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1. Full Text Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
by Tamara J. Nicolson and Elisa A. Bellomo and Nadeeja Wijesekara and Merewyn K. Loder and Jocelyn M. Baldwin and Armen V. Gyulkhandanyan and Vasilij Koshkin and Andrei I. Tarasov and Raffaella Carzaniga and Katrin Kronenberger and Tarvinder K. Taneja and Gabriela da Silva Xavier and Sarah Libert and Philippe Froguel and Raphael Scharfmann and Volodymir Stetsyuk and Philippe Ravassard and Helen Parker and Fiona M. Gribble and Frank Reimann and Robert Sladek and Stephen J. Hughes and Paul R.V. Johnson and Myriam Masseboeuf and Remy Burcelin and Stephen A. Baldwin and Ming Liu and Roberto Lara-Lemus and Peter Arvan and Frans C. Schuit and Michael B. Wheeler and Fabrice Chimienti and Guy A. Rutter
Diabetes (New York, N.Y.), ISSN 0012-1797, 09/2009, Volume 58, Issue 9, pp. 2070 - 2083
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Zinc Transporter 8 | Zinc - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Male | Diabetes Mellitus, Type 2 - metabolism | Exocytosis - physiology | Diabetes Mellitus, Type 2 - epidemiology | Insulin-Secreting Cells - metabolism | Cation Transport Proteins - metabolism | Cytoplasmic Granules - metabolism | Gene Expression - physiology | Cation Transport Proteins - genetics | Female | Insulin Secretion | Insulin-Secreting Cells - physiology | Mice, Inbred C57BL | Risk Factors | Mice, Knockout | Polymorphism, Genetic | Insulin - metabolism | Animals | Homeostasis - physiology | Mice | HeLa Cells | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Type 2 diabetes | Physiological aspects | Zinc in the body | Development and progression | Genetic aspects | Glucose | Insulin | Health aspects | Dextrose | Index Medicus | Abridged Index Medicus | Life Sciences | Cancer | Original
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2. Cardiac and Renal Effects of Sodium-Glucose Co-Transporter 2 Inhibitors in Diabetes: JACC State-of-the-Art Review
by Zelniker, Thomas A and Zelniker, Thomas A and Braunwald, Eugene and Braunwald, Eugene
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2018, Volume 72, Issue 15, pp. 1845 - 1855
heart failure | renal function | diabetes | SGLT2 inhibitor | Diabetes Mellitus, Type 2 - physiopathology | Kidney - drug effects | Humans | Sodium-Glucose Transporter 2 Inhibitors - pharmacology | Treatment Outcome | Cardiovascular System - drug effects | Diabetes Mellitus, Type 2 - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - pharmacology | Myocardial infarction | Heart | Renal function | Heart attacks | Clinical trials | Cardiovascular disease | Glucose | Beta blockers | Diabetes mellitus (non-insulin dependent) | Heart diseases | Glucose transporter | Heart failure | Cerebral infarction | Medical research | Stroke | Mortality | Diabetes mellitus | Health risks | Patients | Inhibitors | Sodium | Infarction | Diabetes | Cardiovascular diseases | Transporter | Adenosine triphosphatase
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3. Full Text Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2
by Ghezzi, Chiara and Loo, Donald D. F and Wright, Ernest M
Diabetologia, ISSN 0012-186X, 10/2018, Volume 61, Issue 10, pp. 2087 - 2097
GLUTs | Human Physiology | SGLTs | Metabolic Diseases | Internal Medicine | Glucose | Review | Type 2 diabetes mellitus | Gliflozins | Kidney | Proximal tubule | Phlorizin | Inhibitors | Medicine & Public Health | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Glucose Transporter Type 2 - genetics | Humans | Sodium-Glucose Transporter 2 Inhibitors - pharmacology | Homeostasis | Diabetes Mellitus, Type 2 - metabolism | Sodium-Glucose Transporter 1 - physiology | Sodium-Glucose Transporter 1 - genetics | Glycosuria - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Sodium-Glucose Transporter 2 - physiology | Kidney - metabolism | Animals | Glucose Transporter Type 2 - physiology | Drug Design | HEK293 Cells | Kidney Tubules, Proximal - metabolism | Glucose - metabolism | Mice | Blood Glucose - metabolism | Kidney Tubules - metabolism | Phlorhizin - pharmacology | Sodium-Glucose Transporter 2 - genetics | Type 2 diabetes | Medical colleges | Analysis | Physiological aspects | Hypoglycemic agents | Dextrose | Membrane proteins | Glucose transporter | Urine | Excretion | Intravenous administration | Renal function | Kidneys | Diabetes mellitus | Reabsorption | Sodium | Physiology | Diabetes | Diabetes mellitus (non-insulin dependent) | Index Medicus
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4. Full Text Tofogliflozin, a novel sodium–glucose co‐transporter 2 inhibitor, improves renal and pancreatic function in db/db mice
by Nagata, T and Fukuzawa, T and Takeda, M and Fukazawa, M and Mori, T and Nihei, T and Honda, K and Suzuki, Y and Kawabe, Y
British journal of pharmacology, ISSN 0007-1188, 10/2013, Volume 170, Issue 3, pp. 519 - 531
tofogliflozin | nephropathy | beta‐cell loss | sodium–glucose co‐transporter inhibitor | sodium-glucose co-transporter inhibitor | beta-cell loss | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Kidney - pathology | Diabetic Nephropathies - etiology | Glycated Hemoglobin A - metabolism | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Angiotensin II Type 1 Receptor Blockers - pharmacology | Insulin-Secreting Cells - metabolism | Kidney - metabolism | Diabetic Nephropathies - physiopathology | Time Factors | Female | Albuminuria - metabolism | Diabetic Nephropathies - prevention & control | Diabetes Mellitus, Type 2 - complications | Kidney - physiopathology | Disease Models, Animal | Glucosides - pharmacology | Kidney - drug effects | Sodium-Glucose Transporter 2 - metabolism | Diabetic Nephropathies - metabolism | Losartan - pharmacology | Biomarkers - blood | Albuminuria - prevention & control | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Animals | Diabetes Mellitus, Type 2 - physiopathology | Insulin-Secreting Cells - drug effects | Benzhydryl Compounds - pharmacology | Mice | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | Pancreatic beta cells | Image processing | Blood sugar | Analysis | Angiotensin | Equipment and supplies | Glucose | Diabetes | Sodium | Pancreas | Insulin | Rodents | Index Medicus | Research Papers | sodium–glucose co-transporter inhibitor
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5. Full Text Sodium‐glucose co‐transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects
by Norton, Luke and Shannon, Christopher E and Fourcaudot, Marcel and Hu, Cheng and Wang, Niansong and Ren, Wei and Song, Jun and Abdul‐Ghani, Muhammad and DeFronzo, Ralph A and Ren, Jimmy and Jia, Weiping
Diabetes, obesity & metabolism, ISSN 1462-8902, 09/2017, Volume 19, Issue 9, pp. 1322 - 1326
kidney | glucose transporters (GLUT) | type 2 diabetes | sodium‐glucose co‐transporters (SGLT) | sodium-glucose co-transporters (SGLT) | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Glycated Hemoglobin A - analysis | Glucose Transporter Type 2 - genetics | Kidney - pathology | Humans | Glucose Transporter Type 1 - metabolism | Male | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Glucose Transporter Type 2 - metabolism | Sodium-Glucose Transporter 1 - genetics | Kidney - metabolism | China | Postprandial Period | Adult | Female | Sodium-Glucose Transporter 1 - metabolism | Sodium-Glucose Transporter 2 - genetics | Hypoglycemic Agents - therapeutic use | Reproducibility of Results | Fasting | Kidney - drug effects | Blood Glucose - analysis | Sodium-Glucose Transporter 2 - metabolism | Gene Expression Regulation - drug effects | Diabetes Mellitus, Type 2 - blood | Glucose Transporter Type 1 - genetics | Biopsy | Diabetes Mellitus, Type 2 - pathology | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Diabetics | Hyperglycemia | RNA | Glycosylated hemoglobin | Glucose | Dextrose | Diabetes | Index Medicus
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6. Full Text Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism
by Le Gall, Maude and Tobin, Vanessa and Stolarczyk, Emilie and Dalet, Véronique and Leturque, Armelle and Brot‐Laroche, Edith
Journal of cellular physiology, ISSN 0021-9541, 12/2007, Volume 213, Issue 3, pp. 834 - 843
Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Polarity | Glucose Transporter Type 2 - genetics | Glucose Transporter Type 5 - metabolism | Enterocytes - metabolism | Sweetening Agents - metabolism | Humans | RNA, Messenger - metabolism | Fructose - metabolism | Glucose Transporter Type 2 - metabolism | Sodium-Glucose Transporter 1 - genetics | Transfection | Cloning, Molecular | Sucrose - metabolism | Jejunum - cytology | Sodium-Glucose Transporter 1 - metabolism | Monosaccharide Transport Proteins - metabolism | Monosaccharide Transport Proteins - genetics | Oligo-1,6-Glucosidase - genetics | Caco-2 Cells | Protein Structure, Tertiary | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | Mice, Inbred C57BL | Hexoses - metabolism | Mice, Knockout | Animals | Glucose Transporter Type 2 - chemistry | Sucrase - genetics | Glucose - metabolism | Mice | Glucose Transporter Type 5 - genetics | Index Medicus | Green Fluorescent Proteins | Sucrose | Glucose | Cellular Biology | Tissues and Organs | Life Sciences | Jejunum | Oligo-1,6-Glucosidase | Sucrase | Food and Nutrition | Hexoses | Glucose Transporter Type 5 | Glucose Transporter Type 2 | Biochemistry, Molecular Biology | Sodium-Glucose Transporter 1 | Fructose | Human health and pathology | Enterocytes | Monosaccharide Transport Proteins | RNA, Messenger | Sweetening Agents
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7. Full Text Variants in pharmacokinetic transporters and glycemic response to metformin: A metgen meta-analysis
by Dujic, T and Zhou, K and Yee, S.W and Leeuwen, Nienke and Keyser, Catherina Elisabeth and Javorský, M and Goswami, S and Zaharenko, L and Hougaard Christensen, M.M and Out, Mattijs and Tavendale, Roger and Kubo, M and Hedderson, M.M and Heijden, Amber A. W and Klimčáková, L and Pirags, Valdis and Kooy, Aiaan and Brøsen, K and Klovins, Janis and Semiz, S and Tkáč, Ivan and Stricker, Bruno and Palmer, Colin and Hart, Leen and Giacomini, Kathleen and Pearson, Ewan
Clinical pharmacology and therapeutics, ISSN 0009-9236, 06/2017, Volume 101, Issue 6, pp. 763 - 772
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Metformin - therapeutic use | Diabetes Mellitus, Type 2 - genetics | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Organic Cation Transporter 2 | Membrane Transport Proteins - genetics | Symporters | Aged, 80 and over | Pharmacogenomic Variants | Female | Membrane Transport Proteins - metabolism | Databases, Factual | Hypoglycemic Agents - therapeutic use | Organic Cation Transport Proteins - metabolism | Genotype | Treatment Outcome | Octamer Transcription Factor-1 - genetics | Biomarkers - blood | Blood Glucose - drug effects | Diabetes Mellitus, Type 2 - diagnosis | Diabetes Mellitus, Type 2 - blood | Phenotype | Aged | Polymorphism, Single Nucleotide | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Organic Cation Transport Proteins - genetics | Octamer Transcription Factor-1 - metabolism | Type 2 diabetes | Analysis | Dosage and administration | Genetic aspects | Research | Metformin | Pharmacokinetics | Drug therapy | Genetic polymorphisms | Index Medicus | Abridged Index Medicus
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8. Full Text The role of the kidneys in glucose homeostasis in type 2 diabetes: Clinical implications and therapeutic significance through sodium glucose co-transporter 2 inhibitors
by Wilding, John P.H
Metabolism, clinical and experimental, ISSN 0026-0495, 2014, Volume 63, Issue 10, pp. 1228 - 1237
Endocrinology & Metabolism | Sodium glucose co-transporter 2 (SGLT2) inhibitor | Kidneys | Type 2 diabetes mellitus | Life Sciences & Biomedicine | Science & Technology | Kidney - metabolism | Diabetes Mellitus, Type 2 - physiopathology | Sodium-Glucose Transporter 2 - metabolism | Homeostasis - physiology | Humans | Glucose - metabolism | Diabetes Mellitus, Type 2 - metabolism | Kidney - physiopathology | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Type 2 diabetes | Homeostasis | Glucose metabolism | Glucose | Health aspects | Dextrose | Index Medicus
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