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Journal Article
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 551 - 564
Hepatic glucose phosphorylation by GK (glucokinase) is regulated by GKRP (GK regulatory protein). GKRP forms a cytosolic complex with GK followed by nuclear... 
Allosteric regulation | Fructose phosphate ester | Glucokinase regulatory protein | Glucokinase | Metabolic regulation | Diabetes | Co-operativity | RAT-LIVER | GLYCEMIC CONTROL | ACTIVATION | fructose phosphate ester | BIOCHEMISTRY & MOLECULAR BIOLOGY | allosteric regulation | co-operativity | glucokinase regulatory protein | HEPATIC GLUCOKINASE | P446L VARIANT | FRUCTOSE | HUMAN GLUCOKINASE | STRUCTURAL BASIS | GLUCOSE | DIABETES THERAPY | diabetes | glucokinase | metabolic regulation | Adaptor Proteins, Signal Transducing - chemistry | Protein Unfolding | Allosteric Regulation | Humans | Protein Multimerization | Tryptophan - chemistry | Fructosephosphates - metabolism | Protein Interaction Domains and Motifs | Protein Stability | Glucokinase - chemistry | Recombinant Proteins - metabolism | Protein Refolding | Models, Molecular | Recombinant Proteins - chemistry | Spectrometry, Fluorescence | Glucokinase - genetics | Mutant Proteins - metabolism | Glucokinase - metabolism | Protein Transport | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Ligands | Protein Conformation | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Index Medicus | T2D, Type 2 diabetes | WT, wild-type | rGKRP, rat GKRP | NPC, nuclear pore complex | PPI, protein–protein interaction | NATA, N-acetyl-L-tryptophanamide | xGKRP, Xenopus GKRP | MH, D-mannoheptulose | GKA, GK activator | hGK, human GK | F6P, fructose 6-phosphate | hGKRP, human GKRP | GCKR | xGK, Xenopus GK | GKRPI, GKRP inhibitor | GK, glucokinase | TF, tryptophan fluorescence | GCK | GKRP, GK regulatory protein | SIS, sugar isomerase | F1P, fructose 1-phosphate
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 06/2014, Volume 1843, Issue 6, pp. 1123 - 1134
Journal Article
Diabetologia, ISSN 0012-186X, 1/2012, Volume 55, Issue 1, pp. 114 - 122
Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR)... 
Medicine & Public Health | Human Physiology | Glucokinase | Molecular mechanism | Metabolic Diseases | Association study | Internal Medicine | Genetics | TRANSLOCATION | TRIGLYCERIDE | GLUCOKINASE REGULATORY PROTEIN | RAT PRIMARY HEPATOCYTES | LIVER GLUCOKINASE | NUCLEAR EXPORT | LOCI | GLUCOSE | IMAGE-ANALYSIS | ENDOCRINOLOGY & METABOLISM | FRUCTOSE 1-PHOSPHATE | Adaptor Proteins, Signal Transducing - chemistry | Diabetes Mellitus, Type 2 - genetics | Humans | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Recombinant Fusion Proteins - metabolism | Cell Nucleus - enzymology | Cytosol - enzymology | Cell Nucleus - metabolism | Cell Nucleus - pathology | Luminescent Proteins - chemistry | Carrier Proteins - chemistry | Cytosol - pathology | Glucokinase - chemistry | Gene Library | Mice, Inbred C57BL | Cells, Cultured | Rats | Glucokinase - genetics | Mutant Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Glucokinase - metabolism | Protein Transport | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Cytosol - metabolism | Luminescent Proteins - genetics | Mice | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Hepatocytes - enzymology | Luminescent Proteins - metabolism | Type 2 diabetes | Glucose metabolism | Isoenzymes | Genes | Physiological aspects | Fluorescence | Glucose | Risk factors | Dextrose | Blood proteins | Beer | Proteins | Diabetes mellitus | Lipids | Biosynthesis | Kinetics | Energy transfer | Index Medicus
Journal Article
Journal Article
Journal Article
1995, Molecular biology intelligence unit (Unnumbered), ISBN 1570592071, 210
Book
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 546 - 9
Journal Article
IUBMB Life, ISSN 1521-6543, 01/2011, Volume 63, Issue 1, pp. 1 - 6
Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or... 
glucose homeostasis | transcriptional and post‐transcriptional glucokinase activity regulation | liver | liver glucokinase activity | glucokinase | transcriptional and post-transcriptional glucokinase activity regulation
Journal Article