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Journal Article
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2017, Volume 27, Issue 12, pp. 2678 - 2682
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 4/2012, Volume 45, Issue 2, pp. 348 - 361
The anorexigenic peptide, glucagon-like peptide-1 (GLP-1), reduces glucose metabolism in the human hypothalamus and brain stem. The brain activity of metabolic... 
Neurology | Control of feeding | Neurosciences | Biomedicine | Neurobiology | mTOR/S6K | AMPK | Antidiabetogenic agents | Hypothalamus | Zucker rats | Cell Biology | MTOR/S6K | RECEPTOR AGONISTS | GLUCOKINASE | NEUROSCIENCES | VENTROMEDIAL HYPOTHALAMUS | INSULIN | COUNTERREGULATORY HORMONE RESPONSES | NEURONS | INDUCED ANOREXIA | RAT-BRAIN | EXPRESSION | REGULATES FOOD-INTAKE | Hypothalamic Area, Lateral - metabolism | Ventromedial Hypothalamic Nucleus - enzymology | AMP-Activated Protein Kinases - metabolism | Rats, Wistar | Ribosomal Protein S6 Kinases - metabolism | Hypothalamic Area, Lateral - cytology | Glucagon-Like Peptide 1 - physiology | Male | Glucose - biosynthesis | Glucagon-Like Peptide 1 - genetics | Organ Culture Techniques | AMP-Activated Protein Kinases - antagonists & inhibitors | Rats | Hypothalamic Area, Lateral - enzymology | Ventromedial Hypothalamic Nucleus - metabolism | Feeding Behavior - physiology | Feeding Behavior - drug effects | Rats, Zucker | Animals | Hypothalamus - metabolism | Hypothalamus - cytology | Hypothalamus - enzymology | Glucose - metabolism | Ventromedial Hypothalamic Nucleus - cytology | Ribosomal Protein S6 Kinases - antagonists & inhibitors | Ribosomal Protein S6 Kinases - genetics | AMP-Activated Protein Kinases - genetics | Glucose | Hormones | Peptides | Bioenergetics | Kinases | Explants | TOR protein | Obesity | Feeding behavior | Brain stem | Brain slice preparation | Hypothalamus (lateral) | Nervous system | AMP-activated protein kinase | Polymerase chain reaction | Ribosomal protein S6 kinase | Glucose metabolism | Energy | Nutrients | Glucagon-like peptide 1 | Index Medicus
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, pp. e0126082 - e0126082
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 03/2011, Volume 335, Issue 2, pp. 177 - 188
Journal Article
Synthesis, ISSN 0039-7881, 02/2014, Volume 46, Issue 4, pp. 430 - 444
Abstract Discovery, optimization, and early development of drug candidates are very challenging and require a versatile synthetic chemistry toolbox. Organozinc... 
short review | antagonists | inhibitors | integrins | organozinc | activators | B-CELL DEVELOPMENT | ORGANOBORON DERIVATIVES | ACTIVE PRODRUG ESTERS | CHEMISTRY, ORGANIC | OLEFIN METATHESIS | CHRONIC MYELOID-LEUKEMIA | TYROSINE KINASE INHIBITORS | POLYFUNCTIONAL ORGANOZINC | CROSS-COUPLING REACTIONS | GLUCOKINASE ACTIVATORS | DIABETES THERAPY
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 07/2000, Volume 349, Issue Pt 1, pp. 13 - 17
Insulin stimulates the transcription of the sterol regulatory-element binding protein (SREBP) 1/ADD1 gene in liver. Hepatocytes in primary culture were used to... 
FORKHEAD TRANSCRIPTION FACTOR | sterol regulatory-element binding protein (SREBP) | ACTIVATION | ACID | 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | PHOSPHOENOLPYRUVATE CARBOXYKINASE GENE | INDUCTION | GLUCOKINASE | hepatocytes | LEUCINE ZIPPER PROTEIN | MESSENGER-RNA | PKB/cAkt | Receptors, Estrogen - metabolism | Insulin - physiology | Protein-Serine-Threonine Kinases | Estrogen Antagonists - pharmacology | Immunoblotting | Hepatocytes - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Time Factors | CCAAT-Enhancer-Binding Proteins - biosynthesis | Adenoviridae - genetics | Flavonoids - pharmacology | CCAAT-Enhancer-Binding Proteins - genetics | Chromones - pharmacology | Recombinant Proteins - metabolism | Transduction, Genetic | Signal Transduction | Liver - metabolism | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Morpholines - pharmacology | DNA-Binding Proteins - genetics | Precipitin Tests | Proto-Oncogene Proteins c-akt | Androstadienes - pharmacology | Wortmannin | Proto-Oncogene Proteins - physiology | Tamoxifen - pharmacology | Tamoxifen - analogs & derivatives | Transcription Factors | Genetic Vectors | Sterol Regulatory Element Binding Protein 1 | DNA-Binding Proteins - biosynthesis | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 06/2014, Volume 306, Issue 11, pp. E1225 - E1238
A loss of glucose effectiveness to suppress hepatic glucose production as well as increase hepatic glucose uptake and storage as glycogen is associated with a... 
Type 2 diabetes | Hepatic glucose flux | Glucotoxicity | Sodium-glucose cotransporter 2 inhibitor | Glucokinase | TRANSLOCATION | GLYCEMIC CONTROL | PHYSIOLOGY | LIVER GLUCOKINASE | hepatic glucose flux | sodium-glucose cotransporter 2 inhibitor | glucotoxicity | CONSCIOUS RATS | SKELETAL-MUSCLE | type 2 diabetes | HYPERGLYCEMIA | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | REGULATORY PROTEIN | PLASMA-GLUCOSE | ENDOGENOUS GLUCOSE-PRODUCTION | glucokinase | Immunohistochemistry | Liver - enzymology | Body Weight - drug effects | Male | Glucose - biosynthesis | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - biosynthesis | Hyperglycemia - pathology | Glucose - toxicity | Diabetes Mellitus, Type 2 - complications | Hyperinsulinism - metabolism | Glucosides - pharmacology | Obesity - complications | Liver - metabolism | RNA, Messenger - genetics | Oxygen Consumption | Rats | Thiophenes - pharmacology | Glucokinase - metabolism | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Obesity - metabolism | Hyperglycemia - metabolism | Rats, Zucker | Eating - drug effects | Organ Size - drug effects | Animals | Canagliflozin | Glucagon - metabolism | Glucose Clamp Technique | Obesity | Physiological aspects | Diabetes | Research | Phosphotransferases | Health aspects | Proteins | Phosphorylation | Physiology | Glucose | Cytoplasm | Index Medicus
Journal Article
Journal Article