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Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, p. 1377
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2012, Volume 165, Issue 5, pp. 1361 - 1374
BACKGROUND AND PURPOSE Pentoxifylline is in clinical trials for non‐alcoholic fatty liver disease and diabetic nephropathy. Metabolic and hepatic effects of... 
glucose | ChREBP | pentoxifylline | methylxanthine | fatty liver | drug‐induced liver injury | obesity | drug-induced liver injury | TRIGLYCERIDE TRANSFER PROTEIN | ELEMENT-BINDING PROTEIN | FACTOR-KAPPA-B | NONALCOHOLIC STEATOHEPATITIS | DIET-INDUCED OBESITY | PARTIAL LEPTIN DEFICIENCY | CYCLIC-AMP | IN-VIVO | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | METABOLIC-DISORDERS | Glucose Transporter Type 2 - genetics | Humans | Intestinal Absorption - drug effects | Male | Adipocytes - drug effects | Glycolysis - drug effects | Jejunum - metabolism | Glycolysis - genetics | Jejunum - drug effects | Inflammation - metabolism | Lipogenesis - genetics | Liver - drug effects | Pentoxifylline - pharmacology | Biomarkers - metabolism | Fatty Liver - metabolism | Liver - metabolism | Biomarkers - blood | Blood Glucose - drug effects | Cell Line, Tumor | Glucose - metabolism | Blood Glucose - genetics | Mice, Obese | Transaminases - blood | Mice | Oxidative Stress - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - genetics | Glucose Tolerance Test - methods | Diabetes Mellitus, Type 2 - metabolism | Obesity - genetics | Glucose Transporter Type 2 - metabolism | Sodium-Glucose Transporter 1 - genetics | Glycolysis - physiology | Lipids - blood | Sodium-Glucose Transporter 1 - metabolism | Nuclear Proteins - genetics | Sterol Regulatory Element Binding Protein 1 - metabolism | Fatty Liver - genetics | Mice, Inbred C57BL | Oxidative Stress - genetics | Glucose - genetics | Nuclear Proteins - metabolism | Transcription Factors - genetics | Obesity - metabolism | Transcription Factors - metabolism | Animals | Intestinal Absorption - genetics | Sterol Regulatory Element Binding Protein 1 - genetics | Adipocytes - metabolism | Lipogenesis - drug effects | Triglycerides - blood | Inflammation - genetics | Oxidative Stress | Biological Markers | Liver | Lipids | Adipocytes | Glucose | Intestinal Absorption | Life Sciences | Jejunum | Diabetes Mellitus, Type 2 | Lipogenesis | Pharmaceutical sciences | Obesity | Glucose Tolerance Test | Glucose Transporter Type 2 | Sodium-Glucose Transporter 1 | Blood Glucose | Inflammation | Triglycerides | Pharmacology | Nuclear Proteins | Pentoxifylline | Fatty Liver | Transaminases | Glycolysis | Transcription Factors | Sterol Regulatory Element Binding Protein 1 | Research Papers
Journal Article
Diabetologia, ISSN 1432-0428, 2018, Volume 61, Issue 10, pp. 2079 - 2086
Sodium–glucose cotransporters SGLT1 (encoded by SGLT1, also known as SLC5A1) and SGLT2 (encoded by SGLT2, also known as SLC5A2) are important mediators of... 
Heart failure | Intestinal glucose transport | Type 2 diabetes | Human Physiology | Sodium–glucose cotransporter | Metabolic Diseases | Internal Medicine | Chronic kidney disease | Review | Drug development | Medicine & Public Health | Type 1 diabetes | Inhibitor | Renal glucose transport | GLOMERULAR HYPERFILTRATION | DIABETES-MELLITUS | GLUCAGON-LIKE PEPTIDE-1 | ENDOCRINOLOGY & METABOLISM | Sodium-glucose cotransporter | CARDIOVASCULAR-DISEASE | INTESTINAL GLUCOSE | POSTPRANDIAL HYPERGLYCEMIA | IMPROVED GLYCEMIC CONTROL | PLACEBO-CONTROLLED TRIAL | CHRONIC KIDNEY-DISEASE | Sodium-Glucose Transporter 1 - antagonists & inhibitors | Intestinal Mucosa - metabolism | Sodium-Glucose Transporter 2 - metabolism | Humans | Sodium-Glucose Transporter 2 Inhibitors - pharmacology | Diabetes Mellitus, Type 1 - metabolism | Diabetes Mellitus, Type 2 - metabolism | Diabetes Mellitus, Type 1 - drug therapy | Kidney - metabolism | Animals | Drug Design | Glucose - metabolism | Diabetic Ketoacidosis - prevention & control | Mice | Mutation | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Phlorhizin - pharmacology | Disease Models, Animal | Glucose metabolism | Chronic kidney failure | Analysis | Genetically modified organisms | Drug discovery | Glucose | Drug approval | Dextrose | Cardiovascular system | Animal models | Kidneys | Cloning | Diabetes mellitus | Glucose transport | Sodium | Intestine | Renal failure | Malabsorption | Mathematical models | Galactose | Diabetes mellitus (non-insulin dependent) | Heart diseases
Journal Article
Diabetologia, ISSN 1432-0428, 2018, Volume 61, Issue 10, pp. 2087 - 2097
The concentration of glucose in plasma is held within narrow limits (4–10 mmol/l), primarily to ensure fuel supply to the brain. Kidneys play a role in glucose... 
GLUTs | Human Physiology | SGLTs | Metabolic Diseases | Internal Medicine | Glucose | Review | Type 2 diabetes mellitus | Gliflozins | Kidney | Proximal tubule | Phlorizin | Inhibitors | Medicine & Public Health | SODIUM | FANCONI-BICKEL-SYNDROME | LOW-AFFINITY | NA+/GLUCOSE COTRANSPORTER SGLT2 | TRANSPORT | THERAPEUTIC TARGET | ENDOCRINOLOGY & METABOLISM | PHLORHIZIN | EXPRESSION | BINDING | Glucose Transporter Type 2 - genetics | Humans | Sodium-Glucose Transporter 2 Inhibitors - pharmacology | Homeostasis | Diabetes Mellitus, Type 2 - metabolism | Sodium-Glucose Transporter 1 - physiology | Sodium-Glucose Transporter 1 - genetics | Glycosuria - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Sodium-Glucose Transporter 2 - physiology | Kidney - metabolism | Animals | Glucose Transporter Type 2 - physiology | Drug Design | HEK293 Cells | Kidney Tubules, Proximal - metabolism | Glucose - metabolism | Mice | Blood Glucose - metabolism | Kidney Tubules - metabolism | Phlorhizin - pharmacology | Sodium-Glucose Transporter 2 - genetics | Type 2 diabetes | Medical colleges | Analysis | Physiological aspects | Hypoglycemic agents | Dextrose | Membrane proteins | Glucose transporter | Urine | Excretion | Intravenous administration | Renal function | Kidneys | Diabetes mellitus | Reabsorption | Sodium | Physiology | Diabetes | Diabetes mellitus (non-insulin dependent)
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, p. e30555
Background: Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM).... 
SELECTIVE SGLT2 INHIBITOR | SODIUM | HOMEOSTASIS | HYPERGLYCEMIA | DAPAGLIFLOZIN | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | COTRANSPORTER | PROXIMAL TUBULAR CELLS | T-1095 | Thiophenes - therapeutic use | Diabetes Mellitus, Experimental - drug therapy | Humans | Body Weight - drug effects | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | Hyperglycemia - drug therapy | Sodium-Glucose Transporter 1 - genetics | Muscle, Skeletal - drug effects | Hyperglycemia - pathology | Sodium-Glucose Transport Proteins - metabolism | Glucosides - therapeutic use | Weight Gain - drug effects | Sodium-Glucose Transporter 1 - metabolism | Diabetes Mellitus, Experimental - metabolism | Kidney - physiopathology | Sodium-Glucose Transport Proteins - genetics | CHO Cells | Sodium-Glucose Transporter 2 - genetics | Cricetinae | Glucose Tolerance Test | Kidney - drug effects | Sodium-Glucose Transporter 2 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Rats | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hyperglycemia - metabolism | Rats, Zucker | Animals | Canagliflozin | Diabetes Mellitus, Experimental - pathology | Mice, Obese | Mice | Blood Glucose - metabolism | Type 2 diabetes | Glucose metabolism | Obesity | Blood sugar | Analysis | Body weight | Glycosylated hemoglobin | Diabetes therapy | Cell culture | Animal models | Renal function | Laboratories | Liver | Homeostasis | Fuel consumption | Diabetic neuropathy | Glucose | Oocytes | Hyperglycemia | Rodents | Hemoglobin | Glucose transporter | Excretion | Kidneys | Secretion | Research & development--R&D | Diabetes mellitus | Pharmacology | Insulin | Body weight gain | Myoblasts | Beta cells | Sodium | Weight reduction | Insulin resistance | Diabetes | Mutation | Transporter | Kidney transplantation | Pharmaceuticals | Research & development | R&D
Journal Article
by Pogue, Janice and Riddle, Matthew C and Chazova, I and Gilbert, R and Gomis, R and Pīrāgs, V and Bogaty, P and Corson, M and Harper, W.L and Cukierman-Yaffee, T and MacRae, S and Alvarez, N and Amuchastegui, M and Bello, F and Caccavo, A and Calveira, M and Camino, A and Cardone, M and Corinaldesi, F and Crespo, C and Fares Taie, A and Fernandez, A and Ferrari, N and Gutierrez, N and Hasbani, E and Hrabar, A and Lobo Marquez, L and Lugo, M and Mainini, S and Manzano, R and Mendez, N and Odetto, I and Polari, P and Ramirez, A and Sanchez, R and Smith Casabella, T and Streitenberger, P and Villamil, A and Amerena, J and Farshid, A and Lefkovits, J and O'Neal, D and Poynten, A and Simpson, R and Teede, H and Tiong, F and Waddell-Smith, K and Blocher, J and Brath, H and Breuss, J and Jankovic, V and Kann, T and Placher-Sorko, G and Sonnenfeld, M and Vetter, B and Wallner, F and Lazareva, I and Delana, J and Feitosa, G and Garcia, V and Kanedlai, N and Mothe, F and Ninno, T and Oliveira, C and Oliveira, O and Roldan, F and Bailey, A and Belanger, A and Carlson, B and Chagnon, P and Chessex, C and Crepeau, J and Dube, F and Gosselin, G and Harper, W and Ho, K and Hramiak, I and Hutchinson, A and Langlois, M and Lavoie, M and Mercier, M and Nawaz, S and O'Keefe, D and Pruneau, G and Raby, K and Richard, C and Steinson, D and VanRossum, N and Warnica, W and Galloso, R and Stockins, B and Chen, Y and Gao, X and Ji, L and Jia, W and Li, Q and Li, Y and Ling, Y and Lu, B and Peng, Y and ... and unav and The ORIGIN Trial Investigators and ORIGIN Trial Investigators
The New England journal of medicine, ISSN 1533-4406, 2012, Volume 367, Issue 4, pp. 319 - 328
In this study with a 2-by-2 factorial design, patients with cardiovascular risk factors and dysglycemia or type 2 diabetes received insulin glargine or... 
DIABETES-MELLITUS | MEDICINE, GENERAL & INTERNAL | GLYCEMIC CONTROL | THERAPY | GLARGINE | GLUCOSE CONTROL | DISEASE | RISK | PEOPLE | ENDOTHELIAL FUNCTION | BETA-CELL FUNCTION | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Cholesterol - blood | Humans | Middle Aged | Male | Incidence | Glucose Intolerance - drug therapy | Cardiovascular Diseases - epidemiology | Female | Drug Therapy, Combination | Hypoglycemia - chemically induced | Diabetes Mellitus, Type 2 - complications | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - etiology | Fasting | Blood Glucose - analysis | Double-Blind Method | Proportional Hazards Models | Hospitalization | Glucose Intolerance - complications | Insulin, Long-Acting - adverse effects | Insulin Glargine | Insulin, Long-Acting - therapeutic use | Intention to Treat Analysis | Triglycerides - blood | Fatty Acids, Omega-3 - therapeutic use | Aged | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Complications and side effects | Care and treatment | Insulin glargine | Patient outcomes | Causes of | Cardiovascular diseases | Risk factors | Myocardial infarction | Fees & charges | Cerebral infarction | Medical research | Stroke | Heart attacks | Statistical analysis | Diabetes mellitus | Glucose | Hypoglycemia | Fatty acids | Insulin | Glucose tolerance | Insulin resistance | Microvasculature | Diabetes | Diabetes mellitus (non-insulin dependent) | Heart diseases | Drug dosages | Cardiovascular Diseases | Insulin, Long-Acting | Blood Glucose | Triglycerides | Glucose Intolerance | Cholesterol | Life Sciences | Hypoglycemic Agents | Diabetes Mellitus, Type 2 | Fatty Acids, Omega-3
Journal Article