycemia - pathology | Biological Transport | Adenosine Triphosphate - metabolism | Glucagon-Secreting Cells - metabolism | Female | Hypoglycemia - genetics | Gene Expression | Glucose Intolerance - genetics | Glucagon-Secreting Cells - pathology | Glucokinase - deficiency | Liver - metabolism | Glucokinase - genetics | Hypoglycemia - metabolism | Mice, Knockout | KATP Channels - metabolism | Insulin - metabolism | Animals | Glucose - metabolism | Glucagon - metabolism | Mice | Adenosine Diphosphate - metabolism | Phenotypes | Deregulation | Deactivation | Glucagon | Secretion | Diabetes mellitus | Adenosine diphosphate | Diabetes mellitus (insulin dependent) | Glucose | Metabolism | Hypoglycemia | Gene expression | Inactivation | Glucose tolerance | Glucose metabolism | Intolerance | Mouse devices | Rodents | Glucokinase | Pancreas | Diabetes mellitus (non-insulin dependent) | Index Medicus | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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4. Full Text Hetero-substituted sulfonamido-benzamide hybrids as glucokinase activators: Design, synthesis, molecular docking and in-silico ADME evaluation
by Khadse, Saurabh C and Amnerkar, Nikhil D and Dighole, Krushna S and Dhote, Ashish M and Patil, Vikas R and Lokwani, Deepak K and Ugale, Vinod G and Charbe, Nitin B and Chatpalliwar, Vivekanand A
Journal of molecular structure, ISSN 0022-2860, 12/2020, Volume 1222, p. 128916
Docking | Glucokinase activator | ADME | Glucokinase | Sulfonamido-benzamides
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5. Full Text Glucokinase and molecular aspects of liver glycogen metabolism
by Agius, Loranne
Biochemical journal, ISSN 0264-6021, 08/2008, Volume 414, Issue 1, pp. 1 - 18
Glycogen | Glycogen synthase | Glucokinase | Glycogen phosphorylase (GP) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Glucokinase - physiology | Phosphorylation | Glucose-6-Phosphate - physiology | Liver - enzymology | Liver Glycogen - physiology | Humans | Glucokinase - metabolism | Glucose-6-Phosphate - chemistry | Liver - blood supply | Animals | Liver Glycogen - metabolism | Liver - physiology | Signal Transduction - physiology | Liver Glycogen - chemistry | Glucose-6-Phosphate - metabolism | Glucokinase - chemistry | Index Medicus
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6. Full Text Liver glucokinase: An overview on the regulatorymechanisms of its activity
by Massa, María L and Gagliardino, Juan J and Francini, Flavio
IUBMB life, ISSN 1521-6543, 01/2011, Volume 63, Issue 1, pp. 1 - 6
glucose homeostasis | transcriptional and post‐transcriptional glucokinase activity regulation | liver | liver glucokinase activity | glucokinase | transcriptional and post-transcriptional glucokinase activity regulation
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7. Full Text Crystal structure of ADP‐dependent glucokinase from Methanocaldococcus jannaschii in complex with 5‐iodotubercidin reveals phosphoryl transfer mechanism
by Tokarz, Piotr and Wiśniewska, Magdalena and Kamiński, Marcin M and Dubin, Grzegorz and Grudnik, Przemysław
Protein science, ISSN 0961-8368, 03/2018, Volume 27, Issue 3, pp. 790 - 797
kinase inhibitor | ADP‐dependent glucokinase | 5‐iodotubercidin | glycolysis | 5-iodotubercidin | ADP-dependent glucokinase | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Archaeal Proteins - metabolism | Catalytic Domain | Reactive Oxygen Species - metabolism | Protein Structure, Secondary | Jurkat Cells | Humans | Archaeal Proteins - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Crystallography, X-Ray | Glucokinase - metabolism | Tubercidin - pharmacology | Phosphates - metabolism | Methanocaldococcus - enzymology | Tubercidin - analogs & derivatives | Glucokinase - chemistry | Phosphates | Glucose metabolism | Arginine | Isoenzymes | Analysis | Crystals | Catalysis | Glucose | T cells | Gene expression | Structure | Dextrose | Phosphorylation | Archaea | Hyperthermophilic archaea | Adenosine diphosphate | Lymphocytes T | Mimicry | Cell activation | Glucokinase | Glycolysis | Magnesium | Crystal structure | Index Medicus | Protein Structure Report | Protein Structure Reports
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8. Full Text Molecular and cellular regulation of human glucokinase
by Sternisha, Shawn M and Miller, Brian G
Archives of biochemistry and biophysics, ISSN 0003-9861, 03/2019, Volume 663, pp. 199 - 213
Regulation | Diabetes | Protein-protein interaction | Glucokinase | Conformational dynamics | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Carrier Proteins - physiology | Humans | Glucokinase - metabolism | Animals | Phosphofructokinase-2 - metabolism | Glucokinase - antagonists & inhibitors | Protein Binding | Protein Conformation | Protein Processing, Post-Translational | SUMO-1 Protein - metabolism | Enzyme Activation | Glucose - analysis | Glucokinase - chemistry | Post-translational modification | Diabetics | Synthesis | Genetic disorders | Glycogen | Isoenzymes | Liver | Glucose | Protein-protein interactions | Dextrose | Index Medicus
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