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Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 725 - 738
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to... 
TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MOTIF PHOSPHORYLATION | DIABETIC-NEPHROPATHY | GLUCOSE-UTILIZATION | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Glucose Intolerance - metabolism | Phosphorylation | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Homeostasis | Glycogen Synthase Kinase 3 beta | Male | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 2 | Hyperglycemia - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Forkhead Transcription Factors - metabolism | Trans-Activators - genetics | Hyperinsulinism - genetics | Insulin - genetics | Lipogenesis | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Gluconeogenesis | Hyperinsulinism - metabolism | Glucose Intolerance - genetics | Signal Transduction | Liver - metabolism | Glucokinase - genetics | Glucose - genetics | Lipid Metabolism | Forkhead Transcription Factors - genetics | Glucokinase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Trans-Activators - deficiency | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | Glycolysis | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | Transcription Factors | Glucose metabolism | Hyperglycemia | Glucose | Isoenzymes | Dextrose | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 546 - 9
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2004, Volume 279, Issue 19, pp. 20314 - 20326
Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as... 
FATTY-ACID-SYNTHASE | GLUCOSE-HOMEOSTASIS | CARBOHYDRATE RESPONSE ELEMENT | RAT HEPATOCYTES | STEROL REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | PYRUVATE-KINASE GENE | TRANSCRIPTION FACTOR | CARNITINE-PALMITOYLTRANSFERASE-I | TRANSGENIC MICE | Glucokinase - physiology | Liver - enzymology | Fatty Acid Synthases - metabolism | Immunoblotting | Hepatocytes - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Glycogen - metabolism | Time Factors | CCAAT-Enhancer-Binding Proteins - physiology | Adenoviridae - genetics | Transcription, Genetic | Pentosephosphates - metabolism | RNA - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | DNA-Binding Proteins - physiology | Pyruvate Kinase - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Carbohydrate Metabolism | Cells, Cultured | Gene Expression Regulation | Lipid Metabolism | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Nuclear Proteins | Transcription Factors - metabolism | Blotting, Northern | Animals | Proteins - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors | Glucose - metabolism | Mice | Kinetics | Sterol Regulatory Element Binding Protein 1 | Glucose-6-Phosphate - metabolism | Acetyl-CoA Carboxylase - metabolism | Microscopy, Fluorescence | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1154 - 1166
During insulin-resistant states such as type II diabetes mellitus (T2DM), insulin fails to suppress hepatic glucose production (HGP) yet promotes lipid... 
HEPATIC GLUCOKINASE | LIPID-METABOLISM | TRANSCRIPTION FACTOR FOXO1 | IN-VIVO | FATTY-ACID | LIVER | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RESISTANCE | METABOLOMIC ANALYSIS | GLUCOKINASE EXPRESSION | CELL BIOLOGY | TOR Serine-Threonine Kinases - metabolism | Gluconeogenesis - drug effects | Vagus Nerve - drug effects | Male | Glucose - biosynthesis | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 1 | Liver - innervation | Adipose Tissue - metabolism | Efferent Pathways - drug effects | Fatty Acids, Nonesterified - metabolism | Multiprotein Complexes - metabolism | Lipogenesis - genetics | Liver - drug effects | Gene Deletion | Postprandial Period - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Heparin - pharmacology | Hepatocytes - drug effects | Forkhead Box Protein O1 - metabolism | Insulin - pharmacology | Glucose Tolerance Test | Liver - metabolism | Insulin Resistance | Signal Transduction - genetics | Glucokinase - metabolism | Efferent Pathways - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Vagus Nerve - physiology | Insulin - metabolism | Animals | Gluconeogenesis - genetics | Diet | Signal Transduction - drug effects | Lipogenesis - drug effects | Glucagon - metabolism | Adipose Tissue - drug effects | Medical colleges | Glucagon | Analysis | Liver | Insulin resistance | Diabetes | Glucose | Insulin | Dextrose | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2011, Volume 286, Issue 8, pp. 6049 - 6060
Resveratrol, a polyphenol compound, is known for its effects on energy homeostasis. With properties of energy sensors mediating effects of calorie restriction,... 
SIR2-LIKE PROTEINS | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | PANCREATIC-ISLETS | ADP-RIBOSYLTRANSFERASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | UNCOUPLING PROTEIN-2 | SACCHAROMYCES-CEREVISIAE | INCREASED DOSAGE | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Glucose Transporter Type 2 - genetics | Homeodomain Proteins - metabolism | Humans | Mitochondrial Proteins - genetics | Stilbenes - pharmacology | Oxygen Consumption - physiology | Sirtuin 1 - genetics | Glucose Transporter Type 2 - metabolism | DNA-Binding Proteins - metabolism | Insulin-Secreting Cells - metabolism | Mitochondria - genetics | Mitochondrial Proteins - metabolism | Up-Regulation - physiology | Resveratrol | Trans-Activators - genetics | Insulin-Secreting Cells - cytology | Insulin - genetics | Insulin Secretion | High Mobility Group Proteins - metabolism | Hepatocyte Nuclear Factor 1 - metabolism | Enzyme Inhibitors - pharmacology | Rats | Glucokinase - genetics | Glucose - pharmacology | Mitochondria - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Glucokinase - metabolism | Sirtuin 1 - antagonists & inhibitors | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Up-Regulation - drug effects | Insulin - metabolism | Animals | Oxygen Consumption - drug effects | Hepatocyte Nuclear Factor 1 - genetics | Cell Line, Tumor | Glucose - metabolism | Trans-Activators - metabolism | Carbazoles - pharmacology | High Mobility Group Proteins - genetics | Index Medicus | Pancreatic Islet | Sirtuins | Glucose Metabolism | Metabolism | SIRT
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2355 - 2369
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPIRATORY-CHAIN | SKELETAL-MUSCLE | PHOSPHOENOLPYRUVATE CARBOXYKINASE | ACTIVATED PROTEIN-KINASE | GLUCOKINASE TRANSLOCATION | GLUCOSE-METABOLISM | COACTIVATOR TORC2 | AICA RIBOSIDE | UPSTREAM KINASE | ISOLATED RAT HEPATOCYTES | Glucose-6-Phosphatase - genetics | Hypoglycemic Agents - metabolism | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Metformin - metabolism | AMP-Activated Protein Kinases | Hyperglycemia - genetics | Liver - drug effects | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Glucose - genetics | Glucose - pharmacology | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Hyperglycemia - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Up-Regulation - drug effects | Animals | Gluconeogenesis - genetics | Glucose-6-Phosphatase - biosynthesis | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Mice | Protein-Serine-Threonine Kinases - pharmacology | Type 2 diabetes | Control | Usage | Genetic aspects | Research | Metformin | Gene expression | Drug therapy | Health aspects | Gluconeogenesis | Index Medicus | Abridged Index Medicus | Up-Regulation | Glucose-6-Phosphatase | gluconeogenesis, animal models | Liver | Protein-Serine-Threonine Kinases | Glucose | LKB1 | Life Sciences | Hypoglycemic Agents | Phosphoenolpyruvate Carboxykinase (ATP) | Human health and pathology | Hyperglycemia | Hepatocytes | AMPK | Endocrinology and metabolism | Diabetes Mellitus, Type 2
Journal Article
Comparative Biochemistry and Physiology, Part A, ISSN 1095-6433, 02/2014, Volume 168, pp. 40 - 49
To elucidate the short-term time-course of liver metabolic response in rainbow trout to acute handling stress we subjected rainbow trout to 5 min chasing and... 
Energy metabolism | Time-course | Liver | Rainbow trout | Handling | GLYCOGEN-METABOLISM | PHYSIOLOGY | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CORTISOL RESPONSE | GLUCOCORTICOID-RECEPTOR | ZOOLOGY | GROWTH-HORMONE | BROCKMANN BODIES | GLUCOSENSING CAPACITY | GENE-EXPRESSION | SPARUS-AURATA | ENERGY-METABOLISM | Glucose-6-Phosphatase - genetics | Glycogen Phosphorylase - genetics | Fatty Acid Synthases - metabolism | Glycogen Synthase - metabolism | Lactic Acid - blood | Stress, Physiological | Carboxy-Lyases - genetics | Fish Proteins - genetics | Glycogen - metabolism | Carboxy-Lyases - metabolism | Hydrocortisone - blood | Fatty Acid Synthases - genetics | Fatty Acids - metabolism | Oncorhynchus mykiss - metabolism | Glycogen Synthase - genetics | Gene Expression | Pyruvate Kinase - metabolism | Liver - metabolism | Fish Proteins - metabolism | Blood Glucose | Glucokinase - genetics | Glucokinase - metabolism | Glucose-6-Phosphatase - metabolism | Glycogen Phosphorylase - metabolism | Triglycerides - metabolism | Acetyl-CoA C-Acetyltransferase - genetics | Gene Expression Regulation, Enzymologic | Animals | Metabolic Networks and Pathways | Animal Husbandry | Acetyl-CoA C-Acetyltransferase - metabolism | Pyruvate Kinase - genetics | Aquaculture | Glucose metabolism | Corticosteroids | Metabolites | Trout | Glycogen | Physiological aspects | Glucose | Dextrose | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2012, Volume 15, Issue 2, pp. 157 - 170
Journal Article
The Plant Cell, ISSN 1040-4651, 8/2014, Volume 26, Issue 8, pp. 3224 - 3242
A kinetic model combining enzyme activity measurements and subcellular compartmentation was parameterized to fit the sucrose, hexose, and glucose-6-P contents... 
Enzymes | Cell walls | Cell division | Pericarp | LARGE-SCALE BIOLOGY ARTICLE | Kinetics | Plants | Parametric models | Vacuoles | Sugars | Fruits | INVERTASE ACTIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNCTIONAL-CHARACTERIZATION | PLANT SCIENCES | CELL BIOLOGY | KEY ENZYMES | SUCROSE-PHOSPHATE SYNTHASE | ACTIVITY PROFILES | SINK METABOLISM | YOUNG FRUIT | ACCUMULATION | CARBOHYDRATE-METABOLISM | FLUXES | Osmotic Pressure | Vacuoles - physiology | Lycopersicon esculentum - enzymology | Fruit - enzymology | Glucosyltransferases - physiology | Glucosyltransferases - metabolism | Lycopersicon esculentum - growth & development | Biological Transport | Cell Division | Plant Proteins - antagonists & inhibitors | Sucrose - metabolism | Plant Proteins - metabolism | Fruit - metabolism | Lycopersicon esculentum - metabolism | beta-Fructofuranosidase - metabolism | Carbohydrate Metabolism | Glucokinase - metabolism | Fruit - growth & development | Carrier Proteins - metabolism | Plants, Genetically Modified - metabolism | Glucokinase - antagonists & inhibitors | Models, Biological | Vacuoles - metabolism | beta-Fructofuranosidase - antagonists & inhibitors | Glucose metabolism | Carbohydrate metabolism | Analysis | Physiological aspects | Models | Genetic engineering | Glucose | Dextrose | Index Medicus | Life Sciences | Large-Scale Biology
Journal Article
Diabetologia, ISSN 0012-186X, 1/2012, Volume 55, Issue 1, pp. 114 - 122
Translation of genetic association signals into molecular mechanisms for diabetes has been slow. The glucokinase regulatory protein (GKRP; gene symbol GCKR)... 
Medicine & Public Health | Human Physiology | Glucokinase | Molecular mechanism | Metabolic Diseases | Association study | Internal Medicine | Genetics | TRANSLOCATION | TRIGLYCERIDE | GLUCOKINASE REGULATORY PROTEIN | RAT PRIMARY HEPATOCYTES | LIVER GLUCOKINASE | NUCLEAR EXPORT | LOCI | GLUCOSE | IMAGE-ANALYSIS | ENDOCRINOLOGY & METABOLISM | FRUCTOSE 1-PHOSPHATE | Adaptor Proteins, Signal Transducing - chemistry | Diabetes Mellitus, Type 2 - genetics | Humans | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Recombinant Fusion Proteins - metabolism | Cell Nucleus - enzymology | Cytosol - enzymology | Cell Nucleus - metabolism | Cell Nucleus - pathology | Luminescent Proteins - chemistry | Carrier Proteins - chemistry | Cytosol - pathology | Glucokinase - chemistry | Gene Library | Mice, Inbred C57BL | Cells, Cultured | Rats | Glucokinase - genetics | Mutant Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Glucokinase - metabolism | Protein Transport | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Mutant Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Cytosol - metabolism | Luminescent Proteins - genetics | Mice | Polymorphism, Single Nucleotide | Diabetes Mellitus, Type 2 - pathology | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Substitution | Hepatocytes - enzymology | Luminescent Proteins - metabolism | Type 2 diabetes | Glucose metabolism | Isoenzymes | Genes | Physiological aspects | Fluorescence | Glucose | Risk factors | Dextrose | Blood proteins | Beer | Proteins | Diabetes mellitus | Lipids | Biosynthesis | Kinetics | Energy transfer | Index Medicus
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 01/2014, Volume 20, Issue 2, pp. 191 - 203
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 09/2007, Volume 189, Issue 18, pp. 6602 - 6610
Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
FLUX ANALYSIS | CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE LEVELS | CHEMOSTAT CULTURES | CARBON SOURCE | DEGRADATION PATHWAY | ESCHERICHIA-COLI | CRC GLOBAL REGULATOR | TOL PLASMID PWW0 | MICROBIOLOGY |