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1. Full Text Mutational analysis of allosteric activation and inhibition of glucokinase
by Zelent, Bogumil and Odili, Stella and Buettger, Carol and Zelent, Dorothy K and Chen, Pan and Fenner, Deborah and Bass, Joseph and Stanley, Charles and Laberge, Monique and Vanderkooi, Jane M and Sarabu, Ramakanth and Grimsby, Joseph and Matschinsky, Franz M
Biochemical Journal, ISSN 0264-6021, 12/2011, Volume 440, Issue 2, pp. 203 - 215
GK (glucokinase) is activated by glucose binding to its substrate site, is inhibited by GKRP (GK regulatory protein) and stimulated by GKAs (GK activator... 
Glucokinase regulatory protein (GKRP) | Glucokinase activator drug (GKA) | Glucokinase mutant (GK mutant) | Fluorescence quantum yield | Tryptophan fluorescence (TF) | Glucose | Enzyme kinetics | Glucokinase (GK) | glucokinase (GK) | glucose | RAT | ISLETS | fluorescence quantum yield | BIOCHEMISTRY & MOLECULAR BIOLOGY | glucokinase mutant (GK mutant) | enzyme kinetics | glucokinase regulatory protein (GKRP) | LIVER REGULATORY PROTEIN | ENZYME | FLUORESCENCE | METABOLISM | tryptophan fluorescence (TF) | glucokinase activator drug (GKA) | PANCREATIC BETA-CELLS | DIABETES THERAPY | BINDING | Point Mutation | Glucokinase - antagonists & inhibitors | Allosteric Regulation | Humans | Fluorescence | Tryptophan - chemistry | Glucokinase - genetics | Protein Conformation | Glucose - pharmacology | Kinetics | Glucokinase - metabolism | Carrier Proteins | Index Medicus | GKRP | Glucokinase Mutants | Tryptophan Fluorescence | Fluorescence Quantum Yield | Glucokinase | Enzyme Kinetics | GKA
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2. Full Text Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence
by Zelent, Bogumil and Raimondo, Anne and Barrett, Amy and Buettger, Carol W and Chen, Pan and Gloyn, Anna L and Matschinsky, Franz M
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 551 - 564
Hepatic glucose phosphorylation by GK (glucokinase) is regulated by GKRP (GK regulatory protein). GKRP forms a cytosolic complex with GK followed by nuclear... 
Allosteric regulation | Fructose phosphate ester | Glucokinase regulatory protein | Glucokinase | Metabolic regulation | Diabetes | Co-operativity | RAT-LIVER | GLYCEMIC CONTROL | ACTIVATION | fructose phosphate ester | BIOCHEMISTRY & MOLECULAR BIOLOGY | allosteric regulation | co-operativity | glucokinase regulatory protein | HEPATIC GLUCOKINASE | P446L VARIANT | FRUCTOSE | HUMAN GLUCOKINASE | STRUCTURAL BASIS | GLUCOSE | DIABETES THERAPY | diabetes | glucokinase | metabolic regulation | Adaptor Proteins, Signal Transducing - chemistry | Protein Unfolding | Allosteric Regulation | Humans | Protein Multimerization | Tryptophan - chemistry | Fructosephosphates - metabolism | Protein Interaction Domains and Motifs | Protein Stability | Glucokinase - chemistry | Recombinant Proteins - metabolism | Protein Refolding | Models, Molecular | Recombinant Proteins - chemistry | Spectrometry, Fluorescence | Glucokinase - genetics | Mutant Proteins - metabolism | Glucokinase - metabolism | Protein Transport | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Ligands | Protein Conformation | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Index Medicus | T2D, Type 2 diabetes | WT, wild-type | rGKRP, rat GKRP | NPC, nuclear pore complex | PPI, protein–protein interaction | NATA, N-acetyl-L-tryptophanamide | xGKRP, Xenopus GKRP | MH, D-mannoheptulose | GKA, GK activator | hGK, human GK | F6P, fructose 6-phosphate | hGKRP, human GKRP | GCKR | xGK, Xenopus GK | GKRPI, GKRP inhibitor | GK, glucokinase | TF, tryptophan fluorescence | GCK | GKRP, GK regulatory protein | SIS, sugar isomerase | F1P, fructose 1-phosphate
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3. Full Text Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase
by Kamata, Kenji and Mitsuya, Morihiro and Nishimura, Teruyuki and Eiki, Jun-ichi and Nagata, Yasufumi
Structure, ISSN 0969-2126, 2004, Volume 12, Issue 3, pp. 429 - 438
Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a sigmoidal saturation curve for its substrate, two properties that are... 
PROTEIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEXOKINASE I | BETA-CELL GLUCOKINASE | CELL BIOLOGY | GLUCOSE-HOMEOSTASIS | CONFORMATIONAL-CHANGES | HEPATIC GLUCOKINASE | BIOPHYSICS | YEAST HEXOKINASE | R-STATE | RAT-LIVER GLUCOKINASE | Catalytic Domain | Enzyme Activators - therapeutic use | Humans | Models, Molecular | Glucokinase - genetics | Glucokinase - metabolism | Allosteric Regulation - physiology | Protein Conformation | Mutation | Diabetes Mellitus, Type 2 - drug therapy | Hexokinase - genetics | Hexokinase - metabolism | Binding Sites | Glucokinase - chemistry | Hexokinase - chemistry | Index Medicus
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4. Full Text Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein
by Cullen, Kirsty S and Al-Oanzi, Ziad H and O'Harte, Finbarr P.M and Agius, Loranne and Arden, Catherine
BBA - Molecular Cell Research, ISSN 0167-4889, 06/2014, Volume 1843, Issue 6, pp. 1123 - 1134
Glucokinase activity is a major determinant of hepatic glucose metabolism and blood glucose homeostasis. Liver glucokinase activity is regulated acutely by... 
Hepatocyte | Glucagon | 6-phosphofructo 2-kinase/fructose 2,6 bisphosphatase-2 | Glucokinase regulatory protein | Glucokinase | 2,6 bisphosphatase-2 | 6-phosphofructo 2-kinase/fructose | LIVER GLUCOKINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | PHOSPHOFRUCTOKINASE-2/FRUCTOSE BISPHOSPHATASE-2 | SIMPLE-MODEL | HEPATIC GLUCOKINASE | GLUCOSE-METABOLISM | STRUCTURAL BASIS | IMAGE-ANALYSIS | IN-VIVO | FRUCTOSE 2,6-BISPHOSPHATE | DIABETIC FATTY RATS | Rats, Wistar | Humans | Cytoplasm - metabolism | Male | Protein Transport - drug effects | Hepatocytes - metabolism | Glycolysis - drug effects | Immunoenzyme Techniques | Hepatocytes - cytology | Cell Nucleus - metabolism | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | RNA, Messenger - genetics | Cells, Cultured | Rats | Glucokinase - genetics | Glucokinase - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Glucagon - pharmacology | Blotting, Western | Carrier Proteins - genetics | Gastrointestinal Agents - pharmacology | Animals | Carrier Proteins - metabolism | Phosphofructokinase-2 - metabolism | Phosphofructokinase-2 - genetics | Fluorescent Antibody Technique | Blood Glucose - metabolism | Glucose metabolism | Isoenzymes | Blood sugar | Analysis | Physiological aspects | Binding proteins | Protein binding | Blood proteins
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5. Full Text Glucose increases intracellular free Ca 2+ in tanycytes via ATP released through connexin 43 hemichannels
by Orellana, Juan A and Sáez, Pablo J and Cortés-campos, Christian and Elizondo, Roberto J and Shoji, Kenji F and Contreras-Duarte, Susana and Figueroa, Vania and Velarde, Victoria and Jiang, Jean X and Nualart, Francisco and Sáez, Juan C and García, María A
GLIA, ISSN 0894-1491, 01/2012, Volume 60, Issue 1, pp. 53 - 68
Connexons | Glucokinase | Glucosensing | Hypothalamus
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6. Full Text Functional characterization of MODY2 mutations in the nuclear export signal of glucokinase
by Gutierrez-Nogués, Angel and García-Herrero, Carmen-María and Oriola, Josep and Vincent, Olivier and Navas, María-Angeles
BBA - Molecular Basis of Disease, ISSN 0925-4439, 07/2018, Volume 1864, Issue 7, pp. 2385 - 2394
Glucokinase (GCK) plays a key role in glucose homeostasis. Heterozygous inactivating mutations in the gene cause the familial, mild fasting hyperglycaemia... 
MODY | Glucokinase mutation | Glucokinase regulatory protein | Glucokinase | Nuclear export signal | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATORS | IDENTIFICATION | BETA-CELL GLUCOKINASE | HYPERGLYCEMIA | INHIBITION | BIOPHYSICS | STRUCTURAL BASIS | HYPOGLYCEMIA | REGULATORY PROTEIN | DIABETES THERAPY | RESIDUES | Nuclear Export Signals - genetics | Cytoplasm - enzymology | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - enzymology | Glucokinase - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Mutation, Missense | Glucokinase - metabolism | Cytoplasm - pathology | Cell Nucleus - enzymology | Karyopherins - metabolism | Cell Nucleus - pathology | HEK293 Cells | Karyopherins - genetics | Adult | Female | Amino Acid Substitution | Hepatocytes - enzymology | Receptors, Cytoplasmic and Nuclear - metabolism | Genetic aspects | Isoenzymes | Exports | Blood proteins | Protein binding | Index Medicus
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7. Full Text Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk
by Rees, M G and Wincovitch, S and Schultz, J and Waterstradt, R and Beer, N L and Baltrusch, S and Collins, F S and Gloyn, A L
Diabetologia, ISSN 0012-186X, 1/2012, Volume 55, Issue 1, pp. 114 - 122
Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR)... 
Medicine & Public Health | Human Physiology | Glucokinase | Molecular mechanism | Metabolic Diseases | Association study | Internal Medicine | Genetics | TRANSLOCATION | TRIGLYCERIDE | GLUCOKINASE REGULATORY PROTEIN | RAT PRIMARY HEPATOCYTES | LIVER GLUCOKINASE | NUCLEAR EXPORT | LOCI | GLUCOSE | IMAGE-ANALYSIS | ENDOCRINOLOGY & METABOLISM | FRUCTOSE 1-PHOSPHATE | Adaptor Proteins, Signal Transducing - chemistry | Diabetes Mellitus, Type 2 - genetics | Humans | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Recombinant Fusion Proteins - metabolism | Cell Nucleus - enzymology | Cytosol - enzymology | Cell Nucleus - metabolism | Cell Nucleus - pathology | Luminescent Proteins - chemistry | Carrier Proteins - chemistry | Cytosol - pathology | Glucokinase - chemistry | Gene Library | Mice, Inbred C57BL | Cells, Cultured | Rats | Glucokinase - genetics | Mutant Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Glucokinase - metabolism | Protein Transport | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Cytosol - metabolism | Luminescent Proteins - genetics | Mice | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Hepatocytes - enzymology | Luminescent Proteins - metabolism | Type 2 diabetes | Glucose metabolism | Isoenzymes | Genes | Physiological aspects | Fluorescence | Glucose | Risk factors | Dextrose | Blood proteins | Beer | Proteins | Diabetes mellitus | Lipids | Biosynthesis | Kinetics | Energy transfer | Index Medicus
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8. Full Text Convergent Peripheral Pathways Catalyze Initial Glucose Catabolism in Pseudomonas putida: Genomic and Flux Analysis
by Teresa del Castillo and Juan L. Ramos and José J. Rodríguez-Herva and Tobias Fuhrer and Uwe Sauer and Estrella Duque
Journal of Bacteriology, ISSN 0021-9193, 07/2007, Volume 189, Issue 14, pp. 5142 - 5152
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
GC-MS | TRANSPORT | CARBOHYDRATE OXIDATION | AERUGINOSA | BACILLUS-SUBTILIS | KT2440 | GLUCONATE | MICROBIOLOGY | OPERON | METABOLIC FLUXES | MICROARRAY DATA | Pseudomonas putida - genetics | Oligonucleotide Array Sequence Analysis | Bacterial Proteins - genetics | Glucokinase - genetics | Phosphotransferases (Alcohol Group Acceptor) - genetics | Glucokinase - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Citric Acid Cycle | Gluconates - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Pseudomonas putida - metabolism | Models, Biological | Glucose - metabolism | Bacterial Proteins - metabolism | Transcription, Genetic | Biological Transport - genetics | Biological Transport - physiology | Mutation | Gene Expression Regulation, Bacterial | Genomics - methods | Pseudomonas putida - growth & development | Genetic aspects | Research | Pseudomonas putida | Glucokinase | Krebs cycle | Index Medicus | Physiology and Metabolism
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9. Full Text Structural basis for regulation of human glucokinase by glucokinase regulatory protein
by Beck, Tobias and Miller, Brian G
Biochemistry, ISSN 0006-2960, 09/2013, Volume 52, Issue 36, pp. 6232 - 6239
Glucokinase (GCK) is responsible for maintaining glucose homeostasis in the human body. Dysfunction or misregulation of GCK causes hyperinsulinemia,... 
ALLOSTERIC REGULATION | DIABETES-MELLITUS | REFINEMENT | TRANSLOCATION | EFFECTORS | TRIGLYCERIDE LEVELS | VARIANTS | LIVER GLUCOKINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATORS | GENOME-WIDE ASSOCIATION | Carrier Proteins - physiology | Carrier Proteins - genetics | Animals | Glucokinase - antagonists & inhibitors | Humans | Liver - metabolism | Fructosephosphates - pharmacology | Rats | Crystallography, X-Ray | Glucokinase - metabolism | Molecular dynamics | Research | Enzyme kinetics | Glucokinase | Analysis | Protein-protein interactions | Index Medicus | Type 2 Diabetes | Glucokinase Regulatory Protein
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10. Full Text Glucokinase and glucose homeostasis: Proven concepts and new ideas
by Zelent, D and Najafi, H and Odili, S and Buettger, C and Weik-Collins, H and Li, C and Doliba, N and Grimsby, J and Matschinsky, F.M
Biochemical Society Transactions, ISSN 0300-5127, 02/2005, Volume 33, Issue 1, pp. 306 - 310
The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor of insulin-producing beta-cells. GK has... 
Genetics | Drug discovery | Glucose | Glucose homeostasis | Glucokinase | Therapeutics | RAT-LIVER | glucose | therapeutics | ACTIVATION | ISLETS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CELL GLUCOKINASE | glucose homeostasis | genetics | HEPATIC GLUCOKINASE | drug discovery | GENE | COOPERATIVITY | DIABETES THERAPY | LANGERHANS | glucokinase | Point Mutation | Glucokinase - antagonists & inhibitors | Humans | Glucose - metabolism | Homeostasis | Crystallography, X-Ray | Glucokinase - genetics | Protein Conformation | Kinetics | Glucokinase - metabolism | Glucokinase - chemistry | Hypoglycemic Agents - pharmacology | Index Medicus
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11. Full Text Molecular Dynamics Simulations and Kinetic Measurements to Estimate and Predict Protein-Ligand Residence Times
by Mollica, Luca and Theret, Isabelle and Antoine, Mathias and Perron-Sierra, Françoise and Charton, Yves and Fourquez, Jean-Marie and Wierzbicki, Michel and Boutin, Jean A and Ferry, Gilles and Decherchi, Sergio and Bottegoni, Giovanni and Ducrot, Pierre and Cavalli, Andrea
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2016, Volume 59, Issue 15, pp. 7167 - 7176
Ligand-target residence time is emerging as a key drug discovery parameter because it can reliably predict drug efficacy in vivo. Experimental approaches to... 
REPLACEMENT | REFINEMENT | CHEMISTRY, MEDICINAL | GLUCOSE | ALLOSTERIC ACTIVATORS | GLUCOKINASE ACTIVATORS | TOOLKIT | Humans | Models, Molecular | Crystallography, X-Ray | Isoenzymes - chemistry | Structure-Activity Relationship | Diabetes Mellitus, Type 2 - metabolism | Glucokinase - metabolism | Molecular Dynamics Simulation | Time Factors | Glucokinase - antagonists & inhibitors | Isoenzymes - metabolism | Ligands | Molecular Structure | Kinetics | Diabetes Mellitus, Type 2 - drug therapy | Glucokinase - chemistry | Isoenzymes - antagonists & inhibitors | Index Medicus
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12. Full Text MiR-206 is expressed in pancreatic islets and regulates glucokinase activity
by Vinod, Manjula and Patankar, Jay V and Sachdev, Vinay and Frank, Saša and Graier, Wolfgang F and Kratky, Dagmar and Kostner, Gerhard M
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 07/2016, Volume 311, Issue 1, pp. E175 - E185
Glucose homeostasis is a complex indispensable process, and its dysregulation causes hyperglycemia and type 2 diabetes mellitus. Glucokinase (GK) takes a... 
Glucose tolerance | Pancreatic islets | MiR-206 | Insulin sensitivity | Glucose sensing | PHYSIOLOGY | MECHANISM | LIVER GLUCOKINASE | BETA-CELLS | TRANSCRIPTION | MAMMALIAN GLUCOKINASE | MICRORNAS | miR-206 | insulin sensitivity | GLUCOSE-HOMEOSTASIS | METABOLISM | GENETICS | ENDOCRINOLOGY & METABOLISM | MICE | glucose tolerance | glucose sensing | pancreatic islets | Glucose Tolerance Test | RNA Processing, Post-Transcriptional | Lactic Acid - metabolism | Liver - metabolism | Transcriptome | Glucokinase - genetics | Male | Glucokinase - metabolism | RNA, Messenger - metabolism | Mice, Knockout | Insulin - metabolism | Animals | Glycogen - metabolism | Islets of Langerhans - metabolism | Computer Simulation | Diet, High-Fat | Metabolic Syndrome | Glucose - metabolism | Mice | MicroRNAs - genetics | Insulin Secretion | Real-Time Polymerase Chain Reaction | MicroRNA | Glucokinase | Physiological aspects | Islands of Langerhans | Physiological research | Genetic aspects | Research | Genetic regulation | Health aspects | Index Medicus
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13. Glucokinase
: its regulation and role in liver metabolism
by Cárdenas, María Luz
1995, Molecular biology intelligence unit (Unnumbered), ISBN 1570592071, 210
Regulation | Metabolism | Glucokinase | Liver
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14. Full Text α-cell glucokinase suppresses glucose-regulated glucagon secretion
by Basco, Davide and Zhang, Quan and Salehi, Albert and Tarasov, Andrei and Dolci, Wanda and Herrera, Pedro and Spiliotis, Ioannis and Berney, Xavier and Tarussio, David and Rorsman, Patrik and Thorens, Bernard and Lund University and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden and Islet cell physiology
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 546 - 9
Glucagon secretion by pancreatic alpha-cells is triggered by hypoglycemia and suppressed by high glucose levels; impaired suppression of glucagon secretion is... 
INSULIN | HOMEOSTASIS | COUNTERREGULATION | MULTIDISCIPLINARY SCIENCES | HYPOGLYCEMIA | CHANNELS | PANCREATIC ALPHA | Glucose Intolerance - metabolism | KATP Channels - genetics | Male | Glucose Intolerance - pathology | Hypoglycemia - pathology | Biological Transport | Adenosine Triphosphate - metabolism | Glucagon-Secreting Cells - metabolism | Female | Hypoglycemia - genetics | Gene Expression | Glucose Intolerance - genetics | Glucagon-Secreting Cells - pathology | Glucokinase - deficiency | Liver - metabolism | Glucokinase - genetics | Hypoglycemia - metabolism | Mice, Knockout | KATP Channels - metabolism | Insulin - metabolism | Animals | Glucose - metabolism | Glucagon - metabolism | Mice | Adenosine Diphosphate - metabolism | Phenotypes | Deregulation | Deactivation | Glucagon | Secretion | Diabetes mellitus | Liver | Diabetes mellitus (insulin dependent) | Glucose | Metabolism | Hypoglycemia | Gene expression | Inactivation | ADP | Glucose tolerance | Glucose metabolism | Intolerance | Mouse devices | Rodents | Glucokinase | Pancreas | Diabetes mellitus (non-insulin dependent) | Index Medicus | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
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15. Full Text Kinetic Basis of Carbohydrate-Mediated Inhibition of Human Glucokinase by the Glucokinase Regulatory Protein
by Casey, Ashley K and Miller, Brian G
Biochemistry, ISSN 0006-2960, 05/2016, Volume 55, Issue 21, pp. 2899 - 2902
The glucokinase regulatory protein (GKRP) is a competitive inhibitor of glucokinase (GCK), triggering its localization to the hepatocyte nucleus upon glucose... 
EXPLORER | HEPATIC GLUCOKINASE | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACTIVATORS | DIABETES THERAPY | GENOME-WIDE ASSOCIATION | Adaptor Proteins, Signal Transducing - chemistry | Glucokinase - antagonists & inhibitors | Humans | Adaptor Proteins, Signal Transducing - genetics | Fructosephosphates - pharmacology | Glucokinase - genetics | Protein Conformation | Kinetics | Adaptor Proteins, Signal Transducing - metabolism | Glucokinase - metabolism | Carbohydrates | Research | Glucokinase | Analysis | Index Medicus
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16. Full Text Liver glucokinase: An overview on the regulatorymechanisms of its activity
by Massa, María L and Gagliardino, Juan J and Francini, Flavio
IUBMB Life, ISSN 1521-6543, 01/2011, Volume 63, Issue 1, pp. 1 - 6
Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or... 
glucose homeostasis | transcriptional and post‐transcriptional glucokinase activity regulation | liver | liver glucokinase activity | glucokinase | transcriptional and post-transcriptional glucokinase activity regulation
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17. Full Text Correcting postprandial hyperglycemia in Zucker diabetic fatty rats with an SGLT2 inhibitor restores glucose effectiveness in the liver and reduces insulin resistance in skeletal muscle
by O'Brien, Tracy P and Jenkins, Erin C and Estes, Shanea K and Castaneda, Antonio V and Ueta, Kiichiro and Farmer, Tiffany D and Puglisi, Allison E and Swift, Larry L and Printz, Richard L and Shiota, Masakazu
Diabetes, ISSN 0012-1797, 05/2017, Volume 66, Issue 5, pp. 1172 - 1184
Ten-week-old Zucker diabetic fatty (ZDF) rats at an early stage of diabetes embody metabolic characteristics of obese human patients with type 2 diabetes, such... 
SUBSTRATE OXIDATION | HEPATIC GLUCOKINASE | METABOLISM | GLUCOKINASE REGULATORY PROTEIN | DEFECT | ENDOCRINOLOGY & METABOLISM | HYPERINSULINEMIA | KINASE-C | MELLITUS | COTRANSPORTER 2 INHIBITION | CONSCIOUS RATS | Glucose Intolerance - metabolism | Oxidation-Reduction | Canagliflozin - pharmacology | Liver - metabolism | Insulin Resistance | Rats | Muscle, Skeletal - metabolism | Glucokinase - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Blood Glucose - drug effects | Hyperglycemia - metabolism | Rats, Zucker | Hypoglycemic Agents | Glucokinase - drug effects