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glucose-6-phosphatase - metabolism (1229) 1229
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biochemistry & molecular biology (781) 781
glucose-6-phosphatase (719) 719
liver - enzymology (648) 648
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liver - metabolism (465) 465
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liver (416) 416
glucose (409) 409
microsomes, liver - enzymology (400) 400
kinetics (369) 369
female (365) 365
glucose-6-phosphatase - analysis (339) 339
glucose - metabolism (322) 322
glucose-6-phosphatase - genetics (321) 321
liver - drug effects (317) 317
gluconeogenesis (259) 259
metabolism (214) 214
insulin (204) 204
in vitro techniques (199) 199
cell biology (191) 191
glycogen (173) 173
glucose-6-phosphatase - antagonists & inhibitors (172) 172
dextrose (170) 170
enzymes (168) 168
microscopy, electron (163) 163
diabetes (159) 159
time factors (159) 159
blood glucose - metabolism (158) 158
liver - cytology (158) 158
rats, wistar (156) 156
pharmacology & pharmacy (152) 152
phosphatases (151) 151
rats, inbred strains (151) 151
biophysics (148) 148
expression (137) 137
microsomes, liver - metabolism (136) 136
gene expression (133) 133
glucose metabolism (133) 133
glycogen - metabolism (133) 133
microsomes, liver - drug effects (128) 128
microsomes - enzymology (127) 127
physiological aspects (125) 125
hydrogen-ion concentration (121) 121
phosphoenolpyruvate carboxykinase - metabolism (119) 119
research (119) 119
rats, sprague-dawley (116) 116
centrifugation, density gradient (115) 115
kidney - enzymology (115) 115
fructose-bisphosphatase - metabolism (114) 114
histocytochemistry (114) 114
endocrinology & metabolism (113) 113
gluconeogenesis - drug effects (111) 111
phosphorylation (110) 110
cell fractionation (105) 105
glucokinase - metabolism (103) 103
molecular sequence data (100) 100
cells, cultured (99) 99
insulin - blood (97) 97
microsomes (96) 96
hypoglycemic agents - pharmacology (94) 94
mitochondria, liver - enzymology (94) 94
carbohydrate metabolism (93) 93
acid phosphatase - metabolism (92) 92
cell membrane - enzymology (92) 92
phosphates (90) 90
insulin resistance (89) 89
mice, inbred c57bl (89) 89
proteins (89) 89
endoplasmic reticulum - enzymology (88) 88
acid phosphatase - analysis (87) 87
fasting (87) 87
insulin - pharmacology (86) 86
old medline (86) 86
gene-expression (83) 83
rodents (83) 83
hepatocytes (82) 82
homeostasis (82) 82
insulin-resistance (82) 82
system (82) 82
chemistry, medicinal (81) 81
phosphotransferases - metabolism (80) 80
rna, messenger - metabolism (80) 80
genetics & heredity (78) 78
glucosephosphate dehydrogenase - metabolism (78) 78
glycogen storage disease type i - genetics (77) 77
liver glycogen - metabolism (77) 77
research article (77) 77
diabetes mellitus (76) 76
glucose-6-phosphate (76) 76
identification (76) 76
glucokinase (75) 75
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Diabetes, ISSN 0012-1797, 11/2012, Volume 61, Issue 11, pp. 3018 - 3025
Type 1 diabetes is characterized by the autoimmune destruction of pancreatic beta-cells. Recognition of major histocompatibility complex (MHC)-bound peptides... 
INSULIN | DEPENDENT DIABETES-MELLITUS | BINDING MOTIF | PROTEIN | LIGANDS | ENDOCRINOLOGY & METABOLISM | IDENTIFICATION | 26 S-PROTEASOME | EXPRESSION | ANTIGENIC PEPTIDE | MOLECULES | Autoantigens - metabolism | Spleen - immunology | Histocompatibility Antigens - chemistry | Diabetes Mellitus, Type 1 - metabolism | Inflammation Mediators - isolation & purification | Chromatography, High Pressure Liquid | Interferon-gamma - metabolism | Proteins - isolation & purification | Janus Kinase 1 - metabolism | Tandem Mass Spectrometry | Insulin-Secreting Cells - metabolism | Immunodominant Epitopes - metabolism | Inflammation Mediators - metabolism | Female | Histocompatibility Antigens - isolation & purification | Diabetes Mellitus, Type 1 - immunology | Histocompatibility Antigens - metabolism | Thymus Gland - metabolism | Glucose-6-Phosphatase - chemistry | Cell Line | Peptide Fragments - metabolism | Glucose-6-Phosphatase - isolation & purification | Immunodominant Epitopes - chemistry | Peptide Fragments - isolation & purification | Autoantigens - chemistry | Organ Specificity | Insulin-Secreting Cells - immunology | Glucose-6-Phosphatase - metabolism | Janus Kinase 1 - chemistry | Peptide Fragments - chemistry | Animals | Proteins - metabolism | Spleen - metabolism | Autoantigens - isolation & purification | Inflammation Mediators - chemistry | Mice, Inbred NOD | Thymus Gland - immunology | Mice | Immunodominant Epitopes - isolation & purification | Proteins - chemistry | Janus Kinase 1 - isolation & purification | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Genomes | Proteomics
Journal Article
Cell Metabolism, ISSN 1550-4131, 2006, Volume 3, Issue 6, pp. 403 - 416
AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and whole-body energy metabolism. We have identified a thienopyridone family... 
SIGNALING | SKELETAL-MUSCLE | PROTEIN-KINASE CASCADE | FATTY-ACID OXIDATION | MALONYL-COA | GLYCOGEN-PHOSPHORYLASE | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | ACETYL-COA CARBOXYLASE | CELLULAR-ENERGY | ISOLATED RAT HEPATOCYTES | GLOBULAR DOMAIN | CELL BIOLOGY | Enzyme Activators - pharmacology | Glucose-6-Phosphatase - genetics | Thiophenes - therapeutic use | Metformin - therapeutic use | Molecular Weight | Fatty Acid Synthases - metabolism | Enzyme Activators - therapeutic use | Humans | Phosphoenolpyruvate Carboxykinase (GTP) - drug effects | Phosphoenolpyruvate Carboxykinase (GTP) - metabolism | Multienzyme Complexes - metabolism | Metabolic Syndrome - metabolism | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | RNA, Messenger - metabolism | Metabolic Syndrome - drug therapy | Pyrones - pharmacology | AMP-Activated Protein Kinases | Phosphoenolpyruvate Carboxykinase (GTP) - genetics | Dose-Response Relationship, Drug | Pyrones - chemistry | Enzyme Activators - chemistry | Fatty Acid Synthases - genetics | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Fatty Acid Synthases - drug effects | RNA, Messenger - drug effects | Cell Line | Metformin - chemistry | Metformin - pharmacology | RNA, Messenger - genetics | Rats | Thiophenes - pharmacology | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Glucose-6-Phosphatase - metabolism | Glucose-6-Phosphatase - drug effects | Animals | Protein-Serine-Threonine Kinases - drug effects | Pyrones - therapeutic use | Mice, Obese | Mice | Diabetes Mellitus, Type 2 - drug therapy | In Vitro Techniques | Thiophenes - chemistry | Enzyme Activation - physiology | Multienzyme Complexes - drug effects | Type 2 diabetes | Synthesis | Analysis | Insulin resistance | Lipids | Triglycerides | Glucose | Gene expression | Protein kinases | Fatty acids | Dextrose | Index Medicus
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 08/2013, Volume 61, Issue 31, pp. 7515 - 7521
A new biological activity of falcarindiol isolated from Japanese parsley (Oenanthe javanica) using the mutant yeast YNS17 strain (zds1 Delta erg3 Delta pdr1... 
GSK-3β | oral glucose tolerance test | Japanese parsley | glutamate-induced oxidative cell death | Oenanthe javanica | Saccharomyces cerevisiae | falcarindiol | glucose-6-phosphatase | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | FOOD SCIENCE & TECHNOLOGY | KINASE | FLAVONE | POLYACETYLENES | SKELETAL-MUSCLE | INSULIN-RESISTANCE | AGRICULTURE, MULTIDISCIPLINARY | CALCINEURIN | PLANTS | CHEMISTRY, APPLIED | GSK-3 beta | EXPRESSION | Glucose-6-Phosphatase - genetics | Plant Extracts - chemistry | Apoptosis - drug effects | Humans | Oenanthe - chemistry | Male | Diabetes Mellitus, Type 2 - metabolism | Fatty Alcohols - chemistry | Enzyme Inhibitors - administration & dosage | Plant Extracts - administration & dosage | Diynes - isolation & purification | Fatty Alcohols - administration & dosage | Enzyme Inhibitors - chemistry | Fatty Alcohols - isolation & purification | Cell Line | Alzheimer Disease - physiopathology | Diynes - chemistry | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Diabetes Mellitus, Type 2 - enzymology | Alzheimer Disease - drug therapy | Diynes - administration & dosage | Rats | Plant Extracts - isolation & purification | Alzheimer Disease - enzymology | Glycogen Synthase Kinase 3 - metabolism | Enzyme Inhibitors - isolation & purification | Glucose-6-Phosphatase - metabolism | Animals | Glycogen Synthase Kinase 3 - genetics | Glucose-6-Phosphatase - antagonists & inhibitors | Glucose - metabolism | Mice | Kinetics | Diabetes Mellitus, Type 2 - drug therapy | Index Medicus
Journal Article
Biochimie, ISSN 0300-9084, 03/2012, Volume 94, Issue 3, pp. 695 - 703
Glucose-6 phosphatase (G6Pase), a key enzyme of glucose homeostasis, catalyses the hydrolysis of glucose-6 phosphate (G6P) to glucose and inorganic phosphate.... 
Fluorescence energy transfer | Glucose-6-phosphate transporter | Glucose-6-phosphatase | Glucose-6-phosphatase catalytic unit | Glycogen storage disease type 1 | TRANSPORT-SYSTEM | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICROSCOPY | GLUCOSE 6-PHOSPHATASE | INACTIVATION | GLYCOGEN-STORAGE-DISEASE | MICROSOMAL GLUCOSE-6-PHOSPHATASE | METABOLISM | GENE | TRANSMEMBRANE TOPOLOGY | Immunohistochemistry | Glucose-6-Phosphatase - genetics | Antiporters - chemistry | Humans | Intracellular Membranes | Immunoblotting | Protein Subunits - metabolism | Antiporters - genetics | Fluorescence Resonance Energy Transfer | Monosaccharide Transport Proteins - metabolism | Glucose-6-Phosphatase - chemistry | Monosaccharide Transport Proteins - genetics | Protein Subunits - genetics | Recombinant Proteins - metabolism | Protein Structure, Secondary | Recombinant Proteins - chemistry | Antiporters - metabolism | Recombinant Proteins - genetics | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Glycogen Storage Disease Type I - enzymology | Glycogen Storage Disease Type I - genetics | Monosaccharide Transport Proteins - chemistry | Protein Subunits - chemistry | HeLa Cells | Phosphates | Hydrolysis | Enzymes | Phosphatases | Glycogen | Fluorescence | Glucose | Dextrose | Glucose metabolism | Index Medicus | Protein Subunits | Glucose-6-Phosphatase | Biochemistry, Molecular Biology | Recombinant Proteins | Life Sciences | Monosaccharide Transport Proteins | Glycogen Storage Disease Type I | Antiporters
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 05/2019, Volume 305, pp. 180 - 194
Didymin is a naturally occurring orally active flavonoid glycoside (isosakuranetin 7- -rutinoside) found in various citrus fruits, which has been previously... 
Diabetic complication | Enzyme kinetics | Didymin | Diabetes mellitus | Molecular docking | Insulin signaling | OXIDATIVE STRESS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | RECEPTOR | IN-VITRO | POTENT | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INHIBITOR | MOLECULAR-BASIS | ALDOSE REDUCTASE | GLYCATION END-PRODUCTS | Glucose-6-Phosphatase - genetics | Hypoglycemic Agents - metabolism | Gluconeogenesis - drug effects | Humans | Citrus - chemistry | Phosphatidylinositol 3-Kinases - metabolism | Flavonoids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Binding Sites | Glycosides - chemistry | Catalytic Domain | Insulin Resistance | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Hypoglycemic Agents - chemistry | Glycogen Synthase Kinase 3 - metabolism | Glycosides - pharmacology | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Citrus - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Signal Transduction - drug effects | Glycosides - metabolism | Flavonoids - metabolism | Glycation End Products, Advanced - metabolism | Glucose - metabolism | Molecular Docking Simulation | Flavonoids - chemistry | alpha-Glucosidases - metabolism | alpha-Glucosidases - chemistry | Tyrosine | Citrus fruits | Phosphatases | Flavones | Glycogen | Bioflavonoids | Glucose | Insulin | Dextrose | Citrus | Complications and side effects | Flavonoids | Diet therapy | Aldose reductase | Force and energy | Exhibitions | Diabetes | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, pp. e0166557 - e0166557
The purpose of this study was to investigate the effects of leaf extract from Lithocarpus polystachyus Rehd. on type II diabetes mellitus (T2DM) and the active... 
DIHYDROCHALCONES | DIET | METABOLISM | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | LIVER | LEAVES | PHLORHIZIN | ABSORPTION | GLUCOSE-TOLERANCE | TRILOBATIN | Plant Extracts - chemistry | Diabetes Mellitus, Experimental - drug therapy | Plant Extracts - pharmacology | Body Weight - drug effects | Male | Amino Acid Isomerases - analysis | Malondialdehyde - analysis | Glycogen - metabolism | Liver - drug effects | Glutathione - analysis | Diabetes Mellitus, Experimental - chemically induced | Fagaceae - metabolism | Plant Leaves - chemistry | Fagaceae - chemistry | Glucose Tolerance Test | Superoxide Dismutase - analysis | Blood Glucose - analysis | Liver - metabolism | Cells, Cultured | Hypoglycemic Agents - chemistry | Down-Regulation - drug effects | Hypoglycemic Agents - pharmacology | Up-Regulation - drug effects | Insulin - metabolism | Animals | Plant Leaves - metabolism | Liver - cytology | Mice | Streptozocin - toxicity | Plant Extracts - therapeutic use | Type 2 diabetes | Glucose metabolism | Usage | Hyperglycemia | Synthesis | Glycogen | Physiological aspects | Research | Risk factors | Oxidative stress | Physiological effects | Streptozocin | Liver | Body weight | Glucose | Kinases | Blood | Leaves | Rodents | Down-regulation | Gluconeogenesis | Glucose transporter | Stresses | Diabetes mellitus | Pharmacology | Gene expression | Insulin | Substrates | Glucokinase | Insulin resistance | In vivo methods and tests | Glucose-6-phosphatase | In vitro methods and tests | Transporter | Index Medicus
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 01/2011, Volume 133, Issue 2, pp. 598 - 607
This study aims to investigate the hypoglycemic properties of (VA) and its possible mechanisms of action in a single-dose STZ induced diabetic rat model. A... 
Polyphenols | Vernonia amygdalina | Diabetes | Glucose-6-phosphatase | Streptozotocin | GLUT 4 | METFORMIN | SIGNALING PATHWAYS | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | MECHANISMS | MELLITUS | PLANT SCIENCES | INSULIN | SKELETAL-MUSCLE | MODELS | GLUT-4 GLUCOSE TRANSPORTERS | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | Plant Extracts - chemistry | Diabetes Mellitus, Experimental - drug therapy | Glucose Transporter Type 4 - metabolism | Rats, Wistar | Glutathione - metabolism | Plant Extracts - pharmacology | Antioxidants - metabolism | Cholesterol - blood | Glucose Transporter Type 1 - metabolism | Male | Insulin - blood | Dose-Response Relationship, Drug | Plant Extracts - administration & dosage | Hypoglycemic Agents - administration & dosage | Liver - drug effects | Flavonoids - administration & dosage | Flavonoids - pharmacology | Vernonia - chemistry | Phytotherapy | Diabetes Mellitus, Experimental - metabolism | Phenols - pharmacology | Liver - metabolism | Metformin - pharmacology | Pancreas - drug effects | Pancreas - pathology | Rats | Hypoglycemic Agents - chemistry | Pancreas - metabolism | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Ethnopharmacology | Insulin - metabolism | Animals | Triglycerides - blood | Diabetes Mellitus, Experimental - pathology | Phenols - administration & dosage | Phenols - chemistry | Blood Glucose - metabolism | Flavonoids - chemistry | Glucose metabolism | Glucose | Streptozocin | Dextrose | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2014, Volume 57, Issue 24, pp. 10304 - 10313
Journal Article
PLOS ONE, ISSN 1932-6203, 09/2016, Volume 11, Issue 9, pp. e0162397 - e0162397
Nasturtium (Tropaeolum majus L.) contains high concentrations of benzylglcosinolate. We found that a hydrolysis product of benzyl glucosinolate-the benzyl... 
SIGNAL-TRANSDUCTION PATHWAYS | HEPATIC GLUCONEOGENESIS | OXIDATIVE STRESS | IN-VITRO | TYPE-2 DIABETIC-PATIENTS | HIGH-FAT DIET | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | BLIND CLINICAL-TRIAL | FOXO TRANSCRIPTION FACTORS | BROCCOLI SPROUTS | Glucose-6-Phosphatase - genetics | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Gene Expression - drug effects | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Humans | Protein Transport - drug effects | Diabetes Mellitus, Type 2 - metabolism | Recombinant Fusion Proteins - metabolism | Sirtuin 1 - genetics | Proto-Oncogene Proteins c-akt - genetics | Gene Knockdown Techniques | Thiocyanates - chemistry | Isothiocyanates - chemistry | Thiocyanates - pharmacology | NF-E2-Related Factor 2 - genetics | Isothiocyanates - pharmacology | Cell Line | Cell Survival - drug effects | Forkhead Box Protein O1 - metabolism | Plants, Medicinal - chemistry | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Sirtuin 1 - antagonists & inhibitors | Thioglucosides - pharmacology | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Gluconeogenesis - physiology | Gluconeogenesis - genetics | Active Transport, Cell Nucleus - drug effects | Acetylcysteine - pharmacology | Recombinant Fusion Proteins - genetics | Tropaeolum - chemistry | Diabetes Mellitus, Type 2 - drug therapy | Forkhead Box Protein O1 - antagonists & inhibitors | Forkhead Box Protein O1 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Thioglucosides - chemistry | Type 2 diabetes | Antioxidants | Enzymes | Genes | Fluorescence | DNA binding proteins | Gene expression | Protein kinases | Insulin | Cells | Transcription factors | Vegetables | Liver | AKT protein | Glucose | Phosphatase | Proteins | Signal transduction | Hyperglycemia | Forkhead protein | Biocompatibility | Flowers & plants | Gluconeogenesis | Detoxification | Cultures | Metabolism | Osteosarcoma cells | Nutrition research | Phytochemicals | Endocrinology | Oxidative stress | Phosphorylation | Intracellular signalling | Hepatoma | Kinases | Biomedical materials | FOXO1 protein | Metabolites | Osteosarcoma | Rodents | Cell cycle | Localization | Diabetes mellitus (non-insulin dependent) | Translocation | Diabetes mellitus | Isothiocyanate | NAD | Green fluorescent protein | Insulin resistance | Intracellular | Diabetes | Position (location) | Cytoplasm | Cancer | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0151135 - e0151135
Banana is an extensively cultivated plant worldwide, mainly for its fruit, while its ancillary product, the banana flower is consumed as a vegetable and is... 
GLYCOGEN | ANTIOXIDANT | MULTIDISCIPLINARY SCIENCES | Diabetes Mellitus, Experimental - drug therapy | Rats, Wistar | Plant Extracts - pharmacology | Glycated Hemoglobin A - metabolism | Body Weight - drug effects | Male | Flowers - chemistry | Hyperglycemia - drug therapy | Liver - drug effects | Female | Phytotherapy - methods | Diabetes Mellitus, Experimental - metabolism | Liver - metabolism | Rats | Pentacyclic Triterpenes - pharmacology | Streptozocin - pharmacology | Musa - chemistry | Aspartate Aminotransferases - metabolism | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Blood Glucose - drug effects | Hyperglycemia - metabolism | Umbelliferones - pharmacology | Fructose-Bisphosphatase - metabolism | Insulin - metabolism | Animals | Glucose - metabolism | Glucosephosphate Dehydrogenase - metabolism | Alanine Transaminase - metabolism | Complications and side effects | Oxidative stress | Care and treatment | Physiological aspects | Influence | Research | Diabetes | Banana | Pathogenesis | Liver | Body weight | Lipid peroxidation | Glucose | Dehydrogenase | Antioxidants | Glucose 6 phosphate dehydrogenase | Hyperglycemia | Glucose dehydrogenase | Aspartate transaminase | Carbohydrates | Enzymes | Ethanol | Abnormalities | Metabolism | Insulin | Studies | Alloxan | Urea | Hypercholesterolemia | Weight reduction | Biomarkers | Glucose-6-phosphatase | Phosphates | Alkaline phosphatase | Biotechnology | Laboratories | Lipids | Glucose metabolism | Glucosephosphate dehydrogenase | Polydipsia | Urine | Creatinine | Alanine | Engineering schools | Pyruvate kinase | Secretion | Complications | Diabetes mellitus | Lactate dehydrogenase | Hexokinase | Fructose | L-Lactate dehydrogenase | Solvent extraction processes | Regeneration | Glycolysis | Alanine transaminase | In vivo methods and tests | Index Medicus
Journal Article