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The Journal of biological chemistry, ISSN 1083-351X, 2004, Volume 279, Issue 19, pp. 20314 - 20326
...), a step which is essential for glucose metabolism in liver as well as for the induction of glycolytic and lipogenic genes... 
FATTY-ACID-SYNTHASE | GLUCOSE-HOMEOSTASIS | CARBOHYDRATE RESPONSE ELEMENT | RAT HEPATOCYTES | STEROL REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | PYRUVATE-KINASE GENE | TRANSCRIPTION FACTOR | CARNITINE-PALMITOYLTRANSFERASE-I | TRANSGENIC MICE | Glucokinase - physiology | Liver - enzymology | Fatty Acid Synthases - metabolism | Immunoblotting | Hepatocytes - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Glycogen - metabolism | Time Factors | CCAAT-Enhancer-Binding Proteins - physiology | Adenoviridae - genetics | Transcription, Genetic | Pentosephosphates - metabolism | RNA - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | DNA-Binding Proteins - physiology | Pyruvate Kinase - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Carbohydrate Metabolism | Cells, Cultured | Gene Expression Regulation | Lipid Metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Nuclear Proteins | Transcription Factors - metabolism | Blotting, Northern | Animals | Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Glucose - metabolism | Mice | Kinetics | Sterol Regulatory Element Binding Protein 1 | Glucose-6-Phosphate - metabolism | Acetyl-CoA Carboxylase - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism
Journal Article
Cell metabolism, ISSN 1550-4131, 2012, Volume 15, Issue 5, pp. 725 - 738
.... The liver is a key organ in insulin-mediated regulation of metabolism. To assess the role of hepatic mTORC2, we generated liver-specific rictor knockout (LiRiKO) mice... 
TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MOTIF PHOSPHORYLATION | DIABETIC-NEPHROPATHY | GLUCOSE-UTILIZATION | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Glucose Intolerance - metabolism | Phosphorylation | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Homeostasis | Glycogen Synthase Kinase 3 beta | Male | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 2 | Hyperglycemia - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Forkhead Transcription Factors - metabolism | Trans-Activators - genetics | Hyperinsulinism - genetics | Insulin - genetics | Lipogenesis | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Gluconeogenesis | Hyperinsulinism - metabolism | Glucose Intolerance - genetics | Signal Transduction | Liver - metabolism | Glucokinase - genetics | Glucose - genetics | Lipid Metabolism | Forkhead Transcription Factors - genetics | Glucokinase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Trans-Activators - deficiency | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | Glycolysis | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | Transcription Factors | Glucose metabolism | Hyperglycemia | Glucose | Isoenzymes | Dextrose
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 546 - 9
Journal Article
Diabetologia, ISSN 0012-186X, 1/2012, Volume 55, Issue 1, pp. 114 - 122
Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR)... 
Medicine & Public Health | Human Physiology | Glucokinase | Molecular mechanism | Metabolic Diseases | Association study | Internal Medicine | Genetics | RAT-LIVER | TRANSLOCATION | TRIGLYCERIDE | ACTIVATION | GLUCOKINASE REGULATORY PROTEIN | NUCLEAR EXPORT | LOCI | 6-PHOSPHATE | GENE | GLUCOSE | ENDOCRINOLOGY & METABOLISM | Adaptor Proteins, Signal Transducing - chemistry | Diabetes Mellitus, Type 2 - genetics | Humans | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Recombinant Fusion Proteins - metabolism | Cell Nucleus - enzymology | Cytosol - enzymology | Cell Nucleus - metabolism | Cell Nucleus - pathology | Luminescent Proteins - chemistry | Carrier Proteins - chemistry | Cytosol - pathology | Glucokinase - chemistry | Gene Library | Mice, Inbred C57BL | Cells, Cultured | Rats | Glucokinase - genetics | Mutant Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Glucokinase - metabolism | Protein Transport | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Cytosol - metabolism | Luminescent Proteins - genetics | Mice | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Hepatocytes - enzymology | Luminescent Proteins - metabolism | Type 2 diabetes | Glucose metabolism | Isoenzymes | Genes | Physiological aspects | Fluorescence | Glucose | Risk factors | Dextrose | Blood proteins | Beer | Proteins | Diabetes mellitus | Lipids | Biosynthesis | Kinetics | Energy transfer
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 7, p. e68332
Previously, we screened a proteoglycan for anti-hyperglycemic, named FYGL, from Ganoderma Lucidum. For further research of the antidiabetic mechanisms of FYGL... 
INSULIN | CELLS | PROTEIN | MESSENGER-RNA | TYROSINE-PHOSPHATASE 1B | MULTIDISCIPLINARY SCIENCES | LIVER | RESISTANCE | GLUCOKINASE | EXTRACTS | GENE-TRANSCRIPTION | Islets of Langerhans - drug effects | Liver - enzymology | C-Peptide - blood | Antioxidants - metabolism | Glycated Hemoglobin A - metabolism | Male | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Liver - drug effects | Islets of Langerhans - metabolism | Muscle, Skeletal - drug effects | C-Peptide - metabolism | Disease Models, Animal | Glucose Transporter Type 4 | Glucose Transporter Type 2 | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Glucokinase - metabolism | Hypolipidemic Agents - pharmacology | Reishi - metabolism | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Diabetes Mellitus, Type 2 - blood | Insulin - metabolism | Animals | Proteoglycans - pharmacology | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Mice | Oxidative Stress - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Biological Factors - pharmacology | Antioxidants | Isoenzymes | Analysis | Anticholesteremic agents | Muscles | Glycosylated hemoglobin | Amino acids | Hypoglycemic agents | Glucose | Dextrose | Oxidative stress | Animal models | Laboratories | Homeostasis | Pyruvic acid | Phosphatase | Fruit bodies | Proteins | Engineering | Signal transduction | Reduction | Hyperglycemia | Chinese medicine | Rodents | Hemoglobin | Protein transport | Pancreas | Polymers | Drug dosages | Glucose transporter | Enzymes | Secretion | Complications | Mushrooms | Diabetes mellitus | Metabolism | Insulin | Skeletal muscle | Herbal medicine | Glucokinase | Diabetes | Transporter
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 03/2012, Volume 55, Issue 3, pp. 790 - 799
.... Nevertheless, recent data indicate that inactivation of peripheral CB1R could also be directly involved in the control of lipid metabolism independently of central CB1R... 
RISK-FACTORS | COENZYME-A REDUCTASE | CONJUGATED LINOLEIC-ACID | FOOD-INTAKE | OVERWEIGHT PATIENTS | WEIGHT-LOSS | GASTROENTEROLOGY & HEPATOLOGY | TRANSCRIPTIONAL REGULATION | GLUCOKINASE GENE | INDUCED OBESE MICE | CB1 RECEPTORS | Protein Kinases - metabolism | Carbohydrate Metabolism - drug effects | Male | RNA, Messenger - metabolism | Piperidines - pharmacology | Mice, Mutant Strains | Dyslipidemias - prevention & control | Dyslipidemias - etiology | Disease Models, Animal | Pyrazoles - pharmacology | Fatty Liver - metabolism | Obesity - complications | Tissue Culture Techniques | Liver - metabolism | Mice, Inbred C57BL | Fatty Liver - prevention & control | Obesity - physiopathology | Cholesterol - metabolism | Obesity - metabolism | Gene Expression Regulation - drug effects | Animals | Receptor, Cannabinoid, CB1 - genetics | Oxygen Consumption - drug effects | Lipid Metabolism - drug effects | Receptor, Cannabinoid, CB1 - drug effects | Dyslipidemias - metabolism | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Lipid Metabolism - physiology | Fatty Liver - etiology | Obesity | Dyslipidemias | Pyrazoles | Liver | Carbohydrate Metabolism | Gene Expression Regulation | Oxygen Consumption | Lipid Metabolism | Cholesterol | Fatty Liver | Life Sciences | Protein Kinases | Piperidines | Receptor, Cannabinoid, CB1 | Food and Nutrition | RNA, Messenger
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 7, p. e0159077
Dehydroepiandrosterone ( DHEA) has a fat-reducing effect, while little information is available on whether DHEA regulates glucose metabolism, which would in turn affect fat deposition... 
DHEA | ANTIOBESITY | OBESITY | LIPID-METABOLISM PARAMETERS | MULTIDISCIPLINARY SCIENCES | GLUCONEOGENIC ENZYMES | ENDOCRINE FUNCTIONS | BETA-CELLS | IN-VIVO | GENE-EXPRESSION | ADIPOSE-TISSUE | Glucose Transport Proteins, Facilitative - metabolism | Gluconeogenesis - drug effects | Body Weight - drug effects | Dehydroepiandrosterone - administration & dosage | Diet, High-Fat - adverse effects | Phosphatidylinositol 3-Kinases - metabolism | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Glycogen - metabolism | Liver - drug effects | Time Factors | Proto-Oncogene Proteins c-akt - metabolism | Body Mass Index | Dehydroepiandrosterone - pharmacology | Liver - metabolism | RNA, Messenger - genetics | Rats | Rats, Sprague-Dawley | Phosphatidylinositol 3-Kinases - genetics | Animals | Phosphofructokinase-2 - metabolism | Hormones - metabolism | Signal Transduction - drug effects | Receptor, Insulin - metabolism | Blood Glucose - metabolism | Obesity | Metabolic diseases | Dehydroepiandrosterone | Usage | Health aspects | Risk factors | Veterinary colleges | Succinate dehydrogenase | Glycogen synthase | Body weight | Pyruvic acid | AKT protein | Activation | mRNA | Glucose | Kinases | Dehydrogenase | High fat diet | Glucose metabolism | Signal transduction | Rodents | Phosphofructokinase | Glucose transporter | Pyruvate kinase | Glycogen | Dietary supplements | Muscles | Malate dehydrogenase | Metabolism | Insulin | Body weight gain | Substrates | Phosphorylase | 1-Phosphatidylinositol 3-kinase | Signaling | Malate | Diet | Leptin | Glycogen phosphorylase | Glucokinase | Catabolism
Journal Article