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PLoS Biology, ISSN 1544-9173, 04/2017, Volume 15, Issue 4, pp. e2001069 - e2001069
Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by... 
HEPATIC GLUCONEOGENESIS | HUMAN GENOME | CHROMATIN LANDSCAPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | COORDINATE DESCENT | IN-VIVO | BIOLOGY | DNA-BINDING PROTEINS | REV-ERB-ALPHA | HISTONE MODIFICATIONS | CIRCADIAN GENE-EXPRESSION | STRUCTURE PREDICTION | Promoter Regions, Genetic | ARNTL Transcription Factors - genetics | Fasting | Deoxyribonuclease I - genetics | Mice, Inbred C57BL | Circadian Rhythm - genetics | Gene Expression Regulation | ARNTL Transcription Factors - metabolism | Male | CLOCK Proteins - genetics | Circadian Clocks - genetics | Transcription Factors - genetics | Mice, Knockout | CLOCK Proteins - metabolism | Deoxyribonuclease I - metabolism | Multiprotein Complexes - metabolism | Animals | Chromatin Immunoprecipitation | Liver - physiology | RNA Polymerase II - genetics | Transcription, Genetic | Bioengineering | High resolution | Transcription factors | Genomics | Liver | Modules | Biochemistry | Assaying | Loads (forces) | Proteins | Eukaryotes | Life sciences | Bioinformatics | Deoxyribonucleic acid--DNA | Circadian rhythms | Nucleic acids | Gene expression | Mammals | Metabolism | Diurnal | Generalized linear models | Computer applications | Mice | Protein structure | Binding sites | DNA sequencing | Health sciences | Visualization | Chromatin | Animal models | Gene regulation | Genomes | Biology | DNA-directed RNA polymerase | Nanoparticles | Rodents | Dimensional analysis | Hepatocyte nuclear factor 4 | Mathematical models | Adrenal gland | Hepatocyte nuclear factor 1 | Deoxyribonuclease | Data analysis | Hypersensitivity | Diabetes mellitus | Data processing | Circadian rhythm | Ribonucleic acid--RNA | Computer programs | Feeding | Medicine | BMAL1 protein | Diabetes | Control theory | Molecular biology | Index Medicus | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2012, Volume 287, Issue 35, pp. 29579 - 29588
Mammalian target of rapamycin complex 2 (mTORC2) is a key activator of protein kinases that act downstream of insulin and growth factor signaling. Here we... 
TRANSCRIPTION FACTORS | DIABETES-MELLITUS | LIPID-METABOLISM | AKT/PKB | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | MOTIF PHOSPHORYLATION | RICTOR | MICE | KINASE-B | INDUCED INSULIN-RESISTANCE | Phosphorylation - physiology | Humans | Glycogen Synthase Kinase 3 beta | GTPase-Activating Proteins - metabolism | Phosphoproteins - metabolism | Cholesterol - genetics | Proto-Oncogene Proteins c-akt - genetics | Fatty Acids - genetics | Forkhead Transcription Factors - metabolism | Insulin Resistance - physiology | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Insulin - genetics | Proto-Oncogene Proteins c-akt - metabolism | Fatty Acids - metabolism | Lipogenesis - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Tumor Suppressor Proteins - metabolism | Liver - metabolism | Gene Expression Regulation - physiology | Glucose - genetics | Mice, Transgenic | Phosphoproteins - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Hep G2 Cells | Transcription Factors - metabolism | Insulin - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Glucose - metabolism | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | GTPase-Activating Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cholesterol - biosynthesis | Index Medicus | mTOR Complex (mTORC) | Liver Metabolism | mTOR Complex 2 (mTORC2) | Akt | Metabolism | Lipogenesis | Insulin | Gluconeogenesis
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 725 - 738
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to... 
TRANSCRIPTION FACTORS | LIPID-METABOLISM | INSULIN-RESISTANCE | ELEMENT-BINDING PROTEIN-1C | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | MOTIF PHOSPHORYLATION | DIABETIC-NEPHROPATHY | GLUCOSE-UTILIZATION | CELL-GROWTH | PHOSPHOINOSITIDE 3-KINASE | CELL BIOLOGY | Glucose Intolerance - metabolism | Phosphorylation | Liver - enzymology | TOR Serine-Threonine Kinases - metabolism | Homeostasis | Glycogen Synthase Kinase 3 beta | Male | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 2 | Hyperglycemia - genetics | Proto-Oncogene Proteins c-akt - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Forkhead Transcription Factors - metabolism | Trans-Activators - genetics | Hyperinsulinism - genetics | Insulin - genetics | Lipogenesis | Proto-Oncogene Proteins c-akt - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Gluconeogenesis | Hyperinsulinism - metabolism | Glucose Intolerance - genetics | Signal Transduction | Liver - metabolism | Glucokinase - genetics | Glucose - genetics | Lipid Metabolism | Forkhead Transcription Factors - genetics | Glucokinase - metabolism | Glycogen Synthase Kinase 3 - metabolism | Mice, Knockout | Hyperglycemia - metabolism | Proteins - genetics | Insulin - metabolism | Animals | Proteins - metabolism | Trans-Activators - deficiency | Glycogen Synthase Kinase 3 - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Glucose - metabolism | Glycolysis | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | Transcription Factors | Glucose metabolism | Hyperglycemia | Glucose | Isoenzymes | Dextrose | Index Medicus
Journal Article
Plant Physiology, ISSN 0032-0889, 2/2013, Volume 161, Issue 2, pp. 1034 - 1048
The regulation of carbon metabolism in the diatom Phaeodactylum tricornutum at the cell, metabolite, and gene expression levels in exponential fed-batch... 
Enzymes | Scotophase | Photophase | Genes | SYSTEMES AND SYNTHETIC BIOLOGY | Lipids | Gene expression regulation | Biosynthesis | Diatoms | Gene expression | Fatty acids | FATTY-ACID COMPOSITION | MARINE DIATOM | GLYCOLYTIC PATHWAY | MICROALGAE | MITOTIC CHROMOSOME | DARK CYCLE | CELL-CYCLE | NUTRIENT LIMITATION | CARBOHYDRATE-METABOLISM | PHYTOPLANKTON | PLANT SCIENCES | Oligonucleotide Array Sequence Analysis | Diatoms - genetics | Carbohydrate Metabolism - genetics | Gene Expression Profiling | Phylogeny | Pyruvate Dehydrogenase Complex - genetics | Mitosis - genetics | Acclimatization - radiation effects | Diatoms - metabolism | Glycolysis - genetics | Diatoms - radiation effects | Mitochondria - genetics | Membrane Transport Proteins - genetics | Mitochondria - radiation effects | Plastids - genetics | Lipid Metabolism - genetics | Plastids - metabolism | Carbon - metabolism | Mitosis - radiation effects | Carbon Cycle - genetics | Lipid Metabolism - radiation effects | Mitochondria - metabolism | Photoperiod | Pyruvate Dehydrogenase Complex - classification | Carbohydrate Metabolism - radiation effects | Gluconeogenesis - genetics | Gluconeogenesis - radiation effects | Membrane Transport Proteins - classification | Glycolysis - radiation effects | Gene Expression Regulation - radiation effects | Acclimatization - genetics | Plastids - radiation effects | Circadian rhythms | Physiological aspects | Acclimatization | Genetic aspects | Genetic regulation | Carbon | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e61262 - e61262
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is often used as a stable housekeeping marker for constant gene expression. However, the transcriptional... 
GLYCOLYSIS | APOPTOSIS | METABOLISM | MULTIDISCIPLINARY SCIENCES | GROWTH | DEATH | FOXM1 | GAPDH | Cell Cycle - genetics | Adenocarcinoma - pathology | Prognosis | Adenocarcinoma of Lung | Humans | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Case-Control Studies | DNA-Binding Proteins - metabolism | Glycolysis - genetics | Forkhead Transcription Factors - metabolism | Adenocarcinoma - genetics | DNA Helicases - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cellular Senescence - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Up-Regulation - genetics | Glyceraldehyde-3-Phosphate Dehydrogenases - genetics | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | DNA Helicases - metabolism | Gluconeogenesis - genetics | Survival Analysis | Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism | Forkhead Box Protein M1 | Neoplasm Staging | Cluster Analysis | Phosphates | Care and treatment | Patient outcomes | Analysis | Genes | Cell cycle | Genetic aspects | Information management | Genetic transcription | Lung cancer, Non-small cell | Fructose | Cancer | Regulations | Senescence | Dehydrogenases | Transcription | Ontology | Laboratories | Lung | Gene regulation | Lung cancer | Genomes | Kinases | Dehydrogenase | Phase transitions | Datasets | Fibroblasts | Localization | Gluconeogenesis | Enzymes | Data analysis | Cell survival | Cyclin-dependent kinases | Data processing | Metabolism | Gene expression | DNA microarrays | Medical prognosis | Glycolysis | Glyceraldehyde-3-phosphate dehydrogenase | Solid tumors | Aberration | Tumors | Apoptosis | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6670 - 6670
Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid... 
SKELETAL-MUSCLE | HYPERTROPHY | HOMEOSTASIS | GENE | MULTIDISCIPLINARY SCIENCES | MASS | DEGRADATION | ATROGIN-1 | IDENTIFICATION | INVOLVE | EXPRESSION | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2010, Volume 18, Issue 1, pp. 114 - 125
Increasing evidence indicates that epigenetic changes regulate cell genesis. Here, we ask about neural precursors, focusing on CREB binding protein (CBP), a... 
DEVBIO | MOLNEURO | HEPATIC GLUCONEOGENESIS | PHOSPHORYLATION | PROMOTER ELEMENTS | CREB-BINDING-PROTEIN | GENE-EXPRESSION | NEURONS | STEM-CELL | NEUROGENESIS | PROLIFERATION | DEVELOPMENTAL BIOLOGY | GLIOGENESIS | CELL BIOLOGY | Protein Kinase C - genetics | Brain - enzymology | Brain - abnormalities | Promoter Regions, Genetic - genetics | CREB-Binding Protein - genetics | DNA-Binding Proteins - metabolism | CREB-Binding Protein - metabolism | Cell Differentiation - genetics | Mental Disorders - genetics | Mental Disorders - enzymology | Rubinstein-Taybi Syndrome - genetics | Nervous System Malformations - enzymology | RNA Interference | Stem Cells - enzymology | Protein Kinase C - metabolism | Nervous System Malformations - physiopathology | Acetylation | Rubinstein-Taybi Syndrome - enzymology | Nervous System Malformations - genetics | Cell Lineage - genetics | Gene Expression Regulation, Developmental - physiology | Brain - physiopathology | Cells, Cultured | Mice, Transgenic | DNA-Binding Proteins - genetics | Mental Disorders - physiopathology | Mice, Knockout | Animals | Histones - genetics | Neurogenesis - physiology | Mice | Histones - metabolism | Rubinstein-Taybi Syndrome - physiopathology | Genetic disorders | Molecular genetics | Children's hospitals | Analysis | Histones | Protein kinases | Protein binding | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 28, pp. 20633 - 20645
Glucose/carbon metabolism is a fundamental cellular process in living cells. In response to varying environments, eukaryotic cells reprogram their... 
Isocitrate Lyase - genetics | Isocitrate Lyase - metabolism | Basic-Leucine Zipper Transcription Factors - metabolism | Phosphatidylinositol Phosphates - metabolism | Saccharomyces cerevisiae - genetics | Cytoplasm - metabolism | Galactokinase - genetics | Green Fluorescent Proteins - genetics | Protein Transport - drug effects | Glycolysis - genetics | Saccharomyces cerevisiae - metabolism | Glycolysis - physiology | Cell Nucleus - metabolism | Trans-Activators - genetics | Metabolic Networks and Pathways - physiology | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Gene Expression Regulation, Fungal | Green Fluorescent Proteins - metabolism | Repressor Proteins - genetics | Isocitrate Dehydrogenase - genetics | Nuclear Proteins - metabolism | Phosphotransferases (Alcohol Group Acceptor) - genetics | Glucose - pharmacology | Basic-Leucine Zipper Transcription Factors - genetics | Saccharomyces cerevisiae Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Carrier Proteins - genetics | Gluconeogenesis - physiology | Ethanol - pharmacology | Fructose-Bisphosphatase - metabolism | Metabolic Networks and Pathways - genetics | Carrier Proteins - metabolism | Gluconeogenesis - genetics | Galactokinase - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Isocitrate Dehydrogenase - metabolism | Trans-Activators - metabolism | Fructose-Bisphosphatase - genetics | Mutation | Index Medicus | Transcription Regulation | Tup1 Conversion | Glycolysis | Membrane Lipids | Metabolic Reprogramming | Metabolism | Phosphoinositide PI(3,5)P2 Lipid | Gluconeogenesis
Journal Article
Diabetes, ISSN 0012-1797, 08/2015, Volume 64, Issue 8, pp. 2791 - 2804
Understanding the molecular networks controlling ectopic lipid deposition, glucose tolerance, and insulin sensitivity is essential to identifying new... 
NEURONAL MIGRATION | SKELETAL-MUSCLE | HEPATIC INSULIN-RESISTANCE | FATTY-ACID OXIDATION | LIPIDOMIC ANALYSIS | ENDOCRINOLOGY & METABOLISM | MICE | AMYLOID PRECURSOR PROTEIN | ACETYL-COA CARBOXYLASE-1 | DOUBLECORTIN-LIKE-KINASE | CELL-DEATH | Diabetes Mellitus, Type 2 - genetics | Male | Intracellular Signaling Peptides and Proteins - metabolism | Diabetes Mellitus, Type 2 - metabolism | Body Weight - genetics | Hyperglycemia - genetics | Body Composition - genetics | Diet, High-Fat | Hyperinsulinism - genetics | Diabetes Mellitus, Type 2 - etiology | Lipid Metabolism - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Fatty Liver - genetics | Hyperinsulinism - metabolism | Glucose Tolerance Test | Fatty Liver - metabolism | Liver - metabolism | Protein-Serine-Threonine Kinases - genetics | Mice, Knockout | Hyperglycemia - metabolism | Insulin - metabolism | Animals | Gluconeogenesis - genetics | Insulin Resistance - genetics | Mice | Blood Glucose - metabolism | Acetyl-CoA Carboxylase - metabolism | Type 2 diabetes | Complications and side effects | Analysis | Metabolic diseases | Genetic aspects | Protein kinases | Risk factors | Diet | Rodents | Genetics | Lipids | Oxidation | Diabetes | Kinases | Index Medicus | Abridged Index Medicus | Metabolism | NEURONAL | MIGRATION | ACETYL-COA | Endokrinologi och diabetes | Endocrinology & Metabolism | CARBOXYLASE-1 | Endocrinology and Diabetes
Journal Article
Plant Cell, ISSN 1040-4651, 8/2015, Volume 27, Issue 8, pp. 2244 - 2260
Soil salinity increasingly causes crop losses worldwide. Although roots are the primary targets of salt stress, the signaling networks that facilitate... 
Datasets | Transcriptomes | Salts | RESEARCH ARTICLES | Genes | Plant roots | Amino acids | Carbohydrate metabolism | Plants | Amino acid metabolism | Plant cells | ASPARAGINE SYNTHETASE | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIGHT | DROUGHT | PLANT SCIENCES | CELL BIOLOGY | AMINO-ACID-METABOLISM | STRESS RESPONSES | GENE | ELECTRON-TRANSFER FLAVOPROTEIN | TRANSCRIPTION FACTOR | MOLECULAR-BASIS | Carbohydrate Metabolism - drug effects | Basic-Leucine Zipper Transcription Factors - metabolism | Salt-Tolerant Plants - drug effects | Calcium - metabolism | Sodium Chloride - pharmacology | Gluconeogenesis - drug effects | Protein-Serine-Threonine Kinases | Carbohydrate Metabolism - genetics | Plant Roots - genetics | Immunoblotting | Promoter Regions, Genetic - genetics | Plant Roots - drug effects | Arabidopsis Proteins - metabolism | Amino Acids - metabolism | Protein Binding - drug effects | Salt-Tolerant Plants - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | Plant Roots - metabolism | Signal Transduction - genetics | Transcriptome - drug effects | Transcriptome - genetics | Basic-Leucine Zipper Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | Arabidopsis - genetics | Abscisic Acid - pharmacology | Gene Expression Regulation, Plant - drug effects | Gluconeogenesis - genetics | Signal Transduction - drug effects | Mutation | Plant Growth Regulators - pharmacology | Salt-Tolerant Plants - genetics | Arabidopsis thaliana | Genetic aspects | Plant-soil relationships | Abscisic acid | Physiological aspects | Soils, Salts in | Index Medicus | Biological Sciences | Agricultural Biotechnology | Lantbruksvetenskaper | Agricultural Sciences | Cell Biology | Plant Biotechnology | Bioteknologi med applikationer på växter och djur | Naturvetenskap | Biokemi och molekylärbiologi | Biologiska vetenskaper | Biochemistry and Molecular Biology | Natural Sciences | Cellbiologi | Växtbioteknologi
Journal Article