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Journal of Endocrinology, ISSN 0022-0795, 08/2002, Volume 174, Issue 2, pp. 233 - 246
Glucose-dependent insulinotropic polypeptide (GIP) acts as a glucose-dependent growth factor for beta-cells. Here we show that GIP and glucose also act... 
PATHWAYS | IGF-I | RECEPTOR TYROSINE KINASES | ACTIVATED PROTEIN-KINASE | PHOSPHATIDYLINOSITOL 3-KINASE | MAP KINASE | ENDOCRINOLOGY & METABOLISM | ELEMENT-BINDING PROTEIN | INS-1 CELLS | GROWTH-FACTOR | FACTOR-I | Apoptosis - drug effects | Calcium - metabolism | Humans | Maleimides - pharmacology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Kinase 1 | Isoquinolines - pharmacology | Deoxyglucose - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Flavonoids - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Gastric Inhibitory Polypeptide - pharmacology | B-Lymphocytes - metabolism | Cell Line | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Arginase - genetics | Protein Kinase C - antagonists & inhibitors | Chelating Agents - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Sulfonamides - pharmacology | Egtazic Acid - pharmacology | MAP Kinase Signaling System - drug effects | Mitosis - drug effects | Androstadienes - pharmacology | Signal Transduction - drug effects | Glucokinase - antagonists & inhibitors | Plasmids | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Genistein - pharmacology | Glucose - metabolism | Alloxan - pharmacology | Benzylamines - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 04/2014, Volume 306, Issue 7, pp. R447 - R456
Song Z, Levin BE, Stevens W, Sladek CD. Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors. Am J Physiol Regul Integr Comp... 
Hormone release | Calcium imaging | Phosphatidylinositol 3 kinase | Glucose-sensing | Insulin | Glucokinase | PHYSIOLOGY | hormone release | insulin | FOOD-INTAKE | PHOSPHATIDYLINOSITOL 3-KINASE | ONSET OBESITY | ARCUATE NUCLEUS | RECEPTOR-DEFICIENT MICE | ENERGY-BALANCE | GASTRIC DISTENSION | HYPOTHALAMONEUROHYPOPHYSEAL EXPLANTS | INDUCED ANOREXIA | RAT-BRAIN | calcium imaging | phosphatidylinositol 3 kinase | glucokinase | glucose-sensing | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Supraoptic Nucleus - metabolism | Male | Vasopressins - metabolism | RNA, Messenger - metabolism | Oxytocin - metabolism | Supraoptic Nucleus - drug effects | Appetite Regulation | Supraoptic Nucleus - cytology | Time Factors | Receptor, Insulin - genetics | KATP Channels - antagonists & inhibitors | Neurons - metabolism | Neurons - drug effects | Phosphatidylinositol 3-Kinase - metabolism | Potassium Channel Blockers - pharmacology | Hypothalamo-Hypophyseal System - drug effects | Tissue Culture Techniques | Rats | Glucokinase - genetics | Glucokinase - metabolism | Rats, Sprague-Dawley | Hypothalamo-Hypophyseal System - metabolism | KATP Channels - metabolism | Insulin - metabolism | Animals | Hypothalamo-Hypophyseal System - cytology | Calcium Signaling - drug effects | Glucokinase - antagonists & inhibitors | Glucose - metabolism | Receptor, Insulin - metabolism | Protein Kinase Inhibitors - pharmacology | Glucose metabolism | Oxytocin | Research | Metabolism | Neurological research | Health aspects | Vasopressin | Calcium | Neurons | Hormones | Glucose | Cells | Index Medicus | Call for Papers
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 2010, Volume 21, Issue 7, pp. 606 - 612
Besides its role as a carboxylase prosthetic group, biotin has important effects on gene expression. However, the molecular mechanisms through which biotin... 
cGMP | Biotin | Gene expression | Glucokinase | Insulin signaling | CGMP | GLYCEMIC CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | HISTONE BIOTINYLATION | CHROMIUM PICOLINATE | NUTRITION & DIETETICS | HOLOCARBOXYLASE SYNTHETASE | X-RECEPTOR AGONISTS | GENE-EXPRESSION | HEPG2 CELLS | MULTIPLE CARBOXYLASE DEFICIENCY | TYPE-2 DIABETES-MELLITUS | TRANSCRIPTIONAL REGULATION | Cyclic GMP - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Islets of Langerhans - drug effects | Insulin - physiology | Rats, Wistar | Male | Guanylate Cyclase - antagonists & inhibitors | Biotin - physiology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Cyclic GMP - analogs & derivatives | Islets of Langerhans - metabolism | Adenosine Triphosphate - metabolism | Guanylate Cyclase - physiology | Autocrine Communication | Enzyme Inhibitors - pharmacology | Rats | Glucokinase - genetics | Receptors, Cytoplasmic and Nuclear - physiology | Soluble Guanylyl Cyclase | Insulin Antagonists - pharmacology | Glucokinase - metabolism | Animals | Signal Transduction - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Kinetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
The Plant Cell, ISSN 1040-4651, 8/2014, Volume 26, Issue 8, pp. 3224 - 3242
A kinetic model combining enzyme activity measurements and subcellular compartmentation was parameterized to fit the sucrose, hexose, and glucose-6-P contents... 
Enzymes | Cell walls | Cell division | Pericarp | LARGE-SCALE BIOLOGY ARTICLE | Kinetics | Plants | Parametric models | Vacuoles | Sugars | Fruits | INVERTASE ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL-CHARACTERIZATION | PLANT SCIENCES | CELL BIOLOGY | KEY ENZYMES | SUCROSE-PHOSPHATE SYNTHASE | ACTIVITY PROFILES | SINK METABOLISM | YOUNG FRUIT | ACCUMULATION | CARBOHYDRATE-METABOLISM | FLUXES | Osmotic Pressure | Vacuoles - physiology | Lycopersicon esculentum - enzymology | Fruit - enzymology | Glucosyltransferases - physiology | Glucosyltransferases - metabolism | Lycopersicon esculentum - growth & development | Biological Transport | Cell Division | Plant Proteins - antagonists & inhibitors | Sucrose - metabolism | Plant Proteins - metabolism | Fruit - metabolism | Lycopersicon esculentum - metabolism | beta-Fructofuranosidase - metabolism | Carbohydrate Metabolism | Glucokinase - metabolism | Fruit - growth & development | Carrier Proteins - metabolism | Plants, Genetically Modified - metabolism | Glucokinase - antagonists & inhibitors | Models, Biological | Vacuoles - metabolism | beta-Fructofuranosidase - antagonists & inhibitors | Glucose metabolism | Carbohydrate metabolism | Analysis | Physiological aspects | Models | Genetic engineering | Glucose | Dextrose | Index Medicus | Life Sciences | Large-Scale Biology
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2009, Volume 417, Issue 3, pp. 717 - 726
Journal Article
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2017, Volume 19, Issue 8, pp. 1078 - 1087
Aim: Small molecule activators of glucokinase (GKAs) have been explored extensively as potential anti-hyperglycaemic drugs for type 2 diabetes (T2D). Several... 
antidiabetic drug | GLUCOSE-6-PHOSPHATASE | HOMEOSTASIS | HEPATIC GLUCOKINASE | INHIBITION | METABOLISM | GLUCONEOGENESIS | PROTEIN-KINASE | LIVER GLUCOKINASE | ENDOCRINOLOGY & METABOLISM | RATS | TYPE-2 DIABETES-MELLITUS | Enzyme Activators - pharmacology | Gene Expression Regulation, Enzymologic - drug effects | Glucose-6-Phosphatase - genetics | Rats, Wistar | Pyruvate Kinase - chemistry | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Promoter Regions, Genetic - drug effects | Fructosediphosphates - metabolism | Overweight - metabolism | Hepatocytes - cytology | Glucokinase - chemistry | Hepatocytes - drug effects | Glucose-6-Phosphatase - chemistry | Overweight - pathology | Fructose - adverse effects | Pyruvate Kinase - metabolism | Metformin - pharmacology | Overweight - enzymology | Cells, Cultured | Glucokinase - genetics | Glucokinase - metabolism | Diet, Western - adverse effects | Mice, Inbred C3H | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Pyruvate Kinase - antagonists & inhibitors | Animals | Glucokinase - antagonists & inhibitors | Active Transport, Cell Nucleus - drug effects | Glucose-6-Phosphatase - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Thiazoles - pharmacology | Glucose-6-Phosphate - metabolism | Pyruvate Kinase - genetics | Fructose - administration & dosage | Type 2 diabetes | Phosphates | Drugs | Phosphatases | Isoenzymes | Blood sugar | Genes | Gene expression | Fructose | Prescribing | Pyrimidines | Metabolites | Analysis | Hypoglycemic agents | Kinases | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 446 - 14
Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing... 
C-13-METABOLIC FLUX ANALYSIS | METABOLISM | MULTIDISCIPLINARY SCIENCES | GROWTH | PARALLEL LABELING EXPERIMENTS | MASS ISOTOPOMER DISTRIBUTIONS | REDD1 | EXPRESSION | CANCER-THERAPY | MTOR | DELETION | Niacinamide - analogs & derivatives | Metformin - therapeutic use | Humans | Male | Antineoplastic Agents - therapeutic use | Metabolic Flux Analysis | Molecular Targeted Therapy | Carcinogenesis | Carcinoma, Hepatocellular - drug therapy | Antineoplastic Agents - pharmacology | Liver Neoplasms - enzymology | Hypoglycemic Agents - therapeutic use | Hexokinase - antagonists & inhibitors | Metformin - pharmacology | Liver Neoplasms - drug therapy | Oxidative Phosphorylation | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Carcinoma, Hepatocellular - enzymology | Mechanistic Target of Rapamycin Complex 1 - metabolism | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Sorafenib | Glycolysis | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Hexokinase - metabolism | Phosphorylation | Secretion | Serine | Pyruvic acid | Hepatocellular carcinoma | Fluxes | Glycine | Hexokinase | Liver cancer | Mitochondria | Depletion | Clonal deletion | Oxidative phosphorylation | Hepatocytes | Cell death | Rodents | Glucokinase | Deletion | Tumorigenesis | Lactic acid | Metformin | Inhibition | Apoptosis | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, pp. 20491 - 20496
Journal Article
Cell Reports, ISSN 2211-1247, 11/2012, Volume 2, Issue 5, pp. 1300 - 1315
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2015, Volume 4, Issue 1, pp. 5006 - 5006
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2006, Volume 397, Issue 3, pp. 519 - 527
Resveratrol mimics calorie restriction to extend lifespan of Caenorhabditis elegans, yeast and Drosophila, possibly through activation of Sir2 (silent... 
Insulin receptor substrate (IRS) | Insulin signalling pathway | p85 | Lifespan | SirT1 histone deacetylase | Resveratrol | LIFE-SPAN | lifespan | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | PROTEIN DEACETYLASES | RECEPTOR | SACCHAROMYCES-CEREVISIAE | SNELL DWARF MOUSE | SIR2 | insulin receptor substrate (IRS) | LONGEVITY | insulin signalling pathway | SIGNALING PATHWAY | resveratrol | CALORIE RESTRICTION | Fatty Acid Synthases - metabolism | Insulin - physiology | Humans | Depression, Chemical | Phosphatidylinositol 3-Kinases - metabolism | Hepatocytes - metabolism | Stilbenes - pharmacology | Phosphoproteins - metabolism | Protein Subunits - metabolism | RNA Interference | Sirtuin 1 | Insulin Receptor Substrate Proteins | Sirtuins - genetics | Hepatocytes - drug effects | Signal Transduction | Cells, Cultured | Sirtuins - physiology | Rats | Glucokinase - metabolism | Glucose-6-Phosphatase - metabolism | Sirtuins - biosynthesis | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Histone Deacetylase Inhibitors | GRB2 Adaptor Protein - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | EGFR, EGF receptor | RNAi, RNA interference | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | HEK-293 cell, human embryonic kidney cell | PEPCK, phosphoenolpyruvate carboxykinase | ERK, extracellular-signal-regulated kinase | DMEM, Dulbecco's modified Eagle's medium | GK, glucokinase | Sir2, silent information regulator 2 | IGFBP-1, IGF-binding protein 1 | IGF-1, insulin-like growth factor type I | NGF, neuronal growth factor | FAS, fatty acid synthase | MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide | Grb2, growth factor receptor-bound protein 2 | ApoE, apolipoprotein E | IRS-1, insulin receptor substrate 1 | MAPK, mitogen-activated protein kinase
Journal Article